Incidental Mutation 'IGL03298:Ccnb2'
ID 416142
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccnb2
Ensembl Gene ENSMUSG00000032218
Gene Name cyclin B2
Synonyms CycB2
Accession Numbers
Essential gene? Possibly essential (E-score: 0.574) question?
Stock # IGL03298
Quality Score
Status
Chromosome 9
Chromosomal Location 70314974-70328829 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 70326156 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 63 (T63A)
Ref Sequence ENSEMBL: ENSMUSP00000034742 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034742]
AlphaFold P30276
Predicted Effect probably benign
Transcript: ENSMUST00000034742
AA Change: T63A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000034742
Gene: ENSMUSG00000032218
AA Change: T63A

DomainStartEndE-ValueType
CYCLIN 171 255 8.58e-28 SMART
Cyclin_C 264 382 9.83e-34 SMART
CYCLIN 268 349 2.73e-21 SMART
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Cyclin B2 is a member of the cyclin family, specifically the B-type cyclins. The B-type cyclins, B1 and B2, associate with p34cdc2 and are essential components of the cell cycle regulatory machinery. B1 and B2 differ in their subcellular localization. Cyclin B1 co-localizes with microtubules, whereas cyclin B2 is primarily associated with the Golgi region. Cyclin B2 also binds to transforming growth factor beta RII and thus cyclin B2/cdc2 may play a key role in transforming growth factor beta-mediated cell cycle control. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mutation of this gene results in reduced body weight and reduced litter size. Homozygous pups are underrepresented in litters from a heterozygous intercross. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 20 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2ml1 T C 6: 128,520,923 (GRCm39) T1344A probably benign Het
Abcc4 C A 14: 118,848,880 (GRCm39) D491Y probably damaging Het
Casp2 C T 6: 42,245,924 (GRCm39) probably benign Het
Cgrrf1 A G 14: 47,083,778 (GRCm39) I187V probably benign Het
Clstn2 C T 9: 97,338,625 (GRCm39) V845M probably damaging Het
Dmxl1 T C 18: 49,997,885 (GRCm39) M691T probably benign Het
Dnhd1 T G 7: 105,363,682 (GRCm39) I4081M probably damaging Het
H2-T3 T C 17: 36,500,320 (GRCm39) Y125C probably damaging Het
Kif1a T A 1: 92,993,903 (GRCm39) D349V probably damaging Het
L3mbtl3 T C 10: 26,158,696 (GRCm39) T651A unknown Het
Megf10 C T 18: 57,416,910 (GRCm39) Q760* probably null Het
Mroh7 T A 4: 106,571,288 (GRCm39) K22* probably null Het
Or4f53 A T 2: 111,087,879 (GRCm39) M140L probably benign Het
Or7g29 A T 9: 19,286,358 (GRCm39) V273E probably damaging Het
Ppp6r3 A T 19: 3,571,829 (GRCm39) Y107N probably damaging Het
Reln T A 5: 22,115,834 (GRCm39) Q3058L probably damaging Het
Ss18 T C 18: 14,812,484 (GRCm39) M36V possibly damaging Het
Tlr7 C A X: 166,089,703 (GRCm39) K594N probably benign Het
Trim10 A G 17: 37,187,917 (GRCm39) S378G possibly damaging Het
Zfp644 A G 5: 106,782,967 (GRCm39) S1105P possibly damaging Het
Other mutations in Ccnb2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Ccnb2 APN 9 70,326,189 (GRCm39) missense probably damaging 0.96
IGL01474:Ccnb2 APN 9 70,326,305 (GRCm39) missense probably benign
IGL03097:Ccnb2 APN 9 70,316,678 (GRCm39) splice site probably benign
R0042:Ccnb2 UTSW 9 70,326,335 (GRCm39) missense probably benign
R0042:Ccnb2 UTSW 9 70,326,335 (GRCm39) missense probably benign
R1585:Ccnb2 UTSW 9 70,317,559 (GRCm39) splice site probably null
R1756:Ccnb2 UTSW 9 70,318,070 (GRCm39) missense probably benign 0.41
R2046:Ccnb2 UTSW 9 70,316,629 (GRCm39) missense probably benign 0.11
R6045:Ccnb2 UTSW 9 70,326,375 (GRCm39) missense probably benign
R7202:Ccnb2 UTSW 9 70,318,128 (GRCm39) missense probably damaging 1.00
R7623:Ccnb2 UTSW 9 70,326,170 (GRCm39) missense probably benign
R8515:Ccnb2 UTSW 9 70,320,382 (GRCm39) critical splice donor site probably null
R9072:Ccnb2 UTSW 9 70,318,095 (GRCm39) missense possibly damaging 0.65
R9073:Ccnb2 UTSW 9 70,318,095 (GRCm39) missense possibly damaging 0.65
R9235:Ccnb2 UTSW 9 70,318,163 (GRCm39) missense probably damaging 0.98
Posted On 2016-08-02