Incidental Mutation 'IGL03295:Xcl1'
ID 416048
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Xcl1
Ensembl Gene ENSMUSG00000026573
Gene Name chemokine (C motif) ligand 1
Synonyms SCM-1, Lptn, LTN, ATAC, Scyc1, lymphotactin, SCM-1a
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03295
Quality Score
Status
Chromosome 1
Chromosomal Location 164759216-164763094 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 164763004 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 19 (V19E)
Ref Sequence ENSEMBL: ENSMUSP00000027860 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027860]
AlphaFold P47993
Predicted Effect unknown
Transcript: ENSMUST00000027860
AA Change: V19E
SMART Domains Protein: ENSMUSP00000027860
Gene: ENSMUSG00000026573
AA Change: V19E

DomainStartEndE-ValueType
signal peptide 1 21 N/A INTRINSIC
SCY 28 84 2.18e-19 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194322
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene encodes a member of the chemokine superfamily. Chemokines function in inflammatory and immunological responses, inducing leukocyte migration and activation. The encoded protein is a member of the C-chemokine subfamily, retaining only two of four cysteines conserved in other chemokines, and is thought to be specifically chemotactic for T cells. This gene and a closely related family member are located on the long arm of chromosome 1. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit decreased stimulated cytotoxic T cell cytolysis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 31 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930011G23Rik A T 5: 99,390,915 (GRCm39) probably benign Het
Adamts5 T C 16: 85,674,833 (GRCm39) T444A probably damaging Het
Aldh18a1 T C 19: 40,551,386 (GRCm39) E522G probably damaging Het
Bbx T C 16: 50,044,927 (GRCm39) T437A probably damaging Het
Bsx A G 9: 40,785,743 (GRCm39) probably benign Het
Cdc42bpa A G 1: 179,977,769 (GRCm39) N729S probably benign Het
Cdk1 G T 10: 69,178,373 (GRCm39) H162Q possibly damaging Het
Chrac1 A G 15: 72,965,445 (GRCm39) probably benign Het
Cip2a T C 16: 48,814,704 (GRCm39) S22P probably damaging Het
Ddx60 A T 8: 62,409,155 (GRCm39) D397V possibly damaging Het
Edn2 T A 4: 120,019,178 (GRCm39) C56S probably damaging Het
Gm4952 T C 19: 12,595,691 (GRCm39) V27A probably benign Het
Herc1 T A 9: 66,303,985 (GRCm39) S763T possibly damaging Het
Hspd1 G A 1: 55,119,334 (GRCm39) T381I probably benign Het
Krt1c T A 15: 101,724,864 (GRCm39) I249F probably damaging Het
Lman2l T C 1: 36,477,892 (GRCm39) D148G probably damaging Het
Lrp1b C T 2: 40,568,999 (GRCm39) probably null Het
Mier3 C A 13: 111,840,215 (GRCm39) T51K probably benign Het
Ppp1r36 C T 12: 76,485,192 (GRCm39) P305L probably damaging Het
Pramel27 G A 4: 143,579,759 (GRCm39) C448Y probably damaging Het
Prdm1 T C 10: 44,315,866 (GRCm39) I790V probably damaging Het
Sephs2 T C 7: 126,871,941 (GRCm39) E384G possibly damaging Het
Sipa1l1 T A 12: 82,479,714 (GRCm39) W1466R probably damaging Het
Snai2 T C 16: 14,524,638 (GRCm39) L48P possibly damaging Het
Stt3a A G 9: 36,674,627 (GRCm39) probably null Het
Synj1 T A 16: 90,735,318 (GRCm39) N1545I probably benign Het
Vav2 A T 2: 27,165,041 (GRCm39) S607T possibly damaging Het
Wdr27 T C 17: 15,154,837 (GRCm39) K27E possibly damaging Het
Xlr3c A T X: 72,301,240 (GRCm39) probably null Het
Zbtb44 T A 9: 30,964,753 (GRCm39) D54E probably benign Het
Zscan21 A G 5: 138,123,540 (GRCm39) D73G possibly damaging Het
Other mutations in Xcl1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01910:Xcl1 APN 1 164,759,458 (GRCm39) missense probably damaging 1.00
R7742:Xcl1 UTSW 1 164,763,041 (GRCm39) missense unknown
R8532:Xcl1 UTSW 1 164,759,515 (GRCm39) missense probably damaging 1.00
R8671:Xcl1 UTSW 1 164,759,419 (GRCm39) missense probably benign 0.01
R8697:Xcl1 UTSW 1 164,763,008 (GRCm39) missense unknown
R8843:Xcl1 UTSW 1 164,763,079 (GRCm39) start gained probably benign
Posted On 2016-08-02