Incidental Mutation 'IGL03334:Or1j10'
ID 416948
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or1j10
Ensembl Gene ENSMUSG00000068950
Gene Name olfactory receptor family 1 subfamily J member 10
Synonyms GA_x6K02T2NLDC-33070879-33071799, Olfr338, MOR136-5
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL03334
Quality Score
Status
Chromosome 2
Chromosomal Location 36266790-36267710 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 36267063 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 92 (Y92H)
Ref Sequence ENSEMBL: ENSMUSP00000149146 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000072114] [ENSMUST00000091006] [ENSMUST00000217511]
AlphaFold Q8VGK6
Predicted Effect possibly damaging
Transcript: ENSMUST00000072114
AA Change: Y92H

PolyPhen 2 Score 0.656 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000071985
Gene: ENSMUSG00000068950
AA Change: Y92H

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 3.3e-57 PFAM
Pfam:7TM_GPCR_Srsx 35 305 3.8e-8 PFAM
Pfam:7tm_1 41 290 1.1e-24 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000091006
AA Change: Y92H

PolyPhen 2 Score 0.656 (Sensitivity: 0.87; Specificity: 0.91)
SMART Domains Protein: ENSMUSP00000088528
Gene: ENSMUSG00000068950
AA Change: Y92H

DomainStartEndE-ValueType
Pfam:7tm_4 29 306 3.9e-56 PFAM
Pfam:7tm_1 39 288 4.5e-22 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000217511
AA Change: Y92H

PolyPhen 2 Score 0.656 (Sensitivity: 0.87; Specificity: 0.91)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930111J21Rik1 A G 11: 48,838,302 (GRCm39) F762L probably benign Het
Angpt1 T A 15: 42,359,808 (GRCm39) E208V possibly damaging Het
Arhgef18 A T 8: 3,438,023 (GRCm39) I286F probably benign Het
Arhgef5 T C 6: 43,250,934 (GRCm39) S562P possibly damaging Het
Asb6 T C 2: 30,714,496 (GRCm39) T205A probably benign Het
B4galnt4 G A 7: 140,647,354 (GRCm39) probably null Het
Clca4a A T 3: 144,659,627 (GRCm39) M743K probably benign Het
Col14a1 T C 15: 55,312,217 (GRCm39) probably benign Het
Col27a1 A T 4: 63,232,959 (GRCm39) Y359F probably damaging Het
Dhcr7 T A 7: 143,394,234 (GRCm39) V125D possibly damaging Het
Ercc3 T C 18: 32,373,890 (GRCm39) probably null Het
Fnbp1l A G 3: 122,351,598 (GRCm39) V315A probably benign Het
Gm17174 T A 14: 51,829,420 (GRCm39) R48* probably null Het
Golga4 C T 9: 118,366,301 (GRCm39) probably benign Het
Grin1 C T 2: 25,188,405 (GRCm39) probably null Het
Ifi203 T A 1: 173,765,401 (GRCm39) K58* probably null Het
Ighv2-9-1 A G 12: 113,733,543 (GRCm39) S93P probably benign Het
Il27ra A G 8: 84,757,751 (GRCm39) V594A probably benign Het
Krr1 T G 10: 111,815,959 (GRCm39) S275R probably benign Het
Lars1 T C 18: 42,354,571 (GRCm39) D792G probably benign Het
Myo1f G A 17: 33,817,168 (GRCm39) R737H probably damaging Het
Nebl T A 2: 17,418,522 (GRCm39) H292L probably damaging Het
Nell1 C A 7: 49,712,359 (GRCm39) probably null Het
Nktr T C 9: 121,577,242 (GRCm39) F412L probably benign Het
Nlrp3 T A 11: 59,439,842 (GRCm39) I473N probably damaging Het
Phf3 A G 1: 30,844,810 (GRCm39) V1383A probably damaging Het
Prss48 T C 3: 85,904,625 (GRCm39) E191G probably damaging Het
Psg25 T A 7: 18,263,699 (GRCm39) L41F probably benign Het
Sema3b A G 9: 107,481,276 (GRCm39) L78P probably damaging Het
Spen G T 4: 141,197,280 (GRCm39) N3496K probably damaging Het
Tbk1 A T 10: 121,420,104 (GRCm39) H28Q possibly damaging Het
Trpv3 T A 11: 73,172,491 (GRCm39) probably benign Het
Vmn1r218 T C 13: 23,320,788 (GRCm39) L45P probably damaging Het
Vmn2r35 T A 7: 7,789,493 (GRCm39) Y748F probably damaging Het
Vps18 C T 2: 119,127,963 (GRCm39) R929W probably damaging Het
Xpnpep1 T C 19: 52,998,577 (GRCm39) K224E probably damaging Het
Zbed5 T A 5: 129,931,196 (GRCm39) F382I possibly damaging Het
Other mutations in Or1j10
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00958:Or1j10 APN 2 36,266,928 (GRCm39) missense probably damaging 0.99
IGL01089:Or1j10 APN 2 36,267,178 (GRCm39) missense probably damaging 1.00
IGL01298:Or1j10 APN 2 36,267,460 (GRCm39) missense probably benign 0.01
IGL01300:Or1j10 APN 2 36,267,054 (GRCm39) missense probably benign 0.13
IGL01632:Or1j10 APN 2 36,267,576 (GRCm39) missense probably benign 0.02
IGL02480:Or1j10 APN 2 36,267,504 (GRCm39) missense probably damaging 0.98
IGL02519:Or1j10 APN 2 36,267,325 (GRCm39) missense possibly damaging 0.84
IGL02658:Or1j10 APN 2 36,267,072 (GRCm39) missense probably damaging 0.97
IGL02716:Or1j10 APN 2 36,267,355 (GRCm39) missense possibly damaging 0.88
IGL02983:Or1j10 APN 2 36,267,649 (GRCm39) missense probably damaging 1.00
IGL03054:Or1j10 UTSW 2 36,266,944 (GRCm39) missense possibly damaging 0.65
R0469:Or1j10 UTSW 2 36,267,474 (GRCm39) missense probably benign 0.02
R1263:Or1j10 UTSW 2 36,267,006 (GRCm39) missense probably damaging 0.99
R1500:Or1j10 UTSW 2 36,267,633 (GRCm39) missense probably benign 0.04
R2444:Or1j10 UTSW 2 36,267,625 (GRCm39) missense possibly damaging 0.59
R5571:Or1j10 UTSW 2 36,267,129 (GRCm39) missense probably benign 0.01
R5999:Or1j10 UTSW 2 36,267,322 (GRCm39) missense probably damaging 1.00
R6030:Or1j10 UTSW 2 36,267,556 (GRCm39) missense probably damaging 0.97
R6030:Or1j10 UTSW 2 36,267,556 (GRCm39) missense probably damaging 0.97
R6351:Or1j10 UTSW 2 36,267,208 (GRCm39) missense possibly damaging 0.78
R6695:Or1j10 UTSW 2 36,267,117 (GRCm39) missense probably benign 0.28
R6785:Or1j10 UTSW 2 36,266,963 (GRCm39) nonsense probably null
R6785:Or1j10 UTSW 2 36,266,854 (GRCm39) missense probably benign 0.12
R7795:Or1j10 UTSW 2 36,267,453 (GRCm39) missense probably benign 0.05
R7814:Or1j10 UTSW 2 36,266,821 (GRCm39) missense possibly damaging 0.48
R7878:Or1j10 UTSW 2 36,267,145 (GRCm39) missense probably damaging 1.00
R8820:Or1j10 UTSW 2 36,267,006 (GRCm39) missense probably damaging 1.00
R8952:Or1j10 UTSW 2 36,267,402 (GRCm39) missense probably benign 0.01
R9512:Or1j10 UTSW 2 36,267,325 (GRCm39) missense possibly damaging 0.84
R9676:Or1j10 UTSW 2 36,266,848 (GRCm39) missense probably benign 0.01
R9705:Or1j10 UTSW 2 36,266,962 (GRCm39) missense probably damaging 0.98
Posted On 2016-08-02