Incidental Mutation 'IGL03073:Vmn2r89'
ID 417568
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Vmn2r89
Ensembl Gene ENSMUSG00000070448
Gene Name vomeronasal 2, receptor 89
Synonyms V2r10, V2r11
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # IGL03073
Quality Score
Status
Chromosome 14
Chromosomal Location 51689419-51698750 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 51693528 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 293 (I293V)
Ref Sequence ENSEMBL: ENSMUSP00000124256 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159611] [ENSMUST00000159734] [ENSMUST00000161670] [ENSMUST00000162998]
AlphaFold O35199
Predicted Effect possibly damaging
Transcript: ENSMUST00000159611
AA Change: I293V

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124065
Gene: ENSMUSG00000070448
AA Change: I293V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 449 4.8e-30 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000159734
AA Change: I293V

PolyPhen 2 Score 0.953 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124256
Gene: ENSMUSG00000070448
AA Change: I293V

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 420 1.1e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161670
SMART Domains Protein: ENSMUSP00000124261
Gene: ENSMUSG00000070448

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162998
SMART Domains Protein: ENSMUSP00000125409
Gene: ENSMUSG00000068399

DomainStartEndE-ValueType
Pfam:Takusan 35 115 2.2e-25 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 33 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933440M02Rik T C 7: 124,930,735 (GRCm39) noncoding transcript Het
Actr6 A G 10: 89,562,556 (GRCm39) S108P probably damaging Het
Adam34 A T 8: 44,103,940 (GRCm39) N568K probably damaging Het
Anpep A G 7: 79,488,703 (GRCm39) L408P probably damaging Het
Atp13a1 T C 8: 70,251,152 (GRCm39) V459A probably damaging Het
Atp2b1 C T 10: 98,835,713 (GRCm39) T486M probably damaging Het
Cdc42bpa T A 1: 179,921,941 (GRCm39) probably benign Het
Espnl T C 1: 91,272,278 (GRCm39) I502T probably damaging Het
Fancm T C 12: 65,148,406 (GRCm39) Y674H probably damaging Het
Gnaq T A 19: 16,293,470 (GRCm39) N137K probably benign Het
Igf1r T A 7: 67,864,791 (GRCm39) D1196E probably damaging Het
Insrr A G 3: 87,717,245 (GRCm39) probably benign Het
Lypd9 A T 11: 58,338,277 (GRCm39) D38E probably damaging Het
Mcf2l C A 8: 13,050,004 (GRCm39) H313N probably damaging Het
Mdh1b C T 1: 63,760,646 (GRCm39) probably null Het
Mrc1 G A 2: 14,310,153 (GRCm39) V805I probably damaging Het
Ncam2 T G 16: 81,418,235 (GRCm39) D763E possibly damaging Het
Ncapg2 T G 12: 116,415,894 (GRCm39) H1091Q probably benign Het
Or5b112 T G 19: 13,319,386 (GRCm39) I88R probably benign Het
Or8h8 A G 2: 86,753,697 (GRCm39) Y60H probably damaging Het
Pcdh18 T A 3: 49,707,816 (GRCm39) D886V possibly damaging Het
Pdlim4 A G 11: 53,954,467 (GRCm39) V21A probably damaging Het
Safb2 A G 17: 56,878,289 (GRCm39) S24P probably benign Het
Sec16a A G 2: 26,329,195 (GRCm39) M940T probably benign Het
Snx14 A G 9: 88,304,949 (GRCm39) probably null Het
Sox1 T C 8: 12,446,625 (GRCm39) W89R probably damaging Het
Stx12 T C 4: 132,585,760 (GRCm39) M207V probably benign Het
Tex14 A G 11: 87,426,435 (GRCm39) T1154A probably damaging Het
Tmcc3 T G 10: 94,414,813 (GRCm39) S172A probably benign Het
Tnc T A 4: 63,889,461 (GRCm39) I1773F possibly damaging Het
Tshz3 A T 7: 36,470,170 (GRCm39) N720Y probably damaging Het
Usp19 G A 9: 108,373,002 (GRCm39) probably benign Het
Vmn1r170 A C 7: 23,306,273 (GRCm39) Q225P probably damaging Het
Other mutations in Vmn2r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00433:Vmn2r89 APN 14 51,692,422 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r89 APN 14 51,694,950 (GRCm39) missense probably benign
IGL00990:Vmn2r89 APN 14 51,693,428 (GRCm39) missense probably benign 0.14
IGL01991:Vmn2r89 APN 14 51,689,676 (GRCm39) missense probably benign 0.00
IGL03085:Vmn2r89 APN 14 51,689,615 (GRCm39) missense probably damaging 0.99
IGL03278:Vmn2r89 APN 14 51,692,557 (GRCm39) missense probably damaging 0.99
R0115:Vmn2r89 UTSW 14 51,693,577 (GRCm39) missense probably damaging 1.00
R0127:Vmn2r89 UTSW 14 51,693,160 (GRCm39) missense probably damaging 0.98
R0391:Vmn2r89 UTSW 14 51,693,435 (GRCm39) missense probably damaging 0.99
R0481:Vmn2r89 UTSW 14 51,693,577 (GRCm39) missense probably damaging 1.00
R0538:Vmn2r89 UTSW 14 51,695,048 (GRCm39) splice site probably null
R1210:Vmn2r89 UTSW 14 51,692,427 (GRCm39) missense probably benign 0.01
R1332:Vmn2r89 UTSW 14 51,692,559 (GRCm39) missense probably benign 0.00
R1660:Vmn2r89 UTSW 14 51,693,693 (GRCm39) missense possibly damaging 0.48
R1959:Vmn2r89 UTSW 14 51,694,897 (GRCm39) missense probably benign 0.22
R2876:Vmn2r89 UTSW 14 51,692,541 (GRCm39) missense possibly damaging 0.47
R3410:Vmn2r89 UTSW 14 51,693,628 (GRCm39) missense probably damaging 0.98
R4026:Vmn2r89 UTSW 14 51,689,500 (GRCm39) start codon destroyed probably null 1.00
R4398:Vmn2r89 UTSW 14 51,689,551 (GRCm39) missense probably damaging 1.00
R4700:Vmn2r89 UTSW 14 51,694,942 (GRCm39) missense probably damaging 1.00
R4714:Vmn2r89 UTSW 14 51,689,688 (GRCm39) missense probably damaging 0.97
R5162:Vmn2r89 UTSW 14 51,693,620 (GRCm39) missense possibly damaging 0.88
R5294:Vmn2r89 UTSW 14 51,692,570 (GRCm39) missense probably benign 0.00
R5811:Vmn2r89 UTSW 14 51,693,565 (GRCm39) missense probably benign 0.12
R6087:Vmn2r89 UTSW 14 51,695,033 (GRCm39) splice site probably null
R6229:Vmn2r89 UTSW 14 51,693,178 (GRCm39) missense probably benign 0.05
R6246:Vmn2r89 UTSW 14 51,693,503 (GRCm39) missense probably damaging 1.00
R6572:Vmn2r89 UTSW 14 51,693,450 (GRCm39) missense probably damaging 1.00
R7351:Vmn2r89 UTSW 14 51,693,739 (GRCm39) missense probably benign 0.30
R7683:Vmn2r89 UTSW 14 51,692,651 (GRCm39) missense probably benign
R7974:Vmn2r89 UTSW 14 51,693,459 (GRCm39) missense probably damaging 1.00
R8047:Vmn2r89 UTSW 14 51,692,549 (GRCm39) missense probably benign 0.05
R8093:Vmn2r89 UTSW 14 51,693,699 (GRCm39) missense probably benign 0.00
R8348:Vmn2r89 UTSW 14 51,692,548 (GRCm39) missense possibly damaging 0.90
R8723:Vmn2r89 UTSW 14 51,693,910 (GRCm39) missense probably benign
R8737:Vmn2r89 UTSW 14 51,693,722 (GRCm39) missense probably damaging 1.00
R8859:Vmn2r89 UTSW 14 51,693,170 (GRCm39) missense probably benign
R9183:Vmn2r89 UTSW 14 51,692,501 (GRCm39) missense probably benign 0.01
R9197:Vmn2r89 UTSW 14 51,693,596 (GRCm39) missense possibly damaging 0.70
R9377:Vmn2r89 UTSW 14 51,692,601 (GRCm39) missense probably benign 0.02
R9395:Vmn2r89 UTSW 14 51,693,783 (GRCm39) missense probably damaging 1.00
R9452:Vmn2r89 UTSW 14 51,693,288 (GRCm39) missense probably damaging 0.99
R9457:Vmn2r89 UTSW 14 51,693,469 (GRCm39) missense probably damaging 0.99
R9678:Vmn2r89 UTSW 14 51,693,511 (GRCm39) missense probably benign 0.09
X0019:Vmn2r89 UTSW 14 51,693,872 (GRCm39) missense possibly damaging 0.95
Posted On 2016-08-02