Incidental Mutation 'IGL03075:Or5ac20'
| ID |
417643 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Or5ac20
|
| Ensembl Gene |
ENSMUSG00000048810 |
| Gene Name |
olfactory receptor family 5 subfamily AC member 20 |
| Synonyms |
GA_x54KRFPKG5P-55498766-55497843, Olfr202, MOR182-1 |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.056)
|
| Stock # |
IGL03075
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
16 |
| Chromosomal Location |
59103935-59104858 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 59104291 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Threonine to Serine
at position 190
(T190S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000151058
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000049859]
[ENSMUST00000201687]
[ENSMUST00000217485]
|
| AlphaFold |
Q8VGQ3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000049859
AA Change: T190S
PolyPhen 2
Score 0.865 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000059496
Gene: ENSMUSG00000048810
AA Change: T190S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
31 |
307 |
5.9e-47 |
PFAM |
|
Pfam:7TM_GPCR_Srsx
|
35 |
296 |
1.9e-6 |
PFAM |
|
Pfam:7tm_1
|
41 |
290 |
1.2e-22 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000201687
AA Change: T190S
PolyPhen 2
Score 0.865 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000144622
Gene: ENSMUSG00000048810
AA Change: T190S
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:7tm_4
|
30 |
306 |
3.4e-46 |
PFAM |
|
Pfam:7tm_1
|
40 |
289 |
1.4e-19 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000217485
AA Change: T190S
PolyPhen 2
Score 0.865 (Sensitivity: 0.83; Specificity: 0.93)
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 32 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Akr1c12 |
G |
A |
13: 4,322,254 (GRCm39) |
R263C |
probably damaging |
Het |
| Axdnd1 |
A |
T |
1: 156,223,012 (GRCm39) |
S217T |
probably damaging |
Het |
| Crtc3 |
G |
A |
7: 80,254,151 (GRCm39) |
|
probably benign |
Het |
| Ctnna2 |
A |
T |
6: 76,931,713 (GRCm39) |
M642K |
probably benign |
Het |
| Ddx56 |
A |
T |
11: 6,211,632 (GRCm39) |
H491Q |
probably benign |
Het |
| Dvl1 |
A |
G |
4: 155,939,040 (GRCm39) |
E208G |
probably damaging |
Het |
| Fam135a |
A |
G |
1: 24,069,987 (GRCm39) |
|
probably benign |
Het |
| Gabpa |
T |
A |
16: 84,649,495 (GRCm39) |
V234D |
possibly damaging |
Het |
| Gjb4 |
A |
G |
4: 127,245,386 (GRCm39) |
V185A |
possibly damaging |
Het |
| Hlcs |
C |
T |
16: 93,939,706 (GRCm39) |
A149T |
probably damaging |
Het |
| Il1f10 |
T |
A |
2: 24,183,188 (GRCm39) |
I44N |
possibly damaging |
Het |
| Itih4 |
A |
G |
14: 30,614,240 (GRCm39) |
I397V |
probably benign |
Het |
| Kat6b |
C |
T |
14: 21,711,638 (GRCm39) |
R820* |
probably null |
Het |
| Mmp17 |
T |
C |
5: 129,672,138 (GRCm39) |
L137P |
probably damaging |
Het |
| Myh2 |
A |
G |
11: 67,071,662 (GRCm39) |
N493S |
probably benign |
Het |
| Myo9b |
A |
T |
8: 71,807,171 (GRCm39) |
Q1589L |
probably damaging |
Het |
| Or1e29 |
A |
T |
11: 73,667,298 (GRCm39) |
L285Q |
probably damaging |
Het |
| Osbpl8 |
A |
G |
10: 111,127,417 (GRCm39) |
I834V |
probably benign |
Het |
| P2ry12 |
A |
T |
3: 59,125,579 (GRCm39) |
V32D |
probably damaging |
Het |
| Polg |
A |
G |
7: 79,101,660 (GRCm39) |
V1052A |
probably damaging |
Het |
| Prss38 |
A |
C |
11: 59,263,881 (GRCm39) |
V277G |
probably damaging |
Het |
| Rell2 |
G |
T |
18: 38,090,734 (GRCm39) |
R137L |
probably damaging |
Het |
| Ro60 |
A |
C |
1: 143,646,509 (GRCm39) |
S79A |
probably benign |
Het |
| Scara3 |
C |
T |
14: 66,168,603 (GRCm39) |
R338H |
probably damaging |
Het |
| Skint4 |
T |
C |
4: 111,944,239 (GRCm39) |
L17P |
probably damaging |
Het |
| Slco1a6 |
C |
T |
6: 142,048,875 (GRCm39) |
|
probably benign |
Het |
| Smyd2 |
T |
A |
1: 189,621,029 (GRCm39) |
I230F |
probably damaging |
Het |
| Sv2b |
G |
T |
7: 74,786,068 (GRCm39) |
H451N |
probably benign |
Het |
| Tbpl2 |
A |
T |
2: 23,961,997 (GRCm39) |
|
probably benign |
Het |
| Tmprss9 |
A |
G |
10: 80,719,863 (GRCm39) |
D144G |
possibly damaging |
Het |
| Vwa8 |
T |
C |
14: 79,171,196 (GRCm39) |
Y247H |
probably damaging |
Het |
| Zc3h15 |
T |
C |
2: 83,492,535 (GRCm39) |
Y337H |
possibly damaging |
Het |
|
| Other mutations in Or5ac20 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL02271:Or5ac20
|
APN |
16 |
59,104,584 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02439:Or5ac20
|
APN |
16 |
59,104,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02798:Or5ac20
|
APN |
16 |
59,104,478 (GRCm39) |
nonsense |
probably null |
|
|
IGL03186:Or5ac20
|
APN |
16 |
59,104,266 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0270:Or5ac20
|
UTSW |
16 |
59,104,116 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0631:Or5ac20
|
UTSW |
16 |
59,104,570 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R1441:Or5ac20
|
UTSW |
16 |
59,104,228 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1546:Or5ac20
|
UTSW |
16 |
59,104,366 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3403:Or5ac20
|
UTSW |
16 |
59,104,475 (GRCm39) |
missense |
probably benign |
0.09 |
|
R4790:Or5ac20
|
UTSW |
16 |
59,104,821 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4960:Or5ac20
|
UTSW |
16 |
59,104,348 (GRCm39) |
missense |
probably benign |
0.23 |
|
R5369:Or5ac20
|
UTSW |
16 |
59,104,743 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5419:Or5ac20
|
UTSW |
16 |
59,104,704 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5646:Or5ac20
|
UTSW |
16 |
59,104,342 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6048:Or5ac20
|
UTSW |
16 |
59,104,342 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6732:Or5ac20
|
UTSW |
16 |
59,104,314 (GRCm39) |
missense |
probably benign |
0.16 |
|
R6994:Or5ac20
|
UTSW |
16 |
59,104,453 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7265:Or5ac20
|
UTSW |
16 |
59,104,287 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7956:Or5ac20
|
UTSW |
16 |
59,104,856 (GRCm39) |
start codon destroyed |
probably null |
0.20 |
|
R8074:Or5ac20
|
UTSW |
16 |
59,104,549 (GRCm39) |
missense |
probably benign |
0.22 |
|
R8082:Or5ac20
|
UTSW |
16 |
59,104,750 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R8769:Or5ac20
|
UTSW |
16 |
59,104,194 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Or5ac20
|
UTSW |
16 |
59,104,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8923:Or5ac20
|
UTSW |
16 |
59,104,399 (GRCm39) |
missense |
probably benign |
0.19 |
|
Z1177:Or5ac20
|
UTSW |
16 |
59,104,293 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Or5ac20
|
UTSW |
16 |
59,104,071 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
| Posted On |
2016-08-02 |
Incidental Mutation