Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03101:Clec12b'

418747

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Clec12b

Ensembl Gene

ENSMUSG00000030158

Gene Name

C-type lectin domain family 12, member B

Synonyms

4933425B16Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.050) question?

Stock #

IGL03101

Quality Score

Status

Chromosome

Chromosomal Location

129352478-129362837 bp(-) (GRCm39)

Type of Mutation

splice site (6 bp from exon)

DNA Base Change (assembly)

A to G at 129356480 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000107713 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032261] [ENSMUST00000112082]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000032261

SMART Domains

Protein: ENSMUSP00000032261
Gene: ENSMUSG00000030158

Domain	Start	End	E-Value	Type
low complexity region	46	60	N/A	INTRINSIC
CLECT	142	263	6.62e-25	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000112082

SMART Domains

Protein: ENSMUSP00000107713
Gene: ENSMUSG00000030158

Domain	Start	End	E-Value	Type
low complexity region	46	60	N/A	INTRINSIC
CLECT	142	263	6.62e-25	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 32 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
AA474408	A	T	7: 109,660,177 (GRCm39)		probably benign	Het
Abcc1	T	A	16: 14,207,732 (GRCm39)	V23D	probably damaging	Het
Adam8	G	T	7: 139,568,456 (GRCm39)	N260K	possibly damaging	Het
Ap3b1	A	T	13: 94,591,906 (GRCm39)	I457L	probably benign	Het
Apaf1	T	C	10: 90,867,421 (GRCm39)	N808S	possibly damaging	Het
Arhgef26	A	G	3: 62,327,082 (GRCm39)	T532A	possibly damaging	Het
Cfap65	G	T	1: 74,967,592 (GRCm39)	T162N	possibly damaging	Het
Creb3	T	C	4: 43,563,081 (GRCm39)	V60A	probably benign	Het
Cyp11b1	A	G	15: 74,707,703 (GRCm39)	F469L	probably benign	Het
Defb28	A	T	2: 152,362,047 (GRCm39)	E69V	possibly damaging	Het
Etnppl	T	C	3: 130,415,967 (GRCm39)	L118S	probably damaging	Het
Fsip1	T	C	2: 118,072,144 (GRCm39)	Y213C	probably damaging	Het
Glb1l2	A	G	9: 26,676,421 (GRCm39)	W480R	probably damaging	Het
Herc1	A	T	9: 66,395,279 (GRCm39)	M4205L	probably benign	Het
Kif5a	A	T	10: 127,071,478 (GRCm39)		probably benign	Het
Lmbrd2	C	T	15: 9,186,695 (GRCm39)	R557C	probably damaging	Het
Map4k3	A	G	17: 80,963,284 (GRCm39)		probably null	Het
Npc1	A	G	18: 12,331,596 (GRCm39)	I858T	probably benign	Het
Or7e173	T	C	9: 19,938,725 (GRCm39)	T170A	probably benign	Het
Pecam1	A	G	11: 106,588,177 (GRCm39)	V92A	probably damaging	Het
Rbm43	A	T	2: 51,816,757 (GRCm39)	I70N	probably benign	Het
Rps6kb1	T	C	11: 86,393,708 (GRCm39)	Y474C	probably benign	Het
Slco2a1	G	A	9: 102,954,205 (GRCm39)	G459R	possibly damaging	Het
Snca	T	A	6: 60,804,595 (GRCm39)		probably benign	Het
Spata31f1e	T	C	4: 42,793,424 (GRCm39)	D236G	possibly damaging	Het
Stap2	T	A	17: 56,309,029 (GRCm39)	I113F	probably damaging	Het
Tas2r140	T	C	6: 40,468,764 (GRCm39)	M198T	probably benign	Het
Trim9	T	C	12: 70,393,428 (GRCm39)	E172G	probably damaging	Het
Ttll7	T	C	3: 146,602,445 (GRCm39)	V81A	possibly damaging	Het
Vmn2r103	A	G	17: 19,993,782 (GRCm39)	Y53C	probably damaging	Het
Vmn2r22	C	A	6: 123,614,295 (GRCm39)	A432S	probably benign	Het
Zfp943	T	C	17: 22,211,156 (GRCm39)	S81P	probably damaging	Het

Other mutations in Clec12b

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01014:Clec12b	APN	6	129,362,393 (GRCm39)	missense	probably damaging	0.98
IGL01328:Clec12b	APN	6	129,356,517 (GRCm39)	missense	probably damaging	1.00
IGL01985:Clec12b	APN	6	129,359,334 (GRCm39)	splice site	probably benign
R0662:Clec12b	UTSW	6	129,353,200 (GRCm39)	missense	probably damaging	1.00
R0786:Clec12b	UTSW	6	129,357,651 (GRCm39)	missense	probably benign	0.07
R1468:Clec12b	UTSW	6	129,357,603 (GRCm39)	missense	probably damaging	0.98
R1468:Clec12b	UTSW	6	129,357,603 (GRCm39)	missense	probably damaging	0.98
R1513:Clec12b	UTSW	6	129,353,265 (GRCm39)	missense	probably damaging	1.00
R4757:Clec12b	UTSW	6	129,357,655 (GRCm39)	missense	probably damaging	1.00
R5566:Clec12b	UTSW	6	129,362,438 (GRCm39)	missense	probably damaging	0.99
R5643:Clec12b	UTSW	6	129,356,923 (GRCm39)	missense	probably benign
R5644:Clec12b	UTSW	6	129,356,923 (GRCm39)	missense	probably benign
R7351:Clec12b	UTSW	6	129,356,874 (GRCm39)	critical splice donor site	probably null
R7600:Clec12b	UTSW	6	129,353,226 (GRCm39)	missense	probably damaging	1.00
R8347:Clec12b	UTSW	6	129,357,450 (GRCm39)	critical splice donor site	probably null
R9076:Clec12b	UTSW	6	129,356,580 (GRCm39)	missense	possibly damaging	0.94

Posted On

2016-08-02