Incidental Mutation 'IGL03295:Gm13103'
ID416038
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm13103
Ensembl Gene ENSMUSG00000029451
Gene Namepredicted gene 13103
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.077) question?
Stock #IGL03295
Quality Score
Status
Chromosome4
Chromosomal Location143846497-143853637 bp(+) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) G to A at 143853189 bp
ZygosityHeterozygous
Amino Acid Change Cysteine to Tyrosine at position 448 (C448Y)
Ref Sequence ENSEMBL: ENSMUSP00000092099 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094522] [ENSMUST00000105768] [ENSMUST00000139747]
Predicted Effect probably damaging
Transcript: ENSMUST00000094522
AA Change: C448Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000092099
Gene: ENSMUSG00000029451
AA Change: C448Y

DomainStartEndE-ValueType
low complexity region 403 413 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000105768
Predicted Effect probably benign
Transcript: ENSMUST00000139747
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik A T 5: 99,243,056 probably benign Het
Adamts5 T C 16: 85,877,945 T444A probably damaging Het
Aldh18a1 T C 19: 40,562,942 E522G probably damaging Het
Bbx T C 16: 50,224,564 T437A probably damaging Het
Bsx A G 9: 40,874,447 probably benign Het
C330027C09Rik T C 16: 48,994,341 S22P probably damaging Het
Cdc42bpa A G 1: 180,150,204 N729S probably benign Het
Cdk1 G T 10: 69,342,543 H162Q possibly damaging Het
Chrac1 A G 15: 73,093,596 probably benign Het
Ddx60 A T 8: 61,956,121 D397V possibly damaging Het
Edn2 T A 4: 120,161,981 C56S probably damaging Het
Gm4952 T C 19: 12,618,327 V27A probably benign Het
Herc1 T A 9: 66,396,703 S763T possibly damaging Het
Hspd1 G A 1: 55,080,175 T381I probably benign Het
Krt2 T A 15: 101,816,429 I249F probably damaging Het
Lman2l T C 1: 36,438,811 D148G probably damaging Het
Lrp1b C T 2: 40,678,987 probably null Het
Mier3 C A 13: 111,703,681 T51K probably benign Het
Ppp1r36 C T 12: 76,438,418 P305L probably damaging Het
Prdm1 T C 10: 44,439,870 I790V probably damaging Het
Sephs2 T C 7: 127,272,769 E384G possibly damaging Het
Sipa1l1 T A 12: 82,432,940 W1466R probably damaging Het
Snai2 T C 16: 14,706,774 L48P possibly damaging Het
Stt3a A G 9: 36,763,331 probably null Het
Synj1 T A 16: 90,938,430 N1545I probably benign Het
Vav2 A T 2: 27,275,029 S607T possibly damaging Het
Wdr27 T C 17: 14,934,575 K27E possibly damaging Het
Xcl1 A T 1: 164,935,435 V19E unknown Het
Xlr3c A T X: 73,257,634 probably null Het
Zbtb44 T A 9: 31,053,457 D54E probably benign Het
Zscan21 A G 5: 138,125,278 D73G possibly damaging Het
Other mutations in Gm13103
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01363:Gm13103 APN 4 143853276 missense probably benign 0.01
IGL01383:Gm13103 APN 4 143846532 utr 5 prime probably benign
IGL01735:Gm13103 APN 4 143851831 missense probably damaging 1.00
IGL01976:Gm13103 APN 4 143852793 missense probably benign 0.17
IGL03096:Gm13103 APN 4 143850915 missense probably benign 0.01
IGL03280:Gm13103 APN 4 143851919 missense possibly damaging 0.74
FR4342:Gm13103 UTSW 4 143851643 frame shift probably null
PIT4687001:Gm13103 UTSW 4 143846533 start gained probably benign
R0218:Gm13103 UTSW 4 143851831 missense probably damaging 1.00
R0612:Gm13103 UTSW 4 143852088 unclassified probably benign
R1755:Gm13103 UTSW 4 143850810 missense probably damaging 1.00
R2509:Gm13103 UTSW 4 143851991 missense probably benign 0.01
R2510:Gm13103 UTSW 4 143851991 missense probably benign 0.01
R2511:Gm13103 UTSW 4 143851991 missense probably benign 0.01
R4603:Gm13103 UTSW 4 143852881 missense probably benign 0.01
R4694:Gm13103 UTSW 4 143852960 missense probably damaging 0.97
R4856:Gm13103 UTSW 4 143853303 missense probably benign 0.00
R4886:Gm13103 UTSW 4 143853303 missense probably benign 0.00
R4927:Gm13103 UTSW 4 143851617 missense probably damaging 1.00
R5168:Gm13103 UTSW 4 143853198 missense probably benign 0.02
R5270:Gm13103 UTSW 4 143851898 missense probably damaging 0.97
R5402:Gm13103 UTSW 4 143851655 critical splice donor site probably null
R5618:Gm13103 UTSW 4 143850693 missense possibly damaging 0.92
R6078:Gm13103 UTSW 4 143851585 missense possibly damaging 0.58
R6138:Gm13103 UTSW 4 143851585 missense possibly damaging 0.58
R6362:Gm13103 UTSW 4 143852865 missense probably damaging 0.99
R6526:Gm13103 UTSW 4 143852814 missense probably damaging 1.00
R6555:Gm13103 UTSW 4 143851570 missense possibly damaging 0.58
R6595:Gm13103 UTSW 4 143852756 missense probably damaging 1.00
R6675:Gm13103 UTSW 4 143853258 missense probably damaging 0.98
R7216:Gm13103 UTSW 4 143851829 missense probably damaging 0.96
R7282:Gm13103 UTSW 4 143851881 missense possibly damaging 0.85
U15987:Gm13103 UTSW 4 143851585 missense possibly damaging 0.58
Posted On2016-08-02