Incidental Mutation 'IGL03338:Ccl25'
ID 417129
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ccl25
Ensembl Gene ENSMUSG00000023235
Gene Name C-C motif chemokine ligand 25
Synonyms Scya25, CKb15, TECK
Accession Numbers
Essential gene? Probably non essential (E-score: 0.053) question?
Stock # IGL03338
Quality Score
Status
Chromosome 8
Chromosomal Location 4375210-4410020 bp(+) (GRCm39)
Type of Mutation intron
DNA Base Change (assembly) T to C at 4399898 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000140747 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000024004] [ENSMUST00000069762] [ENSMUST00000098949] [ENSMUST00000110982] [ENSMUST00000127460] [ENSMUST00000136191] [ENSMUST00000155797]
AlphaFold O35903
Predicted Effect probably benign
Transcript: ENSMUST00000024004
SMART Domains Protein: ENSMUSP00000024004
Gene: ENSMUSG00000023235

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
SCY 27 88 1.34e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000069762
Predicted Effect probably benign
Transcript: ENSMUST00000098949
Predicted Effect probably benign
Transcript: ENSMUST00000110982
SMART Domains Protein: ENSMUSP00000106610
Gene: ENSMUSG00000023235

DomainStartEndE-ValueType
SCY 27 88 1.34e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000127460
SMART Domains Protein: ENSMUSP00000120719
Gene: ENSMUSG00000023235

DomainStartEndE-ValueType
transmembrane domain 87 109 N/A INTRINSIC
SCY 111 172 1.34e-5 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000136191
SMART Domains Protein: ENSMUSP00000117515
Gene: ENSMUSG00000023235

DomainStartEndE-ValueType
Pfam:IL8 23 66 2.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000155797
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit impaired accumulation of antigen-specific CD8+ T lymphocytes within both lamina propria and epithelium of the small intestine. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 49 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb1a G A 5: 8,744,153 (GRCm39) V260M probably damaging Het
Accsl T A 2: 93,686,092 (GRCm39) H575L probably benign Het
Armc3 A T 2: 19,253,512 (GRCm39) I218F possibly damaging Het
Bora C A 14: 99,310,178 (GRCm39) N502K probably damaging Het
Brd4 T A 17: 32,432,046 (GRCm39) D606V probably damaging Het
Ccdc190 T A 1: 169,757,544 (GRCm39) M1K probably null Het
Cep78 G T 19: 15,936,987 (GRCm39) T573K probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Cntn4 C T 6: 106,632,550 (GRCm39) H525Y probably damaging Het
D630039A03Rik T C 4: 57,910,509 (GRCm39) E101G probably benign Het
Dnah2 A G 11: 69,387,403 (GRCm39) V941A probably benign Het
Exoc6b A G 6: 84,821,112 (GRCm39) I559T probably damaging Het
Fmr1 T C X: 67,731,942 (GRCm39) probably null Het
Ghr A T 15: 3,377,024 (GRCm39) C66S probably damaging Het
Hook1 C A 4: 95,886,929 (GRCm39) probably benign Het
Igsf1 T C X: 48,876,376 (GRCm39) T73A probably benign Het
Ipo8 T C 6: 148,701,755 (GRCm39) K451R probably benign Het
Irs1 A G 1: 82,266,122 (GRCm39) V698A probably benign Het
Kat2a T C 11: 100,602,301 (GRCm39) D151G probably benign Het
Lyrm1 A T 7: 119,513,469 (GRCm39) Q78L probably benign Het
Madd C T 2: 90,992,507 (GRCm39) G1012E possibly damaging Het
Mboat1 T A 13: 30,320,742 (GRCm39) D31E probably benign Het
Myh8 C A 11: 67,189,172 (GRCm39) A1116D probably damaging Het
Nop2 G A 6: 125,116,695 (GRCm39) probably null Het
Notch1 A G 2: 26,349,971 (GRCm39) S2390P probably benign Het
Or10ag57 T G 2: 87,218,470 (GRCm39) N140K probably benign Het
Or52z14 T A 7: 103,253,615 (GRCm39) C251* probably null Het
Or6c66b A G 10: 129,376,925 (GRCm39) D173G probably damaging Het
Pigg T C 5: 108,467,816 (GRCm39) S272P probably damaging Het
Plg A G 17: 12,637,959 (GRCm39) Y795C probably damaging Het
Polr3e A G 7: 120,536,843 (GRCm39) K335R probably benign Het
Pramel13 T A 4: 144,121,397 (GRCm39) Y209F probably benign Het
Pramel24 T C 4: 143,453,312 (GRCm39) I140T probably benign Het
Pramel28 T C 4: 143,692,411 (GRCm39) I197V probably benign Het
Pramel28 T A 4: 143,692,608 (GRCm39) Q131L probably benign Het
Prdm4 A T 10: 85,743,685 (GRCm39) M190K possibly damaging Het
Prex2 T A 1: 11,210,489 (GRCm39) F597L probably benign Het
Ranbp3l A G 15: 9,060,940 (GRCm39) E403G probably damaging Het
Rgmb C T 17: 16,027,565 (GRCm39) A385T possibly damaging Het
Scn4a T A 11: 106,211,671 (GRCm39) I1449F probably damaging Het
Slc17a9 T C 2: 180,382,311 (GRCm39) probably benign Het
Slc26a2 T C 18: 61,331,974 (GRCm39) I486V probably damaging Het
Sntn A T 14: 13,678,991 (GRCm38) D55V probably damaging Het
Snx25 T A 8: 46,498,247 (GRCm39) R595S probably benign Het
Spag11b C T 8: 19,191,426 (GRCm39) T33I probably damaging Het
Sval2 A G 6: 41,841,181 (GRCm39) I81M probably damaging Het
Tab2 A G 10: 7,795,039 (GRCm39) V481A probably damaging Het
Zfp867 G A 11: 59,355,003 (GRCm39) Q109* probably null Het
Zfp935 T C 13: 62,602,247 (GRCm39) T318A probably benign Het
Other mutations in Ccl25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02070:Ccl25 APN 8 4,398,700 (GRCm39) intron probably benign
IGL02188:Ccl25 APN 8 4,398,552 (GRCm39) intron probably benign
R0584:Ccl25 UTSW 8 4,404,085 (GRCm39) splice site probably benign
R0613:Ccl25 UTSW 8 4,399,850 (GRCm39) missense probably benign 0.42
R1208:Ccl25 UTSW 8 4,407,631 (GRCm39) missense possibly damaging 0.92
R1208:Ccl25 UTSW 8 4,407,631 (GRCm39) missense possibly damaging 0.92
R1413:Ccl25 UTSW 8 4,403,892 (GRCm39) makesense probably null
R3844:Ccl25 UTSW 8 4,404,183 (GRCm39) missense possibly damaging 0.86
R4279:Ccl25 UTSW 8 4,399,829 (GRCm39) missense probably damaging 1.00
R4921:Ccl25 UTSW 8 4,403,913 (GRCm39) missense possibly damaging 0.92
R7021:Ccl25 UTSW 8 4,399,641 (GRCm39) intron probably benign
R7033:Ccl25 UTSW 8 4,399,641 (GRCm39) intron probably benign
R7630:Ccl25 UTSW 8 4,403,955 (GRCm39) missense probably damaging 1.00
R8317:Ccl25 UTSW 8 4,404,138 (GRCm39) missense probably benign 0.00
R8550:Ccl25 UTSW 8 4,377,890 (GRCm39) missense possibly damaging 0.72
R9799:Ccl25 UTSW 8 4,377,799 (GRCm39) missense unknown
Posted On 2016-08-02