Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03343:Or5m12'

417320

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or5m12

Ensembl Gene

ENSMUSG00000075206

Gene Name

olfactory receptor family 5 subfamily M member 12

Synonyms

Olfr1024, GA_x6K02T2Q125-47384320-47383337, MOR197-1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.153) question?

Stock #

IGL03343

Quality Score

Status

Chromosome

Chromosomal Location

85734413-85735396 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 85735285 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Alanine at position 38 (T38A)

Ref Sequence

ENSEMBL: ENSMUSP00000097496 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099912]

AlphaFold

A2ASU7

Predicted Effect

probably benign
Transcript: ENSMUST00000099912
AA Change: T38A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000097496
Gene: ENSMUSG00000075206
AA Change: T38A

Domain	Start	End	E-Value	Type
Pfam:7tm_4	36	313	7.6e-52	PFAM
Pfam:7tm_1	46	295	4.1e-25	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000215677

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts17	A	G	7: 66,725,064 (GRCm39)	H795R	probably damaging	Het
Adgrl2	A	T	3: 148,565,016 (GRCm39)	I188K	probably damaging	Het
Adgrv1	A	G	13: 81,431,507 (GRCm39)	Y5974H	probably damaging	Het
Angpt4	A	G	2: 151,778,623 (GRCm39)	T336A	probably damaging	Het
Arhgap30	C	A	1: 171,236,662 (GRCm39)	T1012N	probably damaging	Het
Asl	A	T	5: 130,040,908 (GRCm39)	Y178N	probably damaging	Het
Brd1	C	A	15: 88,591,454 (GRCm39)	L714F	possibly damaging	Het
Ccdc47	A	G	11: 106,095,788 (GRCm39)	S303P	probably damaging	Het
Cdcp3	T	A	7: 130,848,420 (GRCm39)	I858N	probably damaging	Het
Cdk16	A	G	X: 20,561,998 (GRCm39)	K264E	probably damaging	Het
Cenpc1	A	T	5: 86,164,181 (GRCm39)	F813L	probably damaging	Het
Cfp	A	C	X: 20,794,248 (GRCm39)	F291C	possibly damaging	Het
Chordc1	T	G	9: 18,223,762 (GRCm39)	F276V	probably damaging	Het
Clic4	C	T	4: 134,945,889 (GRCm39)	R176H	possibly damaging	Het
Fcer1a	T	G	1: 173,053,040 (GRCm39)	N52T	possibly damaging	Het
Fndc7	A	T	3: 108,774,624 (GRCm39)	C545S	probably damaging	Het
Frem2	T	C	3: 53,559,674 (GRCm39)	D1611G	probably damaging	Het
Fryl	G	A	5: 73,234,038 (GRCm39)	P1496S	probably benign	Het
Gga3	A	T	11: 115,483,312 (GRCm39)	N82K	probably damaging	Het
Gm43638	G	A	5: 87,608,484 (GRCm39)	P452S	possibly damaging	Het
Gpn1	T	C	5: 31,662,309 (GRCm39)	S244P	probably damaging	Het
Hspa12a	T	C	19: 58,787,828 (GRCm39)	S665G	probably benign	Het
Htt	A	G	5: 34,983,385 (GRCm39)	I995V	probably benign	Het
Iars1	A	T	13: 49,878,223 (GRCm39)	I916L	probably benign	Het
Ice1	C	A	13: 70,751,048 (GRCm39)	L1679F	probably damaging	Het
Inpp1	A	T	1: 52,838,486 (GRCm39)	D54E	probably damaging	Het
Irf2bpl	T	C	12: 86,929,713 (GRCm39)	E320G	possibly damaging	Het
Itprid1	T	G	6: 55,945,569 (GRCm39)	D763E	probably damaging	Het
Kcnn2	T	C	18: 45,810,026 (GRCm39)	V421A	probably damaging	Het
Micu2	A	G	14: 58,154,768 (GRCm39)	V419A	probably benign	Het
Nek9	C	T	12: 85,350,383 (GRCm39)	C897Y	probably damaging	Het
Ofcc1	A	C	13: 40,226,140 (GRCm39)	H797Q	probably benign	Het
Or12d17	G	A	17: 37,777,300 (GRCm39)	D68N	probably damaging	Het
Or2y16	C	A	11: 49,335,070 (GRCm39)	H131N	probably damaging	Het
Or6c69c	T	G	10: 129,911,125 (GRCm39)	L282R	probably damaging	Het
Pakap	C	T	4: 57,688,502 (GRCm39)	T115M	probably damaging	Het
Papss1	G	A	3: 131,288,950 (GRCm39)	G151S	probably benign	Het
Plxnb1	A	G	9: 108,943,780 (GRCm39)	T1956A	probably damaging	Het
Pomt1	A	G	2: 32,143,724 (GRCm39)		probably benign	Het
Ppfibp2	T	A	7: 107,337,126 (GRCm39)	Y570*	probably null	Het
Ppp1r9a	A	G	6: 5,046,015 (GRCm39)	E493G	probably damaging	Het
Ptk2b	A	G	14: 66,406,870 (GRCm39)	F621L	probably benign	Het
Ptpn13	G	T	5: 103,702,816 (GRCm39)	D1261Y	possibly damaging	Het
Ptprd	C	T	4: 75,977,966 (GRCm39)	G181D	probably damaging	Het
Rabgap1l	T	C	1: 160,270,853 (GRCm39)	T645A	probably benign	Het
Slc2a7	T	C	4: 150,252,797 (GRCm39)	I479T	probably damaging	Het
Smc3	A	G	19: 53,602,273 (GRCm39)	N40S	probably damaging	Het
Spata31	A	T	13: 65,067,587 (GRCm39)	D83V	probably benign	Het
Sptb	C	T	12: 76,630,330 (GRCm39)		probably benign	Het
Ssc4d	A	T	5: 135,990,028 (GRCm39)	C493*	probably null	Het
Styxl2	T	C	1: 165,927,017 (GRCm39)	D865G	probably benign	Het
Ubr2	C	A	17: 47,262,844 (GRCm39)	V1256L	probably benign	Het
Ubr3	T	C	2: 69,803,490 (GRCm39)		probably benign	Het
Vmn2r105	C	T	17: 20,446,631 (GRCm39)	W456*	probably null	Het
Vmn2r24	T	A	6: 123,793,070 (GRCm39)	I799N	probably damaging	Het
Vps13b	G	A	15: 35,917,316 (GRCm39)	G3720D	possibly damaging	Het

Other mutations in Or5m12

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01632:Or5m12	APN	2	85,734,714 (GRCm39)	missense	probably benign
IGL02108:Or5m12	APN	2	85,734,494 (GRCm39)	missense	possibly damaging	0.67
IGL02738:Or5m12	APN	2	85,735,293 (GRCm39)	missense	probably benign	0.06
IGL02802:Or5m12	UTSW	2	85,734,733 (GRCm39)	missense	probably damaging	1.00
R0265:Or5m12	UTSW	2	85,734,591 (GRCm39)	missense	probably benign	0.01
R0271:Or5m12	UTSW	2	85,734,633 (GRCm39)	missense	possibly damaging	0.68
R0432:Or5m12	UTSW	2	85,734,501 (GRCm39)	missense	probably damaging	1.00
R0501:Or5m12	UTSW	2	85,735,348 (GRCm39)	missense	probably damaging	1.00
R0504:Or5m12	UTSW	2	85,735,030 (GRCm39)	missense	possibly damaging	0.95
R1513:Or5m12	UTSW	2	85,735,015 (GRCm39)	missense	probably damaging	1.00
R2224:Or5m12	UTSW	2	85,735,099 (GRCm39)	missense	probably benign	0.11
R2516:Or5m12	UTSW	2	85,734,900 (GRCm39)	missense	probably benign	0.01
R3845:Or5m12	UTSW	2	85,735,081 (GRCm39)	missense	probably damaging	0.99
R4871:Or5m12	UTSW	2	85,734,715 (GRCm39)	missense	probably benign
R4889:Or5m12	UTSW	2	85,735,092 (GRCm39)	missense	possibly damaging	0.48
R4890:Or5m12	UTSW	2	85,735,092 (GRCm39)	missense	possibly damaging	0.48
R5543:Or5m12	UTSW	2	85,734,672 (GRCm39)	missense	probably damaging	1.00
R5865:Or5m12	UTSW	2	85,734,865 (GRCm39)	missense	probably benign	0.00
R6254:Or5m12	UTSW	2	85,734,849 (GRCm39)	missense	probably damaging	1.00
R6331:Or5m12	UTSW	2	85,734,560 (GRCm39)	missense	probably benign	0.32
R6465:Or5m12	UTSW	2	85,734,883 (GRCm39)	missense	probably benign	0.05
R7183:Or5m12	UTSW	2	85,734,486 (GRCm39)	missense	probably benign	0.00
R7427:Or5m12	UTSW	2	85,734,475 (GRCm39)	nonsense	probably null
R7428:Or5m12	UTSW	2	85,734,475 (GRCm39)	nonsense	probably null
R7552:Or5m12	UTSW	2	85,734,447 (GRCm39)	missense	probably benign	0.01
R7654:Or5m12	UTSW	2	85,734,663 (GRCm39)	missense	possibly damaging	0.95
R7674:Or5m12	UTSW	2	85,734,880 (GRCm39)	missense	probably damaging	1.00
R7980:Or5m12	UTSW	2	85,734,942 (GRCm39)	missense	probably benign	0.22
R8209:Or5m12	UTSW	2	85,734,547 (GRCm39)	missense	probably benign	0.14
R8226:Or5m12	UTSW	2	85,734,547 (GRCm39)	missense	probably benign	0.14
Z1177:Or5m12	UTSW	2	85,735,389 (GRCm39)	missense	probably benign

Posted On

2016-08-02