Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03102:Or9i14'

418773

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Or9i14

Ensembl Gene

ENSMUSG00000045395

Gene Name

olfactory receptor family 9 subfamily I member 14

Synonyms

GA_x6K02T2RE5P-4147744-4146800, Olfr1499, MOR211-2

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.280) question?

Stock #

IGL03102

Quality Score

Status

Chromosome

Chromosomal Location

13792008-13792952 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 13792735 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Cysteine at position 73 (Y73C)

Ref Sequence

ENSEMBL: ENSMUSP00000150330 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000055672] [ENSMUST00000216659]

AlphaFold

Q8VG65

Predicted Effect

probably damaging
Transcript: ENSMUST00000055672
AA Change: Y73C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000059747
Gene: ENSMUSG00000045395
AA Change: Y73C

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	307	2.6e-44	PFAM
Pfam:7tm_1	41	290	1.5e-19	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000216659
AA Change: Y73C

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

Coding Region Coverage

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 65 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Alpk3	T	C	7: 80,744,804 (GRCm39)		probably null	Het
Alyref	G	A	11: 120,488,591 (GRCm39)	P79L	possibly damaging	Het
Arhgap28	T	C	17: 68,203,231 (GRCm39)	D74G	probably damaging	Het
Atp1a4	T	A	1: 172,058,718 (GRCm39)	D909V	probably damaging	Het
Cdc5l	A	T	17: 45,718,857 (GRCm39)	D586E	probably damaging	Het
Chd3	G	T	11: 69,252,022 (GRCm39)	Y79*	probably null	Het
Cnot3	C	A	7: 3,659,155 (GRCm39)	S467*	probably null	Het
Col18a1	A	T	10: 76,903,457 (GRCm39)		probably benign	Het
Col19a1	C	A	1: 24,367,134 (GRCm39)	G483C	probably damaging	Het
Col5a3	A	C	9: 20,715,931 (GRCm39)		probably null	Het
Dctn5	A	T	7: 121,732,382 (GRCm39)	N9I	probably benign	Het
Emc10	T	A	7: 44,141,413 (GRCm39)	N225I	probably damaging	Het
Fam219b	A	G	9: 57,447,981 (GRCm39)	Y158C	probably damaging	Het
Fras1	T	C	5: 96,874,394 (GRCm39)	V2273A	probably benign	Het
Frem3	T	A	8: 81,339,661 (GRCm39)	H651Q	possibly damaging	Het
Gm4076	T	A	13: 85,275,438 (GRCm39)		noncoding transcript	Het
Gpr35	A	T	1: 92,910,299 (GRCm39)	T4S	probably benign	Het
Ifnab	T	G	4: 88,609,062 (GRCm39)	T135P	possibly damaging	Het
Jag1	T	C	2: 136,926,608 (GRCm39)	I979V	probably benign	Het
Kank1	G	T	19: 25,403,282 (GRCm39)	M1097I	probably damaging	Het
Kcnq3	A	G	15: 65,900,637 (GRCm39)	V206A	probably damaging	Het
Kel	T	C	6: 41,679,917 (GRCm39)	K91R	probably benign	Het
Kirrel1	G	T	3: 86,990,807 (GRCm39)	R672S	probably damaging	Het
Kmt2d	A	G	15: 98,753,424 (GRCm39)	M143T	probably benign	Het
Kpna1	A	G	16: 35,833,289 (GRCm39)	I122V	probably damaging	Het
Lrpap1	A	G	5: 35,250,694 (GRCm39)	S353P	probably damaging	Het
Mtfr1l	T	A	4: 134,259,543 (GRCm39)	Q11L	probably damaging	Het
Muc5b	G	A	7: 141,416,806 (GRCm39)	V3251M	probably benign	Het
Mup8	C	T	4: 60,219,746 (GRCm39)	D174N	probably benign	Het
Nup155	A	T	15: 8,176,768 (GRCm39)	E1015D	probably benign	Het
Or10ak14	C	A	4: 118,611,131 (GRCm39)	L201F	probably benign	Het
P2rx7	T	C	5: 122,801,668 (GRCm39)	F188L	possibly damaging	Het
Pacrg	A	G	17: 11,058,719 (GRCm39)	F13L	probably benign	Het
Palb2	A	T	7: 121,723,722 (GRCm39)	S676T	possibly damaging	Het
Pdia6	T	A	12: 17,331,040 (GRCm39)		probably null	Het
Pfkm	A	T	15: 98,024,266 (GRCm39)	I425F	possibly damaging	Het
Pikfyve	C	T	1: 65,291,626 (GRCm39)	R1282*	probably null	Het
Pole	C	T	5: 110,444,939 (GRCm39)	L432F	probably damaging	Het
Pramel25	T	C	4: 143,520,116 (GRCm39)	V120A	possibly damaging	Het
Prr5	G	T	15: 84,650,508 (GRCm39)		probably benign	Het
Prxl2b	T	C	4: 154,981,058 (GRCm39)		probably benign	Het
Psat1	A	G	19: 15,883,487 (GRCm39)	Y343H	probably damaging	Het
Ptprj	C	T	2: 90,309,312 (GRCm39)	R51K	probably benign	Het
Qars1	A	G	9: 108,386,118 (GRCm39)	D103G	probably benign	Het
Rims2	A	T	15: 39,322,989 (GRCm39)	I768F	possibly damaging	Het
Robo4	T	A	9: 37,315,481 (GRCm39)	V275E	probably damaging	Het
Ryr2	A	G	13: 11,650,468 (GRCm39)		probably benign	Het
Sez6l	T	C	5: 112,623,269 (GRCm39)	H94R	probably benign	Het
Slco1c1	T	A	6: 141,490,553 (GRCm39)	N211K	possibly damaging	Het
Strbp	T	C	2: 37,476,515 (GRCm39)		probably benign	Het
Tceanc2	T	A	4: 107,004,878 (GRCm39)	H90L	probably damaging	Het
Tdrkh	A	T	3: 94,331,844 (GRCm39)	T90S	possibly damaging	Het
Tiam2	A	G	17: 3,559,823 (GRCm39)	D1288G	probably damaging	Het
Tln1	T	C	4: 43,532,861 (GRCm39)	D2447G	possibly damaging	Het
Tmem63c	G	A	12: 87,112,323 (GRCm39)	V141M	probably benign	Het
Tpp2	T	A	1: 43,995,649 (GRCm39)	V268E	probably damaging	Het
Tprkb	T	A	6: 85,901,400 (GRCm39)	C13S	probably benign	Het
Traf3ip3	T	C	1: 192,877,385 (GRCm39)	T184A	probably damaging	Het
Trpc6	T	A	9: 8,649,302 (GRCm39)	M504K	probably benign	Het
Ttn	G	T	2: 76,597,567 (GRCm39)	S18036*	probably null	Het
Wdfy4	A	T	14: 32,688,392 (GRCm39)	C2914S	probably damaging	Het
Ylpm1	T	A	12: 85,096,032 (GRCm39)		probably benign	Het
Zfp644	T	C	5: 106,785,134 (GRCm39)	H471R	probably damaging	Het
Zfp747l1	T	C	7: 126,983,951 (GRCm39)	T384A	probably benign	Het
Zfyve16	C	T	13: 92,648,325 (GRCm39)	E910K	possibly damaging	Het

Other mutations in Or9i14

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01534:Or9i14	APN	19	13,792,666 (GRCm39)	missense	probably benign	0.09
IGL01844:Or9i14	APN	19	13,792,180 (GRCm39)	missense	possibly damaging	0.95
IGL03352:Or9i14	APN	19	13,792,292 (GRCm39)	missense	probably damaging	1.00
R0218:Or9i14	UTSW	19	13,792,342 (GRCm39)	missense	probably benign	0.19
R0490:Or9i14	UTSW	19	13,792,219 (GRCm39)	missense	probably damaging	1.00
R0682:Or9i14	UTSW	19	13,792,501 (GRCm39)	missense	possibly damaging	0.94
R1301:Or9i14	UTSW	19	13,792,726 (GRCm39)	missense	probably damaging	1.00
R1328:Or9i14	UTSW	19	13,792,900 (GRCm39)	missense	probably benign	0.01
R2100:Or9i14	UTSW	19	13,792,600 (GRCm39)	missense	possibly damaging	0.95
R3701:Or9i14	UTSW	19	13,792,712 (GRCm39)	missense	probably benign	0.03
R4563:Or9i14	UTSW	19	13,792,646 (GRCm39)	missense	probably benign	0.01
R4709:Or9i14	UTSW	19	13,792,814 (GRCm39)	missense	possibly damaging	0.94
R5231:Or9i14	UTSW	19	13,792,711 (GRCm39)	missense	probably damaging	0.99
R5301:Or9i14	UTSW	19	13,792,933 (GRCm39)	missense	probably damaging	0.99
R5343:Or9i14	UTSW	19	13,792,324 (GRCm39)	missense	probably damaging	1.00
R6268:Or9i14	UTSW	19	13,792,671 (GRCm39)	nonsense	probably null
R6442:Or9i14	UTSW	19	13,792,992 (GRCm39)	start gained	probably benign
R7132:Or9i14	UTSW	19	13,792,786 (GRCm39)	missense	probably benign	0.09
R7764:Or9i14	UTSW	19	13,792,111 (GRCm39)	missense	probably benign	0.01
R7943:Or9i14	UTSW	19	13,792,600 (GRCm39)	missense	probably damaging	0.99
R8703:Or9i14	UTSW	19	13,792,105 (GRCm39)	missense	probably damaging	1.00
R8736:Or9i14	UTSW	19	13,792,358 (GRCm39)	missense	probably benign	0.05
R9069:Or9i14	UTSW	19	13,792,735 (GRCm39)	missense	probably damaging	1.00
R9177:Or9i14	UTSW	19	13,792,388 (GRCm39)	missense	probably damaging	1.00
R9258:Or9i14	UTSW	19	13,792,099 (GRCm39)	nonsense	probably null
R9268:Or9i14	UTSW	19	13,792,388 (GRCm39)	missense	probably damaging	1.00
Z1088:Or9i14	UTSW	19	13,792,912 (GRCm39)	missense	probably damaging	1.00
Z1177:Or9i14	UTSW	19	13,792,408 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02