Incidental Mutation 'IGL03076:Olfr551'
ID417699
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr551
Ensembl Gene ENSMUSG00000073974
Gene Nameolfactory receptor 551
SynonymsMOR29-1, GA_x6K02T2PBJ9-5307445-5306498
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.084) question?
Stock #IGL03076
Quality Score
Status
Chromosome7
Chromosomal Location102583510-102591886 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 102588472 bp
ZygosityHeterozygous
Amino Acid Change Asparagine to Lysine at position 90 (N90K)
Ref Sequence ENSEMBL: ENSMUSP00000150582 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000098224] [ENSMUST00000213540]
Predicted Effect probably benign
Transcript: ENSMUST00000098224
AA Change: N90K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000095827
Gene: ENSMUSG00000073974
AA Change: N90K

DomainStartEndE-ValueType
Pfam:7tm_4 33 310 2.8e-105 PFAM
Pfam:7TM_GPCR_Srsx 37 152 2e-9 PFAM
Pfam:7tm_1 43 293 1.9e-17 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000213540
AA Change: N90K

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Ankmy2 T C 12: 36,165,918 V39A probably damaging Het
Bcl2 A G 1: 106,543,307 V223A probably benign Het
Bsn T A 9: 108,105,382 Y3724F unknown Het
Chd8 T C 14: 52,226,162 probably benign Het
Cyp2a5 T C 7: 26,835,874 V87A probably damaging Het
Dnah10 T C 5: 124,730,162 probably null Het
Dync1h1 C T 12: 110,657,893 R3652W probably damaging Het
Epha5 T A 5: 84,331,690 T152S probably damaging Het
Flnb T G 14: 7,901,988 N950K probably benign Het
Fmn1 A G 2: 113,584,092 D1128G probably damaging Het
Fndc3a T A 14: 72,556,468 T922S possibly damaging Het
Fsip2 A T 2: 82,982,138 N2934Y possibly damaging Het
Gm5415 A G 1: 32,545,545 I428T probably damaging Het
Gnptab T C 10: 88,440,289 V1146A possibly damaging Het
Gsg1l A G 7: 125,923,493 F188L probably benign Het
Kmt2c C A 5: 25,299,151 E309* probably null Het
Krt71 C T 15: 101,734,597 R492H probably benign Het
Lama1 T A 17: 67,716,799 V63E possibly damaging Het
Lrch3 T C 16: 32,981,853 V58A possibly damaging Het
Lrrc8b T A 5: 105,481,549 L587Q probably damaging Het
Lrrtm1 T C 6: 77,244,585 C342R probably damaging Het
Mdm1 T C 10: 118,159,683 S541P possibly damaging Het
Mdn1 T A 4: 32,735,564 V3410D probably damaging Het
Neb G A 2: 52,169,088 H213Y probably damaging Het
Olfr869 T C 9: 20,137,727 S204P probably benign Het
Pigt A G 2: 164,497,665 E36G probably damaging Het
Plxnb1 T A 9: 109,106,902 V1120D probably damaging Het
Rapgef6 T C 11: 54,625,967 L350P probably damaging Het
Rasgef1c C A 11: 49,970,246 T302K probably damaging Het
Riox2 C A 16: 59,491,212 A386D possibly damaging Het
Slc12a2 T C 18: 57,926,397 probably benign Het
Trim24 T A 6: 37,965,632 S992R probably damaging Het
Trpc3 T C 3: 36,640,655 N717D probably damaging Het
Vwa5b1 T C 4: 138,600,188 D359G probably damaging Het
Wapl A G 14: 34,692,089 T303A probably benign Het
Zfp128 A G 7: 12,884,709 T45A possibly damaging Het
Zfp280d T C 9: 72,312,662 S240P probably damaging Het
Other mutations in Olfr551
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01680:Olfr551 APN 7 102588229 nonsense probably null
IGL03034:Olfr551 APN 7 102587940 missense probably benign 0.42
R0564:Olfr551 UTSW 7 102588531 missense probably benign
R0890:Olfr551 UTSW 7 102588201 nonsense probably null
R0909:Olfr551 UTSW 7 102588447 missense probably damaging 1.00
R1053:Olfr551 UTSW 7 102587959 nonsense probably null
R4708:Olfr551 UTSW 7 102587836 missense probably benign 0.00
R4932:Olfr551 UTSW 7 102588416 missense probably damaging 0.98
R6248:Olfr551 UTSW 7 102588030 missense probably benign 0.00
R6343:Olfr551 UTSW 7 102588546 missense probably damaging 0.98
R6389:Olfr551 UTSW 7 102588472 missense probably benign
R6455:Olfr551 UTSW 7 102588671 missense probably benign 0.00
R7305:Olfr551 UTSW 7 102587955 missense possibly damaging 0.94
Posted On2016-08-02