Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03280:Crygf'

415565

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Crygf

Ensembl Gene

ENSMUSG00000025945

Gene Name

crystallin, gamma F

Synonyms

Len-2, DGcry-2, Cryg-2, 3110001K11Rik

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.448) question?

Stock #

IGL03280

Quality Score

Status

Chromosome

Chromosomal Location

65965679-65967466 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 65967329 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 151 (Y151C)

Ref Sequence

ENSEMBL: ENSMUSP00000027082 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027082] [ENSMUST00000114027]

AlphaFold

Q9CXV3

Predicted Effect

probably damaging
Transcript: ENSMUST00000027082
AA Change: Y151C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000027082
Gene: ENSMUSG00000025945
AA Change: Y151C

Domain	Start	End	E-Value	Type
XTALbg	3	82	1.11e-43	SMART
XTALbg	89	170	2.19e-47	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000114027

SMART Domains

Protein: ENSMUSP00000109661
Gene: ENSMUSG00000025945

Domain	Start	End	E-Value	Type
XTALbg	3	82	1.11e-43	SMART
low complexity region	104	113	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a chemically-induced single point mutation exhibit homogeneous cataracts while heterozygotes display less severe rays and concentric circles of lens opacity. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Asb4	T	C	6: 5,423,416 (GRCm39)	S188P	probably benign	Het
Bbs5	A	G	2: 69,497,315 (GRCm39)		probably benign	Het
Cdh13	G	T	8: 120,040,873 (GRCm39)	G693W	probably damaging	Het
Cdh20	T	A	1: 110,036,498 (GRCm39)	Y559*	probably null	Het
Cemip	G	A	7: 83,636,538 (GRCm39)		probably benign	Het
Crem	A	G	18: 3,273,415 (GRCm39)		probably benign	Het
Dcp1b	T	C	6: 119,157,019 (GRCm39)		probably benign	Het
Fanca	A	G	8: 124,043,198 (GRCm39)		probably benign	Het
Fkbp15	A	C	4: 62,221,504 (GRCm39)		probably benign	Het
Gabrp	C	T	11: 33,502,616 (GRCm39)	R416Q	probably benign	Het
Iho1	T	C	9: 108,282,099 (GRCm39)	S530G	possibly damaging	Het
Impg2	T	A	16: 56,088,631 (GRCm39)	Y1052*	probably null	Het
Isg15	T	C	4: 156,284,319 (GRCm39)	M70V	probably benign	Het
Krit1	T	A	5: 3,861,248 (GRCm39)		probably benign	Het
Lrrn3	T	C	12: 41,504,146 (GRCm39)	D57G	probably damaging	Het
Macrod1	A	G	19: 7,174,937 (GRCm39)	E309G	possibly damaging	Het
Notch1	A	T	2: 26,367,886 (GRCm39)		probably benign	Het
Nptx1	T	C	11: 119,435,555 (GRCm39)	T254A	probably damaging	Het
Or12e9	A	T	2: 87,202,467 (GRCm39)	D197V	probably damaging	Het
Pigm	A	G	1: 172,204,420 (GRCm39)	Y52C	probably damaging	Het
Pramel27	A	T	4: 143,578,489 (GRCm39)	T250S	possibly damaging	Het
Rif1	A	G	2: 52,002,611 (GRCm39)	T2022A	probably benign	Het
Rint1	T	A	5: 24,022,076 (GRCm39)	L646Q	probably damaging	Het
Rpe65	A	T	3: 159,309,978 (GRCm39)	I84F	probably damaging	Het
Scgb2b7	A	T	7: 31,404,506 (GRCm39)	C65S	probably damaging	Het
Scnn1a	T	C	6: 125,319,744 (GRCm39)		probably benign	Het
Selenop	T	C	15: 3,310,104 (GRCm39)		probably benign	Het
Siglecf	T	G	7: 43,005,354 (GRCm39)	V438G	probably benign	Het
St8sia4	T	A	1: 95,581,499 (GRCm39)		probably benign	Het
Tfeb	T	C	17: 48,096,862 (GRCm39)	F43S	probably benign	Het
Tgm6	A	G	2: 129,980,851 (GRCm39)	Y216C	probably damaging	Het
Try10	T	A	6: 41,331,154 (GRCm39)	V10E	probably benign	Het
Ttn	A	T	2: 76,728,811 (GRCm39)	C1234*	probably null	Het
Ugt2a3	G	A	5: 87,484,439 (GRCm39)	P195L	probably damaging	Het
Usp24	T	G	4: 106,237,627 (GRCm39)	I1095R	probably damaging	Het
Usp34	C	T	11: 23,304,897 (GRCm39)	H377Y	probably damaging	Het

Other mutations in Crygf

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0632:Crygf	UTSW	1	65,967,156 (GRCm39)	nonsense	probably null
R1514:Crygf	UTSW	1	65,967,197 (GRCm39)	missense	possibly damaging	0.53
R2312:Crygf	UTSW	1	65,965,717 (GRCm39)	start codon destroyed	probably benign	0.00
R6541:Crygf	UTSW	1	65,967,224 (GRCm39)	missense	probably damaging	0.99
R7018:Crygf	UTSW	1	65,967,130 (GRCm39)	missense	probably benign	0.00
R8803:Crygf	UTSW	1	65,967,148 (GRCm39)	missense	probably damaging	0.99
X0023:Crygf	UTSW	1	65,965,924 (GRCm39)	missense	probably damaging	0.99

Posted On

2016-08-02