Incidental Mutation 'IGL03080:Ffar3'
ID 417829
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Ffar3
Ensembl Gene ENSMUSG00000019429
Gene Name free fatty acid receptor 3
Synonyms LOC233080, Gpr41
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03080
Quality Score
Status
Chromosome 7
Chromosomal Location 30553755-30555603 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 30554747 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glutamic Acid at position 191 (V191E)
Ref Sequence ENSEMBL: ENSMUSP00000140252 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000052700] [ENSMUST00000094583] [ENSMUST00000185748]
AlphaFold Q3UFD7
Predicted Effect probably benign
Transcript: ENSMUST00000052700
SMART Domains Protein: ENSMUSP00000055564
Gene: ENSMUSG00000044453

DomainStartEndE-ValueType
Pfam:7tm_1 22 275 1.3e-18 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000094583
AA Change: V191E

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000092163
Gene: ENSMUSG00000019429
AA Change: V191E

DomainStartEndE-ValueType
low complexity region 12 25 N/A INTRINSIC
Pfam:7tm_1 27 272 2.9e-32 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000185748
AA Change: V191E

PolyPhen 2 Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000140252
Gene: ENSMUSG00000019429
AA Change: V191E

DomainStartEndE-ValueType
low complexity region 12 25 N/A INTRINSIC
Pfam:7tm_1 27 272 9.1e-39 PFAM
Coding Region Coverage
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a null allele colonized with a model fermentative community are lean and exhibit decreased weight gain, increased intestinal transit rate, and reduced caloric extraction. Mice homozygous for a knock-out allele exhibit a slight increase in serum insulin when fed a high-fat diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 38 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abce1 T C 8: 80,429,630 (GRCm39) probably null Het
Adgrf3 T C 5: 30,401,827 (GRCm39) M734V probably benign Het
Aqp8 T G 7: 123,065,802 (GRCm39) probably benign Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Cntn4 A G 6: 106,632,500 (GRCm39) D508G probably damaging Het
Cyp11b1 A T 15: 74,711,285 (GRCm39) probably null Het
Dnah8 A G 17: 30,937,980 (GRCm39) D1619G probably benign Het
Eif1ad17 A T 12: 87,978,615 (GRCm39) probably benign Het
Ephb4 T A 5: 137,352,345 (GRCm39) probably benign Het
Galnt1 T A 18: 24,402,574 (GRCm39) D310E probably damaging Het
Igf2r T C 17: 12,945,563 (GRCm39) Y342C probably benign Het
Jade1 T A 3: 41,554,510 (GRCm39) C251* probably null Het
Jhy T C 9: 40,855,653 (GRCm39) E278G probably damaging Het
Kif24 A C 4: 41,394,417 (GRCm39) S819A probably benign Het
Lrp8 T C 4: 107,712,996 (GRCm39) L344P probably damaging Het
Lrrc27 A G 7: 138,810,153 (GRCm39) T375A probably benign Het
Mbd3 C T 10: 80,229,085 (GRCm39) R204Q probably damaging Het
Nab2 T C 10: 127,500,663 (GRCm39) N143S possibly damaging Het
Nkiras2 T C 11: 100,515,105 (GRCm39) probably null Het
Or7e174 A T 9: 20,012,705 (GRCm39) I217F probably damaging Het
Palm C A 10: 79,654,951 (GRCm39) H74Q probably damaging Het
Pros1 T A 16: 62,738,506 (GRCm39) N408K probably damaging Het
Psg23 T A 7: 18,340,910 (GRCm39) Y448F probably damaging Het
Ranbp2 C A 10: 58,312,613 (GRCm39) P1111Q probably benign Het
Rims2 A G 15: 39,399,299 (GRCm39) S1115G probably damaging Het
Scn7a T C 2: 66,528,160 (GRCm39) T777A probably benign Het
Spata31h1 T C 10: 82,119,816 (GRCm39) D428G probably damaging Het
Stard3nl A T 13: 19,554,648 (GRCm39) probably null Het
Sult1d1 T C 5: 87,704,847 (GRCm39) D214G probably benign Het
Tmprss12 T C 15: 100,190,529 (GRCm39) W300R probably damaging Het
Tmprss2 T C 16: 97,398,044 (GRCm39) Y44C probably damaging Het
Ttk A G 9: 83,725,136 (GRCm39) N154D probably damaging Het
Tut4 T A 4: 108,363,021 (GRCm39) S444R probably damaging Het
Tyw1 T C 5: 130,295,896 (GRCm39) Y108H probably damaging Het
Vmn2r44 C A 7: 8,386,244 (GRCm39) probably benign Het
Zfand1 A G 3: 10,405,797 (GRCm39) *269Q probably null Het
Zfp142 A T 1: 74,610,368 (GRCm39) D1039E probably benign Het
Zkscan5 G T 5: 145,155,460 (GRCm39) S377I probably damaging Het
Other mutations in Ffar3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL03167:Ffar3 APN 7 30,554,780 (GRCm39) missense probably damaging 1.00
R0555:Ffar3 UTSW 7 30,554,962 (GRCm39) nonsense probably null
R0751:Ffar3 UTSW 7 30,554,529 (GRCm39) missense probably damaging 1.00
R1184:Ffar3 UTSW 7 30,554,529 (GRCm39) missense probably damaging 1.00
R3116:Ffar3 UTSW 7 30,555,231 (GRCm39) missense probably benign 0.00
R7276:Ffar3 UTSW 7 30,555,273 (GRCm39) missense possibly damaging 0.46
R8345:Ffar3 UTSW 7 30,554,789 (GRCm39) missense probably damaging 1.00
R9016:Ffar3 UTSW 7 30,554,454 (GRCm39) missense probably damaging 0.97
R9691:Ffar3 UTSW 7 30,555,119 (GRCm39) missense probably damaging 1.00
Z1176:Ffar3 UTSW 7 30,554,618 (GRCm39) missense probably damaging 1.00
Z1186:Ffar3 UTSW 7 30,555,495 (GRCm39) start gained probably benign
Posted On 2016-08-02