Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03301:Arl14'

416220

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Arl14

Ensembl Gene

ENSMUSG00000098207

Gene Name

ADP-ribosylation factor-like 14

Synonyms

Arf7, 9130014L17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.163) question?

Stock #

IGL03301

Quality Score

Status

Chromosome

Chromosomal Location

69129752-69130951 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 69130276 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 141 (F141S)

Ref Sequence

ENSEMBL: ENSMUSP00000138370 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000183126]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000183126
AA Change: F141S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000138370
Gene: ENSMUSG00000098207
AA Change: F141S

Domain	Start	End	E-Value	Type
ARF	1	180	9.31e-56	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 30 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts3	T	C	5: 89,855,263 (GRCm39)	E418G	probably damaging	Het
C1s1	A	T	6: 124,518,283 (GRCm39)		probably benign	Het
Cilp	T	C	9: 65,187,499 (GRCm39)	V1198A	probably benign	Het
Cnbd1	A	T	4: 19,055,039 (GRCm39)	I129K	probably benign	Het
Ctdp1	G	A	18: 80,492,849 (GRCm39)	Q549*	probably null	Het
Cyp2ab1	T	A	16: 20,132,549 (GRCm39)	I250F	possibly damaging	Het
Dmd	G	A	X: 82,952,120 (GRCm39)	R1765Q	probably damaging	Het
Dnah1	C	T	14: 31,014,649 (GRCm39)	G1739R	probably damaging	Het
Eml6	T	C	11: 29,714,083 (GRCm39)	K1350E	probably benign	Het
Ephx4	C	A	5: 107,574,730 (GRCm39)	T256K	probably benign	Het
Fnd3c2	G	T	X: 105,295,869 (GRCm39)	Q49K	probably benign	Het
Heatr1	G	T	13: 12,449,086 (GRCm39)	G1889W	probably damaging	Het
Igkv19-93	A	T	6: 68,713,465 (GRCm39)	W55R	probably damaging	Het
Jak1	T	C	4: 101,032,370 (GRCm39)	Y412C	probably damaging	Het
Moxd1	A	T	10: 24,155,382 (GRCm39)	N261I	probably damaging	Het
Mrgpra1	T	C	7: 46,985,164 (GRCm39)	N172D	probably benign	Het
Papolg	T	C	11: 23,824,503 (GRCm39)	N293S	probably benign	Het
Piezo2	A	G	18: 63,160,775 (GRCm39)	S2294P	probably damaging	Het
Ppp3cb	A	T	14: 20,574,052 (GRCm39)	V262D	probably damaging	Het
Rhox7a	A	G	X: 36,928,888 (GRCm39)	T235A	probably benign	Het
Saal1	A	G	7: 46,351,944 (GRCm39)		probably benign	Het
Scrn1	G	A	6: 54,525,322 (GRCm39)	R16*	probably null	Het
Slc22a2	A	G	17: 12,824,926 (GRCm39)	R263G	probably damaging	Het
Speer3	T	A	5: 13,845,447 (GRCm39)	L160H	probably damaging	Het
Tmcc2	T	C	1: 132,288,557 (GRCm39)	M377V	possibly damaging	Het
Tsen2	T	G	6: 115,545,732 (GRCm39)	Y341D	probably damaging	Het
Vmn2r13	A	T	5: 109,305,955 (GRCm39)	V541D	probably damaging	Het
Vmn2r15	A	G	5: 109,445,221 (GRCm39)		probably null	Het
Zfp711	T	C	X: 111,543,098 (GRCm39)	Y710H	probably damaging	Het
Zmiz2	C	T	11: 6,351,170 (GRCm39)	T566M	probably damaging	Het

Other mutations in Arl14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R5665:Arl14	UTSW	3	69,130,371 (GRCm39)	missense	probably damaging	1.00
R5894:Arl14	UTSW	3	69,130,009 (GRCm39)	missense	probably benign	0.35
R6577:Arl14	UTSW	3	69,130,405 (GRCm39)	missense	probably benign	0.06
R6860:Arl14	UTSW	3	69,130,029 (GRCm39)	missense	probably benign
R8283:Arl14	UTSW	3	69,129,868 (GRCm39)	missense	probably benign	0.00
Z1176:Arl14	UTSW	3	69,129,981 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02