Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03285:Lrrc37a'

415678

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lrrc37a

Ensembl Gene

ENSMUSG00000078632

Gene Name

leucine rich repeat containing 37A

Synonyms

LOC237954

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.110) question?

Stock #

IGL03285

Quality Score

Status

Chromosome

Chromosomal Location

103341535-103395423 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 103388499 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Lysine at position 2309 (E2309K)

Ref Sequence

ENSEMBL: ENSMUSP00000121903 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000153273]

AlphaFold

no structure available at present

Predicted Effect

unknown
Transcript: ENSMUST00000153273
AA Change: E2309K

SMART Domains

Protein: ENSMUSP00000121903
Gene: ENSMUSG00000078632
AA Change: E2309K

Domain	Start	End	E-Value	Type
Pfam:LRRC37	199	269	2.6e-15	PFAM
low complexity region	313	329	N/A	INTRINSIC
Pfam:LRRC37	363	432	4e-18	PFAM
low complexity region	457	467	N/A	INTRINSIC
low complexity region	480	492	N/A	INTRINSIC
Pfam:LRRC37	550	619	2.1e-21	PFAM
Pfam:LRRC37	637	704	2.9e-12	PFAM
Pfam:LRRC37	780	851	2.5e-12	PFAM
Pfam:LRRC37	1078	1148	2.7e-18	PFAM
Pfam:LRRC37	1149	1190	2.1e-7	PFAM
Pfam:LRRC37	1187	1258	2.5e-25	PFAM
Pfam:LRRC37	1255	1300	2.6e-7	PFAM
Pfam:LRRC37	1299	1370	2.4e-27	PFAM
Pfam:LRRC37	1369	1420	2.9e-8	PFAM
Pfam:LRRC37	1419	1488	1.3e-24	PFAM
Pfam:LRRC37	1509	1578	9.2e-21	PFAM
Pfam:LRRC37	1575	1620	1.7e-6	PFAM
Pfam:LRRC37	1619	1686	1.7e-20	PFAM
Pfam:LRRC37	1690	1736	7e-10	PFAM
Pfam:LRRC37	1733	1799	7.5e-17	PFAM
Pfam:LRRC37	1789	1854	5.1e-12	PFAM
Pfam:LRRC37	1850	1921	4.2e-21	PFAM
Pfam:LRRC37	1915	1969	1.1e-9	PFAM
low complexity region	2143	2167	N/A	INTRINSIC
low complexity region	2185	2209	N/A	INTRINSIC
low complexity region	2228	2249	N/A	INTRINSIC
low complexity region	2262	2274	N/A	INTRINSIC
low complexity region	2284	2297	N/A	INTRINSIC
LRR	2419	2438	3.09e1	SMART
LRR	2439	2462	9.96e-1	SMART
LRR	2463	2486	8.24e0	SMART
LRR	2490	2514	3.18e1	SMART
low complexity region	2535	2547	N/A	INTRINSIC
coiled coil region	2712	2735	N/A	INTRINSIC
low complexity region	2861	2871	N/A	INTRINSIC
low complexity region	2937	2950	N/A	INTRINSIC
Pfam:LRRC37AB_C	3063	3209	1.1e-77	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 24 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ank2	C	A	3: 126,749,519 (GRCm39)	E503D	probably damaging	Het
Atp7a	A	T	X: 105,153,381 (GRCm39)	E1094D	probably benign	Het
Carf	A	G	1: 60,185,313 (GRCm39)	T453A	probably damaging	Het
Catsperg1	T	C	7: 28,897,597 (GRCm39)	N229S	possibly damaging	Het
Ctdspl2	T	C	2: 121,817,480 (GRCm39)	Y176H	probably damaging	Het
Dnah7b	A	T	1: 46,221,535 (GRCm39)	N1213I	probably benign	Het
Fgfr3	G	A	5: 33,892,557 (GRCm39)	R726H	probably damaging	Het
Garre1	T	C	7: 33,984,416 (GRCm39)	H69R	possibly damaging	Het
Gm1527	A	T	3: 28,974,566 (GRCm39)	I460F	probably damaging	Het
Gm382	T	C	X: 125,969,318 (GRCm39)	I501T	possibly damaging	Het
Igfl3	T	C	7: 17,914,172 (GRCm39)		probably benign	Het
Igkv2-109	T	C	6: 68,279,902 (GRCm39)	I41T	probably damaging	Het
Itga4	A	C	2: 79,109,510 (GRCm39)	K236N	possibly damaging	Het
Kcnj1	A	T	9: 32,308,157 (GRCm39)	T174S	possibly damaging	Het
Kif17	A	G	4: 137,996,301 (GRCm39)	T93A	probably damaging	Het
Lamc1	G	T	1: 153,103,431 (GRCm39)	N1378K	possibly damaging	Het
Ldlrad2	T	C	4: 137,300,955 (GRCm39)	M28V	probably benign	Het
Met	T	C	6: 17,553,336 (GRCm39)	S1041P	probably damaging	Het
Nscme3l	A	G	19: 5,553,205 (GRCm39)	L192P	probably damaging	Het
Rimbp3	T	C	16: 17,031,096 (GRCm39)	S1507P	probably benign	Het
Slc7a2	A	G	8: 41,368,030 (GRCm39)	D598G	possibly damaging	Het
Tdo2	A	G	3: 81,866,096 (GRCm39)		probably null	Het
Ugt2b37	T	C	5: 87,388,734 (GRCm39)	D493G	probably damaging	Het
Vps50	G	A	6: 3,555,011 (GRCm39)	V395I	possibly damaging	Het

Other mutations in Lrrc37a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00518:Lrrc37a	APN	11	103,391,177 (GRCm39)	missense	probably benign	0.09
IGL01339:Lrrc37a	APN	11	103,388,763 (GRCm39)	missense	unknown
IGL01352:Lrrc37a	APN	11	103,390,181 (GRCm39)	missense	probably benign	0.39
IGL01382:Lrrc37a	APN	11	103,389,581 (GRCm39)	missense	probably damaging	0.99
IGL01395:Lrrc37a	APN	11	103,394,687 (GRCm39)	missense	probably benign	0.24
IGL01645:Lrrc37a	APN	11	103,395,090 (GRCm39)	missense	probably benign	0.01
IGL01925:Lrrc37a	APN	11	103,389,245 (GRCm39)	missense	probably benign	0.01
IGL02006:Lrrc37a	APN	11	103,347,317 (GRCm39)	missense	probably damaging	1.00
IGL02127:Lrrc37a	APN	11	103,395,365 (GRCm39)	missense	probably benign	0.01
IGL02184:Lrrc37a	APN	11	103,388,435 (GRCm39)	missense	unknown
IGL02218:Lrrc37a	APN	11	103,391,207 (GRCm39)	missense	probably benign	0.03
IGL02436:Lrrc37a	APN	11	103,389,003 (GRCm39)	missense	unknown
IGL02487:Lrrc37a	APN	11	103,386,863 (GRCm39)	missense	unknown
IGL02597:Lrrc37a	APN	11	103,395,113 (GRCm39)	missense	probably benign	0.01
IGL02634:Lrrc37a	APN	11	103,389,938 (GRCm39)	missense	probably benign	0.09
IGL02818:Lrrc37a	APN	11	103,392,132 (GRCm39)	missense	possibly damaging	0.47
IGL02829:Lrrc37a	APN	11	103,382,000 (GRCm39)	missense	unknown
IGL02987:Lrrc37a	APN	11	103,391,239 (GRCm39)	missense	probably benign	0.03
IGL03081:Lrrc37a	APN	11	103,347,421 (GRCm39)	missense	unknown
IGL03210:Lrrc37a	APN	11	103,390,331 (GRCm39)	missense	probably benign	0.29
IGL03239:Lrrc37a	APN	11	103,390,233 (GRCm39)	missense	probably benign	0.03
IGL03296:Lrrc37a	APN	11	103,388,499 (GRCm39)	missense	unknown
IGL03299:Lrrc37a	APN	11	103,388,499 (GRCm39)	missense	unknown
IGL03370:Lrrc37a	APN	11	103,388,499 (GRCm39)	missense	unknown
IGL03390:Lrrc37a	APN	11	103,386,857 (GRCm39)	missense	unknown
Lark	UTSW	11	103,355,180 (GRCm39)	critical splice donor site	probably null
Longspur	UTSW	11	103,393,140 (GRCm39)	missense	probably benign	0.42
F5770:Lrrc37a	UTSW	11	103,346,338 (GRCm39)	missense	possibly damaging	0.95
P0035:Lrrc37a	UTSW	11	103,393,958 (GRCm39)	missense	possibly damaging	0.84
PIT4458001:Lrrc37a	UTSW	11	103,395,338 (GRCm39)	missense	probably benign	0.04
R0112:Lrrc37a	UTSW	11	103,391,739 (GRCm39)	missense	probably benign	0.19
R0194:Lrrc37a	UTSW	11	103,390,616 (GRCm39)	missense	possibly damaging	0.82
R0360:Lrrc37a	UTSW	11	103,391,466 (GRCm39)	missense	possibly damaging	0.89
R0364:Lrrc37a	UTSW	11	103,391,466 (GRCm39)	missense	possibly damaging	0.89
R0395:Lrrc37a	UTSW	11	103,355,221 (GRCm39)	missense	unknown
R0418:Lrrc37a	UTSW	11	103,394,264 (GRCm39)	missense	probably benign	0.03
R0505:Lrrc37a	UTSW	11	103,393,851 (GRCm39)	missense	probably benign	0.10
R0583:Lrrc37a	UTSW	11	103,389,263 (GRCm39)	missense	probably benign	0.01
R1078:Lrrc37a	UTSW	11	103,388,457 (GRCm39)	missense	unknown
R1581:Lrrc37a	UTSW	11	103,347,843 (GRCm39)	nonsense	probably null
R1888:Lrrc37a	UTSW	11	103,389,587 (GRCm39)	missense	probably benign	0.18
R1888:Lrrc37a	UTSW	11	103,389,587 (GRCm39)	missense	probably benign	0.18
R1907:Lrrc37a	UTSW	11	103,347,982 (GRCm39)	missense	unknown
R1982:Lrrc37a	UTSW	11	103,389,792 (GRCm39)	missense	probably benign	0.20
R1991:Lrrc37a	UTSW	11	103,391,087 (GRCm39)	missense	probably benign	0.29
R2017:Lrrc37a	UTSW	11	103,391,951 (GRCm39)	missense	probably benign	0.03
R2103:Lrrc37a	UTSW	11	103,391,087 (GRCm39)	missense	probably benign	0.29
R2110:Lrrc37a	UTSW	11	103,388,648 (GRCm39)	missense	unknown
R2190:Lrrc37a	UTSW	11	103,390,869 (GRCm39)	missense	possibly damaging	0.82
R2252:Lrrc37a	UTSW	11	103,392,293 (GRCm39)	missense	probably benign	0.01
R2253:Lrrc37a	UTSW	11	103,392,293 (GRCm39)	missense	probably benign	0.01
R2894:Lrrc37a	UTSW	11	103,388,690 (GRCm39)	missense	unknown
R2899:Lrrc37a	UTSW	11	103,388,690 (GRCm39)	missense	unknown
R3439:Lrrc37a	UTSW	11	103,388,690 (GRCm39)	missense	unknown
R3899:Lrrc37a	UTSW	11	103,388,372 (GRCm39)	missense	unknown
R3916:Lrrc37a	UTSW	11	103,346,344 (GRCm39)	missense	possibly damaging	0.83
R3921:Lrrc37a	UTSW	11	103,392,296 (GRCm39)	missense	probably benign	0.10
R3977:Lrrc37a	UTSW	11	103,348,430 (GRCm39)	missense	unknown
R4043:Lrrc37a	UTSW	11	103,389,479 (GRCm39)	missense	possibly damaging	0.95
R4077:Lrrc37a	UTSW	11	103,388,808 (GRCm39)	missense	unknown
R4237:Lrrc37a	UTSW	11	103,393,115 (GRCm39)	missense	probably damaging	0.97
R4461:Lrrc37a	UTSW	11	103,355,180 (GRCm39)	critical splice donor site	probably null
R4498:Lrrc37a	UTSW	11	103,392,624 (GRCm39)	missense	probably benign	0.20
R4593:Lrrc37a	UTSW	11	103,389,795 (GRCm39)	missense	possibly damaging	0.64
R4670:Lrrc37a	UTSW	11	103,395,363 (GRCm39)	missense	probably benign	0.10
R4698:Lrrc37a	UTSW	11	103,394,930 (GRCm39)	missense	possibly damaging	0.83
R4750:Lrrc37a	UTSW	11	103,346,306 (GRCm39)	missense	probably benign	0.24
R4805:Lrrc37a	UTSW	11	103,395,135 (GRCm39)	missense	probably benign	0.01
R4940:Lrrc37a	UTSW	11	103,388,438 (GRCm39)	missense	unknown
R4983:Lrrc37a	UTSW	11	103,388,444 (GRCm39)	missense	unknown
R4989:Lrrc37a	UTSW	11	103,347,565 (GRCm39)	missense	unknown
R5046:Lrrc37a	UTSW	11	103,389,066 (GRCm39)	missense	unknown
R5217:Lrrc37a	UTSW	11	103,347,780 (GRCm39)	missense	unknown
R5300:Lrrc37a	UTSW	11	103,347,784 (GRCm39)	missense	unknown
R5509:Lrrc37a	UTSW	11	103,391,361 (GRCm39)	missense	probably benign	0.23
R5550:Lrrc37a	UTSW	11	103,389,003 (GRCm39)	missense	unknown
R5655:Lrrc37a	UTSW	11	103,389,381 (GRCm39)	missense	probably benign	0.28
R5668:Lrrc37a	UTSW	11	103,391,001 (GRCm39)	missense	probably benign	0.03
R5750:Lrrc37a	UTSW	11	103,348,923 (GRCm39)	missense	unknown
R5815:Lrrc37a	UTSW	11	103,394,612 (GRCm39)	missense	probably benign	0.01
R5976:Lrrc37a	UTSW	11	103,389,897 (GRCm39)	missense	possibly damaging	0.73
R5990:Lrrc37a	UTSW	11	103,391,784 (GRCm39)	missense	probably benign	0.19
R6004:Lrrc37a	UTSW	11	103,393,362 (GRCm39)	missense	possibly damaging	0.56
R6019:Lrrc37a	UTSW	11	103,347,422 (GRCm39)	missense	unknown
R6056:Lrrc37a	UTSW	11	103,388,484 (GRCm39)	missense	unknown
R6125:Lrrc37a	UTSW	11	103,392,386 (GRCm39)	missense	probably benign	0.19
R6190:Lrrc37a	UTSW	11	103,392,042 (GRCm39)	missense	possibly damaging	0.67
R6295:Lrrc37a	UTSW	11	103,388,459 (GRCm39)	missense	unknown
R6320:Lrrc37a	UTSW	11	103,394,877 (GRCm39)	missense	probably benign	0.10
R6354:Lrrc37a	UTSW	11	103,355,213 (GRCm39)	missense	unknown
R6375:Lrrc37a	UTSW	11	103,391,915 (GRCm39)	missense	probably benign	0.19
R6406:Lrrc37a	UTSW	11	103,388,361 (GRCm39)	missense	unknown
R6468:Lrrc37a	UTSW	11	103,351,666 (GRCm39)	missense	unknown
R6490:Lrrc37a	UTSW	11	103,347,486 (GRCm39)	missense	unknown
R6502:Lrrc37a	UTSW	11	103,383,005 (GRCm39)	missense	unknown
R6509:Lrrc37a	UTSW	11	103,395,240 (GRCm39)	missense	probably benign	0.04
R6749:Lrrc37a	UTSW	11	103,392,923 (GRCm39)	missense	probably benign	0.29
R6768:Lrrc37a	UTSW	11	103,390,949 (GRCm39)	missense	probably benign	0.36
R6912:Lrrc37a	UTSW	11	103,348,369 (GRCm39)	missense	unknown
R7081:Lrrc37a	UTSW	11	103,348,781 (GRCm39)	missense	unknown
R7083:Lrrc37a	UTSW	11	103,394,166 (GRCm39)	missense	probably benign	0.03
R7154:Lrrc37a	UTSW	11	103,393,682 (GRCm39)	missense	probably benign	0.03
R7195:Lrrc37a	UTSW	11	103,348,601 (GRCm39)	missense	unknown
R7265:Lrrc37a	UTSW	11	103,389,767 (GRCm39)	missense	probably benign	0.09
R7276:Lrrc37a	UTSW	11	103,347,572 (GRCm39)	missense	unknown
R7362:Lrrc37a	UTSW	11	103,348,335 (GRCm39)	missense	unknown
R7450:Lrrc37a	UTSW	11	103,389,152 (GRCm39)	missense	probably benign	0.01
R7458:Lrrc37a	UTSW	11	103,388,258 (GRCm39)	missense	unknown
R7487:Lrrc37a	UTSW	11	103,389,045 (GRCm39)	missense	unknown
R7535:Lrrc37a	UTSW	11	103,392,683 (GRCm39)	missense	possibly damaging	0.68
R7593:Lrrc37a	UTSW	11	103,391,778 (GRCm39)	missense	probably benign	0.03
R7677:Lrrc37a	UTSW	11	103,390,464 (GRCm39)	missense	probably benign	0.26
R7686:Lrrc37a	UTSW	11	103,389,062 (GRCm39)	missense	unknown
R7694:Lrrc37a	UTSW	11	103,395,204 (GRCm39)	missense	probably benign	0.12
R7696:Lrrc37a	UTSW	11	103,389,263 (GRCm39)	missense	probably benign	0.01
R7717:Lrrc37a	UTSW	11	103,395,126 (GRCm39)	missense	probably benign	0.01
R7736:Lrrc37a	UTSW	11	103,388,285 (GRCm39)	missense	unknown
R7841:Lrrc37a	UTSW	11	103,391,931 (GRCm39)	missense	probably benign	0.03
R7885:Lrrc37a	UTSW	11	103,393,868 (GRCm39)	missense	probably benign	0.01
R7888:Lrrc37a	UTSW	11	103,392,307 (GRCm39)	missense	probably benign	0.19
R7993:Lrrc37a	UTSW	11	103,348,787 (GRCm39)	missense	unknown
R8051:Lrrc37a	UTSW	11	103,393,952 (GRCm39)	missense	possibly damaging	0.48
R8082:Lrrc37a	UTSW	11	103,348,248 (GRCm39)	missense	unknown
R8097:Lrrc37a	UTSW	11	103,394,925 (GRCm39)	missense	probably benign	0.04
R8108:Lrrc37a	UTSW	11	103,393,883 (GRCm39)	missense	probably benign	0.24
R8269:Lrrc37a	UTSW	11	103,388,724 (GRCm39)	missense	unknown
R8311:Lrrc37a	UTSW	11	103,394,247 (GRCm39)	missense	probably benign	0.05
R8403:Lrrc37a	UTSW	11	103,392,411 (GRCm39)	missense	probably benign	0.10
R8408:Lrrc37a	UTSW	11	103,351,635 (GRCm39)	missense	unknown
R8529:Lrrc37a	UTSW	11	103,348,373 (GRCm39)	missense	unknown
R8711:Lrrc37a	UTSW	11	103,388,350 (GRCm39)	nonsense	probably null
R8757:Lrrc37a	UTSW	11	103,348,766 (GRCm39)	missense	unknown
R8759:Lrrc37a	UTSW	11	103,348,766 (GRCm39)	missense	unknown
R8769:Lrrc37a	UTSW	11	103,389,536 (GRCm39)	missense	probably benign	0.10
R8785:Lrrc37a	UTSW	11	103,347,242 (GRCm39)	missense	probably damaging	1.00
R8837:Lrrc37a	UTSW	11	103,394,795 (GRCm39)	missense	probably benign	0.43
R8850:Lrrc37a	UTSW	11	103,393,481 (GRCm39)	missense
R8871:Lrrc37a	UTSW	11	103,347,375 (GRCm39)	missense	unknown
R8894:Lrrc37a	UTSW	11	103,347,449 (GRCm39)	missense	unknown
R8971:Lrrc37a	UTSW	11	103,391,490 (GRCm39)	missense	probably benign	0.19
R8979:Lrrc37a	UTSW	11	103,393,833 (GRCm39)	missense	possibly damaging	0.48
R9012:Lrrc37a	UTSW	11	103,389,978 (GRCm39)	missense	probably benign	0.05
R9047:Lrrc37a	UTSW	11	103,391,375 (GRCm39)	missense	probably damaging	0.97
R9167:Lrrc37a	UTSW	11	103,347,658 (GRCm39)	missense	unknown
R9171:Lrrc37a	UTSW	11	103,393,140 (GRCm39)	missense	probably benign	0.42
R9194:Lrrc37a	UTSW	11	103,391,676 (GRCm39)	missense	probably benign	0.03
R9258:Lrrc37a	UTSW	11	103,393,022 (GRCm39)	missense	probably benign	0.20
R9282:Lrrc37a	UTSW	11	103,391,633 (GRCm39)	missense	probably benign	0.03
R9294:Lrrc37a	UTSW	11	103,395,359 (GRCm39)	missense	probably benign	0.10
R9349:Lrrc37a	UTSW	11	103,388,454 (GRCm39)	missense	unknown
R9560:Lrrc37a	UTSW	11	103,347,420 (GRCm39)	missense	unknown
R9595:Lrrc37a	UTSW	11	103,392,552 (GRCm39)	missense	probably benign	0.01
R9628:Lrrc37a	UTSW	11	103,394,330 (GRCm39)	missense	probably benign	0.03
V7580:Lrrc37a	UTSW	11	103,346,338 (GRCm39)	missense	possibly damaging	0.95
X0018:Lrrc37a	UTSW	11	103,390,370 (GRCm39)	missense	possibly damaging	0.78
Z1176:Lrrc37a	UTSW	11	103,391,920 (GRCm39)	missense	probably benign	0.09
Z1176:Lrrc37a	UTSW	11	103,389,860 (GRCm39)	missense	possibly damaging	0.68
Z1176:Lrrc37a	UTSW	11	103,347,312 (GRCm39)	missense	probably damaging	1.00
Z1177:Lrrc37a	UTSW	11	103,391,346 (GRCm39)	missense	probably benign	0.43
Z1177:Lrrc37a	UTSW	11	103,390,793 (GRCm39)	missense	possibly damaging	0.46
Z1177:Lrrc37a	UTSW	11	103,393,853 (GRCm39)	missense	probably benign	0.20
Z1177:Lrrc37a	UTSW	11	103,391,424 (GRCm39)	missense	probably benign	0.20

Posted On

2016-08-02