Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03342:Gpr155'

417261

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Gpr155

Ensembl Gene

ENSMUSG00000041762

Gene Name

G protein-coupled receptor 155

Synonyms

DEPDC3, 1110017O10Rik, PGR22, F730029F15Rik

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL03342

Quality Score

Status

Chromosome

Chromosomal Location

73171850-73216842 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 73180022 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Phenylalanine to Serine at position 146 (F146S)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000076463] [ENSMUST00000112043] [ENSMUST00000112044]

AlphaFold

A2AWR3

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000048504

SMART Domains

Protein: ENSMUSP00000037772
Gene: ENSMUSG00000041762

Domain	Start	End	E-Value	Type
Pfam:Mem_trans	40	205	1.9e-16	PFAM
Pfam:Mem_trans	187	360	4.9e-12	PFAM
transmembrane domain	380	402	N/A	INTRINSIC
transmembrane domain	415	432	N/A	INTRINSIC
transmembrane domain	442	464	N/A	INTRINSIC
transmembrane domain	477	499	N/A	INTRINSIC
transmembrane domain	519	538	N/A	INTRINSIC
transmembrane domain	657	679	N/A	INTRINSIC

Predicted Effect

probably damaging
Transcript: ENSMUST00000076463
AA Change: F706S

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000075788
Gene: ENSMUSG00000041762
AA Change: F706S

Domain	Start	End	E-Value	Type
Pfam:Mem_trans	40	205	3.3e-15	PFAM
transmembrane domain	209	231	N/A	INTRINSIC
transmembrane domain	241	260	N/A	INTRINSIC
transmembrane domain	272	291	N/A	INTRINSIC
transmembrane domain	311	330	N/A	INTRINSIC
transmembrane domain	343	365	N/A	INTRINSIC
transmembrane domain	380	402	N/A	INTRINSIC
transmembrane domain	415	432	N/A	INTRINSIC
transmembrane domain	442	464	N/A	INTRINSIC
transmembrane domain	477	499	N/A	INTRINSIC
transmembrane domain	519	538	N/A	INTRINSIC
transmembrane domain	657	679	N/A	INTRINSIC
transmembrane domain	689	711	N/A	INTRINSIC
DEP	759	833	8.28e-12	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000112043
AA Change: F706S

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000107674
Gene: ENSMUSG00000041762
AA Change: F706S

Domain	Start	End	E-Value	Type
Pfam:Mem_trans	40	205	3.3e-15	PFAM
transmembrane domain	209	231	N/A	INTRINSIC
transmembrane domain	241	260	N/A	INTRINSIC
transmembrane domain	272	291	N/A	INTRINSIC
transmembrane domain	311	330	N/A	INTRINSIC
transmembrane domain	343	365	N/A	INTRINSIC
transmembrane domain	380	402	N/A	INTRINSIC
transmembrane domain	415	432	N/A	INTRINSIC
transmembrane domain	442	464	N/A	INTRINSIC
transmembrane domain	477	499	N/A	INTRINSIC
transmembrane domain	519	538	N/A	INTRINSIC
transmembrane domain	657	679	N/A	INTRINSIC
transmembrane domain	689	711	N/A	INTRINSIC
DEP	759	833	8.28e-12	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000112044
AA Change: F678S

PolyPhen 2 Score 0.957 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000107675
Gene: ENSMUSG00000041762
AA Change: F678S

Domain	Start	End	E-Value	Type
Pfam:Mem_trans	40	205	3.3e-15	PFAM
Pfam:Mem_trans	187	360	8.3e-11	PFAM
transmembrane domain	382	404	N/A	INTRINSIC
transmembrane domain	414	436	N/A	INTRINSIC
transmembrane domain	449	471	N/A	INTRINSIC
transmembrane domain	491	510	N/A	INTRINSIC
transmembrane domain	629	651	N/A	INTRINSIC
transmembrane domain	661	683	N/A	INTRINSIC
DEP	731	805	8.28e-12	SMART

Predicted Effect

probably damaging
Transcript: ENSMUST00000131430
AA Change: F146S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000114294
Gene: ENSMUSG00000041762
AA Change: F146S

Domain	Start	End	E-Value	Type
transmembrane domain	98	120	N/A	INTRINSIC
transmembrane domain	130	152	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000184503

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 63 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca5	G	A	11: 110,178,517 (GRCm39)	T1152M	possibly damaging	Het
Abcg2	G	T	6: 58,642,120 (GRCm39)	R136I	probably damaging	Het
Acap2	A	G	16: 30,924,310 (GRCm39)	V641A	probably damaging	Het
Afg3l2	A	T	18: 67,540,390 (GRCm39)	D706E	probably benign	Het
Bbs1	A	T	19: 4,947,621 (GRCm39)	L311Q	probably damaging	Het
Cacna1e	A	G	1: 154,342,690 (GRCm39)		probably null	Het
Car2	A	T	3: 14,960,629 (GRCm39)	D129V	probably benign	Het
Catsper2	T	C	2: 121,237,217 (GRCm39)	I228V	probably damaging	Het
Cdhr3	C	A	12: 33,101,054 (GRCm39)	R452M	probably benign	Het
Chrm1	A	T	19: 8,656,672 (GRCm39)	Q459L	probably benign	Het
Cnbd1	C	T	4: 19,098,264 (GRCm39)		probably benign	Het
Coa7	A	G	4: 108,189,426 (GRCm39)	D42G	probably damaging	Het
Ctsz	T	C	2: 174,270,933 (GRCm39)	Y187C	possibly damaging	Het
Cxcr6	C	T	9: 123,639,472 (GRCm39)	Q165*	probably null	Het
Cyp3a11	G	A	5: 145,791,927 (GRCm39)	P489S	probably damaging	Het
Cyp4f15	A	T	17: 32,916,910 (GRCm39)	I276F	probably damaging	Het
Dsg1b	T	A	18: 20,542,517 (GRCm39)	M1008K	probably benign	Het
Dsg4	T	A	18: 20,584,880 (GRCm39)	I198N	probably damaging	Het
Dtymk	C	A	1: 93,722,541 (GRCm39)	E87D	probably benign	Het
Dysf	T	A	6: 84,167,854 (GRCm39)	D1749E	probably benign	Het
Dzip3	G	T	16: 48,749,986 (GRCm39)	Q1050K	probably damaging	Het
Echs1	C	T	7: 139,690,026 (GRCm39)		probably benign	Het
Enc1	T	A	13: 97,382,978 (GRCm39)	I496N	possibly damaging	Het
Epc2	A	T	2: 49,426,658 (GRCm39)	Y139F	probably benign	Het
Exo1	A	T	1: 175,719,693 (GRCm39)	N246I	probably benign	Het
Flg2	A	G	3: 93,108,542 (GRCm39)	K190R	probably damaging	Het
Gm5424	A	T	10: 61,907,971 (GRCm39)		noncoding transcript	Het
Gpbp1l1	A	C	4: 116,431,740 (GRCm39)	T133P	probably benign	Het
Grm1	T	A	10: 10,955,715 (GRCm39)	I190L	probably benign	Het
Hif3a	C	T	7: 16,775,047 (GRCm39)	R515H	possibly damaging	Het
Itprid2	G	A	2: 79,490,796 (GRCm39)	M971I	probably damaging	Het
Kdm5b	G	A	1: 134,530,314 (GRCm39)	D442N	probably benign	Het
Manba	A	T	3: 135,223,748 (GRCm39)	I212F	possibly damaging	Het
Map3k13	A	G	16: 21,710,981 (GRCm39)	E88G	possibly damaging	Het
Mapk7	A	G	11: 61,382,216 (GRCm39)	L163P	probably damaging	Het
Med1	A	T	11: 98,080,006 (GRCm39)		probably null	Het
Mtrf1	T	A	14: 79,653,312 (GRCm39)		probably null	Het
Mtrf1	A	G	14: 79,653,420 (GRCm39)	D365G	possibly damaging	Het
Mtrf1	C	T	14: 79,653,311 (GRCm39)		probably benign	Het
Myadm	C	T	7: 3,345,403 (GRCm39)	T55I	possibly damaging	Het
Nlgn1	A	T	3: 26,187,411 (GRCm39)	I158N	probably damaging	Het
Nlrc4	A	G	17: 74,752,313 (GRCm39)	L690P	probably damaging	Het
Nlrp1a	A	T	11: 71,013,617 (GRCm39)	D544E	probably benign	Het
Nlrp2	A	T	7: 5,320,482 (GRCm39)	L20Q	probably damaging	Het
Or1e30	T	A	11: 73,678,309 (GRCm39)	S182T	probably benign	Het
Or8k21	A	T	2: 86,145,579 (GRCm39)	I17N	possibly damaging	Het
Or9i16	A	G	19: 13,864,801 (GRCm39)	Y258H	probably damaging	Het
Padi3	G	A	4: 140,537,909 (GRCm39)	Q4*	probably null	Het
Pfkl	A	T	10: 77,841,309 (GRCm39)	I13K	possibly damaging	Het
Pinx1	A	G	14: 64,157,018 (GRCm39)	D315G	probably benign	Het
Prickle3	A	G	X: 7,529,735 (GRCm39)	D47G	probably benign	Het
Psmd10	A	T	X: 139,857,403 (GRCm39)	V5E	probably damaging	Het
Rasgrf2	C	A	13: 92,136,098 (GRCm39)	V605F	probably damaging	Het
Smarca1	G	T	X: 46,981,146 (GRCm39)	A84D	probably damaging	Het
Sp2	A	G	11: 96,852,588 (GRCm39)	V112A	probably damaging	Het
Srgap3	G	A	6: 112,752,648 (GRCm39)	R279C	probably damaging	Het
Trav21-dv12	T	C	14: 54,113,501 (GRCm39)	L10P	unknown	Het
Vmn1r236	A	T	17: 21,507,236 (GRCm39)	H118L	probably benign	Het
Vmn2r120	A	G	17: 57,816,372 (GRCm39)	M661T	probably benign	Het
Vmn2r17	A	T	5: 109,575,782 (GRCm39)	I218F	probably damaging	Het
Vmn2r41	G	T	7: 8,141,682 (GRCm39)	A594D	probably damaging	Het
Zc2hc1a	A	G	3: 7,589,283 (GRCm39)	E103G	possibly damaging	Het
Zfp62	G	T	11: 49,106,298 (GRCm39)	G130*	probably null	Het

Other mutations in Gpr155

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00731:Gpr155	APN	2	73,192,957 (GRCm39)	missense	probably damaging	1.00
IGL01432:Gpr155	APN	2	73,182,229 (GRCm39)	missense	possibly damaging	0.51
IGL01528:Gpr155	APN	2	73,192,767 (GRCm39)	critical splice donor site	probably null
IGL01718:Gpr155	APN	2	73,212,576 (GRCm39)	missense	probably benign
IGL01733:Gpr155	APN	2	73,183,956 (GRCm39)	splice site	probably null
PIT1430001:Gpr155	UTSW	2	73,200,482 (GRCm39)	missense	probably benign	0.08
PIT4810001:Gpr155	UTSW	2	73,178,607 (GRCm39)	missense	probably benign	0.08
R0226:Gpr155	UTSW	2	73,197,936 (GRCm39)	missense	probably benign	0.02
R0399:Gpr155	UTSW	2	73,200,346 (GRCm39)	missense	possibly damaging	0.91
R0445:Gpr155	UTSW	2	73,200,488 (GRCm39)	splice site	probably benign
R1570:Gpr155	UTSW	2	73,200,382 (GRCm39)	missense	possibly damaging	0.87
R1598:Gpr155	UTSW	2	73,200,434 (GRCm39)	missense	probably damaging	0.98
R1647:Gpr155	UTSW	2	73,194,508 (GRCm39)	splice site	probably null
R1648:Gpr155	UTSW	2	73,194,508 (GRCm39)	splice site	probably null
R1756:Gpr155	UTSW	2	73,197,921 (GRCm39)	missense	probably benign	0.00
R1760:Gpr155	UTSW	2	73,212,279 (GRCm39)	missense	probably damaging	1.00
R2033:Gpr155	UTSW	2	73,178,526 (GRCm39)	missense	probably benign	0.18
R2044:Gpr155	UTSW	2	73,203,977 (GRCm39)	missense	probably damaging	1.00
R2145:Gpr155	UTSW	2	73,187,002 (GRCm39)	missense	probably benign	0.01
R2172:Gpr155	UTSW	2	73,212,471 (GRCm39)	missense	probably benign	0.00
R2274:Gpr155	UTSW	2	73,178,479 (GRCm39)	critical splice donor site	probably null
R3878:Gpr155	UTSW	2	73,198,736 (GRCm39)	nonsense	probably null
R3924:Gpr155	UTSW	2	73,200,420 (GRCm39)	missense	probably damaging	1.00
R4910:Gpr155	UTSW	2	73,197,882 (GRCm39)	nonsense	probably null
R4950:Gpr155	UTSW	2	73,212,529 (GRCm39)	missense	probably benign
R5337:Gpr155	UTSW	2	73,178,592 (GRCm39)	missense	probably benign	0.32
R5830:Gpr155	UTSW	2	73,200,433 (GRCm39)	missense	possibly damaging	0.93
R5887:Gpr155	UTSW	2	73,174,062 (GRCm39)	nonsense	probably null
R5929:Gpr155	UTSW	2	73,204,011 (GRCm39)	nonsense	probably null
R6293:Gpr155	UTSW	2	73,204,341 (GRCm39)	missense	possibly damaging	0.47
R6553:Gpr155	UTSW	2	73,179,989 (GRCm39)	missense	probably damaging	1.00
R6585:Gpr155	UTSW	2	73,179,989 (GRCm39)	missense	probably damaging	1.00
R7003:Gpr155	UTSW	2	73,173,961 (GRCm39)	missense	probably damaging	0.99
R7353:Gpr155	UTSW	2	73,197,835 (GRCm39)	nonsense	probably null
R7506:Gpr155	UTSW	2	73,198,683 (GRCm39)	missense	probably damaging	0.97
R7631:Gpr155	UTSW	2	73,213,291 (GRCm39)	intron	probably benign
R7753:Gpr155	UTSW	2	73,212,550 (GRCm39)	missense	probably benign	0.27
R7810:Gpr155	UTSW	2	73,212,296 (GRCm39)	missense	probably damaging	0.99
R7813:Gpr155	UTSW	2	73,212,329 (GRCm39)	nonsense	probably null
R7815:Gpr155	UTSW	2	73,192,904 (GRCm39)	missense	probably benign
R7873:Gpr155	UTSW	2	73,173,934 (GRCm39)	missense	possibly damaging	0.51
R8506:Gpr155	UTSW	2	73,173,806 (GRCm39)	missense	probably damaging	0.99
R8680:Gpr155	UTSW	2	73,174,039 (GRCm39)	missense	probably damaging	0.99
R8856:Gpr155	UTSW	2	73,203,993 (GRCm39)	missense	probably benign	0.27
R8872:Gpr155	UTSW	2	73,197,936 (GRCm39)	missense	probably benign	0.02
R9116:Gpr155	UTSW	2	73,204,109 (GRCm39)	missense	possibly damaging	0.78
R9683:Gpr155	UTSW	2	73,192,780 (GRCm39)	missense	probably benign

Posted On

2016-08-02