Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03309:Zbtb41'

416507

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zbtb41

Ensembl Gene

ENSMUSG00000033964

Gene Name

zinc finger and BTB domain containing 41

Synonyms

8430415N23Rik, 9830132G07Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.200) question?

Stock #

IGL03309

Quality Score

Status

Chromosome

Chromosomal Location

139350026-139380743 bp(+) (GRCm39)

Type of Mutation

critical splice donor site (2 bp from exon)

DNA Base Change (assembly)

T to A at 139359816 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000142797 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000039867] [ENSMUST00000200243] [ENSMUST00000200243]

AlphaFold

Q811F1

Predicted Effect

probably null
Transcript: ENSMUST00000039867

SMART Domains

Protein: ENSMUSP00000045570
Gene: ENSMUSG00000033964

Domain	Start	End	E-Value	Type
low complexity region	70	81	N/A	INTRINSIC
BTB	89	183	7.06e-16	SMART
ZnF_C2H2	208	231	3.78e-1	SMART
low complexity region	234	245	N/A	INTRINSIC
low complexity region	265	279	N/A	INTRINSIC
low complexity region	301	327	N/A	INTRINSIC
ZnF_C2H2	360	382	4.17e-3	SMART
ZnF_C2H2	388	410	8.34e-3	SMART
ZnF_C2H2	421	444	2.67e-1	SMART
ZnF_C2H2	462	484	1.72e-4	SMART
ZnF_C2H2	490	513	1.41e0	SMART
ZnF_C2H2	517	540	1.12e-3	SMART
ZnF_C2H2	546	568	1.36e-2	SMART
ZnF_C2H2	574	596	2.91e-2	SMART
ZnF_C2H2	602	624	7.37e-4	SMART
ZnF_C2H2	630	653	3.39e-3	SMART
ZnF_C2H2	667	689	2.75e-3	SMART
ZnF_C2H2	695	717	3.16e-3	SMART
ZnF_C2H2	723	746	3.34e-2	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000199011

Predicted Effect

probably null
Transcript: ENSMUST00000200243

SMART Domains

Protein: ENSMUSP00000142797
Gene: ENSMUSG00000033964

Domain	Start	End	E-Value	Type
low complexity region	70	81	N/A	INTRINSIC
BTB	89	183	4.7e-18	SMART
ZnF_C2H2	208	231	1.6e-3	SMART
low complexity region	234	245	N/A	INTRINSIC
low complexity region	265	279	N/A	INTRINSIC
low complexity region	301	327	N/A	INTRINSIC
ZnF_C2H2	360	382	1.7e-5	SMART
ZnF_C2H2	388	410	3.5e-5	SMART
ZnF_C2H2	421	444	1.1e-3	SMART
ZnF_C2H2	462	484	7.2e-7	SMART
ZnF_C2H2	490	513	5.9e-3	SMART
ZnF_C2H2	517	540	4.7e-6	SMART
ZnF_C2H2	546	568	5.7e-5	SMART
ZnF_C2H2	574	596	1.3e-4	SMART
ZnF_C2H2	602	624	3e-6	SMART
ZnF_C2H2	630	653	1.5e-5	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000200243

SMART Domains

Protein: ENSMUSP00000142797
Gene: ENSMUSG00000033964

Domain	Start	End	E-Value	Type
low complexity region	70	81	N/A	INTRINSIC
BTB	89	183	4.7e-18	SMART
ZnF_C2H2	208	231	1.6e-3	SMART
low complexity region	234	245	N/A	INTRINSIC
low complexity region	265	279	N/A	INTRINSIC
low complexity region	301	327	N/A	INTRINSIC
ZnF_C2H2	360	382	1.7e-5	SMART
ZnF_C2H2	388	410	3.5e-5	SMART
ZnF_C2H2	421	444	1.1e-3	SMART
ZnF_C2H2	462	484	7.2e-7	SMART
ZnF_C2H2	490	513	5.9e-3	SMART
ZnF_C2H2	517	540	4.7e-6	SMART
ZnF_C2H2	546	568	5.7e-5	SMART
ZnF_C2H2	574	596	1.3e-4	SMART
ZnF_C2H2	602	624	3e-6	SMART
ZnF_C2H2	630	653	1.5e-5	SMART

Meta Mutation Damage Score

0.9499

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 33 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadac	A	G	3: 59,947,303 (GRCm39)	T334A	possibly damaging	Het
Armc9	A	G	1: 86,202,155 (GRCm39)	E771G	possibly damaging	Het
Cd207	G	T	6: 83,654,735 (GRCm39)	T16K	possibly damaging	Het
Cd44	C	T	2: 102,644,522 (GRCm39)	E421K	probably damaging	Het
Cfap221	A	G	1: 119,862,331 (GRCm39)	Y584H	probably damaging	Het
Clock	A	G	5: 76,379,241 (GRCm39)		probably null	Het
Clpx	T	G	9: 65,229,974 (GRCm39)	L474R	probably damaging	Het
Cntd1	T	C	11: 101,175,590 (GRCm39)	V143A	probably damaging	Het
Cttnbp2	A	G	6: 18,381,035 (GRCm39)	V877A	probably damaging	Het
Dlx6	G	T	6: 6,867,289 (GRCm39)	M158I	possibly damaging	Het
Fank1	A	G	7: 133,463,902 (GRCm39)	T33A	probably damaging	Het
Fbf1	A	G	11: 116,038,637 (GRCm39)	L828P	probably damaging	Het
Fh1	A	T	1: 175,431,609 (GRCm39)	S426T	probably benign	Het
Gabrg3	G	T	7: 56,632,433 (GRCm39)	Q172K	probably damaging	Het
Glipr1l1	A	G	10: 111,908,141 (GRCm39)		probably benign	Het
Hypk	T	A	2: 121,288,673 (GRCm39)	L113*	probably null	Het
Hypk	G	T	2: 121,288,674 (GRCm39)	L113F	probably damaging	Het
Ipo5	G	A	14: 121,157,416 (GRCm39)	V85I	probably benign	Het
Kif1a	A	T	1: 92,986,579 (GRCm39)	Y575*	probably null	Het
Morf4l1	T	A	9: 89,985,798 (GRCm39)	E60V	probably benign	Het
Or52ac1	A	G	7: 104,246,248 (GRCm39)	F47L	probably benign	Het
Or6c6	A	T	10: 129,187,178 (GRCm39)	T249S	probably benign	Het
Parp4	A	T	14: 56,825,265 (GRCm39)	T130S	probably benign	Het
Prkd1	A	G	12: 50,435,207 (GRCm39)	Y507H	probably damaging	Het
Psme2b	A	C	11: 48,836,626 (GRCm39)		probably null	Het
Rbm44	T	C	1: 91,096,562 (GRCm39)		probably null	Het
Rngtt	C	A	4: 33,339,091 (GRCm39)	R299S	probably damaging	Het
Ros1	A	G	10: 51,994,357 (GRCm39)	S1308P	possibly damaging	Het
Rpl3l	A	G	17: 24,954,998 (GRCm39)	K398E	possibly damaging	Het
Scube3	C	T	17: 28,383,331 (GRCm39)	R374*	probably null	Het
Srcap	A	G	7: 127,129,965 (GRCm39)	T616A	probably damaging	Het
Stk3	G	A	15: 35,099,697 (GRCm39)		probably benign	Het
Tas2r124	A	T	6: 132,731,898 (GRCm39)	D69V	probably benign	Het

Other mutations in Zbtb41

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00885:Zbtb41	APN	1	139,358,062 (GRCm39)	missense	probably benign	0.01
IGL01796:Zbtb41	APN	1	139,370,621 (GRCm39)	missense	probably damaging	0.99
IGL01844:Zbtb41	APN	1	139,375,065 (GRCm39)	missense	probably benign	0.01
IGL02150:Zbtb41	APN	1	139,368,186 (GRCm39)	missense	possibly damaging	0.73
IGL02346:Zbtb41	APN	1	139,374,838 (GRCm39)	missense	probably damaging	1.00
IGL03139:Zbtb41	APN	1	139,351,576 (GRCm39)	missense	probably benign	0.00
IGL03215:Zbtb41	APN	1	139,374,688 (GRCm39)	missense	probably damaging	1.00
memorialized	UTSW	1	139,368,132 (GRCm39)	missense	probably benign	0.00
Noted	UTSW	1	139,366,769 (GRCm39)	missense	probably damaging	0.99
R7584_zbtb41_939	UTSW	1	139,351,795 (GRCm39)	missense	probably benign	0.14
unforgotten	UTSW	1	139,359,816 (GRCm39)	critical splice donor site	probably null
R0004:Zbtb41	UTSW	1	139,370,626 (GRCm39)	missense	possibly damaging	0.90
R0010:Zbtb41	UTSW	1	139,351,268 (GRCm39)	missense	probably damaging	1.00
R0010:Zbtb41	UTSW	1	139,351,268 (GRCm39)	missense	probably damaging	1.00
R0048:Zbtb41	UTSW	1	139,369,572 (GRCm39)	missense	probably damaging	1.00
R0230:Zbtb41	UTSW	1	139,374,673 (GRCm39)	missense	probably damaging	1.00
R0309:Zbtb41	UTSW	1	139,366,722 (GRCm39)	missense	probably damaging	0.99
R0458:Zbtb41	UTSW	1	139,351,214 (GRCm39)	missense	probably damaging	1.00
R0606:Zbtb41	UTSW	1	139,351,348 (GRCm39)	missense	probably benign	0.28
R0964:Zbtb41	UTSW	1	139,366,769 (GRCm39)	missense	probably damaging	0.99
R1531:Zbtb41	UTSW	1	139,350,931 (GRCm39)	missense	probably benign	0.00
R1723:Zbtb41	UTSW	1	139,351,301 (GRCm39)	missense	probably benign	0.39
R1765:Zbtb41	UTSW	1	139,368,132 (GRCm39)	missense	probably benign	0.00
R1829:Zbtb41	UTSW	1	139,374,660 (GRCm39)	nonsense	probably null
R2077:Zbtb41	UTSW	1	139,351,831 (GRCm39)	missense	probably damaging	1.00
R2292:Zbtb41	UTSW	1	139,368,097 (GRCm39)	missense	probably damaging	0.99
R2380:Zbtb41	UTSW	1	139,351,552 (GRCm39)	missense	probably damaging	0.99
R2402:Zbtb41	UTSW	1	139,350,925 (GRCm39)	nonsense	probably null
R2402:Zbtb41	UTSW	1	139,350,923 (GRCm39)	missense	probably benign	0.10
R3847:Zbtb41	UTSW	1	139,351,734 (GRCm39)	missense	probably benign
R3848:Zbtb41	UTSW	1	139,351,734 (GRCm39)	missense	probably benign
R3849:Zbtb41	UTSW	1	139,351,734 (GRCm39)	missense	probably benign
R4077:Zbtb41	UTSW	1	139,357,064 (GRCm39)	missense	probably benign	0.11
R4641:Zbtb41	UTSW	1	139,370,557 (GRCm39)	missense	probably damaging	0.98
R4772:Zbtb41	UTSW	1	139,375,152 (GRCm39)	missense	probably damaging	1.00
R5646:Zbtb41	UTSW	1	139,351,501 (GRCm39)	missense	probably benign	0.05
R5754:Zbtb41	UTSW	1	139,359,816 (GRCm39)	critical splice donor site	probably null
R6002:Zbtb41	UTSW	1	139,351,397 (GRCm39)	missense	probably damaging	1.00
R6045:Zbtb41	UTSW	1	139,351,770 (GRCm39)	missense	probably benign	0.34
R6302:Zbtb41	UTSW	1	139,357,027 (GRCm39)	missense	possibly damaging	0.67
R6318:Zbtb41	UTSW	1	139,358,044 (GRCm39)	missense	possibly damaging	0.91
R6430:Zbtb41	UTSW	1	139,374,945 (GRCm39)	missense	probably benign	0.02
R6906:Zbtb41	UTSW	1	139,351,128 (GRCm39)	missense	possibly damaging	0.59
R7584:Zbtb41	UTSW	1	139,351,795 (GRCm39)	missense	probably benign	0.14
R7753:Zbtb41	UTSW	1	139,374,895 (GRCm39)	missense	probably benign
R8132:Zbtb41	UTSW	1	139,350,955 (GRCm39)	missense	probably benign	0.00
R8138:Zbtb41	UTSW	1	139,369,545 (GRCm39)	missense	probably damaging	1.00
R8205:Zbtb41	UTSW	1	139,356,919 (GRCm39)	missense	possibly damaging	0.96
R8823:Zbtb41	UTSW	1	139,350,892 (GRCm39)	missense	probably damaging	1.00
R8967:Zbtb41	UTSW	1	139,370,587 (GRCm39)	missense	probably benign
R9431:Zbtb41	UTSW	1	139,350,781 (GRCm39)	start gained	probably benign
R9500:Zbtb41	UTSW	1	139,359,806 (GRCm39)	missense	probably damaging	1.00
R9559:Zbtb41	UTSW	1	139,358,053 (GRCm39)	missense	probably benign	0.14
R9603:Zbtb41	UTSW	1	139,375,255 (GRCm39)	missense	probably damaging	1.00
R9789:Zbtb41	UTSW	1	139,368,084 (GRCm39)	missense	probably damaging	1.00
Z1177:Zbtb41	UTSW	1	139,351,154 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02