Incidental Mutation 'IGL03288:Med10'
ID 415813
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Med10
Ensembl Gene ENSMUSG00000021598
Gene Name mediator complex subunit 10
Synonyms D13Wsu50e
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL03288
Quality Score
Status
Chromosome 13
Chromosomal Location 69950514-69964223 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 69963816 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000152842 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000022089] [ENSMUST00000221893] [ENSMUST00000222387] [ENSMUST00000223376]
AlphaFold Q9CXU0
Predicted Effect probably benign
Transcript: ENSMUST00000022089
SMART Domains Protein: ENSMUSP00000022089
Gene: ENSMUSG00000021598

DomainStartEndE-ValueType
Pfam:Med10 9 126 1.1e-39 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000180656
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220649
Predicted Effect noncoding transcript
Transcript: ENSMUST00000221045
Predicted Effect probably benign
Transcript: ENSMUST00000221893
Predicted Effect probably benign
Transcript: ENSMUST00000222387
Predicted Effect probably benign
Transcript: ENSMUST00000223376
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] MED10 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]
Allele List at MGI
Other mutations in this stock
Total: 42 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arap2 T C 5: 62,761,959 (GRCm39) K1589R probably benign Het
Armc3 T C 2: 19,240,293 (GRCm39) F17L probably damaging Het
Ccdc17 T A 4: 116,456,626 (GRCm39) L465H probably damaging Het
Cdh9 A T 15: 16,856,135 (GRCm39) D725V probably damaging Het
Cert1 T A 13: 96,770,700 (GRCm39) D536E probably benign Het
Chl1 C T 6: 103,652,058 (GRCm39) R309C probably damaging Het
Dbt T A 3: 116,341,847 (GRCm39) *483K probably null Het
Ddx46 A G 13: 55,785,907 (GRCm39) D29G unknown Het
Des T C 1: 75,338,985 (GRCm39) I222T possibly damaging Het
Dnah8 A G 17: 30,891,323 (GRCm39) N776S probably benign Het
Fbn1 A T 2: 125,145,103 (GRCm39) L2712Q probably benign Het
Glb1l3 A C 9: 26,729,601 (GRCm39) V622G probably damaging Het
Grin2a T C 16: 9,487,704 (GRCm39) D398G possibly damaging Het
Itgb3 T C 11: 104,524,293 (GRCm39) M143T probably damaging Het
Lama2 G A 10: 27,245,047 (GRCm39) R245C probably damaging Het
Lgals9 G A 11: 78,875,626 (GRCm39) A6V probably benign Het
Lman2l A T 1: 36,482,628 (GRCm39) Y83N probably damaging Het
Lrp2 T A 2: 69,256,383 (GRCm39) T4586S probably benign Het
Myo18b A C 5: 112,937,863 (GRCm39) L1754R probably damaging Het
Myom2 T C 8: 15,172,679 (GRCm39) L1202S probably damaging Het
Nav3 T C 10: 109,594,878 (GRCm39) E1441G probably damaging Het
Nme8 T C 13: 19,880,776 (GRCm39) E60G possibly damaging Het
Npffr2 G T 5: 89,731,020 (GRCm39) A317S probably damaging Het
Nrxn2 A G 19: 6,540,726 (GRCm39) D893G probably damaging Het
Nup153 T C 13: 46,858,681 (GRCm39) E410G possibly damaging Het
Or11h7 T C 14: 50,890,832 (GRCm39) I46T possibly damaging Het
Or7e178 A G 9: 20,247,207 (GRCm39) probably null Het
Pcdhb10 A G 18: 37,546,358 (GRCm39) D478G probably damaging Het
Phf13 T C 4: 152,076,826 (GRCm39) D122G possibly damaging Het
Pkhd1 A T 1: 20,271,243 (GRCm39) H3103Q probably benign Het
Prr11 A C 11: 86,987,787 (GRCm39) probably null Het
Rac3 C T 11: 120,614,092 (GRCm39) T118M possibly damaging Het
Rad54b T C 4: 11,569,833 (GRCm39) S50P possibly damaging Het
Rp1 T C 1: 4,419,747 (GRCm39) Q455R possibly damaging Het
Semp2l1 T A 1: 32,584,841 (GRCm39) E356D probably benign Het
Sorl1 T C 9: 41,944,858 (GRCm39) probably benign Het
Spink5 A T 18: 44,147,827 (GRCm39) I858F possibly damaging Het
Stxbp5 A T 10: 9,742,447 (GRCm39) probably null Het
Svep1 A C 4: 58,116,532 (GRCm39) V906G probably benign Het
Tlr4 A G 4: 66,757,990 (GRCm39) E261G probably damaging Het
Zfp704 C T 3: 9,504,951 (GRCm39) probably benign Het
Zfyve9 A T 4: 108,580,996 (GRCm39) probably benign Het
Other mutations in Med10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02022:Med10 APN 13 69,961,819 (GRCm39) splice site probably benign
IGL02071:Med10 APN 13 69,963,747 (GRCm39) missense probably benign 0.01
IGL03091:Med10 APN 13 69,963,816 (GRCm39) unclassified probably benign
R0138:Med10 UTSW 13 69,959,817 (GRCm39) splice site probably benign
R0627:Med10 UTSW 13 69,963,720 (GRCm39) missense possibly damaging 0.85
R1571:Med10 UTSW 13 69,958,159 (GRCm39) missense probably damaging 1.00
R3932:Med10 UTSW 13 69,958,101 (GRCm39) missense probably damaging 1.00
R8825:Med10 UTSW 13 69,962,046 (GRCm39) missense unknown
R9672:Med10 UTSW 13 69,963,711 (GRCm39) missense probably benign 0.05
Z1177:Med10 UTSW 13 69,958,089 (GRCm39) missense probably benign 0.02
Posted On 2016-08-02