Incidental Mutation 'IGL03102:Or10ak14'
ID 418751
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ak14
Ensembl Gene ENSMUSG00000095218
Gene Name olfactory receptor family 10 subfamily AK member 14
Synonyms GA_x6K02T2QD9B-18795136-18796077, MOR259-4P, MOR259-9, Olfr1338, MOR259-4P, Olfr1524-ps1
Accession Numbers
Essential gene? Probably essential (E-score: 0.778) question?
Stock # IGL03102
Quality Score
Status
Chromosome 4
Chromosomal Location 118610386-118614155 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 118611131 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Phenylalanine at position 201 (L201F)
Ref Sequence ENSEMBL: ENSMUSP00000092427 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000084315] [ENSMUST00000214922] [ENSMUST00000216559]
AlphaFold A0A1L1SSB4
Predicted Effect probably benign
Transcript: ENSMUST00000084315
AA Change: L201F

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000092427
Gene: ENSMUSG00000095218
AA Change: L201F

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 3.3e-55 PFAM
Pfam:7TM_GPCR_Srsx 36 306 1e-8 PFAM
Pfam:7tm_1 42 291 1.8e-26 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214922
AA Change: L203F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect probably benign
Transcript: ENSMUST00000216559
AA Change: L203F

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Alpk3 T C 7: 80,744,804 (GRCm39) probably null Het
Alyref G A 11: 120,488,591 (GRCm39) P79L possibly damaging Het
Arhgap28 T C 17: 68,203,231 (GRCm39) D74G probably damaging Het
Atp1a4 T A 1: 172,058,718 (GRCm39) D909V probably damaging Het
Cdc5l A T 17: 45,718,857 (GRCm39) D586E probably damaging Het
Chd3 G T 11: 69,252,022 (GRCm39) Y79* probably null Het
Cnot3 C A 7: 3,659,155 (GRCm39) S467* probably null Het
Col18a1 A T 10: 76,903,457 (GRCm39) probably benign Het
Col19a1 C A 1: 24,367,134 (GRCm39) G483C probably damaging Het
Col5a3 A C 9: 20,715,931 (GRCm39) probably null Het
Dctn5 A T 7: 121,732,382 (GRCm39) N9I probably benign Het
Emc10 T A 7: 44,141,413 (GRCm39) N225I probably damaging Het
Fam219b A G 9: 57,447,981 (GRCm39) Y158C probably damaging Het
Fras1 T C 5: 96,874,394 (GRCm39) V2273A probably benign Het
Frem3 T A 8: 81,339,661 (GRCm39) H651Q possibly damaging Het
Gm4076 T A 13: 85,275,438 (GRCm39) noncoding transcript Het
Gpr35 A T 1: 92,910,299 (GRCm39) T4S probably benign Het
Ifnab T G 4: 88,609,062 (GRCm39) T135P possibly damaging Het
Jag1 T C 2: 136,926,608 (GRCm39) I979V probably benign Het
Kank1 G T 19: 25,403,282 (GRCm39) M1097I probably damaging Het
Kcnq3 A G 15: 65,900,637 (GRCm39) V206A probably damaging Het
Kel T C 6: 41,679,917 (GRCm39) K91R probably benign Het
Kirrel1 G T 3: 86,990,807 (GRCm39) R672S probably damaging Het
Kmt2d A G 15: 98,753,424 (GRCm39) M143T probably benign Het
Kpna1 A G 16: 35,833,289 (GRCm39) I122V probably damaging Het
Lrpap1 A G 5: 35,250,694 (GRCm39) S353P probably damaging Het
Mtfr1l T A 4: 134,259,543 (GRCm39) Q11L probably damaging Het
Muc5b G A 7: 141,416,806 (GRCm39) V3251M probably benign Het
Mup8 C T 4: 60,219,746 (GRCm39) D174N probably benign Het
Nup155 A T 15: 8,176,768 (GRCm39) E1015D probably benign Het
Or9i14 T C 19: 13,792,735 (GRCm39) Y73C probably damaging Het
P2rx7 T C 5: 122,801,668 (GRCm39) F188L possibly damaging Het
Pacrg A G 17: 11,058,719 (GRCm39) F13L probably benign Het
Palb2 A T 7: 121,723,722 (GRCm39) S676T possibly damaging Het
Pdia6 T A 12: 17,331,040 (GRCm39) probably null Het
Pfkm A T 15: 98,024,266 (GRCm39) I425F possibly damaging Het
Pikfyve C T 1: 65,291,626 (GRCm39) R1282* probably null Het
Pole C T 5: 110,444,939 (GRCm39) L432F probably damaging Het
Pramel25 T C 4: 143,520,116 (GRCm39) V120A possibly damaging Het
Prr5 G T 15: 84,650,508 (GRCm39) probably benign Het
Prxl2b T C 4: 154,981,058 (GRCm39) probably benign Het
Psat1 A G 19: 15,883,487 (GRCm39) Y343H probably damaging Het
Ptprj C T 2: 90,309,312 (GRCm39) R51K probably benign Het
Qars1 A G 9: 108,386,118 (GRCm39) D103G probably benign Het
Rims2 A T 15: 39,322,989 (GRCm39) I768F possibly damaging Het
Robo4 T A 9: 37,315,481 (GRCm39) V275E probably damaging Het
Ryr2 A G 13: 11,650,468 (GRCm39) probably benign Het
Sez6l T C 5: 112,623,269 (GRCm39) H94R probably benign Het
Slco1c1 T A 6: 141,490,553 (GRCm39) N211K possibly damaging Het
Strbp T C 2: 37,476,515 (GRCm39) probably benign Het
Tceanc2 T A 4: 107,004,878 (GRCm39) H90L probably damaging Het
Tdrkh A T 3: 94,331,844 (GRCm39) T90S possibly damaging Het
Tiam2 A G 17: 3,559,823 (GRCm39) D1288G probably damaging Het
Tln1 T C 4: 43,532,861 (GRCm39) D2447G possibly damaging Het
Tmem63c G A 12: 87,112,323 (GRCm39) V141M probably benign Het
Tpp2 T A 1: 43,995,649 (GRCm39) V268E probably damaging Het
Tprkb T A 6: 85,901,400 (GRCm39) C13S probably benign Het
Traf3ip3 T C 1: 192,877,385 (GRCm39) T184A probably damaging Het
Trpc6 T A 9: 8,649,302 (GRCm39) M504K probably benign Het
Ttn G T 2: 76,597,567 (GRCm39) S18036* probably null Het
Wdfy4 A T 14: 32,688,392 (GRCm39) C2914S probably damaging Het
Ylpm1 T A 12: 85,096,032 (GRCm39) probably benign Het
Zfp644 T C 5: 106,785,134 (GRCm39) H471R probably damaging Het
Zfp747l1 T C 7: 126,983,951 (GRCm39) T384A probably benign Het
Zfyve16 C T 13: 92,648,325 (GRCm39) E910K possibly damaging Het
Other mutations in Or10ak14
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01092:Or10ak14 APN 4 118,610,959 (GRCm39) missense possibly damaging 0.78
IGL02726:Or10ak14 APN 4 118,610,961 (GRCm39) missense probably benign 0.00
IGL02928:Or10ak14 APN 4 118,611,697 (GRCm39) missense probably damaging 1.00
R0062:Or10ak14 UTSW 4 118,611,100 (GRCm39) missense probably benign 0.00
R0062:Or10ak14 UTSW 4 118,611,100 (GRCm39) missense probably benign 0.00
R0299:Or10ak14 UTSW 4 118,611,732 (GRCm39) start codon destroyed probably null 0.82
R0501:Or10ak14 UTSW 4 118,611,027 (GRCm39) missense probably benign 0.00
R1301:Or10ak14 UTSW 4 118,610,816 (GRCm39) missense probably benign
R1719:Or10ak14 UTSW 4 118,610,797 (GRCm39) missense possibly damaging 0.78
R2327:Or10ak14 UTSW 4 118,611,331 (GRCm39) missense probably benign 0.13
R3110:Or10ak14 UTSW 4 118,611,421 (GRCm39) missense probably damaging 0.99
R3112:Or10ak14 UTSW 4 118,611,421 (GRCm39) missense probably damaging 0.99
R4582:Or10ak14 UTSW 4 118,611,090 (GRCm39) missense probably damaging 1.00
R4615:Or10ak14 UTSW 4 118,611,334 (GRCm39) missense probably benign 0.34
R5640:Or10ak14 UTSW 4 118,610,986 (GRCm39) missense probably benign 0.07
R6513:Or10ak14 UTSW 4 118,611,224 (GRCm39) nonsense probably null
R6889:Or10ak14 UTSW 4 118,611,504 (GRCm39) missense probably damaging 0.99
R7157:Or10ak14 UTSW 4 118,611,615 (GRCm39) missense possibly damaging 0.93
R7168:Or10ak14 UTSW 4 118,611,048 (GRCm39) missense probably damaging 0.98
R7378:Or10ak14 UTSW 4 118,611,372 (GRCm39) missense possibly damaging 0.74
R7451:Or10ak14 UTSW 4 118,610,884 (GRCm39) missense probably benign 0.03
R7770:Or10ak14 UTSW 4 118,611,254 (GRCm39) missense probably benign 0.04
R7847:Or10ak14 UTSW 4 118,611,565 (GRCm39) missense possibly damaging 0.79
R8839:Or10ak14 UTSW 4 118,611,411 (GRCm39) missense probably damaging 0.99
R8942:Or10ak14 UTSW 4 118,611,594 (GRCm39) missense possibly damaging 0.94
R9274:Or10ak14 UTSW 4 118,610,883 (GRCm39) missense probably benign 0.03
Posted On 2016-08-02