Incidental Mutation 'IGL03286:Zfp688'
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp688
Ensembl Gene ENSMUSG00000045251
Gene Namezinc finger protein 688
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.114) question?
Stock #IGL03286
Quality Score
Chromosomal Location127418967-127422068 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to A at 127419531 bp
Amino Acid Change Methionine to Leucine at position 141 (M141L)
Ref Sequence ENSEMBL: ENSMUSP00000101907 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000106300] [ENSMUST00000148483]
Predicted Effect probably benign
Transcript: ENSMUST00000106300
AA Change: M141L

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000101907
Gene: ENSMUSG00000045251
AA Change: M141L

KRAB 26 86 9.17e-32 SMART
ZnF_C2H2 181 203 5.42e-2 SMART
ZnF_C2H2 209 231 7.55e-1 SMART
low complexity region 236 252 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000126756
AA Change: M51L
SMART Domains Protein: ENSMUSP00000119731
Gene: ENSMUSG00000045251
AA Change: M51L

SCOP:d1fgja_ 83 113 5e-4 SMART
Blast:ZnF_C2H2 92 113 1e-9 BLAST
Predicted Effect probably benign
Transcript: ENSMUST00000129038
Predicted Effect noncoding transcript
Transcript: ENSMUST00000135886
Predicted Effect noncoding transcript
Transcript: ENSMUST00000136123
Predicted Effect probably benign
Transcript: ENSMUST00000148483
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 51 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aox1 G A 1: 58,049,384 G110S probably benign Het
Arhgap32 T C 9: 32,259,520 S1548P probably benign Het
Cacna1s A G 1: 136,077,659 D147G probably benign Het
Calcoco2 A G 11: 96,103,272 V116A possibly damaging Het
Chd5 A T 4: 152,385,495 M1842L probably benign Het
Comt T C 16: 18,411,740 D73G probably damaging Het
Ctnna1 A G 18: 35,175,153 I175M probably benign Het
Dnah6 A T 6: 73,083,085 Y2839N probably damaging Het
Dph7 T A 2: 24,966,616 H193Q probably damaging Het
Eif2b5 A G 16: 20,502,262 D258G probably damaging Het
Eml5 T C 12: 98,860,503 D630G probably damaging Het
Ext2 C T 2: 93,707,272 V590M probably damaging Het
Fchsd2 T C 7: 101,259,775 probably null Het
Gm13272 A G 4: 88,780,349 Q167R probably benign Het
Gm21834 A G 17: 57,741,927 V98A possibly damaging Het
Grid1 T A 14: 35,520,685 probably benign Het
H2-DMa T A 17: 34,137,109 probably null Het
Ighv5-17 T G 12: 113,859,177 E108A possibly damaging Het
Invs A G 4: 48,382,261 T144A probably benign Het
Ipo9 A G 1: 135,407,078 probably benign Het
Itga4 A T 2: 79,289,362 Y504F probably damaging Het
Krt5 A G 15: 101,707,548 F544S unknown Het
Larp4 A G 15: 99,986,086 Y67C probably damaging Het
Msh2 T C 17: 87,682,667 M261T possibly damaging Het
Nav1 A T 1: 135,454,536 C1367S probably benign Het
Nox4 T A 7: 87,370,141 probably benign Het
Noxa1 A G 2: 25,085,720 probably null Het
Olfr1450 A C 19: 12,954,168 Y193S probably benign Het
Olfr414 A C 1: 174,431,177 I250L probably benign Het
Pde4d T A 13: 109,954,506 probably benign Het
Pdlim2 C T 14: 70,174,476 G36S possibly damaging Het
Plekhm2 A G 4: 141,634,347 S262P possibly damaging Het
Pnpla6 C A 8: 3,531,473 T582K probably damaging Het
Rap1b A T 10: 117,818,575 L120* probably null Het
Rft1 C T 14: 30,661,366 T121I probably benign Het
Scn1a A G 2: 66,277,576 I1613T probably damaging Het
Slc47a2 T G 11: 61,342,467 E79A possibly damaging Het
Slc9a4 A G 1: 40,580,768 I85V probably null Het
Slfn8 A T 11: 83,013,468 F365L probably damaging Het
Smcr8 T A 11: 60,778,027 probably benign Het
Sntb1 T C 15: 55,792,046 D258G possibly damaging Het
Sorbs1 A G 19: 40,344,414 I520T probably damaging Het
Sptbn2 T C 19: 4,747,832 S1896P probably damaging Het
Sptlc3 G A 2: 139,589,659 G367D probably damaging Het
Stab1 C T 14: 31,159,326 probably benign Het
Tars2 T C 3: 95,754,755 probably benign Het
Tchhl1 C T 3: 93,471,123 A378V probably benign Het
Tet3 A T 6: 83,375,778 F1012Y probably damaging Het
Tuba8 A G 6: 121,222,954 D199G possibly damaging Het
Vmn2r110 T A 17: 20,584,206 T151S possibly damaging Het
Xirp2 T C 2: 67,516,310 I2965T probably damaging Het
Other mutations in Zfp688
AlleleSourceChrCoordTypePredicted EffectPPH Score
R1051:Zfp688 UTSW 7 127419225 missense probably damaging 1.00
R1893:Zfp688 UTSW 7 127419237 missense probably damaging 1.00
R4804:Zfp688 UTSW 7 127421885 missense probably damaging 1.00
R4970:Zfp688 UTSW 7 127419155 missense probably damaging 1.00
R7179:Zfp688 UTSW 7 127419312 missense probably damaging 1.00
R7504:Zfp688 UTSW 7 127419311 missense not run
Posted On2016-08-02