Incidental Mutation 'IGL03279:Pglyrp3'
ID 415518
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Pglyrp3
Ensembl Gene ENSMUSG00000042244
Gene Name peptidoglycan recognition protein 3
Synonyms LOC242100
Accession Numbers
Essential gene? Probably non essential (E-score: 0.078) question?
Stock # IGL03279
Quality Score
Status
Chromosome 3
Chromosomal Location 91921890-91938889 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 91933834 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 160 (Y160H)
Ref Sequence ENSEMBL: ENSMUSP00000035737 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000047660]
AlphaFold A1A547
Predicted Effect probably damaging
Transcript: ENSMUST00000047660
AA Change: Y160H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000035737
Gene: ENSMUSG00000042244
AA Change: Y160H

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
PGRP 28 169 2.64e-45 SMART
Ami_2 39 169 1.06e-2 SMART
PGRP 185 326 3.23e-72 SMART
Ami_2 195 332 1.75e-17 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000118636
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria. [provided by RefSeq, Oct 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aatk T A 11: 119,904,504 (GRCm39) D224V probably damaging Het
Abca4 C A 3: 121,935,381 (GRCm39) N1526K probably benign Het
Aif1 T A 17: 35,390,523 (GRCm39) K76* probably null Het
Arap2 A G 5: 62,779,253 (GRCm39) S1446P probably damaging Het
Cyb5rl A T 4: 106,941,325 (GRCm39) E250V possibly damaging Het
Dock3 T C 9: 106,788,447 (GRCm39) probably benign Het
Dppa2 A G 16: 48,132,028 (GRCm39) T42A possibly damaging Het
Drosha C T 15: 12,859,478 (GRCm39) P562L probably benign Het
Egfl7 C A 2: 26,480,719 (GRCm39) H126N probably benign Het
Gm5852 T C 3: 93,634,584 (GRCm39) noncoding transcript Het
Gpr161 T C 1: 165,138,098 (GRCm39) F228S probably damaging Het
Grid1 T A 14: 34,667,722 (GRCm39) M83K probably damaging Het
Gsdma2 T C 11: 98,548,549 (GRCm39) S434P unknown Het
Hao2 T A 3: 98,787,712 (GRCm39) N239I possibly damaging Het
Hsd17b14 A T 7: 45,215,617 (GRCm39) I206F possibly damaging Het
Kansl1l A T 1: 66,774,825 (GRCm39) V667E probably damaging Het
Kdm3a T C 6: 71,588,659 (GRCm39) D450G probably benign Het
Lmo7 C A 14: 102,137,944 (GRCm39) A882E probably benign Het
P4ha3 A G 7: 99,949,893 (GRCm39) Y254C probably damaging Het
Pcdh15 A G 10: 74,152,904 (GRCm39) Y408C probably damaging Het
Pnma5 G A X: 72,079,605 (GRCm39) T359I probably benign Het
Ptbp3 A T 4: 59,476,937 (GRCm39) H440Q possibly damaging Het
Rbx1 A G 15: 81,352,399 (GRCm39) N41S probably damaging Het
Rpl3 G A 15: 79,962,560 (GRCm39) T340I probably benign Het
Scrn1 G A 6: 54,525,322 (GRCm39) R16* probably null Het
Sema6a A T 18: 47,433,157 (GRCm39) C91* probably null Het
Slco6d1 T A 1: 98,394,405 (GRCm39) V363E probably damaging Het
Stk38 A G 17: 29,203,179 (GRCm39) probably benign Het
Tanc2 G A 11: 105,803,918 (GRCm39) probably null Het
Thada A G 17: 84,742,988 (GRCm39) F812S probably benign Het
Tubb4b-ps1 A G 5: 7,229,630 (GRCm39) probably benign Het
Veph1 T C 3: 66,162,443 (GRCm39) T72A probably damaging Het
Vps52 T A 17: 34,176,848 (GRCm39) D67E probably damaging Het
Other mutations in Pglyrp3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00335:Pglyrp3 APN 3 91,929,986 (GRCm39) missense probably damaging 0.96
IGL00769:Pglyrp3 APN 3 91,921,929 (GRCm39) utr 5 prime probably benign
IGL02491:Pglyrp3 APN 3 91,921,944 (GRCm39) missense possibly damaging 0.77
R0056:Pglyrp3 UTSW 3 91,933,111 (GRCm39) splice site probably benign
R1128:Pglyrp3 UTSW 3 91,935,479 (GRCm39) missense probably benign 0.22
R2097:Pglyrp3 UTSW 3 91,935,478 (GRCm39) missense possibly damaging 0.91
R2140:Pglyrp3 UTSW 3 91,933,874 (GRCm39) missense probably benign 0.00
R3697:Pglyrp3 UTSW 3 91,935,481 (GRCm39) missense probably damaging 1.00
R4369:Pglyrp3 UTSW 3 91,935,386 (GRCm39) missense probably damaging 1.00
R4430:Pglyrp3 UTSW 3 91,938,798 (GRCm39) missense probably damaging 1.00
R4775:Pglyrp3 UTSW 3 91,933,037 (GRCm39) missense possibly damaging 0.64
R6020:Pglyrp3 UTSW 3 91,938,841 (GRCm39) missense probably damaging 1.00
R7352:Pglyrp3 UTSW 3 91,921,947 (GRCm39) nonsense probably null
R7437:Pglyrp3 UTSW 3 91,937,985 (GRCm39) missense probably benign 0.00
R8150:Pglyrp3 UTSW 3 91,933,790 (GRCm39) missense probably benign 0.00
R8466:Pglyrp3 UTSW 3 91,921,941 (GRCm39) missense probably benign 0.16
R8695:Pglyrp3 UTSW 3 91,933,762 (GRCm39) missense probably null 1.00
R9413:Pglyrp3 UTSW 3 91,930,106 (GRCm39) missense probably damaging 1.00
R9479:Pglyrp3 UTSW 3 91,935,310 (GRCm39) missense probably benign 0.04
R9592:Pglyrp3 UTSW 3 91,938,859 (GRCm39) missense probably benign 0.22
R9722:Pglyrp3 UTSW 3 91,938,695 (GRCm39) missense possibly damaging 0.67
Z1176:Pglyrp3 UTSW 3 91,935,392 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02