Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03075:Prss38'

417662

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Prss38

Ensembl Gene

ENSMUSG00000049291

Gene Name

serine protease 38

Synonyms

Gm249, LOC216797

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.080) question?

Stock #

IGL03075

Quality Score

Status

Chromosome

Chromosomal Location

59263495-59266483 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to C at 59263881 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glycine at position 277 (V277G)

Ref Sequence

ENSEMBL: ENSMUSP00000052010 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000061481]

AlphaFold

Q3UKY7

Predicted Effect

probably damaging
Transcript: ENSMUST00000061481
AA Change: V277G

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000052010
Gene: ENSMUSG00000049291
AA Change: V277G

Domain	Start	End	E-Value	Type
signal peptide	1	21	N/A	INTRINSIC
Tryp_SPc	55	284	7.08e-75	SMART
low complexity region	288	305	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000133698

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1c12	G	A	13: 4,322,254 (GRCm39)	R263C	probably damaging	Het
Axdnd1	A	T	1: 156,223,012 (GRCm39)	S217T	probably damaging	Het
Crtc3	G	A	7: 80,254,151 (GRCm39)		probably benign	Het
Ctnna2	A	T	6: 76,931,713 (GRCm39)	M642K	probably benign	Het
Ddx56	A	T	11: 6,211,632 (GRCm39)	H491Q	probably benign	Het
Dvl1	A	G	4: 155,939,040 (GRCm39)	E208G	probably damaging	Het
Fam135a	A	G	1: 24,069,987 (GRCm39)		probably benign	Het
Gabpa	T	A	16: 84,649,495 (GRCm39)	V234D	possibly damaging	Het
Gjb4	A	G	4: 127,245,386 (GRCm39)	V185A	possibly damaging	Het
Hlcs	C	T	16: 93,939,706 (GRCm39)	A149T	probably damaging	Het
Il1f10	T	A	2: 24,183,188 (GRCm39)	I44N	possibly damaging	Het
Itih4	A	G	14: 30,614,240 (GRCm39)	I397V	probably benign	Het
Kat6b	C	T	14: 21,711,638 (GRCm39)	R820*	probably null	Het
Mmp17	T	C	5: 129,672,138 (GRCm39)	L137P	probably damaging	Het
Myh2	A	G	11: 67,071,662 (GRCm39)	N493S	probably benign	Het
Myo9b	A	T	8: 71,807,171 (GRCm39)	Q1589L	probably damaging	Het
Or1e29	A	T	11: 73,667,298 (GRCm39)	L285Q	probably damaging	Het
Or5ac20	T	A	16: 59,104,291 (GRCm39)	T190S	possibly damaging	Het
Osbpl8	A	G	10: 111,127,417 (GRCm39)	I834V	probably benign	Het
P2ry12	A	T	3: 59,125,579 (GRCm39)	V32D	probably damaging	Het
Polg	A	G	7: 79,101,660 (GRCm39)	V1052A	probably damaging	Het
Rell2	G	T	18: 38,090,734 (GRCm39)	R137L	probably damaging	Het
Ro60	A	C	1: 143,646,509 (GRCm39)	S79A	probably benign	Het
Scara3	C	T	14: 66,168,603 (GRCm39)	R338H	probably damaging	Het
Skint4	T	C	4: 111,944,239 (GRCm39)	L17P	probably damaging	Het
Slco1a6	C	T	6: 142,048,875 (GRCm39)		probably benign	Het
Smyd2	T	A	1: 189,621,029 (GRCm39)	I230F	probably damaging	Het
Sv2b	G	T	7: 74,786,068 (GRCm39)	H451N	probably benign	Het
Tbpl2	A	T	2: 23,961,997 (GRCm39)		probably benign	Het
Tmprss9	A	G	10: 80,719,863 (GRCm39)	D144G	possibly damaging	Het
Vwa8	T	C	14: 79,171,196 (GRCm39)	Y247H	probably damaging	Het
Zc3h15	T	C	2: 83,492,535 (GRCm39)	Y337H	possibly damaging	Het

Other mutations in Prss38

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
LCD18:Prss38	UTSW	11	59,266,467 (GRCm39)	utr 5 prime	probably benign
R0001:Prss38	UTSW	11	59,264,006 (GRCm39)	splice site	probably benign
R0097:Prss38	UTSW	11	59,266,434 (GRCm39)	missense	possibly damaging	0.86
R0097:Prss38	UTSW	11	59,266,434 (GRCm39)	missense	possibly damaging	0.86
R0540:Prss38	UTSW	11	59,266,369 (GRCm39)	missense	possibly damaging	0.50
R0607:Prss38	UTSW	11	59,266,369 (GRCm39)	missense	possibly damaging	0.50
R1966:Prss38	UTSW	11	59,264,310 (GRCm39)	missense	probably damaging	1.00
R4394:Prss38	UTSW	11	59,263,854 (GRCm39)	missense	probably damaging	1.00
R4397:Prss38	UTSW	11	59,263,854 (GRCm39)	missense	probably damaging	1.00
R4529:Prss38	UTSW	11	59,264,325 (GRCm39)	missense	probably damaging	1.00
R4738:Prss38	UTSW	11	59,263,771 (GRCm39)	missense	probably benign	0.00
R5061:Prss38	UTSW	11	59,265,196 (GRCm39)	missense	probably damaging	0.98
R5219:Prss38	UTSW	11	59,266,309 (GRCm39)	splice site	probably benign
R5306:Prss38	UTSW	11	59,263,821 (GRCm39)	missense	probably benign	0.00
R6894:Prss38	UTSW	11	59,263,850 (GRCm39)	missense	probably benign	0.19
R7286:Prss38	UTSW	11	59,266,384 (GRCm39)	missense	probably benign	0.00
R7860:Prss38	UTSW	11	59,265,996 (GRCm39)	missense	probably damaging	1.00
T0970:Prss38	UTSW	11	59,263,974 (GRCm39)	missense	possibly damaging	0.81
Z1176:Prss38	UTSW	11	59,265,160 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02