Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03080:Zfand1'

417835

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfand1

Ensembl Gene

ENSMUSG00000039795

Gene Name

zinc finger, AN1-type domain 1

Synonyms

2310008M20Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.112) question?

Stock #

IGL03080

Quality Score

Status

Chromosome

Chromosomal Location

10405013-10416377 bp(-) (GRCm39)

Type of Mutation

makesense

DNA Base Change (assembly)

A to G at 10405797 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Stop codon to Glutamine at position 269 (*269Q)

Ref Sequence

ENSEMBL: ENSMUSP00000037459 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000037839] [ENSMUST00000108377] [ENSMUST00000140634] [ENSMUST00000184644]

AlphaFold

Q8BFR6

PDB Structure

Solution structure of the 2nd zf-AN1 domain of mouse RIKEN cDNA 2310008M20 protein [SOLUTION NMR]
Solution structure of the first zf-AN1 domain of mouse RIKEN cDNA 2310008M20 protein [SOLUTION NMR]

Predicted Effect

probably null
Transcript: ENSMUST00000037839
AA Change: *269Q

SMART Domains

Protein: ENSMUSP00000037459
Gene: ENSMUSG00000039795
AA Change: *269Q

Domain	Start	End	E-Value	Type
ZnF_AN1	10	49	1.4e-8	SMART
ZnF_AN1	64	103	2.64e-4	SMART
low complexity region	121	142	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000108377

SMART Domains

Protein: ENSMUSP00000104014
Gene: ENSMUSG00000039795

Domain	Start	End	E-Value	Type
ZnF_AN1	10	49	1.4e-8	SMART
ZnF_AN1	64	103	2.64e-4	SMART
low complexity region	121	142	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000125734

Predicted Effect

probably benign
Transcript: ENSMUST00000140634

SMART Domains

Protein: ENSMUSP00000122048
Gene: ENSMUSG00000039795

Domain	Start	End	E-Value	Type
ZnF_AN1	19	55	5.62e-3	SMART
ZnF_AN1	70	109	2.64e-4	SMART
low complexity region	127	148	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000156414

Predicted Effect

probably benign
Transcript: ENSMUST00000184644

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 38 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abce1	T	C	8: 80,429,630 (GRCm39)		probably null	Het
Adgrf3	T	C	5: 30,401,827 (GRCm39)	M734V	probably benign	Het
Aqp8	T	G	7: 123,065,802 (GRCm39)		probably benign	Het
Ces1d	C	A	8: 93,896,346 (GRCm39)		probably null	Het
Cntn4	A	G	6: 106,632,500 (GRCm39)	D508G	probably damaging	Het
Cyp11b1	A	T	15: 74,711,285 (GRCm39)		probably null	Het
Dnah8	A	G	17: 30,937,980 (GRCm39)	D1619G	probably benign	Het
Eif1ad17	A	T	12: 87,978,615 (GRCm39)		probably benign	Het
Ephb4	T	A	5: 137,352,345 (GRCm39)		probably benign	Het
Ffar3	A	T	7: 30,554,747 (GRCm39)	V191E	probably damaging	Het
Galnt1	T	A	18: 24,402,574 (GRCm39)	D310E	probably damaging	Het
Igf2r	T	C	17: 12,945,563 (GRCm39)	Y342C	probably benign	Het
Jade1	T	A	3: 41,554,510 (GRCm39)	C251*	probably null	Het
Jhy	T	C	9: 40,855,653 (GRCm39)	E278G	probably damaging	Het
Kif24	A	C	4: 41,394,417 (GRCm39)	S819A	probably benign	Het
Lrp8	T	C	4: 107,712,996 (GRCm39)	L344P	probably damaging	Het
Lrrc27	A	G	7: 138,810,153 (GRCm39)	T375A	probably benign	Het
Mbd3	C	T	10: 80,229,085 (GRCm39)	R204Q	probably damaging	Het
Nab2	T	C	10: 127,500,663 (GRCm39)	N143S	possibly damaging	Het
Nkiras2	T	C	11: 100,515,105 (GRCm39)		probably null	Het
Or7e174	A	T	9: 20,012,705 (GRCm39)	I217F	probably damaging	Het
Palm	C	A	10: 79,654,951 (GRCm39)	H74Q	probably damaging	Het
Pros1	T	A	16: 62,738,506 (GRCm39)	N408K	probably damaging	Het
Psg23	T	A	7: 18,340,910 (GRCm39)	Y448F	probably damaging	Het
Ranbp2	C	A	10: 58,312,613 (GRCm39)	P1111Q	probably benign	Het
Rims2	A	G	15: 39,399,299 (GRCm39)	S1115G	probably damaging	Het
Scn7a	T	C	2: 66,528,160 (GRCm39)	T777A	probably benign	Het
Spata31h1	T	C	10: 82,119,816 (GRCm39)	D428G	probably damaging	Het
Stard3nl	A	T	13: 19,554,648 (GRCm39)		probably null	Het
Sult1d1	T	C	5: 87,704,847 (GRCm39)	D214G	probably benign	Het
Tmprss12	T	C	15: 100,190,529 (GRCm39)	W300R	probably damaging	Het
Tmprss2	T	C	16: 97,398,044 (GRCm39)	Y44C	probably damaging	Het
Ttk	A	G	9: 83,725,136 (GRCm39)	N154D	probably damaging	Het
Tut4	T	A	4: 108,363,021 (GRCm39)	S444R	probably damaging	Het
Tyw1	T	C	5: 130,295,896 (GRCm39)	Y108H	probably damaging	Het
Vmn2r44	C	A	7: 8,386,244 (GRCm39)		probably benign	Het
Zfp142	A	T	1: 74,610,368 (GRCm39)	D1039E	probably benign	Het
Zkscan5	G	T	5: 145,155,460 (GRCm39)	S377I	probably damaging	Het

Other mutations in Zfand1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00094:Zfand1	APN	3	10,413,590 (GRCm39)	missense	probably null	0.26
IGL00671:Zfand1	APN	3	10,411,084 (GRCm39)	missense	probably damaging	1.00
IGL01775:Zfand1	APN	3	10,409,926 (GRCm39)	missense	probably damaging	1.00
R0678:Zfand1	UTSW	3	10,413,577 (GRCm39)	missense	probably benign	0.23
R1394:Zfand1	UTSW	3	10,411,269 (GRCm39)	missense	probably benign	0.04
R1637:Zfand1	UTSW	3	10,411,042 (GRCm39)	missense	probably benign	0.10
R1699:Zfand1	UTSW	3	10,406,115 (GRCm39)	missense	possibly damaging	0.67
R4020:Zfand1	UTSW	3	10,405,816 (GRCm39)	missense	probably benign	0.06
R5700:Zfand1	UTSW	3	10,406,079 (GRCm39)	missense	probably damaging	1.00
R6798:Zfand1	UTSW	3	10,411,236 (GRCm39)	missense	probably benign	0.30
R6817:Zfand1	UTSW	3	10,405,884 (GRCm39)	missense	probably benign	0.34
R7520:Zfand1	UTSW	3	10,411,009 (GRCm39)	missense	probably damaging	0.98
R8304:Zfand1	UTSW	3	10,413,615 (GRCm39)	nonsense	probably null
R8855:Zfand1	UTSW	3	10,405,811 (GRCm39)	missense	probably benign	0.05
R8886:Zfand1	UTSW	3	10,409,862 (GRCm39)	missense	probably null	0.89
R8964:Zfand1	UTSW	3	10,413,631 (GRCm39)	missense	probably benign	0.00
R9099:Zfand1	UTSW	3	10,406,148 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02