Incidental Mutation 'IGL03101:Or7e173'
ID 418725
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or7e173
Ensembl Gene ENSMUSG00000050803
Gene Name olfactory receptor family 7 subfamily E member 173
Synonyms Olfr866, MOR145-5, GA_x6K02T2PVTD-13768406-13767468
Accession Numbers
Essential gene? Probably non essential (E-score: 0.093) question?
Stock # IGL03101
Quality Score
Status
Chromosome 9
Chromosomal Location 19938255-19939331 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19938725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 170 (T170A)
Ref Sequence ENSEMBL: ENSMUSP00000054864 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062248]
AlphaFold Q8VFI7
Predicted Effect probably benign
Transcript: ENSMUST00000062248
AA Change: T170A

PolyPhen 2 Score 0.026 (Sensitivity: 0.95; Specificity: 0.81)
SMART Domains Protein: ENSMUSP00000054864
Gene: ENSMUSG00000050803
AA Change: T170A

DomainStartEndE-ValueType
Pfam:7tm_4 34 310 2e-47 PFAM
Pfam:7TM_GPCR_Srsx 38 282 8.7e-7 PFAM
Pfam:7tm_1 44 293 5.1e-21 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000197056
Predicted Effect noncoding transcript
Transcript: ENSMUST00000212071
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 32 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
AA474408 A T 7: 109,660,177 (GRCm39) probably benign Het
Abcc1 T A 16: 14,207,732 (GRCm39) V23D probably damaging Het
Adam8 G T 7: 139,568,456 (GRCm39) N260K possibly damaging Het
Ap3b1 A T 13: 94,591,906 (GRCm39) I457L probably benign Het
Apaf1 T C 10: 90,867,421 (GRCm39) N808S possibly damaging Het
Arhgef26 A G 3: 62,327,082 (GRCm39) T532A possibly damaging Het
Cfap65 G T 1: 74,967,592 (GRCm39) T162N possibly damaging Het
Clec12b A G 6: 129,356,480 (GRCm39) probably null Het
Creb3 T C 4: 43,563,081 (GRCm39) V60A probably benign Het
Cyp11b1 A G 15: 74,707,703 (GRCm39) F469L probably benign Het
Defb28 A T 2: 152,362,047 (GRCm39) E69V possibly damaging Het
Etnppl T C 3: 130,415,967 (GRCm39) L118S probably damaging Het
Fsip1 T C 2: 118,072,144 (GRCm39) Y213C probably damaging Het
Glb1l2 A G 9: 26,676,421 (GRCm39) W480R probably damaging Het
Herc1 A T 9: 66,395,279 (GRCm39) M4205L probably benign Het
Kif5a A T 10: 127,071,478 (GRCm39) probably benign Het
Lmbrd2 C T 15: 9,186,695 (GRCm39) R557C probably damaging Het
Map4k3 A G 17: 80,963,284 (GRCm39) probably null Het
Npc1 A G 18: 12,331,596 (GRCm39) I858T probably benign Het
Pecam1 A G 11: 106,588,177 (GRCm39) V92A probably damaging Het
Rbm43 A T 2: 51,816,757 (GRCm39) I70N probably benign Het
Rps6kb1 T C 11: 86,393,708 (GRCm39) Y474C probably benign Het
Slco2a1 G A 9: 102,954,205 (GRCm39) G459R possibly damaging Het
Snca T A 6: 60,804,595 (GRCm39) probably benign Het
Spata31f1e T C 4: 42,793,424 (GRCm39) D236G possibly damaging Het
Stap2 T A 17: 56,309,029 (GRCm39) I113F probably damaging Het
Tas2r140 T C 6: 40,468,764 (GRCm39) M198T probably benign Het
Trim9 T C 12: 70,393,428 (GRCm39) E172G probably damaging Het
Ttll7 T C 3: 146,602,445 (GRCm39) V81A possibly damaging Het
Vmn2r103 A G 17: 19,993,782 (GRCm39) Y53C probably damaging Het
Vmn2r22 C A 6: 123,614,295 (GRCm39) A432S probably benign Het
Zfp943 T C 17: 22,211,156 (GRCm39) S81P probably damaging Het
Other mutations in Or7e173
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01353:Or7e173 APN 9 19,938,343 (GRCm39) missense probably damaging 1.00
IGL01554:Or7e173 APN 9 19,938,704 (GRCm39) missense possibly damaging 0.55
IGL01561:Or7e173 APN 9 19,938,818 (GRCm39) missense probably benign 0.20
IGL01597:Or7e173 APN 9 19,938,982 (GRCm39) missense probably damaging 0.98
IGL02986:Or7e173 APN 9 19,939,007 (GRCm39) missense probably benign 0.43
R0863:Or7e173 UTSW 9 19,938,509 (GRCm39) missense probably damaging 1.00
R1747:Or7e173 UTSW 9 19,938,613 (GRCm39) missense probably benign 0.01
R2121:Or7e173 UTSW 9 19,938,797 (GRCm39) missense probably benign
R2124:Or7e173 UTSW 9 19,938,797 (GRCm39) missense probably benign
R2240:Or7e173 UTSW 9 19,938,440 (GRCm39) missense probably damaging 1.00
R3793:Or7e173 UTSW 9 19,938,359 (GRCm39) missense probably damaging 1.00
R4498:Or7e173 UTSW 9 19,939,029 (GRCm39) missense possibly damaging 0.50
R5084:Or7e173 UTSW 9 19,938,551 (GRCm39) missense probably damaging 0.99
R5420:Or7e173 UTSW 9 19,938,355 (GRCm39) missense probably damaging 0.98
R6314:Or7e173 UTSW 9 19,938,958 (GRCm39) missense probably damaging 0.98
R6357:Or7e173 UTSW 9 19,938,925 (GRCm39) missense probably damaging 1.00
R6588:Or7e173 UTSW 9 19,939,162 (GRCm39) missense probably damaging 0.97
R6886:Or7e173 UTSW 9 19,938,428 (GRCm39) missense probably benign 0.00
R7480:Or7e173 UTSW 9 19,939,230 (GRCm39) start codon destroyed probably null
R9026:Or7e173 UTSW 9 19,938,344 (GRCm39) missense
R9168:Or7e173 UTSW 9 19,938,818 (GRCm39) missense probably benign 0.20
R9280:Or7e173 UTSW 9 19,938,639 (GRCm39) missense probably benign 0.00
R9559:Or7e173 UTSW 9 19,939,216 (GRCm39) missense probably benign
R9562:Or7e173 UTSW 9 19,939,045 (GRCm39) missense probably damaging 1.00
Z1088:Or7e173 UTSW 9 19,938,575 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02