Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03092:Vmn1r70'

418406

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r70

Ensembl Gene

ENSMUSG00000045340

Gene Name

vomeronasal 1 receptor 70

Synonyms

V1rl1

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

IGL03092

Quality Score

Status

Chromosome

Chromosomal Location

10367514-10368410 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 10368186 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 225 (S225P)

Ref Sequence

ENSEMBL: ENSMUSP00000154041 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055847] [ENSMUST00000226255] [ENSMUST00000228090]

AlphaFold

Q8R254

Predicted Effect

probably benign
Transcript: ENSMUST00000055847
AA Change: S225P

PolyPhen 2 Score 0.229 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000054445
Gene: ENSMUSG00000045340
AA Change: S225P

Domain	Start	End	E-Value	Type
Pfam:TAS2R	1	292	2.6e-9	PFAM
Pfam:V1R	33	295	3.1e-31	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000226182

Predicted Effect

probably benign
Transcript: ENSMUST00000226255
AA Change: S225P

PolyPhen 2 Score 0.229 (Sensitivity: 0.91; Specificity: 0.88)

Predicted Effect

probably benign
Transcript: ENSMUST00000228090
AA Change: S206P

PolyPhen 2 Score 0.104 (Sensitivity: 0.93; Specificity: 0.86)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 36 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700006A11Rik	A	G	3: 124,200,119 (GRCm39)	L491P	probably damaging	Het
Abcc6	T	A	7: 45,635,894 (GRCm39)	D1051V	probably damaging	Het
Actmap	T	C	7: 26,900,561 (GRCm39)	M180T	probably damaging	Het
Aqr	T	A	2: 113,989,424 (GRCm39)	E133V	probably benign	Het
Bag6	A	G	17: 35,364,603 (GRCm39)	N911D	probably damaging	Het
Cdcp3	G	T	7: 130,803,527 (GRCm39)		probably null	Het
Ces4a	C	T	8: 105,874,836 (GRCm39)		probably benign	Het
Clec3b	A	T	9: 122,980,100 (GRCm39)		probably benign	Het
Cnot1	T	C	8: 96,496,243 (GRCm39)		probably benign	Het
Ctsg	T	A	14: 56,337,417 (GRCm39)	*262L	probably null	Het
Cyp17a1	T	A	19: 46,661,050 (GRCm39)	H78L	possibly damaging	Het
Dcaf13	C	A	15: 38,991,371 (GRCm39)		probably benign	Het
Dcun1d1	G	T	3: 35,975,141 (GRCm39)	Q52K	possibly damaging	Het
Ddb1	C	T	19: 10,590,309 (GRCm39)	R279W	probably damaging	Het
Dock1	A	G	7: 134,366,945 (GRCm39)		probably benign	Het
Dsel	A	G	1: 111,787,793 (GRCm39)	L914P	probably damaging	Het
Fbxo31	A	G	8: 122,286,757 (GRCm39)	F174L	probably benign	Het
Gm9116	A	G	3: 93,817,513 (GRCm39)		noncoding transcript	Het
Gspt1	C	T	16: 11,056,763 (GRCm39)	V211I	probably benign	Het
Hmgb1	A	T	5: 148,987,508 (GRCm39)	S14T	probably benign	Het
Igsf8	A	G	1: 172,140,096 (GRCm39)		probably benign	Het
Klf13	A	G	7: 63,541,417 (GRCm39)	F237L	probably damaging	Het
Mon2	A	T	10: 122,854,005 (GRCm39)	I962N	probably damaging	Het
Nfx1	A	G	4: 41,024,851 (GRCm39)	D1108G	probably damaging	Het
Nr2e1	T	C	10: 42,447,478 (GRCm39)	Y178C	probably damaging	Het
Or4d10c	C	A	19: 12,065,230 (GRCm39)	E309*	probably null	Het
Or52d1	A	T	7: 103,755,854 (GRCm39)	I123F	probably damaging	Het
Pde3b	A	T	7: 114,122,583 (GRCm39)	H717L	probably damaging	Het
Polr1b	T	C	2: 128,965,049 (GRCm39)	Y712H	probably damaging	Het
Pramel16	C	A	4: 143,676,767 (GRCm39)	K112N	probably damaging	Het
Rnf157	T	A	11: 116,238,795 (GRCm39)		probably null	Het
Ros1	T	C	10: 51,974,902 (GRCm39)	E1561G	probably damaging	Het
Serpina6	A	G	12: 103,620,154 (GRCm39)		probably null	Het
St18	A	G	1: 6,839,118 (GRCm39)		probably benign	Het
Ugp2	A	G	11: 21,279,722 (GRCm39)		probably benign	Het
Zfp641	T	C	15: 98,188,397 (GRCm39)	D161G	probably damaging	Het

Other mutations in Vmn1r70

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03250:Vmn1r70	APN	7	10,368,208 (GRCm39)	missense	probably damaging	1.00
R0375:Vmn1r70	UTSW	7	10,367,987 (GRCm39)	missense	probably damaging	1.00
R0482:Vmn1r70	UTSW	7	10,368,204 (GRCm39)	missense	probably damaging	1.00
R0497:Vmn1r70	UTSW	7	10,367,953 (GRCm39)	missense	probably benign	0.19
R1964:Vmn1r70	UTSW	7	10,367,737 (GRCm39)	missense	possibly damaging	0.88
R2067:Vmn1r70	UTSW	7	10,368,264 (GRCm39)	missense	possibly damaging	0.61
R3807:Vmn1r70	UTSW	7	10,367,715 (GRCm39)	missense	probably benign	0.01
R4573:Vmn1r70	UTSW	7	10,367,556 (GRCm39)	splice site	probably null
R5070:Vmn1r70	UTSW	7	10,368,325 (GRCm39)	missense	probably benign	0.04
R5442:Vmn1r70	UTSW	7	10,367,877 (GRCm39)	missense	possibly damaging	0.69
R5558:Vmn1r70	UTSW	7	10,368,402 (GRCm39)	missense	probably benign	0.01
R6036:Vmn1r70	UTSW	7	10,367,830 (GRCm39)	missense	probably damaging	1.00
R6036:Vmn1r70	UTSW	7	10,367,830 (GRCm39)	missense	probably damaging	1.00
R6189:Vmn1r70	UTSW	7	10,367,598 (GRCm39)	missense	probably benign	0.04
R6976:Vmn1r70	UTSW	7	10,367,971 (GRCm39)	missense	probably benign	0.02
R7571:Vmn1r70	UTSW	7	10,367,871 (GRCm39)	missense	probably benign	0.00
R9236:Vmn1r70	UTSW	7	10,368,016 (GRCm39)	missense	probably damaging	1.00
R9568:Vmn1r70	UTSW	7	10,368,292 (GRCm39)	missense	probably benign	0.03
R9673:Vmn1r70	UTSW	7	10,368,364 (GRCm39)	missense	probably damaging	1.00
X0020:Vmn1r70	UTSW	7	10,367,517 (GRCm39)	missense	probably benign

Posted On

2016-08-02