Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03301:Vmn2r13'

416206

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r13

Ensembl Gene

ENSMUSG00000091635

Gene Name

vomeronasal 2, receptor 13

Synonyms

Gm4867

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL03301

Quality Score

Status

Chromosome

Chromosomal Location

109303889-109339973 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 109305955 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Aspartic acid at position 541 (V541D)

Ref Sequence

ENSEMBL: ENSMUSP00000052977 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000053253]

AlphaFold

L7N1X2

Predicted Effect

probably damaging
Transcript: ENSMUST00000053253
AA Change: V541D

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000052977
Gene: ENSMUSG00000091635
AA Change: V541D

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Pfam:ANF_receptor	76	463	2.8e-29	PFAM
Pfam:NCD3G	506	560	1.3e-18	PFAM
Pfam:7tm_3	593	828	1.8e-54	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts3	T	C	5: 89,855,263 (GRCm39)	E418G	probably damaging	Het
Arl14	T	C	3: 69,130,276 (GRCm39)	F141S	probably damaging	Het
C1s1	A	T	6: 124,518,283 (GRCm39)		probably benign	Het
Cilp	T	C	9: 65,187,499 (GRCm39)	V1198A	probably benign	Het
Cnbd1	A	T	4: 19,055,039 (GRCm39)	I129K	probably benign	Het
Ctdp1	G	A	18: 80,492,849 (GRCm39)	Q549*	probably null	Het
Cyp2ab1	T	A	16: 20,132,549 (GRCm39)	I250F	possibly damaging	Het
Dmd	G	A	X: 82,952,120 (GRCm39)	R1765Q	probably damaging	Het
Dnah1	C	T	14: 31,014,649 (GRCm39)	G1739R	probably damaging	Het
Eml6	T	C	11: 29,714,083 (GRCm39)	K1350E	probably benign	Het
Ephx4	C	A	5: 107,574,730 (GRCm39)	T256K	probably benign	Het
Fnd3c2	G	T	X: 105,295,869 (GRCm39)	Q49K	probably benign	Het
Heatr1	G	T	13: 12,449,086 (GRCm39)	G1889W	probably damaging	Het
Igkv19-93	A	T	6: 68,713,465 (GRCm39)	W55R	probably damaging	Het
Jak1	T	C	4: 101,032,370 (GRCm39)	Y412C	probably damaging	Het
Moxd1	A	T	10: 24,155,382 (GRCm39)	N261I	probably damaging	Het
Mrgpra1	T	C	7: 46,985,164 (GRCm39)	N172D	probably benign	Het
Papolg	T	C	11: 23,824,503 (GRCm39)	N293S	probably benign	Het
Piezo2	A	G	18: 63,160,775 (GRCm39)	S2294P	probably damaging	Het
Ppp3cb	A	T	14: 20,574,052 (GRCm39)	V262D	probably damaging	Het
Rhox7a	A	G	X: 36,928,888 (GRCm39)	T235A	probably benign	Het
Saal1	A	G	7: 46,351,944 (GRCm39)		probably benign	Het
Scrn1	G	A	6: 54,525,322 (GRCm39)	R16*	probably null	Het
Slc22a2	A	G	17: 12,824,926 (GRCm39)	R263G	probably damaging	Het
Speer3	T	A	5: 13,845,447 (GRCm39)	L160H	probably damaging	Het
Tmcc2	T	C	1: 132,288,557 (GRCm39)	M377V	possibly damaging	Het
Tsen2	T	G	6: 115,545,732 (GRCm39)	Y341D	probably damaging	Het
Vmn2r15	A	G	5: 109,445,221 (GRCm39)		probably null	Het
Zfp711	T	C	X: 111,543,098 (GRCm39)	Y710H	probably damaging	Het
Zmiz2	C	T	11: 6,351,170 (GRCm39)	T566M	probably damaging	Het

Other mutations in Vmn2r13

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00965:Vmn2r13	APN	5	109,303,964 (GRCm39)	missense	probably damaging	1.00
IGL01373:Vmn2r13	APN	5	109,304,568 (GRCm39)	missense	probably damaging	1.00
IGL01946:Vmn2r13	APN	5	109,322,085 (GRCm39)	missense	probably benign	0.01
IGL01971:Vmn2r13	APN	5	109,321,981 (GRCm39)	missense	probably benign	0.01
IGL02636:Vmn2r13	APN	5	109,339,883 (GRCm39)	missense	probably damaging	0.98
IGL03062:Vmn2r13	APN	5	109,304,148 (GRCm39)	missense	probably damaging	1.00
IGL03173:Vmn2r13	APN	5	109,319,645 (GRCm39)	missense	possibly damaging	0.95
IGL03383:Vmn2r13	APN	5	109,304,398 (GRCm39)	missense	probably damaging	0.98
IGL03048:Vmn2r13	UTSW	5	109,304,151 (GRCm39)	missense	probably damaging	1.00
R0123:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0134:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0220:Vmn2r13	UTSW	5	109,304,332 (GRCm39)	missense	probably damaging	1.00
R0225:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R0393:Vmn2r13	UTSW	5	109,304,395 (GRCm39)	missense	probably benign	0.01
R0410:Vmn2r13	UTSW	5	109,321,679 (GRCm39)	missense	probably benign	0.35
R0787:Vmn2r13	UTSW	5	109,304,713 (GRCm39)	missense	probably damaging	0.99
R1200:Vmn2r13	UTSW	5	109,322,068 (GRCm39)	missense	probably damaging	1.00
R1448:Vmn2r13	UTSW	5	109,322,001 (GRCm39)	missense	probably damaging	1.00
R1782:Vmn2r13	UTSW	5	109,306,040 (GRCm39)	missense	probably benign	0.08
R1939:Vmn2r13	UTSW	5	109,339,852 (GRCm39)	missense	possibly damaging	0.88
R2029:Vmn2r13	UTSW	5	109,339,943 (GRCm39)	missense	probably benign	0.13
R2125:Vmn2r13	UTSW	5	109,306,058 (GRCm39)	missense	probably benign	0.00
R2126:Vmn2r13	UTSW	5	109,306,058 (GRCm39)	missense	probably benign	0.00
R2379:Vmn2r13	UTSW	5	109,319,644 (GRCm39)	missense	probably benign	0.05
R2680:Vmn2r13	UTSW	5	109,322,178 (GRCm39)	missense	possibly damaging	0.66
R2888:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R2889:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R2890:Vmn2r13	UTSW	5	109,339,840 (GRCm39)	missense	possibly damaging	0.88
R3014:Vmn2r13	UTSW	5	109,319,627 (GRCm39)	missense	possibly damaging	0.81
R3683:Vmn2r13	UTSW	5	109,304,721 (GRCm39)	missense	probably damaging	1.00
R4074:Vmn2r13	UTSW	5	109,304,566 (GRCm39)	missense	probably damaging	1.00
R4599:Vmn2r13	UTSW	5	109,304,322 (GRCm39)	missense	probably damaging	1.00
R4614:Vmn2r13	UTSW	5	109,323,065 (GRCm39)	missense	probably benign	0.01
R4805:Vmn2r13	UTSW	5	109,304,331 (GRCm39)	missense	probably damaging	1.00
R4822:Vmn2r13	UTSW	5	109,321,938 (GRCm39)	missense	probably damaging	0.99
R4943:Vmn2r13	UTSW	5	109,322,915 (GRCm39)	missense	probably benign	0.00
R5263:Vmn2r13	UTSW	5	109,321,841 (GRCm39)	missense	probably benign	0.00
R5297:Vmn2r13	UTSW	5	109,339,805 (GRCm39)	missense	probably benign	0.00
R5502:Vmn2r13	UTSW	5	109,321,580 (GRCm39)	missense	probably damaging	1.00
R5554:Vmn2r13	UTSW	5	109,339,860 (GRCm39)	missense	possibly damaging	0.49
R5563:Vmn2r13	UTSW	5	109,321,846 (GRCm39)	missense	probably benign	0.00
R5819:Vmn2r13	UTSW	5	109,321,966 (GRCm39)	missense	possibly damaging	0.79
R6074:Vmn2r13	UTSW	5	109,322,167 (GRCm39)	missense	probably benign	0.04
R6416:Vmn2r13	UTSW	5	109,321,982 (GRCm39)	missense	probably damaging	0.99
R6419:Vmn2r13	UTSW	5	109,323,085 (GRCm39)	missense	possibly damaging	0.87
R6484:Vmn2r13	UTSW	5	109,304,540 (GRCm39)	nonsense	probably null
R6486:Vmn2r13	UTSW	5	109,304,425 (GRCm39)	missense	probably benign	0.05
R6545:Vmn2r13	UTSW	5	109,304,806 (GRCm39)	splice site	probably null
R6700:Vmn2r13	UTSW	5	109,322,938 (GRCm39)	missense	probably benign	0.00
R6897:Vmn2r13	UTSW	5	109,306,015 (GRCm39)	missense	possibly damaging	0.90
R6957:Vmn2r13	UTSW	5	109,304,753 (GRCm39)	nonsense	probably null
R7276:Vmn2r13	UTSW	5	109,321,645 (GRCm39)	missense	probably damaging	1.00
R7363:Vmn2r13	UTSW	5	109,339,909 (GRCm39)	missense	probably benign	0.03
R7443:Vmn2r13	UTSW	5	109,339,909 (GRCm39)	missense	probably benign	0.03
R7555:Vmn2r13	UTSW	5	109,319,557 (GRCm39)	splice site	probably null
R7607:Vmn2r13	UTSW	5	109,321,506 (GRCm39)	missense	probably damaging	0.98
R7719:Vmn2r13	UTSW	5	109,319,618 (GRCm39)	missense	probably benign	0.00
R8116:Vmn2r13	UTSW	5	109,322,926 (GRCm39)	missense	probably benign	0.12
R8242:Vmn2r13	UTSW	5	109,322,872 (GRCm39)	missense	possibly damaging	0.65
R8294:Vmn2r13	UTSW	5	109,322,978 (GRCm39)	missense	probably benign	0.02
R8340:Vmn2r13	UTSW	5	109,322,006 (GRCm39)	missense	probably benign	0.00
R8692:Vmn2r13	UTSW	5	109,319,514 (GRCm39)	missense	probably benign	0.03
R8742:Vmn2r13	UTSW	5	109,304,263 (GRCm39)	missense	probably benign	0.02
R9022:Vmn2r13	UTSW	5	109,304,242 (GRCm39)	missense	possibly damaging	0.94
R9281:Vmn2r13	UTSW	5	109,303,953 (GRCm39)	missense	probably damaging	1.00
R9529:Vmn2r13	UTSW	5	109,304,064 (GRCm39)	missense	probably damaging	1.00
R9708:Vmn2r13	UTSW	5	109,322,007 (GRCm39)	missense	probably benign	0.00
R9746:Vmn2r13	UTSW	5	109,339,773 (GRCm39)	critical splice donor site	probably null
X0066:Vmn2r13	UTSW	5	109,304,085 (GRCm39)	missense	probably benign	0.44

Posted On

2016-08-02