Incidental Mutation 'IGL03299:Rps6ka4'
ID |
416194 |
Institutional Source |
Australian Phenomics Network
(link to record)
|
Gene Symbol |
Rps6ka4
|
Ensembl Gene |
ENSMUSG00000024952 |
Gene Name |
ribosomal protein S6 kinase, polypeptide 4 |
Synonyms |
90kDa, MSK2, 1110069D02Rik |
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.880)
|
Stock # |
IGL03299
|
Quality Score |
|
Status
|
|
Chromosome |
19 |
Chromosomal Location |
6806578-6818004 bp(-) (GRCm39) |
Type of Mutation |
splice site |
DNA Base Change (assembly) |
C to T
at 6809615 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
|
Ref Sequence |
ENSEMBL: ENSMUSP00000131581
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000025903]
[ENSMUST00000170516]
|
AlphaFold |
no structure available at present |
Predicted Effect |
probably benign
Transcript: ENSMUST00000025903
|
SMART Domains |
Protein: ENSMUSP00000025903 Gene: ENSMUSG00000024952
Domain | Start | End | E-Value | Type |
S_TKc
|
33 |
301 |
1.93e-98 |
SMART |
S_TK_X
|
302 |
363 |
5.72e-14 |
SMART |
low complexity region
|
381 |
395 |
N/A |
INTRINSIC |
S_TKc
|
411 |
674 |
1.15e-87 |
SMART |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000170516
|
SMART Domains |
Protein: ENSMUSP00000131581 Gene: ENSMUSG00000024952
Domain | Start | End | E-Value | Type |
S_TKc
|
33 |
301 |
1.93e-98 |
SMART |
S_TK_X
|
302 |
363 |
5.72e-14 |
SMART |
low complexity region
|
381 |
395 |
N/A |
INTRINSIC |
S_TKc
|
411 |
674 |
1.15e-87 |
SMART |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000199140
|
Coding Region Coverage |
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and ATF1. The encoded protein can also phosphorylate histone H3 to regulate certain inflammatory genes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] PHENOTYPE: No phenotypic information associated with mutations in this gene have been reported. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 33 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4921511C20Rik |
A |
G |
X: 126,303,476 (GRCm39) |
|
probably benign |
Het |
Abca17 |
A |
T |
17: 24,484,565 (GRCm39) |
C1566S |
probably damaging |
Het |
Akr1cl |
A |
T |
1: 65,063,874 (GRCm39) |
L105H |
probably damaging |
Het |
Ano1 |
A |
G |
7: 144,207,993 (GRCm39) |
F256S |
probably damaging |
Het |
Arfip2 |
C |
T |
7: 105,287,150 (GRCm39) |
R138H |
probably damaging |
Het |
Cers6 |
T |
A |
2: 68,692,128 (GRCm39) |
M50K |
probably benign |
Het |
Dnah1 |
G |
A |
14: 31,037,079 (GRCm39) |
Q256* |
probably null |
Het |
Dync1h1 |
G |
A |
12: 110,585,644 (GRCm39) |
E852K |
possibly damaging |
Het |
Fars2 |
C |
T |
13: 36,721,384 (GRCm39) |
Q443* |
probably null |
Het |
Glb1l3 |
T |
C |
9: 26,770,748 (GRCm39) |
N106S |
probably damaging |
Het |
Haus7 |
T |
C |
X: 72,496,670 (GRCm39) |
|
probably null |
Het |
Hectd1 |
C |
T |
12: 51,847,671 (GRCm39) |
|
probably benign |
Het |
Hyal5 |
G |
T |
6: 24,877,881 (GRCm39) |
G326C |
probably damaging |
Het |
Ibtk |
A |
T |
9: 85,603,189 (GRCm39) |
D605E |
probably benign |
Het |
Kif26b |
T |
C |
1: 178,649,125 (GRCm39) |
L415P |
probably benign |
Het |
Lrrc37a |
C |
T |
11: 103,388,499 (GRCm39) |
E2309K |
unknown |
Het |
Muc5b |
A |
G |
7: 141,395,117 (GRCm39) |
D41G |
unknown |
Het |
Mxra7 |
A |
G |
11: 116,695,360 (GRCm39) |
|
probably benign |
Het |
Ncoa6 |
T |
C |
2: 155,249,207 (GRCm39) |
T1366A |
probably damaging |
Het |
Nmd3 |
C |
T |
3: 69,637,762 (GRCm39) |
|
probably null |
Het |
Or6c206 |
T |
C |
10: 129,097,196 (GRCm39) |
V122A |
probably benign |
Het |
Pla2g4a |
T |
C |
1: 149,727,118 (GRCm39) |
N546S |
probably damaging |
Het |
Prkcz |
T |
C |
4: 155,371,247 (GRCm39) |
T139A |
possibly damaging |
Het |
Rarb |
T |
C |
14: 16,434,168 (GRCm38) |
K337E |
probably damaging |
Het |
Scamp2 |
A |
G |
9: 57,485,023 (GRCm39) |
|
probably null |
Het |
Scn3a |
T |
A |
2: 65,327,860 (GRCm39) |
M877L |
probably benign |
Het |
Sh3pxd2b |
T |
C |
11: 32,361,448 (GRCm39) |
|
probably benign |
Het |
Slc22a29 |
C |
T |
19: 8,140,012 (GRCm39) |
|
probably null |
Het |
Slc34a1 |
T |
C |
13: 24,005,094 (GRCm39) |
|
probably null |
Het |
Srbd1 |
A |
T |
17: 86,428,087 (GRCm39) |
I382N |
possibly damaging |
Het |
Tm7sf2 |
T |
C |
19: 6,112,958 (GRCm39) |
I387M |
probably benign |
Het |
Wfs1 |
C |
A |
5: 37,125,731 (GRCm39) |
E311* |
probably null |
Het |
Zc3h13 |
G |
A |
14: 75,531,381 (GRCm39) |
R93H |
probably damaging |
Het |
|
Other mutations in Rps6ka4 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01146:Rps6ka4
|
APN |
19 |
6,808,496 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01548:Rps6ka4
|
APN |
19 |
6,809,691 (GRCm39) |
missense |
probably benign |
0.02 |
IGL02536:Rps6ka4
|
APN |
19 |
6,809,439 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02902:Rps6ka4
|
APN |
19 |
6,809,623 (GRCm39) |
critical splice donor site |
probably null |
|
R0510:Rps6ka4
|
UTSW |
19 |
6,817,866 (GRCm39) |
missense |
probably benign |
0.13 |
R1104:Rps6ka4
|
UTSW |
19 |
6,808,364 (GRCm39) |
missense |
probably damaging |
1.00 |
R1620:Rps6ka4
|
UTSW |
19 |
6,815,517 (GRCm39) |
missense |
probably damaging |
1.00 |
R1647:Rps6ka4
|
UTSW |
19 |
6,816,730 (GRCm39) |
missense |
probably benign |
0.15 |
R1648:Rps6ka4
|
UTSW |
19 |
6,816,730 (GRCm39) |
missense |
probably benign |
0.15 |
R1939:Rps6ka4
|
UTSW |
19 |
6,816,834 (GRCm39) |
missense |
probably damaging |
1.00 |
R2370:Rps6ka4
|
UTSW |
19 |
6,807,468 (GRCm39) |
missense |
possibly damaging |
0.93 |
R2412:Rps6ka4
|
UTSW |
19 |
6,807,309 (GRCm39) |
makesense |
probably null |
|
R2571:Rps6ka4
|
UTSW |
19 |
6,815,471 (GRCm39) |
missense |
probably damaging |
1.00 |
R2698:Rps6ka4
|
UTSW |
19 |
6,814,720 (GRCm39) |
missense |
probably benign |
0.08 |
R3427:Rps6ka4
|
UTSW |
19 |
6,815,123 (GRCm39) |
critical splice donor site |
probably null |
|
R3721:Rps6ka4
|
UTSW |
19 |
6,816,645 (GRCm39) |
missense |
possibly damaging |
0.73 |
R3844:Rps6ka4
|
UTSW |
19 |
6,815,171 (GRCm39) |
nonsense |
probably null |
|
R4092:Rps6ka4
|
UTSW |
19 |
6,809,623 (GRCm39) |
critical splice donor site |
probably null |
|
R4169:Rps6ka4
|
UTSW |
19 |
6,809,188 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4677:Rps6ka4
|
UTSW |
19 |
6,816,854 (GRCm39) |
missense |
probably damaging |
1.00 |
R4897:Rps6ka4
|
UTSW |
19 |
6,815,467 (GRCm39) |
missense |
probably benign |
0.02 |
R4975:Rps6ka4
|
UTSW |
19 |
6,817,678 (GRCm39) |
splice site |
probably null |
|
R5631:Rps6ka4
|
UTSW |
19 |
6,808,345 (GRCm39) |
splice site |
probably benign |
|
R6462:Rps6ka4
|
UTSW |
19 |
6,814,957 (GRCm39) |
missense |
possibly damaging |
0.90 |
R6643:Rps6ka4
|
UTSW |
19 |
6,809,731 (GRCm39) |
missense |
probably damaging |
1.00 |
R6939:Rps6ka4
|
UTSW |
19 |
6,815,437 (GRCm39) |
missense |
probably damaging |
1.00 |
R7030:Rps6ka4
|
UTSW |
19 |
6,816,992 (GRCm39) |
missense |
probably damaging |
1.00 |
R7902:Rps6ka4
|
UTSW |
19 |
6,808,679 (GRCm39) |
missense |
possibly damaging |
0.81 |
R8021:Rps6ka4
|
UTSW |
19 |
6,807,777 (GRCm39) |
missense |
probably benign |
0.01 |
R8166:Rps6ka4
|
UTSW |
19 |
6,814,811 (GRCm39) |
missense |
possibly damaging |
0.78 |
R8988:Rps6ka4
|
UTSW |
19 |
6,808,667 (GRCm39) |
missense |
possibly damaging |
0.58 |
R9481:Rps6ka4
|
UTSW |
19 |
6,809,372 (GRCm39) |
missense |
possibly damaging |
0.62 |
R9664:Rps6ka4
|
UTSW |
19 |
6,809,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
R9723:Rps6ka4
|
UTSW |
19 |
6,816,663 (GRCm39) |
missense |
probably damaging |
0.99 |
U24488:Rps6ka4
|
UTSW |
19 |
6,809,724 (GRCm39) |
missense |
probably damaging |
1.00 |
X0019:Rps6ka4
|
UTSW |
19 |
6,815,508 (GRCm39) |
missense |
probably damaging |
0.97 |
X0027:Rps6ka4
|
UTSW |
19 |
6,815,140 (GRCm39) |
missense |
probably benign |
0.37 |
|
Posted On |
2016-08-02 |