Incidental Mutation 'IGL03292:Lilrb4a'
ID415946
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lilrb4a
Ensembl Gene ENSMUSG00000112148
Gene Nameleukocyte immunoglobulin-like receptor, subfamily B, member 4A
SynonymsLilrb4, CD85K, ILT3, HM18, Gp49b
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.156) question?
Stock #IGL03292
Quality Score
Status
Chromosome10
Chromosomal Location51490956-51496611 bp(+) (GRCm38)
Type of Mutationunclassified (1 bp from exon)
DNA Base Change (assembly) G to A at 51494846 bp
ZygosityHeterozygous
Amino Acid Change
Gene Model predicted gene model for transcript(s): [ENSMUST00000078778] [ENSMUST00000217705] [ENSMUST00000217706] [ENSMUST00000218123] [ENSMUST00000218617] [ENSMUST00000219696] [ENSMUST00000220182] [ENSMUST00000220226]
Predicted Effect probably benign
Transcript: ENSMUST00000078778
SMART Domains Protein: ENSMUSP00000077833
Gene: ENSMUSG00000112148

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IG_like 28 118 4.91e1 SMART
IG_like 129 219 1.84e1 SMART
transmembrane domain 239 261 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000105481
SMART Domains Protein: ENSMUSP00000101121
Gene: ENSMUSG00000062593

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IG_like 28 118 4.91e1 SMART
IG_like 129 219 1.84e1 SMART
transmembrane domain 239 261 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000105482
SMART Domains Protein: ENSMUSP00000101122
Gene: ENSMUSG00000062593

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
IG_like 28 118 4.91e1 SMART
IG_like 129 219 1.84e1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000217705
Predicted Effect probably benign
Transcript: ENSMUST00000217706
Predicted Effect unknown
Transcript: ENSMUST00000218123
AA Change: V289M
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218217
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218340
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218413
Predicted Effect probably benign
Transcript: ENSMUST00000218617
Predicted Effect noncoding transcript
Transcript: ENSMUST00000218753
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219029
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219175
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219388
Predicted Effect probably benign
Transcript: ENSMUST00000219696
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219828
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219848
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220166
Predicted Effect probably benign
Transcript: ENSMUST00000220182
Predicted Effect probably benign
Transcript: ENSMUST00000220226
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220402
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Homozygotes for a targeted null mutation exhibit increased sensitivity to IgE-dependent passive cutaneous anaphylaxis and a reduced threshold for antigen challenge in active cutaneous anaphylaxis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 24 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a G A 5: 8,715,827 C713Y possibly damaging Het
Arhgap45 A G 10: 80,020,969 N205S probably benign Het
Arhgef5 T G 6: 43,280,246 F1244V probably damaging Het
Bbs2 A G 8: 94,075,121 probably null Het
Chsy1 A C 7: 66,125,372 M150L probably benign Het
Dync1h1 T A 12: 110,666,555 probably null Het
Efhc1 T C 1: 20,960,272 I143T possibly damaging Het
Elf4 A C X: 48,414,706 F642C probably damaging Het
Fgfr1 A G 8: 25,557,755 D128G possibly damaging Het
Fras1 T A 5: 96,707,491 I1953N probably damaging Het
Frmpd4 A T X: 167,477,590 I1052K probably benign Het
Ift52 T A 2: 163,023,400 I57N probably damaging Het
Mob3a A T 10: 80,691,086 I135N probably benign Het
Pcdhb16 T A 18: 37,480,384 I799N probably damaging Het
Rad52 T C 6: 119,918,973 L265P possibly damaging Het
Sorbs1 T A 19: 40,373,565 Q155L possibly damaging Het
Taok1 A T 11: 77,540,136 M821K probably benign Het
Tars T A 15: 11,384,021 E720V probably benign Het
Tec T C 5: 72,757,364 E603G probably null Het
Timp1 A G X: 20,872,818 T56A probably benign Het
Txnrd2 C A 16: 18,477,729 H511Q possibly damaging Het
Ubr4 A T 4: 139,440,435 D2743V probably damaging Het
Vmn1r211 C T 13: 22,852,443 G18D probably damaging Het
Zfhx4 C T 3: 5,411,780 Q3127* probably null Het
Other mutations in Lilrb4a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01399:Lilrb4a APN 10 51494065 missense probably benign 0.42
IGL02057:Lilrb4a APN 10 51492007 missense possibly damaging 0.81
IGL02386:Lilrb4a APN 10 51491226 nonsense probably null
IGL02999:Lilrb4a APN 10 51494143 missense probably damaging 1.00
IGL03382:Lilrb4a APN 10 51491520 missense probably benign 0.10
R0276:Lilrb4a UTSW 10 51491581 missense probably benign 0.01
R0470:Lilrb4a UTSW 10 51494827 missense possibly damaging 0.87
R1459:Lilrb4a UTSW 10 51491587 missense probably benign 0.44
R1675:Lilrb4a UTSW 10 51496185 missense probably benign 0.37
R1819:Lilrb4a UTSW 10 51496028 missense probably damaging 1.00
R1914:Lilrb4a UTSW 10 51491949 missense probably benign 0.04
R2265:Lilrb4a UTSW 10 51491537 nonsense probably null
R2338:Lilrb4a UTSW 10 51491700 missense probably benign 0.13
R2884:Lilrb4a UTSW 10 51491613 missense probably benign 0.01
R2886:Lilrb4a UTSW 10 51491613 missense probably benign 0.01
R4322:Lilrb4a UTSW 10 51491611 missense probably damaging 1.00
R4624:Lilrb4a UTSW 10 51491488 missense probably damaging 1.00
R4923:Lilrb4a UTSW 10 51492043 missense possibly damaging 0.67
R5001:Lilrb4a UTSW 10 51491420 splice site probably null
R5262:Lilrb4a UTSW 10 51493207 critical splice donor site probably null
R6224:Lilrb4a UTSW 10 51491649 missense probably damaging 1.00
R7447:Lilrb4a UTSW 10 51491053 critical splice donor site probably null
Posted On2016-08-02