Incidental Mutation 'IGL03280:Try10'
ID 415558
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Try10
Ensembl Gene ENSMUSG00000071521
Gene Name trypsin 10
Synonyms trypsinogen 10
Accession Numbers
Essential gene? Probably non essential (E-score: 0.073) question?
Stock # IGL03280
Quality Score
Status
Chromosome 6
Chromosomal Location 41331039-41334848 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 41331154 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 10 (V10E)
Ref Sequence ENSEMBL: ENSMUSP00000071976 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072103]
AlphaFold Q792Z1
Predicted Effect probably benign
Transcript: ENSMUST00000072103
AA Change: V10E

PolyPhen 2 Score 0.178 (Sensitivity: 0.92; Specificity: 0.87)
SMART Domains Protein: ENSMUSP00000071976
Gene: ENSMUSG00000071521
AA Change: V10E

DomainStartEndE-ValueType
low complexity region 4 16 N/A INTRINSIC
Tryp_SPc 23 239 3.38e-104 SMART
Meta Mutation Damage Score 0.0649 question?
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 36 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Asb4 T C 6: 5,423,416 (GRCm39) S188P probably benign Het
Bbs5 A G 2: 69,497,315 (GRCm39) probably benign Het
Cdh13 G T 8: 120,040,873 (GRCm39) G693W probably damaging Het
Cdh20 T A 1: 110,036,498 (GRCm39) Y559* probably null Het
Cemip G A 7: 83,636,538 (GRCm39) probably benign Het
Crem A G 18: 3,273,415 (GRCm39) probably benign Het
Crygf A G 1: 65,967,329 (GRCm39) Y151C probably damaging Het
Dcp1b T C 6: 119,157,019 (GRCm39) probably benign Het
Fanca A G 8: 124,043,198 (GRCm39) probably benign Het
Fkbp15 A C 4: 62,221,504 (GRCm39) probably benign Het
Gabrp C T 11: 33,502,616 (GRCm39) R416Q probably benign Het
Iho1 T C 9: 108,282,099 (GRCm39) S530G possibly damaging Het
Impg2 T A 16: 56,088,631 (GRCm39) Y1052* probably null Het
Isg15 T C 4: 156,284,319 (GRCm39) M70V probably benign Het
Krit1 T A 5: 3,861,248 (GRCm39) probably benign Het
Lrrn3 T C 12: 41,504,146 (GRCm39) D57G probably damaging Het
Macrod1 A G 19: 7,174,937 (GRCm39) E309G possibly damaging Het
Notch1 A T 2: 26,367,886 (GRCm39) probably benign Het
Nptx1 T C 11: 119,435,555 (GRCm39) T254A probably damaging Het
Or12e9 A T 2: 87,202,467 (GRCm39) D197V probably damaging Het
Pigm A G 1: 172,204,420 (GRCm39) Y52C probably damaging Het
Pramel27 A T 4: 143,578,489 (GRCm39) T250S possibly damaging Het
Rif1 A G 2: 52,002,611 (GRCm39) T2022A probably benign Het
Rint1 T A 5: 24,022,076 (GRCm39) L646Q probably damaging Het
Rpe65 A T 3: 159,309,978 (GRCm39) I84F probably damaging Het
Scgb2b7 A T 7: 31,404,506 (GRCm39) C65S probably damaging Het
Scnn1a T C 6: 125,319,744 (GRCm39) probably benign Het
Selenop T C 15: 3,310,104 (GRCm39) probably benign Het
Siglecf T G 7: 43,005,354 (GRCm39) V438G probably benign Het
St8sia4 T A 1: 95,581,499 (GRCm39) probably benign Het
Tfeb T C 17: 48,096,862 (GRCm39) F43S probably benign Het
Tgm6 A G 2: 129,980,851 (GRCm39) Y216C probably damaging Het
Ttn A T 2: 76,728,811 (GRCm39) C1234* probably null Het
Ugt2a3 G A 5: 87,484,439 (GRCm39) P195L probably damaging Het
Usp24 T G 4: 106,237,627 (GRCm39) I1095R probably damaging Het
Usp34 C T 11: 23,304,897 (GRCm39) H377Y probably damaging Het
Other mutations in Try10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02001:Try10 APN 6 41,333,523 (GRCm39) missense probably benign 0.00
IGL02608:Try10 APN 6 41,332,421 (GRCm39) missense probably damaging 1.00
R0332:Try10 UTSW 6 41,331,154 (GRCm39) missense probably benign 0.18
R1628:Try10 UTSW 6 41,334,390 (GRCm39) missense probably damaging 1.00
R2149:Try10 UTSW 6 41,333,495 (GRCm39) missense probably benign 0.02
R2471:Try10 UTSW 6 41,333,680 (GRCm39) missense probably damaging 1.00
R3764:Try10 UTSW 6 41,333,458 (GRCm39) missense probably benign 0.07
R4008:Try10 UTSW 6 41,333,608 (GRCm39) missense probably benign 0.00
R4660:Try10 UTSW 6 41,334,761 (GRCm39) missense probably damaging 1.00
R4792:Try10 UTSW 6 41,332,386 (GRCm39) missense probably benign 0.33
R5185:Try10 UTSW 6 41,333,483 (GRCm39) missense probably damaging 0.96
R6103:Try10 UTSW 6 41,333,484 (GRCm39) missense probably damaging 0.98
R6301:Try10 UTSW 6 41,332,523 (GRCm39) missense probably benign 0.30
R6692:Try10 UTSW 6 41,334,755 (GRCm39) missense probably damaging 1.00
R7786:Try10 UTSW 6 41,332,463 (GRCm39) missense possibly damaging 0.86
R8391:Try10 UTSW 6 41,334,306 (GRCm39) missense probably damaging 1.00
R9309:Try10 UTSW 6 41,333,559 (GRCm39) missense probably benign
R9636:Try10 UTSW 6 41,332,505 (GRCm39) missense probably benign 0.00
R9697:Try10 UTSW 6 41,331,041 (GRCm39) start gained probably benign
Posted On 2016-08-02