Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03077:Trbc1'

417741

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Trbc1

Ensembl Gene

ENSMUSG00000076490

Gene Name

T cell receptor beta, constant region 1

Synonyms

Gm16802, Tcrb-C1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.176) question?

Stock #

IGL03077

Quality Score

Status

Chromosome

Chromosomal Location

41515153-41516599 bp(+) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

T to A at 41515383 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000141199 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103296] [ENSMUST00000178862] [ENSMUST00000193061] [ENSMUST00000103295]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000103284

Predicted Effect

probably benign
Transcript: ENSMUST00000103285

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000103286

Predicted Effect

probably benign
Transcript: ENSMUST00000103287

Predicted Effect

probably benign
Transcript: ENSMUST00000103288

Predicted Effect

probably benign
Transcript: ENSMUST00000103289

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000103290

Predicted Effect

unknown
Transcript: ENSMUST00000103291
AA Change: V77D

SMART Domains

Protein: ENSMUSP00000100099
Gene: ENSMUSG00000076490
AA Change: V77D

Domain	Start	End	E-Value	Type
IGc1	26	102	9.51e-28	SMART
transmembrane domain	142	164	N/A	INTRINSIC

Predicted Effect

unknown
Transcript: ENSMUST00000192856
AA Change: V77D

Predicted Effect

probably benign
Transcript: ENSMUST00000192366

Predicted Effect

probably benign
Transcript: ENSMUST00000103296

Predicted Effect

probably benign
Transcript: ENSMUST00000178862

Predicted Effect

probably benign
Transcript: ENSMUST00000103294

Predicted Effect

probably benign
Transcript: ENSMUST00000193061

Predicted Effect

probably benign
Transcript: ENSMUST00000103295

Predicted Effect

probably benign
Transcript: ENSMUST00000103293

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcg8	A	G	17: 84,999,308 (GRCm39)	N135D	probably damaging	Het
Ak4	T	C	4: 101,277,148 (GRCm39)	L44P	probably damaging	Het
Angpt1	C	A	15: 42,339,818 (GRCm39)	G298*	probably null	Het
Appl2	C	T	10: 83,457,623 (GRCm39)		probably benign	Het
Arhgap19	T	A	19: 41,769,760 (GRCm39)	H341L	probably benign	Het
Chmp5	T	C	4: 40,952,438 (GRCm39)	S98P	probably benign	Het
Chp1	A	T	2: 119,415,081 (GRCm39)	Q161L	probably benign	Het
Clgn	T	C	8: 84,150,769 (GRCm39)	V478A	probably benign	Het
Cplane1	G	A	15: 8,242,279 (GRCm39)		probably benign	Het
Cyp2b19	A	T	7: 26,461,809 (GRCm39)	M210L	probably benign	Het
Eif4g3	T	A	4: 137,853,166 (GRCm39)	V244D	probably damaging	Het
Ftcd	T	C	10: 76,417,461 (GRCm39)	I300T	probably damaging	Het
Gm12886	C	T	4: 121,272,697 (GRCm39)		probably benign	Het
Klrb1f	A	T	6: 129,030,765 (GRCm39)	E92V	probably null	Het
Krt23	A	G	11: 99,374,700 (GRCm39)		probably benign	Het
Mib2	T	G	4: 155,743,900 (GRCm39)	R47S	probably benign	Het
Mindy4	A	G	6: 55,286,315 (GRCm39)	T728A	probably damaging	Het
Myh15	A	G	16: 48,916,901 (GRCm39)	N407S	probably benign	Het
Nlrp4f	A	G	13: 65,342,412 (GRCm39)	V411A	probably benign	Het
Or10ag56	T	C	2: 87,140,056 (GRCm39)	*328Q	probably null	Het
Or4c12b	A	C	2: 89,647,486 (GRCm39)	D266A	probably damaging	Het
Otud4	T	G	8: 80,400,087 (GRCm39)	S934A	probably damaging	Het
P3h1	C	T	4: 119,093,983 (GRCm39)	R213W	probably damaging	Het
Phrf1	A	T	7: 140,834,881 (GRCm39)	K19*	probably null	Het
Prl3b1	A	T	13: 27,429,759 (GRCm39)	M66L	probably benign	Het
Psmd7	T	C	8: 108,309,099 (GRCm39)	T149A	probably benign	Het
Samd4b	T	C	7: 28,105,868 (GRCm39)	D450G	probably damaging	Het
Scn3a	G	A	2: 65,367,016 (GRCm39)	A2V	probably damaging	Het
Snrpa	G	A	7: 26,891,186 (GRCm39)	T95I	probably benign	Het
Traip	A	G	9: 107,840,125 (GRCm39)		probably benign	Het
Trim72	A	T	7: 127,607,013 (GRCm39)	M181L	probably benign	Het
Ttc41	T	C	10: 86,594,212 (GRCm39)	Y882H	probably damaging	Het
Vmn1r191	A	C	13: 22,363,316 (GRCm39)	I146S	probably benign	Het
Vmn2r9	G	T	5: 108,996,173 (GRCm39)		probably benign	Het
Vps13a	A	G	19: 16,688,246 (GRCm39)	S854P	probably benign	Het
Wdfy1	T	C	1: 79,692,622 (GRCm39)	K232E	possibly damaging	Het
Xpr1	A	T	1: 155,156,774 (GRCm39)	D625E	possibly damaging	Het
Zbbx	T	A	3: 74,989,153 (GRCm39)	T317S	possibly damaging	Het

Other mutations in Trbc1

Allele	Source	Chr	Coord	Type	Predicted Effect
R1888:Trbc1	UTSW	6	41,512,570 (GRCm39)	unclassified	probably benign
R3552:Trbc1	UTSW	6	41,516,579 (GRCm39)	unclassified	probably benign
R4845:Trbc1	UTSW	6	41,516,169 (GRCm39)	unclassified	probably benign
R4998:Trbc1	UTSW	6	41,516,270 (GRCm39)	unclassified	probably benign
R5233:Trbc1	UTSW	6	41,515,383 (GRCm39)	unclassified	probably benign
R6159:Trbc1	UTSW	6	41,515,385 (GRCm39)	unclassified	probably benign
R7800:Trbc1	UTSW	6	41,516,195 (GRCm39)	missense
R7978:Trbc1	UTSW	6	41,515,236 (GRCm39)	missense
R8334:Trbc1	UTSW	6	41,516,046 (GRCm39)	critical splice acceptor site	probably benign

Posted On

2016-08-02