Incidental Mutation 'IGL03276:Olfm2'
| ID |
415433 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Olfm2
|
| Ensembl Gene |
ENSMUSG00000032172 |
| Gene Name |
olfactomedin 2 |
| Synonyms |
A030009A06Rik |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.542)
|
| Stock # |
IGL03276
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
9 |
| Chromosomal Location |
20578986-20657645 bp(-) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
A to G
at 20580083 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151018
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000034689]
[ENSMUST00000034692]
[ENSMUST00000215999]
[ENSMUST00000217198]
|
| AlphaFold |
Q8BM13 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000034689
|
| SMART Domains |
Protein: ENSMUSP00000034689
Gene: ENSMUSG00000032171
| Domain | Start | End | E-Value | Type |
|---|
|
WW
|
6 |
39 |
3.57e-14 |
SMART |
|
Pfam:Rotamase_3
|
45 |
165 |
1.6e-23 |
PFAM |
|
Pfam:Rotamase
|
61 |
165 |
1.4e-25 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000034692
|
| SMART Domains |
Protein: ENSMUSP00000034692
Gene: ENSMUSG00000032172
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Noelin-1
|
19 |
118 |
3.8e-44 |
PFAM |
|
Blast:OLF
|
132 |
177 |
2e-18 |
BLAST |
|
OLF
|
190 |
440 |
4.32e-123 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000215039
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000215999
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000217198
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Mice homozygous for a knock-out allele exhibit moderate locomotor and anxiety-related behavioral abnormalities, altered visual evoked potential, and reduced compactness of myelin sheaths in the optic nerve. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 25 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Arhgef25 |
A |
C |
10: 127,021,794 (GRCm39) |
F202V |
possibly damaging |
Het |
| Atrnl1 |
A |
T |
19: 57,641,359 (GRCm39) |
N336Y |
probably damaging |
Het |
| Bicc1 |
T |
C |
10: 70,789,268 (GRCm39) |
D381G |
possibly damaging |
Het |
| Cabin1 |
A |
T |
10: 75,568,247 (GRCm39) |
L912Q |
probably damaging |
Het |
| Fam83e |
A |
G |
7: 45,372,884 (GRCm39) |
D165G |
possibly damaging |
Het |
| Foxn1 |
T |
A |
11: 78,261,950 (GRCm39) |
T140S |
probably benign |
Het |
| Ggt1 |
A |
G |
10: 75,416,331 (GRCm39) |
|
probably benign |
Het |
| Kctd8 |
A |
T |
5: 69,497,929 (GRCm39) |
M239K |
possibly damaging |
Het |
| Kdm4d |
A |
T |
9: 14,375,838 (GRCm39) |
C7S |
probably benign |
Het |
| Kdm5a |
T |
A |
6: 120,379,669 (GRCm39) |
|
probably benign |
Het |
| Klrb1b |
T |
C |
6: 128,792,168 (GRCm39) |
N191S |
probably benign |
Het |
| Krt35 |
C |
T |
11: 99,983,953 (GRCm39) |
S349N |
probably benign |
Het |
| Krt75 |
A |
T |
15: 101,476,811 (GRCm39) |
D359E |
probably damaging |
Het |
| Lipo5 |
T |
C |
19: 33,445,242 (GRCm39) |
D109G |
unknown |
Het |
| Lsm12 |
T |
G |
11: 102,073,770 (GRCm39) |
I58L |
probably benign |
Het |
| Mxd4 |
T |
C |
5: 34,335,088 (GRCm39) |
D99G |
probably benign |
Het |
| Nlrp4a |
T |
A |
7: 26,163,615 (GRCm39) |
N927K |
probably damaging |
Het |
| Pkhd1l1 |
T |
C |
15: 44,457,980 (GRCm39) |
V4103A |
possibly damaging |
Het |
| Slc30a9 |
T |
C |
5: 67,507,260 (GRCm39) |
|
probably benign |
Het |
| Snap91 |
T |
C |
9: 86,707,065 (GRCm39) |
T242A |
possibly damaging |
Het |
| Srp19 |
A |
C |
18: 34,464,843 (GRCm39) |
T28P |
probably damaging |
Het |
| Tenm2 |
C |
T |
11: 35,963,603 (GRCm39) |
V943I |
possibly damaging |
Het |
| Tgfb3 |
T |
C |
12: 86,104,642 (GRCm39) |
E384G |
probably damaging |
Het |
| Tmem39a |
T |
A |
16: 38,405,646 (GRCm39) |
N74K |
probably benign |
Het |
| Tnfrsf11a |
A |
G |
1: 105,749,215 (GRCm39) |
Y211C |
probably damaging |
Het |
|
| Other mutations in Olfm2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02105:Olfm2
|
APN |
9 |
20,583,476 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03352:Olfm2
|
APN |
9 |
20,580,019 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0015:Olfm2
|
UTSW |
9 |
20,580,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0847:Olfm2
|
UTSW |
9 |
20,579,953 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1051:Olfm2
|
UTSW |
9 |
20,579,759 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3730:Olfm2
|
UTSW |
9 |
20,584,063 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5366:Olfm2
|
UTSW |
9 |
20,579,708 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5665:Olfm2
|
UTSW |
9 |
20,579,840 (GRCm39) |
splice site |
probably null |
|
|
R5986:Olfm2
|
UTSW |
9 |
20,586,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6046:Olfm2
|
UTSW |
9 |
20,579,824 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6709:Olfm2
|
UTSW |
9 |
20,584,009 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7020:Olfm2
|
UTSW |
9 |
20,579,864 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7636:Olfm2
|
UTSW |
9 |
20,579,593 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R8341:Olfm2
|
UTSW |
9 |
20,583,918 (GRCm39) |
splice site |
probably null |
|
|
R8782:Olfm2
|
UTSW |
9 |
20,579,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9743:Olfm2
|
UTSW |
9 |
20,579,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Posted On |
2016-08-02 |
Incidental Mutation