Incidental Mutation 'IGL03277:Vmn2r32'
| ID |
415434 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Vmn2r32
|
| Ensembl Gene |
ENSMUSG00000096743 |
| Gene Name |
vomeronasal 2, receptor 32 |
| Synonyms |
V2r5 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.249)
|
| Stock # |
IGL03277
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
7466968-7482972 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 7477251 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Valine
at position 380
(D380V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000092462
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000094866]
|
| AlphaFold |
K7N686 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000094866
AA Change: D380V
PolyPhen 2
Score 0.233 (Sensitivity: 0.91; Specificity: 0.88)
|
| SMART Domains |
Protein: ENSMUSP00000092462
Gene: ENSMUSG00000096743
AA Change: D380V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
73 |
470 |
3.6e-33 |
PFAM |
|
Pfam:NCD3G
|
512 |
565 |
8.1e-21 |
PFAM |
|
Pfam:7tm_3
|
598 |
833 |
9.5e-55 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 37 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Amt |
A |
G |
9: 108,178,418 (GRCm39) |
T342A |
probably benign |
Het |
| Atosa |
G |
A |
9: 74,916,514 (GRCm39) |
R371Q |
probably damaging |
Het |
| B3glct |
T |
C |
5: 149,650,299 (GRCm39) |
L134P |
probably damaging |
Het |
| Bms1 |
A |
T |
6: 118,382,083 (GRCm39) |
M485K |
probably benign |
Het |
| Chd6 |
T |
C |
2: 160,824,981 (GRCm39) |
N1226S |
probably null |
Het |
| Cpne2 |
T |
C |
8: 95,275,000 (GRCm39) |
Y3H |
probably benign |
Het |
| Dmxl2 |
A |
G |
9: 54,311,504 (GRCm39) |
V1739A |
probably damaging |
Het |
| Dnah7a |
T |
A |
1: 53,669,481 (GRCm39) |
T543S |
probably benign |
Het |
| Dock11 |
T |
G |
X: 35,277,603 (GRCm39) |
V1000G |
probably benign |
Het |
| Ednrb |
T |
A |
14: 104,080,735 (GRCm39) |
N60Y |
probably benign |
Het |
| Eif3d |
A |
G |
15: 77,843,849 (GRCm39) |
M499T |
possibly damaging |
Het |
| Elmod1 |
G |
A |
9: 53,833,272 (GRCm39) |
L178F |
probably damaging |
Het |
| Hrh4 |
T |
C |
18: 13,148,940 (GRCm39) |
S101P |
probably damaging |
Het |
| Ift172 |
A |
G |
5: 31,424,642 (GRCm39) |
V684A |
possibly damaging |
Het |
| Mtx2 |
A |
G |
2: 74,698,748 (GRCm39) |
T124A |
probably damaging |
Het |
| Nat3 |
T |
A |
8: 68,000,341 (GRCm39) |
H73Q |
probably benign |
Het |
| Ndst2 |
A |
G |
14: 20,780,234 (GRCm39) |
L2P |
possibly damaging |
Het |
| Nipsnap3a |
G |
T |
4: 52,997,219 (GRCm39) |
A162S |
probably benign |
Het |
| Or2a57 |
T |
G |
6: 43,212,876 (GRCm39) |
C111W |
probably damaging |
Het |
| Or5m5 |
T |
C |
2: 85,814,517 (GRCm39) |
I111T |
probably damaging |
Het |
| Peg3 |
T |
C |
7: 6,714,673 (GRCm39) |
D183G |
probably damaging |
Het |
| Prlr |
A |
G |
15: 10,328,887 (GRCm39) |
E454G |
probably benign |
Het |
| Prom1 |
G |
A |
5: 44,190,313 (GRCm39) |
Q364* |
probably null |
Het |
| Scgb2b7 |
A |
T |
7: 31,404,506 (GRCm39) |
C65S |
probably damaging |
Het |
| Sema5b |
A |
G |
16: 35,471,682 (GRCm39) |
D425G |
probably damaging |
Het |
| Slc16a7 |
A |
T |
10: 125,066,560 (GRCm39) |
C360S |
probably benign |
Het |
| Slc38a7 |
T |
A |
8: 96,575,104 (GRCm39) |
I59F |
probably damaging |
Het |
| Slc5a6 |
A |
G |
5: 31,195,372 (GRCm39) |
C449R |
possibly damaging |
Het |
| Slc9b1 |
T |
C |
3: 135,096,269 (GRCm39) |
Y357H |
possibly damaging |
Het |
| Snx17 |
A |
T |
5: 31,353,084 (GRCm39) |
|
probably benign |
Het |
| Stk32b |
A |
C |
5: 37,786,320 (GRCm39) |
M48R |
probably damaging |
Het |
| Tspan9 |
A |
G |
6: 127,944,038 (GRCm39) |
|
probably null |
Het |
| Tst |
A |
T |
15: 78,289,521 (GRCm39) |
N171K |
probably damaging |
Het |
| Vmn1r180 |
T |
A |
7: 23,652,710 (GRCm39) |
I291N |
probably damaging |
Het |
| Wdfy4 |
T |
C |
14: 32,790,861 (GRCm39) |
T2189A |
probably benign |
Het |
| Zbtb20 |
A |
G |
16: 43,438,800 (GRCm39) |
N640S |
possibly damaging |
Het |
| Zfp142 |
A |
G |
1: 74,610,193 (GRCm39) |
S1098P |
probably damaging |
Het |
|
| Other mutations in Vmn2r32 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02140:Vmn2r32
|
APN |
7 |
7,479,696 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02333:Vmn2r32
|
APN |
7 |
7,467,143 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02406:Vmn2r32
|
APN |
7 |
7,479,709 (GRCm39) |
missense |
probably benign |
|
|
IGL02428:Vmn2r32
|
APN |
7 |
7,477,283 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL02484:Vmn2r32
|
APN |
7 |
7,467,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03366:Vmn2r32
|
APN |
7 |
7,467,029 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1055:Vmn2r32
|
UTSW |
7 |
7,477,326 (GRCm39) |
nonsense |
probably null |
|
|
R1695:Vmn2r32
|
UTSW |
7 |
7,466,991 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2172:Vmn2r32
|
UTSW |
7 |
7,477,614 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2262:Vmn2r32
|
UTSW |
7 |
7,477,618 (GRCm39) |
missense |
probably benign |
|
|
R3150:Vmn2r32
|
UTSW |
7 |
7,475,554 (GRCm39) |
missense |
probably benign |
|
|
R4362:Vmn2r32
|
UTSW |
7 |
7,482,857 (GRCm39) |
nonsense |
probably null |
|
|
R4432:Vmn2r32
|
UTSW |
7 |
7,482,918 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4851:Vmn2r32
|
UTSW |
7 |
7,482,953 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
R4949:Vmn2r32
|
UTSW |
7 |
7,467,083 (GRCm39) |
missense |
probably benign |
0.22 |
|
R5990:Vmn2r32
|
UTSW |
7 |
7,482,809 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6083:Vmn2r32
|
UTSW |
7 |
7,467,209 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6084:Vmn2r32
|
UTSW |
7 |
7,467,209 (GRCm39) |
missense |
probably benign |
0.15 |
|
R6116:Vmn2r32
|
UTSW |
7 |
7,467,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6263:Vmn2r32
|
UTSW |
7 |
7,479,691 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R6889:Vmn2r32
|
UTSW |
7 |
7,475,573 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7286:Vmn2r32
|
UTSW |
7 |
7,482,807 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7390:Vmn2r32
|
UTSW |
7 |
7,482,851 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7412:Vmn2r32
|
UTSW |
7 |
7,477,212 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7508:Vmn2r32
|
UTSW |
7 |
7,470,373 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8812:Vmn2r32
|
UTSW |
7 |
7,477,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8968:Vmn2r32
|
UTSW |
7 |
7,477,204 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9331:Vmn2r32
|
UTSW |
7 |
7,467,402 (GRCm39) |
nonsense |
probably null |
|
|
R9358:Vmn2r32
|
UTSW |
7 |
7,477,197 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Vmn2r32
|
UTSW |
7 |
7,477,160 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Posted On |
2016-08-02 |
Incidental Mutation