Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03333:Lvrn'

416945

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Lvrn

Ensembl Gene

ENSMUSG00000024481

Gene Name

laeverin

Synonyms

4833403I15Rik, Aqpep

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.342) question?

Stock #

IGL03333

Quality Score

Status

Chromosome

Chromosomal Location

46983105-47040309 bp(+) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

G to A at 46997731 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000025358 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000025358]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000025358

SMART Domains

Protein: ENSMUSP00000025358
Gene: ENSMUSG00000024481

Domain	Start	End	E-Value	Type
transmembrane domain	13	35	N/A	INTRINSIC
Pfam:Peptidase_M1	94	504	1.6e-110	PFAM
Pfam:ERAP1_C	645	968	2.5e-60	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Arhgap39	T	C	15: 76,610,932 (GRCm39)	M893V	probably benign	Het
Ccdc185	C	A	1: 182,576,398 (GRCm39)	G97V	probably damaging	Het
Cep170	T	C	1: 176,597,092 (GRCm39)	T422A	possibly damaging	Het
Ckap2l	A	C	2: 129,138,228 (GRCm39)		probably null	Het
Cpa3	A	G	3: 20,269,992 (GRCm39)	Y411H	possibly damaging	Het
Dnah2	C	A	11: 69,385,949 (GRCm39)	R1011L	probably damaging	Het
Efnb2	T	A	8: 8,689,275 (GRCm39)	K30*	probably null	Het
Ep400	C	T	5: 110,851,432 (GRCm39)	R1350H	unknown	Het
Epha6	T	C	16: 59,503,051 (GRCm39)	D952G	probably damaging	Het
Exoc7	C	A	11: 116,191,987 (GRCm39)	V195L	probably benign	Het
Fbxw8	T	C	5: 118,233,660 (GRCm39)	M324V	possibly damaging	Het
Fchsd2	T	C	7: 100,847,703 (GRCm39)	S198P	probably damaging	Het
Gcdh	T	C	8: 85,617,700 (GRCm39)	T202A	probably benign	Het
Gm6619	G	A	6: 131,467,471 (GRCm39)		probably benign	Het
Itpr1	A	T	6: 108,357,871 (GRCm39)		probably benign	Het
Kif2c	A	C	4: 117,037,833 (GRCm39)	V31G	possibly damaging	Het
Kpna7	T	C	5: 144,942,765 (GRCm39)	I74V	possibly damaging	Het
Man2b2	T	A	5: 36,973,483 (GRCm39)	I499F	probably damaging	Het
Mmd2	G	T	5: 142,553,693 (GRCm39)		probably benign	Het
Or11h7	C	T	14: 50,890,855 (GRCm39)	Q54*	probably null	Het
Or2r11	T	C	6: 42,437,773 (GRCm39)	Y60C	probably damaging	Het
Or6b1	T	A	6: 42,815,637 (GRCm39)	I274N	possibly damaging	Het
Or8g2b	T	A	9: 39,751,308 (GRCm39)	Y193N	probably damaging	Het
Parp14	A	G	16: 35,661,800 (GRCm39)	S1412P	probably benign	Het
Prr30	A	T	14: 101,435,827 (GRCm39)	V245E	possibly damaging	Het
Ros1	T	A	10: 52,031,267 (GRCm39)	D458V	probably damaging	Het
Sec22c	A	G	9: 121,517,284 (GRCm39)	L138P	probably damaging	Het
Sema6d	C	A	2: 124,506,290 (GRCm39)	H699Q	possibly damaging	Het
Spata17	A	T	1: 186,872,667 (GRCm39)	M1K	probably null	Het
Tpr	T	A	1: 150,302,718 (GRCm39)	D1331E	probably benign	Het
Ttc4	A	G	4: 106,533,828 (GRCm39)	Y120H	probably benign	Het
Tubgcp4	A	G	2: 121,026,654 (GRCm39)		probably null	Het
Usp19	T	A	9: 108,371,348 (GRCm39)	M285K	probably benign	Het
Vmn1r222	A	T	13: 23,417,177 (GRCm39)	F12Y	probably benign	Het
Vmn2r72	T	C	7: 85,400,075 (GRCm39)	K325E	probably benign	Het
Vps33b	T	C	7: 79,923,973 (GRCm39)		probably benign	Het
Zfp784	C	T	7: 5,039,351 (GRCm39)		probably benign	Het

Other mutations in Lvrn

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01287:Lvrn	APN	18	46,997,733 (GRCm39)	splice site	probably benign
IGL01532:Lvrn	APN	18	47,033,551 (GRCm39)	missense	probably damaging	1.00
IGL02430:Lvrn	APN	18	47,027,797 (GRCm39)	missense	probably benign	0.03
IGL02573:Lvrn	APN	18	47,010,016 (GRCm39)	missense	probably damaging	0.98
IGL02592:Lvrn	APN	18	46,983,658 (GRCm39)	missense	probably damaging	1.00
IGL02754:Lvrn	APN	18	47,023,971 (GRCm39)	nonsense	probably null
IGL03089:Lvrn	APN	18	47,013,776 (GRCm39)	missense	probably damaging	0.99
IGL03209:Lvrn	APN	18	47,022,565 (GRCm39)	missense	probably benign	0.00
IGL03098:Lvrn	UTSW	18	47,014,477 (GRCm39)	critical splice acceptor site	probably null
R0319:Lvrn	UTSW	18	46,997,820 (GRCm39)	missense	probably damaging	1.00
R0391:Lvrn	UTSW	18	46,983,533 (GRCm39)	missense	probably benign	0.01
R0398:Lvrn	UTSW	18	47,013,760 (GRCm39)	missense	probably benign	0.06
R0432:Lvrn	UTSW	18	47,038,366 (GRCm39)	missense	possibly damaging	0.94
R0456:Lvrn	UTSW	18	46,997,883 (GRCm39)	critical splice donor site	probably null
R1458:Lvrn	UTSW	18	47,015,452 (GRCm39)	splice site	probably benign
R1612:Lvrn	UTSW	18	47,027,770 (GRCm39)	missense	probably damaging	0.99
R1935:Lvrn	UTSW	18	47,011,387 (GRCm39)	missense	probably benign	0.10
R1936:Lvrn	UTSW	18	47,011,387 (GRCm39)	missense	probably benign	0.10
R1959:Lvrn	UTSW	18	47,027,784 (GRCm39)	missense	probably damaging	1.00
R2000:Lvrn	UTSW	18	47,038,374 (GRCm39)	missense	probably benign	0.04
R2022:Lvrn	UTSW	18	46,999,503 (GRCm39)	missense	possibly damaging	0.81
R2106:Lvrn	UTSW	18	47,011,356 (GRCm39)	missense	probably damaging	1.00
R2197:Lvrn	UTSW	18	47,011,409 (GRCm39)	missense	probably benign	0.03
R2371:Lvrn	UTSW	18	47,011,230 (GRCm39)	splice site	probably null
R4125:Lvrn	UTSW	18	47,010,036 (GRCm39)	missense	possibly damaging	0.53
R4606:Lvrn	UTSW	18	46,997,832 (GRCm39)	missense	possibly damaging	0.92
R4830:Lvrn	UTSW	18	47,038,418 (GRCm39)	missense	probably damaging	1.00
R4866:Lvrn	UTSW	18	47,026,768 (GRCm39)	missense	probably damaging	1.00
R4900:Lvrn	UTSW	18	47,014,479 (GRCm39)	missense	probably damaging	1.00
R4900:Lvrn	UTSW	18	47,026,768 (GRCm39)	missense	probably damaging	1.00
R4924:Lvrn	UTSW	18	47,027,792 (GRCm39)	missense	probably damaging	1.00
R4948:Lvrn	UTSW	18	47,013,803 (GRCm39)	missense	probably damaging	1.00
R5167:Lvrn	UTSW	18	47,013,814 (GRCm39)	missense	probably damaging	0.99
R5527:Lvrn	UTSW	18	47,006,870 (GRCm39)	missense	probably damaging	1.00
R5581:Lvrn	UTSW	18	47,023,932 (GRCm39)	missense	probably benign	0.17
R5615:Lvrn	UTSW	18	46,983,395 (GRCm39)	missense	possibly damaging	0.55
R5859:Lvrn	UTSW	18	47,026,816 (GRCm39)	missense	probably damaging	1.00
R6149:Lvrn	UTSW	18	47,017,499 (GRCm39)	missense	probably benign	0.10
R6183:Lvrn	UTSW	18	46,983,752 (GRCm39)	missense	probably benign	0.14
R6378:Lvrn	UTSW	18	47,028,024 (GRCm39)	missense	probably benign	0.00
R6838:Lvrn	UTSW	18	47,023,947 (GRCm39)	missense	possibly damaging	0.88
R6993:Lvrn	UTSW	18	47,015,365 (GRCm39)	missense	probably benign	0.18
R7017:Lvrn	UTSW	18	46,983,745 (GRCm39)	missense	probably benign	0.00
R7168:Lvrn	UTSW	18	47,014,389 (GRCm39)	missense	probably benign	0.29
R7190:Lvrn	UTSW	18	47,033,570 (GRCm39)	missense	probably benign	0.02
R7315:Lvrn	UTSW	18	47,010,051 (GRCm39)	missense	probably benign	0.34
R8293:Lvrn	UTSW	18	46,983,632 (GRCm39)	missense	possibly damaging	0.75
R8375:Lvrn	UTSW	18	46,983,289 (GRCm39)	missense	probably damaging	0.98
R9563:Lvrn	UTSW	18	47,017,506 (GRCm39)	missense	probably damaging	1.00
R9564:Lvrn	UTSW	18	47,017,506 (GRCm39)	missense	probably damaging	1.00
R9565:Lvrn	UTSW	18	47,017,506 (GRCm39)	missense	probably damaging	1.00
R9585:Lvrn	UTSW	18	47,011,411 (GRCm39)	critical splice donor site	probably null
R9599:Lvrn	UTSW	18	46,999,494 (GRCm39)	missense	probably benign	0.37
R9694:Lvrn	UTSW	18	47,033,609 (GRCm39)	missense	probably damaging	1.00
R9709:Lvrn	UTSW	18	47,006,847 (GRCm39)	critical splice acceptor site	probably null

Posted On

2016-08-02