Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03287:Or1e16'

415755

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or1e16

Ensembl Gene

ENSMUSG00000069823

Gene Name

olfactory receptor family 1 subfamily E member 16

Synonyms

GA_x6K02T2P1NL-3556334-3555390, MOR135-13, I54, Olfr1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.196) question?

Stock #

IGL03287

Quality Score

Status

Chromosome

Chromosomal Location

73285902-73290321 bp(-) (GRCm39)

Type of Mutation

start codon destroyed

DNA Base Change (assembly)

A to T at 73286845 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Lysine at position 1 (M1K)

Ref Sequence

ENSEMBL: ENSMUSP00000120899 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000120303] [ENSMUST00000131253] [ENSMUST00000134011]

AlphaFold

Q8VGI1

Predicted Effect

probably null
Transcript: ENSMUST00000120303
AA Change: M1K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000113707
Gene: ENSMUSG00000069823
AA Change: M1K

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	8.7e-60	PFAM
Pfam:7tm_1	41	290	2e-27	PFAM

Predicted Effect

probably null
Transcript: ENSMUST00000131253
AA Change: M1K

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000120899
Gene: ENSMUSG00000069823
AA Change: M1K

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srx	31	184	1.2e-6	PFAM
Pfam:7TM_GPCR_Srsx	35	171	6.1e-8	PFAM
Pfam:7tm_1	41	191	3.6e-30	PFAM
Pfam:7tm_4	139	196	1.4e-13	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000134011

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 21 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4930519G04Rik	A	T	5: 115,008,237 (GRCm39)	D17V	probably damaging	Het
Cdh5	T	A	8: 104,854,747 (GRCm39)	V225E	probably damaging	Het
Cfap52	C	T	11: 67,826,802 (GRCm39)		probably benign	Het
Cib4	A	G	5: 30,645,887 (GRCm39)	L127P	probably benign	Het
Fbln2	A	G	6: 91,210,476 (GRCm39)	H140R	probably damaging	Het
Grm8	A	G	6: 27,760,254 (GRCm39)	F359L	possibly damaging	Het
Kat7	A	T	11: 95,190,935 (GRCm39)	D150E	probably damaging	Het
Kif1b	A	G	4: 149,299,438 (GRCm39)	I944T	possibly damaging	Het
Krt87	T	C	15: 101,330,218 (GRCm39)		probably benign	Het
Mast1	T	C	8: 85,639,982 (GRCm39)	S1142G	probably benign	Het
Neb	A	G	2: 52,027,335 (GRCm39)	Y6889H	probably damaging	Het
Or10ak13	A	G	4: 118,639,551 (GRCm39)	V77A	possibly damaging	Het
Plk4	A	T	3: 40,759,553 (GRCm39)	I150L	probably benign	Het
Scn5a	T	C	9: 119,318,844 (GRCm39)	D1598G	probably damaging	Het
Skor2	A	G	18: 76,963,830 (GRCm39)	K925E	probably damaging	Het
Slc25a29	A	T	12: 108,797,135 (GRCm39)	F22L	possibly damaging	Het
Slc27a2	A	G	2: 126,395,312 (GRCm39)	T80A	probably damaging	Het
Tlr3	A	G	8: 45,855,817 (GRCm39)	V121A	probably benign	Het
Tubgcp3	A	T	8: 12,689,630 (GRCm39)	D545E	possibly damaging	Het
Zdhhc8	T	C	16: 18,042,964 (GRCm39)	Y412C	probably benign	Het
Zmynd12	A	G	4: 119,310,776 (GRCm39)	E328G	probably damaging	Het

Other mutations in Or1e16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01380:Or1e16	APN	11	73,286,017 (GRCm39)	missense	probably damaging	0.98
IGL01938:Or1e16	APN	11	73,286,471 (GRCm39)	missense	probably damaging	1.00
IGL02270:Or1e16	APN	11	73,286,191 (GRCm39)	missense	probably benign
R0006:Or1e16	UTSW	11	73,286,314 (GRCm39)	missense	probably damaging	0.99
R0907:Or1e16	UTSW	11	73,285,945 (GRCm39)	missense	probably damaging	0.97
R1982:Or1e16	UTSW	11	73,285,918 (GRCm39)	missense	probably benign	0.00
R3804:Or1e16	UTSW	11	73,286,776 (GRCm39)	missense	probably benign	0.01
R4064:Or1e16	UTSW	11	73,286,348 (GRCm39)	missense	probably benign	0.04
R4171:Or1e16	UTSW	11	73,286,365 (GRCm39)	missense	probably damaging	1.00
R4724:Or1e16	UTSW	11	73,285,981 (GRCm39)	missense	probably damaging	1.00
R4732:Or1e16	UTSW	11	73,286,521 (GRCm39)	missense	probably benign	0.03
R4733:Or1e16	UTSW	11	73,286,521 (GRCm39)	missense	probably benign	0.03
R5030:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5097:Or1e16	UTSW	11	73,286,119 (GRCm39)	missense	probably damaging	1.00
R5098:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5101:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5135:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5137:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5192:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5193:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5193:Or1e16	UTSW	11	73,286,479 (GRCm39)	frame shift	probably null
R5197:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5220:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5221:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5222:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5258:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5297:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5396:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5398:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5399:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5432:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5433:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5531:Or1e16	UTSW	11	73,286,003 (GRCm39)	missense	probably benign	0.26
R5634:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5714:Or1e16	UTSW	11	73,286,187 (GRCm39)	splice site	probably null
R5812:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5813:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5814:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5815:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5913:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5955:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5956:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R5968:Or1e16	UTSW	11	73,286,018 (GRCm39)	missense	possibly damaging	0.75
R6029:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R6034:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R6034:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R6176:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R6177:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R6178:Or1e16	UTSW	11	73,286,480 (GRCm39)	frame shift	probably null
R6196:Or1e16	UTSW	11	73,286,299 (GRCm39)	missense	probably benign	0.08
R6995:Or1e16	UTSW	11	73,286,410 (GRCm39)	missense	probably benign
R7035:Or1e16	UTSW	11	73,286,544 (GRCm39)	missense	probably benign	0.00
R7470:Or1e16	UTSW	11	73,286,714 (GRCm39)	missense	probably damaging	1.00
R7530:Or1e16	UTSW	11	73,279,189 (GRCm39)	missense	possibly damaging	0.55
R8461:Or1e16	UTSW	11	73,285,982 (GRCm39)	missense	probably damaging	1.00
R9149:Or1e16	UTSW	11	73,286,853 (GRCm39)	unclassified	probably benign
R9279:Or1e16	UTSW	11	73,279,789 (GRCm39)	missense	probably benign	0.05
R9293:Or1e16	UTSW	11	73,285,955 (GRCm39)	missense	probably damaging	0.99
R9682:Or1e16	UTSW	11	73,286,025 (GRCm39)	missense	probably benign	0.03
R9752:Or1e16	UTSW	11	73,286,479 (GRCm39)	missense	possibly damaging	0.88

Posted On

2016-08-02