Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03072:Nat8f4'

417565

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Nat8f4

Ensembl Gene

ENSMUSG00000068299

Gene Name

N-acetyltransferase 8 (GCN5-related) family member 4

Synonyms

1700019G17Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.078) question?

Stock #

IGL03072

Quality Score

Status

Chromosome

Chromosomal Location

85876033-85881866 bp(-) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 85877836 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000124071 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000095757] [ENSMUST00000159755]

AlphaFold

G5E8L3

Predicted Effect

probably benign
Transcript: ENSMUST00000095757

SMART Domains

Protein: ENSMUSP00000093430
Gene: ENSMUSG00000068299

Domain	Start	End	E-Value	Type
transmembrane domain	33	55	N/A	INTRINSIC
Pfam:Acetyltransf_10	75	192	2.5e-11	PFAM
Pfam:Acetyltransf_8	83	200	2.1e-11	PFAM
Pfam:Acetyltransf_7	104	194	3.3e-14	PFAM
Pfam:Acetyltransf_1	111	193	6.3e-17	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000159755

SMART Domains

Protein: ENSMUSP00000124071
Gene: ENSMUSG00000068299

Domain	Start	End	E-Value	Type
transmembrane domain	33	55	N/A	INTRINSIC
transmembrane domain	60	82	N/A	INTRINSIC
low complexity region	117	130	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 27 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	G	A	13: 77,408,116 (GRCm39)	V148I	probably benign	Het
Ahcyl2	T	C	6: 29,906,500 (GRCm39)		probably benign	Het
Ahnak	T	C	19: 8,983,872 (GRCm39)	S1719P	probably benign	Het
C2cd5	A	G	6: 143,025,609 (GRCm39)	I196T	possibly damaging	Het
Cdhr2	A	G	13: 54,874,474 (GRCm39)	I849V	probably benign	Het
Cpsf3	A	G	12: 21,345,089 (GRCm39)	K134E	possibly damaging	Het
Dnai1	A	G	4: 41,602,979 (GRCm39)	T161A	probably benign	Het
Gm17093	G	T	14: 44,758,129 (GRCm39)		probably benign	Het
Igf2bp2	A	G	16: 21,886,891 (GRCm39)		probably null	Het
Lcor	T	C	19: 41,547,253 (GRCm39)	V279A	possibly damaging	Het
Myo9a	C	A	9: 59,716,725 (GRCm39)	T475K	possibly damaging	Het
Neto1	A	G	18: 86,516,714 (GRCm39)	T344A	probably benign	Het
Or6c203	A	T	10: 129,010,358 (GRCm39)	D177E	probably damaging	Het
Or7c19	A	G	8: 85,957,139 (GRCm39)	N5S	probably benign	Het
Or8k17	A	T	2: 86,066,804 (GRCm39)	M118K	probably damaging	Het
Pde8a	A	T	7: 80,958,557 (GRCm39)	I312F	probably damaging	Het
Ppp3cb	A	G	14: 20,581,793 (GRCm39)	I74T	probably damaging	Het
Prom1	T	C	5: 44,216,004 (GRCm39)		probably benign	Het
Psg29	T	C	7: 16,942,719 (GRCm39)	V240A	probably benign	Het
Reep4	T	C	14: 70,785,675 (GRCm39)	S238P	probably damaging	Het
Stxbp2	A	T	8: 3,691,971 (GRCm39)	I538F	probably benign	Het
Tmprss5	T	A	9: 49,020,318 (GRCm39)	N99K	possibly damaging	Het
Tph1	G	A	7: 46,302,283 (GRCm39)	T313M	probably damaging	Het
Tprn	T	C	2: 25,154,530 (GRCm39)	S611P	probably damaging	Het
Upp2	G	T	2: 58,645,435 (GRCm39)		probably null	Het
Vezt	C	A	10: 93,809,895 (GRCm39)	A549S	probably damaging	Het
Zfp786	A	G	6: 47,798,177 (GRCm39)	Y254H	probably benign	Het

Other mutations in Nat8f4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00158:Nat8f4	APN	6	85,877,969 (GRCm39)	missense	probably benign	0.05
R1341:Nat8f4	UTSW	6	85,878,406 (GRCm39)	missense	probably damaging	0.96
R1725:Nat8f4	UTSW	6	85,878,080 (GRCm39)	nonsense	probably null
R1923:Nat8f4	UTSW	6	85,878,497 (GRCm39)	missense	probably damaging	1.00
R2258:Nat8f4	UTSW	6	85,878,207 (GRCm39)	missense	possibly damaging	0.84
R3975:Nat8f4	UTSW	6	85,878,052 (GRCm39)	missense	possibly damaging	0.62
R4697:Nat8f4	UTSW	6	85,878,368 (GRCm39)	missense	probably benign	0.01
R4784:Nat8f4	UTSW	6	85,878,481 (GRCm39)	missense	probably benign	0.03
R4924:Nat8f4	UTSW	6	85,878,401 (GRCm39)	missense	probably benign	0.03
R4991:Nat8f4	UTSW	6	85,878,122 (GRCm39)	missense	probably benign	0.30
R6074:Nat8f4	UTSW	6	85,878,169 (GRCm39)	missense	probably damaging	0.98
R7058:Nat8f4	UTSW	6	85,878,271 (GRCm39)	missense	possibly damaging	0.73
R7790:Nat8f4	UTSW	6	85,877,873 (GRCm39)	missense	probably benign	0.00
R8079:Nat8f4	UTSW	6	85,877,976 (GRCm39)	missense	probably benign	0.25
R9782:Nat8f4	UTSW	6	85,878,052 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02