Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03345:Vmn2r49'

417393

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r49

Ensembl Gene

ENSMUSG00000096180

Gene Name

vomeronasal 2, receptor 49

Synonyms

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.108) question?

Stock #

IGL03345

Quality Score

Status

Chromosome

Chromosomal Location

9710172-9726066 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 9718621 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Lysine to Threonine at position 481 (K481T)

Ref Sequence

ENSEMBL: ENSMUSP00000104190 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108550]

AlphaFold

D3Z6L3

Predicted Effect

probably damaging
Transcript: ENSMUST00000108550
AA Change: K481T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000104190
Gene: ENSMUSG00000096180
AA Change: K481T

Domain	Start	End	E-Value	Type
signal peptide	1	18	N/A	INTRINSIC
Pfam:ANF_receptor	73	469	1.4e-33	PFAM
Pfam:NCD3G	512	565	5.1e-21	PFAM
Pfam:7tm_3	598	833	3.5e-55	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 37 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc3	A	G	11: 94,250,163 (GRCm39)	W987R	probably damaging	Het
Adcy5	T	C	16: 35,069,184 (GRCm39)	V384A	probably benign	Het
Akap12	T	C	10: 4,306,697 (GRCm39)	V1169A	probably benign	Het
Atp8a2	T	C	14: 60,011,460 (GRCm39)	T950A	probably benign	Het
Avil	T	C	10: 126,844,826 (GRCm39)		probably benign	Het
Bccip	A	G	7: 133,311,220 (GRCm39)	D45G	probably benign	Het
Bcl9	A	G	3: 97,116,508 (GRCm39)	S729P	probably benign	Het
C3	T	A	17: 57,526,585 (GRCm39)	I799F	probably damaging	Het
Cstf2	C	T	X: 132,961,794 (GRCm39)	R80C	probably damaging	Het
Degs1l	A	T	1: 180,882,937 (GRCm39)	H233L	probably benign	Het
Dock7	A	G	4: 98,873,056 (GRCm39)	F1130S	possibly damaging	Het
Elapor1	A	G	3: 108,399,332 (GRCm39)	V86A	possibly damaging	Het
Fat2	C	T	11: 55,173,187 (GRCm39)	D2509N	probably damaging	Het
Fut10	T	C	8: 31,750,069 (GRCm39)	S452P	probably damaging	Het
Gabrb1	T	A	5: 72,293,908 (GRCm39)	M394K	possibly damaging	Het
Gkn3	T	A	6: 87,365,798 (GRCm39)	E7V	probably null	Het
Gpld1	G	A	13: 25,171,007 (GRCm39)	G803R	probably damaging	Het
Hipk2	A	G	6: 38,724,937 (GRCm39)		probably benign	Het
Kcnu1	A	T	8: 26,371,321 (GRCm39)		probably benign	Het
Kidins220	A	T	12: 25,053,044 (GRCm39)	S445C	probably damaging	Het
Ltbp1	A	G	17: 75,373,154 (GRCm39)	K266E	probably damaging	Het
Myh4	A	T	11: 67,146,304 (GRCm39)	D1454V	probably damaging	Het
Nrf1	A	C	6: 30,089,947 (GRCm39)	T9P	probably damaging	Het
Nt5dc1	T	C	10: 34,200,458 (GRCm39)	E187G	probably benign	Het
Obscn	T	A	11: 58,886,308 (GRCm39)		probably benign	Het
Pkd2l2	T	C	18: 34,558,142 (GRCm39)	Y274H	probably damaging	Het
Rgs8	A	G	1: 153,568,556 (GRCm39)	K149R	probably benign	Het
Rinl	A	G	7: 28,496,222 (GRCm39)	E401G	possibly damaging	Het
Rsbn1	A	G	3: 103,822,466 (GRCm39)	R234G	possibly damaging	Het
Slc6a3	A	G	13: 73,719,633 (GRCm39)	D554G	probably benign	Het
Slc7a2	A	G	8: 41,369,530 (GRCm39)	S646G	probably benign	Het
Syt5	A	G	7: 4,545,206 (GRCm39)	V231A	probably benign	Het
Timeless	T	G	10: 128,083,455 (GRCm39)	S695A	probably benign	Het
Tmem131l	G	A	3: 83,868,896 (GRCm39)	P160S	probably damaging	Het
Tspear	C	A	10: 77,710,716 (GRCm39)		probably null	Het
Ubn1	T	A	16: 4,899,828 (GRCm39)	H1113Q	probably damaging	Het
Xdh	T	C	17: 74,213,027 (GRCm39)	N872S	probably damaging	Het

Other mutations in Vmn2r49

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01800:Vmn2r49	APN	7	9,710,601 (GRCm39)	nonsense	probably null
IGL01892:Vmn2r49	APN	7	9,718,690 (GRCm39)	missense	probably benign	0.00
IGL02505:Vmn2r49	APN	7	9,710,378 (GRCm39)	missense	probably benign	0.27
PIT4434001:Vmn2r49	UTSW	7	9,710,762 (GRCm39)	missense	probably damaging	1.00
PIT4520001:Vmn2r49	UTSW	7	9,722,988 (GRCm39)	missense	probably benign	0.06
R0367:Vmn2r49	UTSW	7	9,710,357 (GRCm39)	missense	probably damaging	1.00
R0609:Vmn2r49	UTSW	7	9,710,233 (GRCm39)	missense	probably benign	0.40
R0931:Vmn2r49	UTSW	7	9,720,325 (GRCm39)	missense	possibly damaging	0.55
R1594:Vmn2r49	UTSW	7	9,710,550 (GRCm39)	missense	probably damaging	1.00
R1969:Vmn2r49	UTSW	7	9,720,235 (GRCm39)	missense	probably damaging	0.99
R4831:Vmn2r49	UTSW	7	9,720,352 (GRCm39)	missense	probably benign
R4944:Vmn2r49	UTSW	7	9,722,959 (GRCm39)	missense	probably benign
R4945:Vmn2r49	UTSW	7	9,720,214 (GRCm39)	nonsense	probably null
R5109:Vmn2r49	UTSW	7	9,710,204 (GRCm39)	missense	probably benign	0.01
R5141:Vmn2r49	UTSW	7	9,720,300 (GRCm39)	missense	probably benign	0.01
R5778:Vmn2r49	UTSW	7	9,710,274 (GRCm39)	missense	probably damaging	1.00
R6168:Vmn2r49	UTSW	7	9,718,713 (GRCm39)	missense	probably benign	0.01
R6513:Vmn2r49	UTSW	7	9,710,524 (GRCm39)	missense	probably damaging	0.99
R7347:Vmn2r49	UTSW	7	9,720,741 (GRCm39)	missense	probably benign	0.00
R7464:Vmn2r49	UTSW	7	9,722,820 (GRCm39)	missense	probably benign	0.03
R7495:Vmn2r49	UTSW	7	9,710,826 (GRCm39)	nonsense	probably null
R7750:Vmn2r49	UTSW	7	9,710,185 (GRCm39)	missense	probably damaging	1.00
R8031:Vmn2r49	UTSW	7	9,720,408 (GRCm39)	missense	possibly damaging	0.67
R9158:Vmn2r49	UTSW	7	9,722,835 (GRCm39)	missense	probably damaging	1.00
R9347:Vmn2r49	UTSW	7	9,718,674 (GRCm39)	missense	probably benign	0.00
R9553:Vmn2r49	UTSW	7	9,720,849 (GRCm39)	missense	probably benign	0.41

Posted On

2016-08-02