Incidental Mutation 'IGL03327:Il25'
ID 416709
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Il25
Ensembl Gene ENSMUSG00000040770
Gene Name interleukin 25
Synonyms Il17e, IL-17E
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03327
Quality Score
Status
Chromosome 14
Chromosomal Location 55170152-55173294 bp(+) (GRCm39)
Type of Mutation unclassified
DNA Base Change (assembly) T to C at 55172817 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153874 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037814] [ENSMUST00000037863] [ENSMUST00000227441]
AlphaFold Q8VHH8
Predicted Effect probably benign
Transcript: ENSMUST00000037814
SMART Domains Protein: ENSMUSP00000036138
Gene: ENSMUSG00000040759

DomainStartEndE-ValueType
transmembrane domain 35 56 N/A INTRINSIC
transmembrane domain 60 82 N/A INTRINSIC
transmembrane domain 95 114 N/A INTRINSIC
transmembrane domain 119 136 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000037863
SMART Domains Protein: ENSMUSP00000039641
Gene: ENSMUSG00000040770

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:IL17 77 163 4.2e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000226807
Predicted Effect probably benign
Transcript: ENSMUST00000227441
Predicted Effect noncoding transcript
Transcript: ENSMUST00000227485
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
PHENOTYPE: Mice homozygous for a null allele have increased susceptibility to parasitic infection. Male homozygous mutant mice exhibit notably increased mean serum triglyceride levels in another null allele. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adcy8 T C 15: 64,792,116 (GRCm39) Y280C probably damaging Het
Anapc1 T C 2: 128,465,854 (GRCm39) T1647A probably benign Het
Ano3 T C 2: 110,527,523 (GRCm39) I562V possibly damaging Het
Ash1l C T 3: 88,930,390 (GRCm39) P1956S probably benign Het
Ccdc9b T C 2: 118,592,151 (GRCm39) N79S probably damaging Het
Cd160 C T 3: 96,712,849 (GRCm39) probably null Het
Chd3 G T 11: 69,241,012 (GRCm39) A1527E probably damaging Het
Clcn1 C T 6: 42,288,153 (GRCm39) T797I probably benign Het
Cntnap3 G A 13: 65,035,582 (GRCm39) Q44* probably null Het
Cntnap4 A G 8: 113,500,208 (GRCm39) D500G probably benign Het
Col6a6 T C 9: 105,644,433 (GRCm39) D1285G possibly damaging Het
Cr2 A T 1: 194,852,067 (GRCm39) V94E probably damaging Het
Dcaf1 T C 9: 106,735,823 (GRCm39) S924P possibly damaging Het
Eif5b T C 1: 38,080,772 (GRCm39) probably benign Het
Fat1 A C 8: 45,403,505 (GRCm39) K85N probably damaging Het
Fnip2 T C 3: 79,425,388 (GRCm39) E69G probably damaging Het
Fzr1 T C 10: 81,205,018 (GRCm39) T300A probably benign Het
Galc A G 12: 98,173,735 (GRCm39) probably benign Het
Gm17079 T C 14: 51,930,420 (GRCm39) T142A possibly damaging Het
Hibch G A 1: 52,959,539 (GRCm39) probably benign Het
Hmmr A G 11: 40,606,242 (GRCm39) C243R probably damaging Het
Kif5b G A 18: 6,222,767 (GRCm39) R355W probably damaging Het
Kifc3 C T 8: 95,835,060 (GRCm39) D242N probably damaging Het
Lig1 T G 7: 13,037,781 (GRCm39) I677S probably damaging Het
Lrig1 G T 6: 94,583,104 (GRCm39) A1004E probably benign Het
Nras A G 3: 102,966,340 (GRCm39) T35A probably damaging Het
Nt5c1b C T 12: 10,424,861 (GRCm39) Q136* probably null Het
Or4f54 A T 2: 111,122,807 (GRCm39) N65Y probably damaging Het
Or6c217 T G 10: 129,738,451 (GRCm39) I43L possibly damaging Het
Or8k1 C T 2: 86,047,618 (GRCm39) W145* probably null Het
Plcb3 A G 19: 6,932,420 (GRCm39) F1080L probably benign Het
Plpp2 T C 10: 79,366,818 (GRCm39) probably null Het
Ptpre G A 7: 135,274,551 (GRCm39) probably null Het
Scn3a G A 2: 65,367,016 (GRCm39) A2V probably damaging Het
Sh3bp4 C A 1: 89,071,885 (GRCm39) Y244* probably null Het
Trip11 A T 12: 101,849,677 (GRCm39) N1462K possibly damaging Het
Ttc21b T C 2: 66,068,192 (GRCm39) D278G possibly damaging Het
Virma A G 4: 11,518,984 (GRCm39) T694A probably benign Het
Wdr35 T C 12: 9,028,694 (GRCm39) probably benign Het
Xdh T C 17: 74,223,787 (GRCm39) E535G probably benign Het
Other mutations in Il25
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0035:Il25 UTSW 14 55,170,553 (GRCm39) missense probably damaging 0.99
R0368:Il25 UTSW 14 55,172,631 (GRCm39) splice site probably null
R1212:Il25 UTSW 14 55,170,212 (GRCm39) unclassified probably benign
R6733:Il25 UTSW 14 55,170,490 (GRCm39) missense probably benign 0.07
R7044:Il25 UTSW 14 55,170,615 (GRCm39) missense probably benign
R7464:Il25 UTSW 14 55,170,679 (GRCm39) missense probably null 1.00
R7488:Il25 UTSW 14 55,170,459 (GRCm39) missense probably benign
Z1177:Il25 UTSW 14 55,172,664 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02