Incidental Mutation 'IGL03093:Itpr2'
ID 418469
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Itpr2
Ensembl Gene ENSMUSG00000030287
Gene Name inositol 1,4,5-triphosphate receptor 2
Synonyms Ip3r2, Itpr5
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03093
Quality Score
Status
Chromosome 6
Chromosomal Location 146009797-146403721 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 146281008 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Serine at position 216 (I216S)
Ref Sequence ENSEMBL: ENSMUSP00000121773 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053273] [ENSMUST00000079573] [ENSMUST00000131890] [ENSMUST00000139732]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000053273
AA Change: I574S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049584
Gene: ENSMUSG00000030287
AA Change: I574S

DomainStartEndE-ValueType
low complexity region 68 80 N/A INTRINSIC
MIR 112 166 1.1e-5 SMART
MIR 173 223 8.9e-6 SMART
MIR 231 287 5.11e-6 SMART
MIR 294 402 3.73e-8 SMART
Pfam:RYDR_ITPR 473 670 1.5e-62 PFAM
low complexity region 882 890 N/A INTRINSIC
Pfam:RYDR_ITPR 1183 1346 1.6e-16 PFAM
low complexity region 1773 1785 N/A INTRINSIC
low complexity region 1897 1908 N/A INTRINSIC
Pfam:RIH_assoc 1912 2022 4.6e-34 PFAM
low complexity region 2088 2098 N/A INTRINSIC
transmembrane domain 2228 2250 N/A INTRINSIC
Pfam:Ion_trans 2260 2552 5.1e-20 PFAM
coiled coil region 2631 2686 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000079573
AA Change: I541S

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000078526
Gene: ENSMUSG00000030287
AA Change: I541S

DomainStartEndE-ValueType
low complexity region 68 80 N/A INTRINSIC
MIR 112 166 1.1e-5 SMART
MIR 198 254 5.11e-6 SMART
MIR 261 369 3.73e-8 SMART
Pfam:RYDR_ITPR 438 644 5.4e-75 PFAM
low complexity region 849 857 N/A INTRINSIC
Pfam:RYDR_ITPR 1148 1322 7.2e-60 PFAM
low complexity region 1740 1752 N/A INTRINSIC
Pfam:RIH_assoc 1875 1994 5.8e-35 PFAM
low complexity region 2055 2065 N/A INTRINSIC
transmembrane domain 2195 2217 N/A INTRINSIC
transmembrane domain 2230 2249 N/A INTRINSIC
low complexity region 2268 2279 N/A INTRINSIC
Pfam:Ion_trans 2281 2507 2.4e-12 PFAM
coiled coil region 2598 2653 N/A INTRINSIC
Predicted Effect probably damaging
Transcript: ENSMUST00000131890
AA Change: I216S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000121773
Gene: ENSMUSG00000030287
AA Change: I216S

DomainStartEndE-ValueType
Pfam:MIR 1 74 4.8e-22 PFAM
Pfam:RYDR_ITPR 113 319 1.9e-76 PFAM
low complexity region 524 532 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000139732
SMART Domains Protein: ENSMUSP00000119110
Gene: ENSMUSG00000030287

DomainStartEndE-ValueType
low complexity region 21 33 N/A INTRINSIC
MIR 65 119 1.1e-5 SMART
MIR 126 176 8.9e-6 SMART
MIR 184 240 5.11e-6 SMART
MIR 247 355 3.73e-8 SMART
Pfam:RYDR_ITPR 424 630 3e-76 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145418
Predicted Effect noncoding transcript
Transcript: ENSMUST00000204247
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene belongs to the inositol 1,4,5-triphosphate receptor family, whose members are second messenger intracellular calcium release channels. These proteins mediate a rise in cytoplasmic calcium in response to receptor activated production of inositol triphosphate. Inositol triphosphate receptor-mediated signaling is involved in many processes including cell migration, cell division, smooth muscle contraction, and neuronal signaling. This protein is a type 2 receptor that consists of a cytoplasmic amino-terminus that binds inositol triphosphate, six membrane-spanning helices that contribute to the ion pore, and a short cytoplasmic carboxy-terminus. A mutation in this gene has been associated with anhidrosis, suggesting that intracellular calcium release mediated by this protein is required for eccrine sweat production. [provided by RefSeq, Apr 2015]
PHENOTYPE: Homozygotes for a knock-out allele are viable and fertile but show decreased sweating and disturbed calcium signaling in sweat glands. Mice homozygous for a different knock-out allele have atrial myocytes that are significantly less prone to develop proarrhythmic disturbances in calcium signaling. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Add3 A G 19: 53,219,638 (GRCm39) D121G probably damaging Het
Cacna1s A G 1: 136,043,802 (GRCm39) D1380G probably benign Het
Clca3a1 T C 3: 144,453,262 (GRCm39) Y487C probably damaging Het
Coro2a A G 4: 46,544,158 (GRCm39) S278P possibly damaging Het
Creb3l3 A G 10: 80,927,047 (GRCm39) S128P probably benign Het
Dab2 A G 15: 6,465,892 (GRCm39) R697G probably damaging Het
Erap1 T C 13: 74,823,399 (GRCm39) F811S probably benign Het
Fam170b A G 14: 32,557,482 (GRCm39) S106G probably damaging Het
Galk2 T C 2: 125,771,563 (GRCm39) L196P probably damaging Het
Gan T C 8: 117,910,314 (GRCm39) M81T probably benign Het
Gemin2 A G 12: 59,068,511 (GRCm39) T197A probably benign Het
Hemgn A T 4: 46,396,504 (GRCm39) M244K probably benign Het
Htr6 A G 4: 138,789,080 (GRCm39) F325S probably damaging Het
Igkv9-120 A G 6: 68,027,398 (GRCm39) D104G probably damaging Het
Lingo1 T C 9: 56,526,748 (GRCm39) I614V possibly damaging Het
Mep1b C T 18: 21,226,710 (GRCm39) T524M probably benign Het
Mtif2 A G 11: 29,480,702 (GRCm39) probably benign Het
Mylk G A 16: 34,732,562 (GRCm39) R614H possibly damaging Het
Or2ag2 T C 7: 106,485,410 (GRCm39) T205A probably benign Het
Or52s19 T C 7: 103,007,446 (GRCm39) probably benign Het
Pabpc4 G A 4: 123,180,502 (GRCm39) D75N probably damaging Het
Paics T A 5: 77,109,355 (GRCm39) probably null Het
Prl T A 13: 27,248,870 (GRCm39) I172N probably benign Het
Ripk2 A G 4: 16,152,056 (GRCm39) S168P probably damaging Het
Siglecf T C 7: 43,001,865 (GRCm39) V225A probably damaging Het
Slc36a1 A G 11: 55,110,430 (GRCm39) I86V probably benign Het
Slc6a13 A G 6: 121,309,407 (GRCm39) Y306C probably damaging Het
Soat2 T A 15: 102,066,078 (GRCm39) L250Q probably damaging Het
Tex38 A G 4: 115,637,762 (GRCm39) S14P probably damaging Het
Tm2d1 A T 4: 98,268,921 (GRCm39) C59S possibly damaging Het
Tmco1 A G 1: 167,143,848 (GRCm39) D82G probably damaging Het
Tmem245 G A 4: 56,886,019 (GRCm39) R866W probably damaging Het
Tnip1 G T 11: 54,831,652 (GRCm39) Y7* probably null Het
Trp73 A G 4: 154,189,330 (GRCm39) M48T probably benign Het
Tslp T C 18: 32,948,612 (GRCm39) probably benign Het
Usp47 T C 7: 111,688,827 (GRCm39) F745L probably damaging Het
Vmn2r53 T A 7: 12,334,791 (GRCm39) T290S probably benign Het
Wdr1 T C 5: 38,718,472 (GRCm39) D30G probably benign Het
Zkscan2 T C 7: 123,094,073 (GRCm39) Y247C probably benign Het
Other mutations in Itpr2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00087:Itpr2 APN 6 146,298,510 (GRCm39) missense probably damaging 0.99
IGL00163:Itpr2 APN 6 146,292,334 (GRCm39) missense possibly damaging 0.88
IGL00229:Itpr2 APN 6 146,045,683 (GRCm39) missense probably damaging 1.00
IGL00712:Itpr2 APN 6 146,133,934 (GRCm39) missense possibly damaging 0.63
IGL00952:Itpr2 APN 6 146,060,459 (GRCm39) missense probably damaging 1.00
IGL00983:Itpr2 APN 6 146,212,479 (GRCm39) splice site probably benign
IGL01012:Itpr2 APN 6 146,246,659 (GRCm39) missense probably damaging 1.00
IGL01289:Itpr2 APN 6 146,014,033 (GRCm39) nonsense probably null
IGL01411:Itpr2 APN 6 146,277,560 (GRCm39) critical splice donor site probably null
IGL01557:Itpr2 APN 6 146,060,474 (GRCm39) missense probably damaging 0.99
IGL01669:Itpr2 APN 6 146,081,727 (GRCm39) missense probably damaging 1.00
IGL01809:Itpr2 APN 6 146,129,079 (GRCm39) missense probably damaging 1.00
IGL01814:Itpr2 APN 6 146,134,044 (GRCm39) missense probably benign 0.02
IGL02198:Itpr2 APN 6 146,224,725 (GRCm39) missense probably damaging 1.00
IGL02218:Itpr2 APN 6 146,141,760 (GRCm39) splice site probably benign
IGL02332:Itpr2 APN 6 146,328,040 (GRCm39) missense probably damaging 1.00
IGL02425:Itpr2 APN 6 146,292,819 (GRCm39) missense probably damaging 0.99
IGL02432:Itpr2 APN 6 146,226,671 (GRCm39) missense probably benign 0.05
IGL02726:Itpr2 APN 6 146,277,419 (GRCm39) missense probably benign 0.18
IGL02851:Itpr2 APN 6 146,287,477 (GRCm39) missense probably damaging 0.99
IGL02933:Itpr2 APN 6 146,214,402 (GRCm39) missense probably benign
IGL03015:Itpr2 APN 6 146,277,435 (GRCm39) missense probably benign
IGL03067:Itpr2 APN 6 146,226,680 (GRCm39) missense probably damaging 1.00
IGL03214:Itpr2 APN 6 146,081,742 (GRCm39) missense probably benign 0.02
IGL03275:Itpr2 APN 6 146,060,375 (GRCm39) splice site probably benign
IGL03332:Itpr2 APN 6 146,045,647 (GRCm39) missense probably damaging 0.98
IGL03352:Itpr2 APN 6 146,058,602 (GRCm39) missense probably damaging 1.00
IGL03377:Itpr2 APN 6 146,231,256 (GRCm39) missense probably benign
IGL03377:Itpr2 APN 6 146,231,213 (GRCm39) missense probably damaging 0.96
dollar_short UTSW 6 146,298,517 (GRCm39) nonsense probably null
enfermos UTSW 6 146,135,504 (GRCm39) missense probably damaging 0.98
Hopla UTSW 6 146,096,096 (GRCm39) missense probably damaging 0.98
P0029:Itpr2 UTSW 6 146,280,987 (GRCm39) missense probably damaging 1.00
PIT4431001:Itpr2 UTSW 6 146,256,218 (GRCm39) missense probably benign
PIT4453001:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
PIT4504001:Itpr2 UTSW 6 146,131,369 (GRCm39) missense probably damaging 0.99
R0040:Itpr2 UTSW 6 146,246,638 (GRCm39) missense probably damaging 1.00
R0040:Itpr2 UTSW 6 146,246,638 (GRCm39) missense probably damaging 1.00
R0048:Itpr2 UTSW 6 146,133,789 (GRCm39) splice site probably null
R0048:Itpr2 UTSW 6 146,133,789 (GRCm39) splice site probably null
R0055:Itpr2 UTSW 6 146,224,631 (GRCm39) missense probably benign 0.42
R0055:Itpr2 UTSW 6 146,224,631 (GRCm39) missense probably benign 0.42
R0088:Itpr2 UTSW 6 146,142,683 (GRCm39) missense probably benign
R0089:Itpr2 UTSW 6 146,251,520 (GRCm39) critical splice donor site probably null
R0114:Itpr2 UTSW 6 146,214,377 (GRCm39) missense probably damaging 1.00
R0125:Itpr2 UTSW 6 146,141,951 (GRCm39) missense probably benign 0.00
R0144:Itpr2 UTSW 6 146,228,653 (GRCm39) missense probably damaging 0.98
R0180:Itpr2 UTSW 6 146,403,407 (GRCm39) start gained probably benign
R0211:Itpr2 UTSW 6 146,096,111 (GRCm39) missense probably benign 0.17
R0305:Itpr2 UTSW 6 146,212,601 (GRCm39) missense possibly damaging 0.63
R0367:Itpr2 UTSW 6 146,135,506 (GRCm39) missense probably damaging 1.00
R0374:Itpr2 UTSW 6 146,260,890 (GRCm39) missense probably benign 0.00
R0391:Itpr2 UTSW 6 146,131,271 (GRCm39) missense probably damaging 1.00
R0450:Itpr2 UTSW 6 146,319,477 (GRCm39) missense possibly damaging 0.66
R0464:Itpr2 UTSW 6 146,277,387 (GRCm39) missense probably damaging 1.00
R0510:Itpr2 UTSW 6 146,319,477 (GRCm39) missense possibly damaging 0.66
R0532:Itpr2 UTSW 6 146,013,898 (GRCm39) missense probably damaging 1.00
R0625:Itpr2 UTSW 6 146,068,149 (GRCm39) missense probably benign
R0633:Itpr2 UTSW 6 146,275,954 (GRCm39) missense probably damaging 1.00
R0636:Itpr2 UTSW 6 146,072,910 (GRCm39) missense probably damaging 1.00
R1086:Itpr2 UTSW 6 146,251,543 (GRCm39) missense probably damaging 1.00
R1352:Itpr2 UTSW 6 146,013,240 (GRCm39) missense probably damaging 1.00
R1631:Itpr2 UTSW 6 146,081,788 (GRCm39) missense probably damaging 1.00
R1655:Itpr2 UTSW 6 146,277,646 (GRCm39) missense probably damaging 1.00
R1767:Itpr2 UTSW 6 146,251,566 (GRCm39) missense possibly damaging 0.91
R1779:Itpr2 UTSW 6 146,060,399 (GRCm39) nonsense probably null
R1796:Itpr2 UTSW 6 146,198,171 (GRCm39) missense probably benign
R1815:Itpr2 UTSW 6 146,260,914 (GRCm39) missense probably benign 0.08
R1827:Itpr2 UTSW 6 146,229,830 (GRCm39) missense probably damaging 1.00
R1828:Itpr2 UTSW 6 146,229,830 (GRCm39) missense probably damaging 1.00
R1884:Itpr2 UTSW 6 146,287,469 (GRCm39) missense probably benign 0.16
R1902:Itpr2 UTSW 6 146,131,201 (GRCm39) missense probably damaging 1.00
R1931:Itpr2 UTSW 6 146,141,852 (GRCm39) missense probably benign 0.41
R1964:Itpr2 UTSW 6 146,013,191 (GRCm39) missense probably damaging 1.00
R2010:Itpr2 UTSW 6 146,129,022 (GRCm39) splice site probably null
R2168:Itpr2 UTSW 6 146,013,176 (GRCm39) missense probably benign 0.05
R2179:Itpr2 UTSW 6 146,277,464 (GRCm39) missense probably benign
R2290:Itpr2 UTSW 6 146,324,326 (GRCm39) missense probably damaging 1.00
R2874:Itpr2 UTSW 6 146,327,996 (GRCm39) missense possibly damaging 0.73
R2888:Itpr2 UTSW 6 146,072,791 (GRCm39) missense probably damaging 1.00
R2897:Itpr2 UTSW 6 146,224,667 (GRCm39) missense probably damaging 1.00
R2897:Itpr2 UTSW 6 146,074,839 (GRCm39) missense probably benign 0.03
R2898:Itpr2 UTSW 6 146,224,667 (GRCm39) missense probably damaging 1.00
R2898:Itpr2 UTSW 6 146,074,839 (GRCm39) missense probably benign 0.03
R3024:Itpr2 UTSW 6 146,081,808 (GRCm39) missense probably benign 0.35
R3104:Itpr2 UTSW 6 146,214,335 (GRCm39) critical splice donor site probably null
R3607:Itpr2 UTSW 6 146,129,099 (GRCm39) missense probably damaging 0.98
R3732:Itpr2 UTSW 6 146,284,198 (GRCm39) missense probably damaging 1.00
R3732:Itpr2 UTSW 6 146,284,198 (GRCm39) missense probably damaging 1.00
R3733:Itpr2 UTSW 6 146,284,198 (GRCm39) missense probably damaging 1.00
R3792:Itpr2 UTSW 6 146,316,852 (GRCm39) missense probably damaging 1.00
R3806:Itpr2 UTSW 6 146,133,789 (GRCm39) splice site probably null
R3821:Itpr2 UTSW 6 146,319,224 (GRCm39) missense probably damaging 1.00
R3929:Itpr2 UTSW 6 146,275,857 (GRCm39) splice site probably null
R3958:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R3959:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R3960:Itpr2 UTSW 6 146,131,262 (GRCm39) missense probably damaging 1.00
R3960:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R4074:Itpr2 UTSW 6 146,274,742 (GRCm39) splice site probably null
R4085:Itpr2 UTSW 6 146,045,746 (GRCm39) missense probably damaging 1.00
R4114:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R4115:Itpr2 UTSW 6 146,327,008 (GRCm39) missense probably damaging 0.97
R4588:Itpr2 UTSW 6 146,142,694 (GRCm39) missense probably benign 0.33
R4663:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4673:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4684:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4686:Itpr2 UTSW 6 146,131,273 (GRCm39) missense probably damaging 1.00
R4713:Itpr2 UTSW 6 146,298,456 (GRCm39) missense probably damaging 1.00
R4713:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4729:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4732:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4733:Itpr2 UTSW 6 146,274,671 (GRCm39) missense probably damaging 1.00
R4801:Itpr2 UTSW 6 146,272,829 (GRCm39) missense probably damaging 1.00
R4802:Itpr2 UTSW 6 146,272,829 (GRCm39) missense probably damaging 1.00
R4877:Itpr2 UTSW 6 146,226,703 (GRCm39) missense probably damaging 1.00
R4970:Itpr2 UTSW 6 146,135,489 (GRCm39) missense possibly damaging 0.95
R4986:Itpr2 UTSW 6 146,141,840 (GRCm39) missense probably damaging 0.96
R5112:Itpr2 UTSW 6 146,135,489 (GRCm39) missense possibly damaging 0.95
R5200:Itpr2 UTSW 6 146,045,605 (GRCm39) critical splice donor site probably null
R5224:Itpr2 UTSW 6 146,068,149 (GRCm39) missense probably benign
R5243:Itpr2 UTSW 6 146,089,044 (GRCm39) missense probably damaging 1.00
R5348:Itpr2 UTSW 6 146,378,191 (GRCm39) missense possibly damaging 0.78
R5393:Itpr2 UTSW 6 146,277,653 (GRCm39) nonsense probably null
R5552:Itpr2 UTSW 6 146,195,578 (GRCm39) missense probably benign
R5579:Itpr2 UTSW 6 146,074,864 (GRCm39) nonsense probably null
R5744:Itpr2 UTSW 6 146,277,649 (GRCm39) missense probably damaging 1.00
R5825:Itpr2 UTSW 6 146,045,647 (GRCm39) missense probably damaging 0.98
R5910:Itpr2 UTSW 6 146,231,069 (GRCm39) missense probably benign 0.10
R5911:Itpr2 UTSW 6 146,214,441 (GRCm39) missense probably benign 0.42
R6044:Itpr2 UTSW 6 146,298,449 (GRCm39) missense probably null 0.98
R6072:Itpr2 UTSW 6 146,248,609 (GRCm39) missense probably damaging 0.98
R6191:Itpr2 UTSW 6 146,229,833 (GRCm39) missense probably benign 0.01
R6483:Itpr2 UTSW 6 146,013,975 (GRCm39) missense possibly damaging 0.52
R6511:Itpr2 UTSW 6 146,231,225 (GRCm39) missense probably damaging 1.00
R6524:Itpr2 UTSW 6 146,246,709 (GRCm39) missense probably benign 0.01
R6561:Itpr2 UTSW 6 146,135,504 (GRCm39) missense probably damaging 0.98
R6594:Itpr2 UTSW 6 146,091,978 (GRCm39) missense possibly damaging 0.71
R6603:Itpr2 UTSW 6 146,248,669 (GRCm39) missense probably damaging 0.98
R6736:Itpr2 UTSW 6 146,226,668 (GRCm39) missense probably damaging 1.00
R6783:Itpr2 UTSW 6 146,287,371 (GRCm39) critical splice donor site probably null
R6831:Itpr2 UTSW 6 146,013,927 (GRCm39) missense probably damaging 1.00
R6857:Itpr2 UTSW 6 146,298,517 (GRCm39) nonsense probably null
R7103:Itpr2 UTSW 6 146,226,572 (GRCm39) missense probably damaging 1.00
R7111:Itpr2 UTSW 6 146,226,554 (GRCm39) missense probably damaging 1.00
R7126:Itpr2 UTSW 6 146,259,294 (GRCm39) nonsense probably null
R7165:Itpr2 UTSW 6 146,195,589 (GRCm39) missense probably damaging 1.00
R7184:Itpr2 UTSW 6 146,212,585 (GRCm39) missense possibly damaging 0.79
R7249:Itpr2 UTSW 6 146,212,550 (GRCm39) missense probably damaging 1.00
R7292:Itpr2 UTSW 6 146,060,447 (GRCm39) missense possibly damaging 0.95
R7342:Itpr2 UTSW 6 146,228,685 (GRCm39) missense probably damaging 0.98
R7392:Itpr2 UTSW 6 146,260,838 (GRCm39) missense possibly damaging 0.95
R7414:Itpr2 UTSW 6 146,274,706 (GRCm39) missense probably benign 0.06
R7448:Itpr2 UTSW 6 146,231,006 (GRCm39) missense probably damaging 1.00
R7492:Itpr2 UTSW 6 146,292,436 (GRCm39) missense probably damaging 1.00
R7515:Itpr2 UTSW 6 146,228,608 (GRCm39) missense probably damaging 1.00
R7529:Itpr2 UTSW 6 146,096,096 (GRCm39) missense probably damaging 0.98
R7558:Itpr2 UTSW 6 146,292,363 (GRCm39) missense probably damaging 1.00
R7650:Itpr2 UTSW 6 146,135,492 (GRCm39) missense probably benign 0.36
R7678:Itpr2 UTSW 6 146,089,048 (GRCm39) missense probably benign 0.00
R7790:Itpr2 UTSW 6 146,126,274 (GRCm39) missense probably damaging 1.00
R7798:Itpr2 UTSW 6 146,287,513 (GRCm39) missense probably benign 0.06
R7831:Itpr2 UTSW 6 146,193,082 (GRCm39) missense probably benign 0.04
R8023:Itpr2 UTSW 6 146,088,988 (GRCm39) missense probably damaging 0.97
R8046:Itpr2 UTSW 6 146,327,957 (GRCm39) missense probably damaging 0.96
R8236:Itpr2 UTSW 6 146,292,281 (GRCm39) critical splice donor site probably null
R8241:Itpr2 UTSW 6 146,320,013 (GRCm39) missense possibly damaging 0.90
R8245:Itpr2 UTSW 6 146,274,604 (GRCm39) missense probably damaging 0.98
R8324:Itpr2 UTSW 6 146,229,896 (GRCm39) missense probably damaging 0.97
R8339:Itpr2 UTSW 6 146,214,396 (GRCm39) missense probably benign 0.19
R8458:Itpr2 UTSW 6 146,135,464 (GRCm39) missense possibly damaging 0.62
R8506:Itpr2 UTSW 6 146,319,914 (GRCm39) critical splice donor site probably null
R8529:Itpr2 UTSW 6 146,231,051 (GRCm39) missense probably damaging 1.00
R8672:Itpr2 UTSW 6 146,276,016 (GRCm39) missense probably damaging 1.00
R8755:Itpr2 UTSW 6 146,133,926 (GRCm39) missense probably benign
R8816:Itpr2 UTSW 6 146,142,710 (GRCm39) missense probably damaging 0.98
R9160:Itpr2 UTSW 6 146,276,099 (GRCm39) missense probably damaging 1.00
R9273:Itpr2 UTSW 6 146,226,529 (GRCm39) missense probably damaging 1.00
R9284:Itpr2 UTSW 6 146,256,174 (GRCm39) missense probably benign 0.01
R9322:Itpr2 UTSW 6 146,226,587 (GRCm39) missense probably benign 0.19
R9357:Itpr2 UTSW 6 146,260,814 (GRCm39) missense probably damaging 1.00
R9424:Itpr2 UTSW 6 146,212,505 (GRCm39) missense probably damaging 0.98
R9438:Itpr2 UTSW 6 146,068,166 (GRCm39) missense probably benign
R9576:Itpr2 UTSW 6 146,212,505 (GRCm39) missense probably damaging 0.98
V8831:Itpr2 UTSW 6 146,287,380 (GRCm39) missense probably damaging 1.00
X0054:Itpr2 UTSW 6 146,224,734 (GRCm39) missense probably damaging 1.00
X0063:Itpr2 UTSW 6 146,081,851 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02