Incidental Mutation 'IGL03323:Iigp1'
| ID |
416549 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Iigp1
|
| Ensembl Gene |
ENSMUSG00000054072 |
| Gene Name |
interferon inducible GTPase 1 |
| Synonyms |
2900074L10Rik, Irga6 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.052)
|
| Stock # |
IGL03323
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
18 |
| Chromosomal Location |
60509099-60525706 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 60522896 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 5
(F5L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000063390
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032473]
[ENSMUST00000066912]
|
| AlphaFold |
Q9QZ85 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000032473
AA Change: F5L
PolyPhen 2
Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000032473
Gene: ENSMUSG00000054072
AA Change: F5L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:IIGP
|
35 |
409 |
5.5e-182 |
PFAM |
|
Pfam:MMR_HSR1
|
71 |
210 |
1.4e-7 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000066912
AA Change: F5L
PolyPhen 2
Score 0.039 (Sensitivity: 0.94; Specificity: 0.83)
|
| SMART Domains |
Protein: ENSMUSP00000063390
Gene: ENSMUSG00000054072
AA Change: F5L
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:IIGP
|
35 |
409 |
7.9e-182 |
PFAM |
|
Pfam:MMR_HSR1
|
71 |
212 |
8.2e-9 |
PFAM |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
PHENOTYPE: Targeted deletion of this gene results in partial loss of IFN-gamma-mediated Toxoplasma gondii growth restriction in primary mouse astrocytes. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 29 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Acod1 |
A |
T |
14: 103,292,730 (GRCm39) |
D418V |
probably damaging |
Het |
| Ahdc1 |
G |
A |
4: 132,792,739 (GRCm39) |
G1327S |
probably benign |
Het |
| Bcl2l15 |
A |
T |
3: 103,740,719 (GRCm39) |
I62L |
probably benign |
Het |
| Ccdc7a |
A |
T |
8: 129,785,244 (GRCm39) |
D105E |
probably benign |
Het |
| Cldn12 |
C |
A |
5: 5,558,421 (GRCm39) |
G2V |
probably damaging |
Het |
| Eapp |
G |
T |
12: 54,720,400 (GRCm39) |
H272N |
probably damaging |
Het |
| Fcrla |
A |
G |
1: 170,755,114 (GRCm39) |
|
probably benign |
Het |
| Fmnl3 |
C |
T |
15: 99,219,162 (GRCm39) |
G787S |
probably damaging |
Het |
| Fmo5 |
G |
T |
3: 97,546,323 (GRCm39) |
|
probably null |
Het |
| Golgb1 |
G |
T |
16: 36,733,815 (GRCm39) |
E1021* |
probably null |
Het |
| Hspa4 |
A |
T |
11: 53,155,960 (GRCm39) |
N648K |
probably benign |
Het |
| Lad1 |
T |
A |
1: 135,758,712 (GRCm39) |
|
probably null |
Het |
| Man2b2 |
T |
C |
5: 36,975,858 (GRCm39) |
D399G |
probably benign |
Het |
| Mc5r |
C |
T |
18: 68,472,286 (GRCm39) |
T215I |
probably benign |
Het |
| Mx2 |
A |
G |
16: 97,347,575 (GRCm39) |
S156G |
probably damaging |
Het |
| Necap2 |
A |
T |
4: 140,795,533 (GRCm39) |
I242N |
possibly damaging |
Het |
| Nme8 |
C |
T |
13: 19,873,120 (GRCm39) |
E175K |
probably benign |
Het |
| Notch4 |
T |
A |
17: 34,801,445 (GRCm39) |
C1098S |
probably damaging |
Het |
| Or1j16 |
T |
A |
2: 36,530,153 (GRCm39) |
M34K |
possibly damaging |
Het |
| Or7a42 |
T |
C |
10: 78,791,434 (GRCm39) |
Y132H |
probably benign |
Het |
| Osbpl9 |
A |
G |
4: 108,919,656 (GRCm39) |
|
probably benign |
Het |
| Prag1 |
T |
C |
8: 36,607,162 (GRCm39) |
S968P |
probably damaging |
Het |
| Qsox2 |
A |
G |
2: 26,110,991 (GRCm39) |
S125P |
probably benign |
Het |
| Rptn |
A |
G |
3: 93,304,460 (GRCm39) |
T598A |
probably benign |
Het |
| Slc2a2 |
G |
A |
3: 28,780,439 (GRCm39) |
M375I |
probably damaging |
Het |
| Tmed9 |
C |
T |
13: 55,744,691 (GRCm39) |
T173I |
probably damaging |
Het |
| Trank1 |
A |
G |
9: 111,181,184 (GRCm39) |
D402G |
probably damaging |
Het |
| Ttc21a |
G |
T |
9: 119,769,602 (GRCm39) |
|
probably benign |
Het |
| Vmn2r58 |
T |
C |
7: 41,511,295 (GRCm39) |
M503V |
probably benign |
Het |
|
| Other mutations in Iigp1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00798:Iigp1
|
APN |
18 |
60,524,073 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0025:Iigp1
|
UTSW |
18 |
60,523,859 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R0410:Iigp1
|
UTSW |
18 |
60,523,375 (GRCm39) |
missense |
probably benign |
0.15 |
|
R0564:Iigp1
|
UTSW |
18 |
60,523,523 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0609:Iigp1
|
UTSW |
18 |
60,522,896 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1549:Iigp1
|
UTSW |
18 |
60,522,948 (GRCm39) |
missense |
probably benign |
|
|
R2226:Iigp1
|
UTSW |
18 |
60,522,960 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R2264:Iigp1
|
UTSW |
18 |
60,523,738 (GRCm39) |
missense |
probably benign |
0.20 |
|
R3110:Iigp1
|
UTSW |
18 |
60,523,983 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3112:Iigp1
|
UTSW |
18 |
60,523,983 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4575:Iigp1
|
UTSW |
18 |
60,523,218 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4795:Iigp1
|
UTSW |
18 |
60,522,964 (GRCm39) |
missense |
probably benign |
0.13 |
|
R5439:Iigp1
|
UTSW |
18 |
60,523,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6565:Iigp1
|
UTSW |
18 |
60,523,839 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8775:Iigp1
|
UTSW |
18 |
60,523,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8775-TAIL:Iigp1
|
UTSW |
18 |
60,523,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9298:Iigp1
|
UTSW |
18 |
60,523,063 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9520:Iigp1
|
UTSW |
18 |
60,523,451 (GRCm39) |
missense |
probably benign |
|
|
| Posted On |
2016-08-02 |
Incidental Mutation