Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03306:Rasd1'

416396

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Rasd1

Ensembl Gene

ENSMUSG00000049892

Gene Name

RAS, dexamethasone-induced 1

Synonyms

Dexras1

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03306

Quality Score

Status

Chromosome

Chromosomal Location

59854007-59855770 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 59855181 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 100 (I100F)

Ref Sequence

ENSEMBL: ENSMUSP00000051959 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000062405] [ENSMUST00000081980]

AlphaFold

O35626

Predicted Effect

possibly damaging
Transcript: ENSMUST00000062405
AA Change: I100F

PolyPhen 2 Score 0.638 (Sensitivity: 0.87; Specificity: 0.91)

SMART Domains

Protein: ENSMUSP00000051959
Gene: ENSMUSG00000049892
AA Change: I100F

Domain	Start	End	E-Value	Type
RAS	22	198	4.81e-81	SMART
low complexity region	217	243	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000081980

SMART Domains

Protein: ENSMUSP00000080641
Gene: ENSMUSG00000061650

Domain	Start	End	E-Value	Type
low complexity region	16	52	N/A	INTRINSIC
Pfam:Med9	59	135	3.2e-27	PFAM

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a direct nucleotide exchange factor for Gi-Go proteins. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. [provided by RefSeq, Nov 2015]
PHENOTYPE: Mice homozygous for disruptions in this gene have a reduced ability to entrain to low intensity light with resulting abnormalities in circadian rhythm. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 31 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agbl1	T	A	7: 76,239,252 (GRCm39)	F584Y	probably damaging	Het
Amer2	C	A	14: 60,616,001 (GRCm39)	D65E	probably damaging	Het
Arhgap28	A	T	17: 68,159,930 (GRCm39)	L623Q	probably damaging	Het
Cep152	T	C	2: 125,447,328 (GRCm39)	T407A	possibly damaging	Het
Cmpk2	A	G	12: 26,521,442 (GRCm39)	D238G	possibly damaging	Het
Fam169a	C	A	13: 97,243,497 (GRCm39)	Q176K	possibly damaging	Het
Fbxo17	T	A	7: 28,434,782 (GRCm39)	I189N	probably damaging	Het
Gm5581	T	A	6: 131,145,044 (GRCm39)		noncoding transcript	Het
Gpcpd1	C	T	2: 132,375,993 (GRCm39)		probably null	Het
Lhx2	A	G	2: 38,244,628 (GRCm39)	Y123C	probably damaging	Het
Llgl1	C	A	11: 60,602,180 (GRCm39)	T741N	possibly damaging	Het
Macc1	A	G	12: 119,410,603 (GRCm39)	Q457R	probably benign	Het
Mthfd2l	A	G	5: 91,168,067 (GRCm39)	T321A	probably damaging	Het
Myo6	T	C	9: 80,153,837 (GRCm39)	F271S	probably damaging	Het
Ncoa6	A	G	2: 155,247,427 (GRCm39)	V1959A	probably benign	Het
Npsr1	A	G	9: 24,224,535 (GRCm39)	D304G	probably benign	Het
Nup205	T	C	6: 35,185,104 (GRCm39)	V841A	probably damaging	Het
Or10c1	A	G	17: 37,522,568 (GRCm39)	Y59H	probably damaging	Het
Or1j20	A	T	2: 36,760,537 (GRCm39)		probably benign	Het
Osbpl9	A	G	4: 109,029,529 (GRCm39)		probably benign	Het
Pdgfra	A	G	5: 75,353,194 (GRCm39)	N995D	possibly damaging	Het
Ptgs1	A	T	2: 36,127,717 (GRCm39)	H92L	probably damaging	Het
Rbm26	T	C	14: 105,388,758 (GRCm39)	T378A	probably damaging	Het
Slc12a3	T	C	8: 95,078,386 (GRCm39)	S805P	possibly damaging	Het
Smarcal1	G	A	1: 72,665,625 (GRCm39)	V708I	probably benign	Het
Strn	A	G	17: 78,974,652 (GRCm39)	S408P	probably damaging	Het
Suclg1	A	G	6: 73,247,975 (GRCm39)	N232S	probably benign	Het
Tmbim1	A	G	1: 74,332,225 (GRCm39)	Y101H	probably damaging	Het
Ube3a	T	A	7: 58,935,895 (GRCm39)	L614Q	probably damaging	Het
Wrn	A	G	8: 33,826,149 (GRCm39)	L171P	probably damaging	Het
Zfp335	T	C	2: 164,737,904 (GRCm39)		probably benign	Het

Other mutations in Rasd1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01095:Rasd1	APN	11	59,855,117 (GRCm39)	missense	probably damaging	1.00
IGL02206:Rasd1	APN	11	59,854,778 (GRCm39)	missense	possibly damaging	0.69
IGL02534:Rasd1	APN	11	59,855,615 (GRCm39)	missense	possibly damaging	0.86
R0833:Rasd1	UTSW	11	59,855,379 (GRCm39)	missense	probably damaging	1.00
R0836:Rasd1	UTSW	11	59,855,379 (GRCm39)	missense	probably damaging	1.00
R1160:Rasd1	UTSW	11	59,855,547 (GRCm39)	missense	possibly damaging	0.78
R1647:Rasd1	UTSW	11	59,854,920 (GRCm39)	missense	probably benign	0.26
R5114:Rasd1	UTSW	11	59,854,933 (GRCm39)	missense	possibly damaging	0.69
R8234:Rasd1	UTSW	11	59,855,118 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02