Incidental Mutation 'R0480:Tpr'
| ID |
41889 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Tpr
|
| Ensembl Gene |
ENSMUSG00000006005 |
| Gene Name |
translocated promoter region, nuclear basket protein |
| Synonyms |
2610029M07Rik |
| MMRRC Submission |
038680-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0480 (G1)
|
| Quality Score |
144 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
150268589-150325686 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to G
at 150303992 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Glutamic Acid to Glycine
at position 1455
(E1455G)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000117616
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000119161]
[ENSMUST00000124973]
|
| AlphaFold |
F6ZDS4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000119161
AA Change: E1381G
PolyPhen 2
Score 0.729 (Sensitivity: 0.86; Specificity: 0.92)
|
| SMART Domains |
Protein: ENSMUSP00000112606
Gene: ENSMUSG00000006005
AA Change: E1381G
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
49 |
370 |
N/A |
INTRINSIC |
|
coiled coil region
|
423 |
515 |
N/A |
INTRINSIC |
|
low complexity region
|
518 |
534 |
N/A |
INTRINSIC |
|
coiled coil region
|
539 |
604 |
N/A |
INTRINSIC |
|
low complexity region
|
690 |
703 |
N/A |
INTRINSIC |
|
low complexity region
|
782 |
795 |
N/A |
INTRINSIC |
|
low complexity region
|
811 |
826 |
N/A |
INTRINSIC |
|
low complexity region
|
1003 |
1019 |
N/A |
INTRINSIC |
|
Pfam:TPR_MLP1_2
|
1036 |
1167 |
9.1e-33 |
PFAM |
|
coiled coil region
|
1215 |
1421 |
N/A |
INTRINSIC |
|
coiled coil region
|
1473 |
1629 |
N/A |
INTRINSIC |
|
internal_repeat_3
|
1630 |
1691 |
1.48e-5 |
PROSPERO |
|
low complexity region
|
1695 |
1717 |
N/A |
INTRINSIC |
|
low complexity region
|
1761 |
1777 |
N/A |
INTRINSIC |
|
internal_repeat_5
|
1814 |
1827 |
5.58e-5 |
PROSPERO |
|
internal_repeat_3
|
1819 |
1881 |
1.48e-5 |
PROSPERO |
|
internal_repeat_4
|
1875 |
1895 |
5.58e-5 |
PROSPERO |
|
internal_repeat_1
|
1893 |
1919 |
2.03e-6 |
PROSPERO |
|
low complexity region
|
1920 |
1933 |
N/A |
INTRINSIC |
|
low complexity region
|
1942 |
1981 |
N/A |
INTRINSIC |
|
low complexity region
|
1989 |
2014 |
N/A |
INTRINSIC |
|
internal_repeat_4
|
2017 |
2036 |
5.58e-5 |
PROSPERO |
|
low complexity region
|
2059 |
2078 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
2084 |
2135 |
3.95e-6 |
PROSPERO |
|
internal_repeat_5
|
2127 |
2140 |
5.58e-5 |
PROSPERO |
|
internal_repeat_1
|
2154 |
2179 |
2.03e-6 |
PROSPERO |
|
internal_repeat_2
|
2156 |
2212 |
3.95e-6 |
PROSPERO |
|
low complexity region
|
2239 |
2251 |
N/A |
INTRINSIC |
|
low complexity region
|
2263 |
2277 |
N/A |
INTRINSIC |
|
low complexity region
|
2292 |
2314 |
N/A |
INTRINSIC |
|
low complexity region
|
2346 |
2357 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000124973
AA Change: E1455G
PolyPhen 2
Score 0.831 (Sensitivity: 0.84; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000117616
Gene: ENSMUSG00000006005
AA Change: E1455G
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
3 |
14 |
N/A |
INTRINSIC |
|
low complexity region
|
24 |
77 |
N/A |
INTRINSIC |
|
coiled coil region
|
123 |
444 |
N/A |
INTRINSIC |
|
coiled coil region
|
497 |
589 |
N/A |
INTRINSIC |
|
low complexity region
|
592 |
608 |
N/A |
INTRINSIC |
|
coiled coil region
|
613 |
678 |
N/A |
INTRINSIC |
|
low complexity region
|
764 |
777 |
N/A |
INTRINSIC |
|
low complexity region
|
856 |
869 |
N/A |
INTRINSIC |
|
low complexity region
|
885 |
900 |
N/A |
INTRINSIC |
|
low complexity region
|
1077 |
1093 |
N/A |
INTRINSIC |
|
Pfam:TPR_MLP1_2
|
1112 |
1240 |
5.1e-37 |
PFAM |
|
coiled coil region
|
1289 |
1495 |
N/A |
INTRINSIC |
|
low complexity region
|
1682 |
1698 |
N/A |
INTRINSIC |
|
internal_repeat_5
|
1703 |
1750 |
8.04e-5 |
PROSPERO |
|
internal_repeat_3
|
1704 |
1765 |
1.07e-5 |
PROSPERO |
|
low complexity region
|
1769 |
1791 |
N/A |
INTRINSIC |
|
low complexity region
|
1835 |
1851 |
N/A |
INTRINSIC |
|
internal_repeat_5
|
1857 |
1900 |
8.04e-5 |
PROSPERO |
|
internal_repeat_6
|
1887 |
1911 |
8.04e-5 |
PROSPERO |
|
internal_repeat_3
|
1893 |
1955 |
1.07e-5 |
PROSPERO |
|
internal_repeat_4
|
1949 |
1969 |
4.1e-5 |
PROSPERO |
|
internal_repeat_1
|
1967 |
1993 |
1.42e-6 |
PROSPERO |
|
low complexity region
|
1994 |
2007 |
N/A |
INTRINSIC |
|
low complexity region
|
2016 |
2055 |
N/A |
INTRINSIC |
|
low complexity region
|
2063 |
2088 |
N/A |
INTRINSIC |
|
internal_repeat_4
|
2091 |
2110 |
4.1e-5 |
PROSPERO |
|
internal_repeat_6
|
2108 |
2132 |
8.04e-5 |
PROSPERO |
|
low complexity region
|
2133 |
2152 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
2158 |
2209 |
2.78e-6 |
PROSPERO |
|
internal_repeat_1
|
2228 |
2253 |
1.42e-6 |
PROSPERO |
|
internal_repeat_2
|
2230 |
2286 |
2.78e-6 |
PROSPERO |
|
low complexity region
|
2313 |
2325 |
N/A |
INTRINSIC |
|
low complexity region
|
2337 |
2351 |
N/A |
INTRINSIC |
|
low complexity region
|
2366 |
2388 |
N/A |
INTRINSIC |
|
low complexity region
|
2420 |
2431 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000132522
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000150752
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151563
|
| SMART Domains |
Protein: ENSMUSP00000116012
Gene: ENSMUSG00000006005
| Domain | Start | End | E-Value | Type |
|---|
|
coiled coil region
|
1 |
27 |
N/A |
INTRINSIC |
|
coiled coil region
|
79 |
235 |
N/A |
INTRINSIC |
|
low complexity region
|
302 |
324 |
N/A |
INTRINSIC |
|
low complexity region
|
368 |
384 |
N/A |
INTRINSIC |
|
low complexity region
|
527 |
540 |
N/A |
INTRINSIC |
|
low complexity region
|
549 |
588 |
N/A |
INTRINSIC |
|
| Meta Mutation Damage Score |
0.3977 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.3%
- 20x: 92.6%
|
| Validation Efficiency |
99% (117/118) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(28) : Targeted, other(2) Gene trapped(26) |
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
C |
T |
11: 58,771,012 (GRCm39) |
L165F |
probably damaging |
Het |
| Adamts18 |
A |
G |
8: 114,465,450 (GRCm39) |
V714A |
possibly damaging |
Het |
| Adamtsl1 |
G |
T |
4: 86,171,055 (GRCm39) |
A518S |
probably benign |
Het |
| Adcy2 |
C |
T |
13: 68,880,231 (GRCm39) |
V363M |
probably damaging |
Het |
| Ago4 |
G |
T |
4: 126,419,870 (GRCm39) |
Q36K |
probably benign |
Het |
| Akr1a1 |
A |
G |
4: 116,497,044 (GRCm39) |
V172A |
possibly damaging |
Het |
| Alkbh2 |
T |
A |
5: 114,263,596 (GRCm39) |
N137I |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,715,756 (GRCm39) |
S470T |
probably damaging |
Het |
| Ankrd12 |
T |
C |
17: 66,356,823 (GRCm39) |
T65A |
possibly damaging |
Het |
| Aox1 |
A |
T |
1: 58,082,810 (GRCm39) |
|
probably benign |
Het |
| Arhgap11a |
A |
T |
2: 113,670,163 (GRCm39) |
I320N |
probably benign |
Het |
| Arhgap17 |
G |
A |
7: 122,893,867 (GRCm39) |
H518Y |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,611,348 (GRCm39) |
V1563A |
probably damaging |
Het |
| Atf2 |
G |
A |
2: 73,649,500 (GRCm39) |
|
probably benign |
Het |
| Bmpr2 |
C |
T |
1: 59,884,818 (GRCm39) |
T268I |
probably damaging |
Het |
| Bpifb9a |
A |
G |
2: 154,106,608 (GRCm39) |
I380V |
probably benign |
Het |
| C2cd2 |
G |
A |
16: 97,678,348 (GRCm39) |
T363I |
probably benign |
Het |
| Catsperg2 |
T |
G |
7: 29,420,723 (GRCm39) |
N190H |
probably damaging |
Het |
| Ccdc138 |
T |
C |
10: 58,397,789 (GRCm39) |
L543S |
probably damaging |
Het |
| Ccdc170 |
A |
T |
10: 4,468,939 (GRCm39) |
K162N |
probably benign |
Het |
| Cdca5 |
G |
T |
19: 6,140,328 (GRCm39) |
R163L |
probably damaging |
Het |
| Cdh24 |
A |
G |
14: 54,870,054 (GRCm39) |
F239S |
probably benign |
Het |
| Cdkl3 |
T |
C |
11: 51,895,882 (GRCm39) |
V43A |
probably damaging |
Het |
| Cep152 |
G |
T |
2: 125,423,639 (GRCm39) |
Q921K |
possibly damaging |
Het |
| Cftr |
G |
A |
6: 18,274,517 (GRCm39) |
|
probably benign |
Het |
| Chmp5 |
T |
C |
4: 40,948,690 (GRCm39) |
|
probably benign |
Het |
| Cit |
T |
A |
5: 116,071,452 (GRCm39) |
|
probably benign |
Het |
| Cngb3 |
T |
A |
4: 19,309,517 (GRCm39) |
|
probably benign |
Het |
| Cnr2 |
A |
G |
4: 135,644,912 (GRCm39) |
E330G |
probably benign |
Het |
| Cyp21a1 |
A |
T |
17: 35,020,800 (GRCm39) |
L473Q |
probably damaging |
Het |
| Dchs1 |
T |
C |
7: 105,420,696 (GRCm39) |
T575A |
probably benign |
Het |
| Dedd2 |
A |
G |
7: 24,903,050 (GRCm39) |
V303A |
probably damaging |
Het |
| Dmd |
G |
T |
X: 83,469,344 (GRCm39) |
A2370S |
probably benign |
Het |
| Dnah10 |
T |
A |
5: 124,885,915 (GRCm39) |
N3009K |
probably damaging |
Het |
| Dnajc13 |
G |
T |
9: 104,077,708 (GRCm39) |
N934K |
probably damaging |
Het |
| Dock1 |
C |
T |
7: 134,339,447 (GRCm39) |
L106F |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 15,909,025 (GRCm39) |
Y2326H |
probably benign |
Het |
| Fhl5 |
A |
T |
4: 25,207,101 (GRCm39) |
C222* |
probably null |
Het |
| Gnmt |
T |
C |
17: 47,036,854 (GRCm39) |
T252A |
probably benign |
Het |
| Gpi-ps |
A |
G |
8: 5,689,888 (GRCm39) |
|
noncoding transcript |
Het |
| Gsta5 |
C |
T |
9: 78,210,099 (GRCm39) |
A135V |
probably benign |
Het |
| Gtf2f1 |
A |
G |
17: 57,311,307 (GRCm39) |
|
probably null |
Het |
| Gtf3a |
T |
C |
5: 146,890,039 (GRCm39) |
Y187H |
probably damaging |
Het |
| Hdac2 |
A |
G |
10: 36,850,788 (GRCm39) |
Y14C |
probably damaging |
Het |
| Hnrnph1 |
T |
G |
11: 50,276,589 (GRCm39) |
|
probably benign |
Het |
| Homer2 |
T |
C |
7: 81,268,351 (GRCm39) |
D92G |
possibly damaging |
Het |
| Hspg2 |
T |
C |
4: 137,277,335 (GRCm39) |
S2885P |
probably damaging |
Het |
| Insr |
A |
G |
8: 3,211,770 (GRCm39) |
S1084P |
probably damaging |
Het |
| Ints11 |
T |
A |
4: 155,972,081 (GRCm39) |
V362E |
probably damaging |
Het |
| Kank2 |
T |
C |
9: 21,691,195 (GRCm39) |
N513S |
probably damaging |
Het |
| Kl |
T |
G |
5: 150,876,753 (GRCm39) |
V191G |
probably damaging |
Het |
| Krt23 |
A |
G |
11: 99,377,524 (GRCm39) |
|
probably null |
Het |
| Lama3 |
A |
C |
18: 12,583,481 (GRCm39) |
T690P |
possibly damaging |
Het |
| Lamb1 |
G |
A |
12: 31,332,720 (GRCm39) |
A281T |
possibly damaging |
Het |
| Lck |
T |
C |
4: 129,449,433 (GRCm39) |
E299G |
probably damaging |
Het |
| Lonrf1 |
A |
G |
8: 36,689,864 (GRCm39) |
V703A |
probably damaging |
Het |
| Ly6f |
T |
C |
15: 75,143,526 (GRCm39) |
C78R |
probably damaging |
Het |
| Mapkap1 |
C |
T |
2: 34,423,793 (GRCm39) |
|
probably benign |
Het |
| Mast1 |
T |
A |
8: 85,639,718 (GRCm39) |
I1204F |
probably damaging |
Het |
| Mbd6 |
C |
T |
10: 127,121,742 (GRCm39) |
|
probably benign |
Het |
| Mef2c |
A |
T |
13: 83,741,020 (GRCm39) |
T60S |
probably damaging |
Het |
| Mgat4c |
C |
T |
10: 102,224,980 (GRCm39) |
T398I |
probably damaging |
Het |
| Mmp12 |
C |
A |
9: 7,350,016 (GRCm39) |
H102Q |
probably damaging |
Het |
| Mmp20 |
G |
A |
9: 7,645,374 (GRCm39) |
G308E |
probably damaging |
Het |
| Mms19 |
A |
T |
19: 41,943,285 (GRCm39) |
L395Q |
probably damaging |
Het |
| Mus81 |
A |
G |
19: 5,537,959 (GRCm39) |
|
probably benign |
Het |
| Mypn |
C |
T |
10: 63,028,982 (GRCm39) |
R27H |
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,689,161 (GRCm39) |
E372G |
probably damaging |
Het |
| Ncoa1 |
T |
A |
12: 4,389,105 (GRCm39) |
I57F |
probably damaging |
Het |
| Ncstn |
T |
C |
1: 171,910,159 (GRCm39) |
|
probably benign |
Het |
| Nefm |
C |
T |
14: 68,361,608 (GRCm39) |
D219N |
probably damaging |
Het |
| Notch2 |
C |
T |
3: 98,053,853 (GRCm39) |
T2172I |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 59,024,772 (GRCm39) |
K423* |
probably null |
Het |
| Or51l14 |
A |
G |
7: 103,100,835 (GRCm39) |
N97S |
probably benign |
Het |
| Or5d37 |
A |
C |
2: 87,923,972 (GRCm39) |
S103A |
probably benign |
Het |
| Or5k1 |
T |
C |
16: 58,617,684 (GRCm39) |
N175S |
probably benign |
Het |
| Or9a2 |
A |
T |
6: 41,749,198 (GRCm39) |
C12S |
probably benign |
Het |
| Ostm1 |
T |
A |
10: 42,572,343 (GRCm39) |
M242K |
probably damaging |
Het |
| Oxnad1 |
T |
A |
14: 31,821,437 (GRCm39) |
I154N |
probably damaging |
Het |
| Pcdhb10 |
T |
A |
18: 37,546,152 (GRCm39) |
D409E |
probably damaging |
Het |
| Pdcd11 |
T |
C |
19: 47,113,476 (GRCm39) |
|
probably benign |
Het |
| Peak1 |
C |
A |
9: 56,165,916 (GRCm39) |
V671L |
probably benign |
Het |
| Pex1 |
G |
A |
5: 3,656,444 (GRCm39) |
|
probably null |
Het |
| Plk4 |
T |
A |
3: 40,760,075 (GRCm39) |
F324I |
probably benign |
Het |
| Poglut2 |
C |
T |
1: 44,149,917 (GRCm39) |
W424* |
probably null |
Het |
| Ppfibp1 |
C |
A |
6: 146,920,529 (GRCm39) |
|
probably null |
Het |
| Prcp |
T |
A |
7: 92,568,290 (GRCm39) |
W276R |
probably damaging |
Het |
| Prr14l |
T |
C |
5: 32,987,224 (GRCm39) |
E757G |
probably benign |
Het |
| Prss52 |
T |
A |
14: 64,351,093 (GRCm39) |
Y293N |
probably damaging |
Het |
| Prune2 |
A |
G |
19: 16,984,156 (GRCm39) |
|
probably benign |
Het |
| Ptprk |
G |
C |
10: 28,461,943 (GRCm39) |
A84P |
probably damaging |
Het |
| Ptprk |
C |
T |
10: 28,461,944 (GRCm39) |
A84V |
probably damaging |
Het |
| Rock1 |
A |
G |
18: 10,079,120 (GRCm39) |
L1116P |
possibly damaging |
Het |
| Sdha |
A |
T |
13: 74,475,452 (GRCm39) |
F526Y |
probably benign |
Het |
| Sema4b |
T |
C |
7: 79,869,954 (GRCm39) |
F414S |
probably damaging |
Het |
| Serpina12 |
T |
C |
12: 104,001,960 (GRCm39) |
D252G |
probably damaging |
Het |
| Siglecg |
C |
T |
7: 43,060,550 (GRCm39) |
A310V |
probably benign |
Het |
| Slc30a8 |
A |
G |
15: 52,188,966 (GRCm39) |
I194V |
probably benign |
Het |
| Spred3 |
A |
G |
7: 28,862,400 (GRCm39) |
S148P |
probably damaging |
Het |
| Taf9b |
A |
G |
X: 105,262,014 (GRCm39) |
S58P |
probably damaging |
Het |
| Tgm4 |
A |
T |
9: 122,891,484 (GRCm39) |
Y109F |
probably benign |
Het |
| Tmprss11c |
T |
G |
5: 86,385,468 (GRCm39) |
|
probably benign |
Het |
| Tmtc3 |
A |
T |
10: 100,307,266 (GRCm39) |
V246D |
probably damaging |
Het |
| Tnip1 |
C |
T |
11: 54,828,820 (GRCm39) |
G116R |
probably damaging |
Het |
| Ttc3 |
T |
A |
16: 94,232,863 (GRCm39) |
L986* |
probably null |
Het |
| Txndc15 |
A |
G |
13: 55,872,436 (GRCm39) |
I275V |
possibly damaging |
Het |
| Ugt2b1 |
T |
A |
5: 87,074,315 (GRCm39) |
I15L |
probably benign |
Het |
| Upf2 |
T |
C |
2: 5,962,445 (GRCm39) |
V49A |
possibly damaging |
Het |
| Vmn1r117 |
G |
A |
7: 20,617,371 (GRCm39) |
P226S |
probably benign |
Het |
| Vmn2r28 |
A |
T |
7: 5,493,456 (GRCm39) |
H163Q |
probably benign |
Het |
| Vstm2a |
T |
A |
11: 16,213,240 (GRCm39) |
S208R |
probably damaging |
Het |
| Zfp346 |
T |
A |
13: 55,260,910 (GRCm39) |
C79* |
probably null |
Het |
| Zfp628 |
A |
T |
7: 4,924,615 (GRCm39) |
T946S |
probably benign |
Het |
|
| Other mutations in Tpr |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00327:Tpr
|
APN |
1 |
150,299,447 (GRCm39) |
splice site |
probably benign |
|
|
IGL00424:Tpr
|
APN |
1 |
150,274,346 (GRCm39) |
splice site |
probably benign |
|
|
IGL01095:Tpr
|
APN |
1 |
150,285,891 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01347:Tpr
|
APN |
1 |
150,302,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01519:Tpr
|
APN |
1 |
150,306,919 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01768:Tpr
|
APN |
1 |
150,320,199 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL01939:Tpr
|
APN |
1 |
150,289,496 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
IGL01988:Tpr
|
APN |
1 |
150,302,750 (GRCm39) |
splice site |
probably null |
|
|
IGL02065:Tpr
|
APN |
1 |
150,289,525 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02110:Tpr
|
APN |
1 |
150,311,493 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02311:Tpr
|
APN |
1 |
150,274,404 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02454:Tpr
|
APN |
1 |
150,306,943 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02569:Tpr
|
APN |
1 |
150,301,382 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03168:Tpr
|
APN |
1 |
150,284,508 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL03193:Tpr
|
APN |
1 |
150,315,831 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
IGL03333:Tpr
|
APN |
1 |
150,302,718 (GRCm39) |
missense |
probably benign |
0.04 |
|
gridiron
|
UTSW |
1 |
150,299,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Pouch
|
UTSW |
1 |
150,309,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
punt
|
UTSW |
1 |
150,293,790 (GRCm39) |
missense |
probably benign |
0.02 |
|
Turf
|
UTSW |
1 |
150,317,996 (GRCm39) |
critical splice donor site |
probably null |
|
|
F6893:Tpr
|
UTSW |
1 |
150,269,313 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
PIT4305001:Tpr
|
UTSW |
1 |
150,315,888 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
PIT4469001:Tpr
|
UTSW |
1 |
150,279,707 (GRCm39) |
missense |
probably benign |
0.41 |
|
R0085:Tpr
|
UTSW |
1 |
150,293,164 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0101:Tpr
|
UTSW |
1 |
150,285,053 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Tpr
|
UTSW |
1 |
150,285,898 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0136:Tpr
|
UTSW |
1 |
150,306,346 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0207:Tpr
|
UTSW |
1 |
150,293,178 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R0219:Tpr
|
UTSW |
1 |
150,319,009 (GRCm39) |
splice site |
probably null |
|
|
R0380:Tpr
|
UTSW |
1 |
150,288,698 (GRCm39) |
missense |
probably benign |
0.27 |
|
R0403:Tpr
|
UTSW |
1 |
150,283,165 (GRCm39) |
splice site |
probably benign |
|
|
R0469:Tpr
|
UTSW |
1 |
150,299,418 (GRCm39) |
frame shift |
probably null |
|
|
R0514:Tpr
|
UTSW |
1 |
150,278,024 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R0563:Tpr
|
UTSW |
1 |
150,284,609 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0631:Tpr
|
UTSW |
1 |
150,298,282 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0685:Tpr
|
UTSW |
1 |
150,309,476 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0730:Tpr
|
UTSW |
1 |
150,269,158 (GRCm39) |
utr 5 prime |
probably benign |
|
|
R0739:Tpr
|
UTSW |
1 |
150,283,248 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0780:Tpr
|
UTSW |
1 |
150,307,092 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1018:Tpr
|
UTSW |
1 |
150,317,934 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1084:Tpr
|
UTSW |
1 |
150,317,912 (GRCm39) |
missense |
probably benign |
0.18 |
|
R1532:Tpr
|
UTSW |
1 |
150,293,751 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1551:Tpr
|
UTSW |
1 |
150,312,552 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1608:Tpr
|
UTSW |
1 |
150,302,644 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1759:Tpr
|
UTSW |
1 |
150,305,275 (GRCm39) |
missense |
probably benign |
0.19 |
|
R1817:Tpr
|
UTSW |
1 |
150,295,654 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1932:Tpr
|
UTSW |
1 |
150,297,414 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1978:Tpr
|
UTSW |
1 |
150,295,658 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R2031:Tpr
|
UTSW |
1 |
150,317,870 (GRCm39) |
missense |
probably benign |
|
|
R2176:Tpr
|
UTSW |
1 |
150,295,691 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R2235:Tpr
|
UTSW |
1 |
150,317,843 (GRCm39) |
missense |
probably benign |
0.33 |
|
R2339:Tpr
|
UTSW |
1 |
150,289,525 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2367:Tpr
|
UTSW |
1 |
150,309,479 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2507:Tpr
|
UTSW |
1 |
150,268,695 (GRCm39) |
start codon destroyed |
probably null |
|
|
R3931:Tpr
|
UTSW |
1 |
150,311,655 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4320:Tpr
|
UTSW |
1 |
150,299,325 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R4439:Tpr
|
UTSW |
1 |
150,279,712 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4568:Tpr
|
UTSW |
1 |
150,268,710 (GRCm39) |
unclassified |
probably benign |
|
|
R4644:Tpr
|
UTSW |
1 |
150,299,250 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4665:Tpr
|
UTSW |
1 |
150,320,150 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4672:Tpr
|
UTSW |
1 |
150,299,318 (GRCm39) |
missense |
probably benign |
0.45 |
|
R4673:Tpr
|
UTSW |
1 |
150,299,318 (GRCm39) |
missense |
probably benign |
0.45 |
|
R4735:Tpr
|
UTSW |
1 |
150,317,947 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R4767:Tpr
|
UTSW |
1 |
150,306,280 (GRCm39) |
intron |
probably benign |
|
|
R4772:Tpr
|
UTSW |
1 |
150,288,864 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R4815:Tpr
|
UTSW |
1 |
150,274,359 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4839:Tpr
|
UTSW |
1 |
150,324,948 (GRCm39) |
nonsense |
probably null |
|
|
R4844:Tpr
|
UTSW |
1 |
150,321,630 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4925:Tpr
|
UTSW |
1 |
150,308,316 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4967:Tpr
|
UTSW |
1 |
150,285,810 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5017:Tpr
|
UTSW |
1 |
150,274,388 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5096:Tpr
|
UTSW |
1 |
150,321,953 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5353:Tpr
|
UTSW |
1 |
150,321,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5354:Tpr
|
UTSW |
1 |
150,321,675 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5484:Tpr
|
UTSW |
1 |
150,302,639 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5601:Tpr
|
UTSW |
1 |
150,311,604 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R5642:Tpr
|
UTSW |
1 |
150,299,569 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5779:Tpr
|
UTSW |
1 |
150,299,292 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5787:Tpr
|
UTSW |
1 |
150,271,037 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5892:Tpr
|
UTSW |
1 |
150,283,151 (GRCm39) |
missense |
probably benign |
0.44 |
|
R5915:Tpr
|
UTSW |
1 |
150,301,400 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5928:Tpr
|
UTSW |
1 |
150,303,878 (GRCm39) |
missense |
probably benign |
0.30 |
|
R6146:Tpr
|
UTSW |
1 |
150,298,913 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6154:Tpr
|
UTSW |
1 |
150,299,567 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6234:Tpr
|
UTSW |
1 |
150,293,790 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6263:Tpr
|
UTSW |
1 |
150,317,996 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6318:Tpr
|
UTSW |
1 |
150,321,639 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6550:Tpr
|
UTSW |
1 |
150,299,728 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6592:Tpr
|
UTSW |
1 |
150,287,656 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6704:Tpr
|
UTSW |
1 |
150,282,259 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6716:Tpr
|
UTSW |
1 |
150,290,516 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6836:Tpr
|
UTSW |
1 |
150,312,424 (GRCm39) |
splice site |
probably null |
|
|
R6886:Tpr
|
UTSW |
1 |
150,299,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6894:Tpr
|
UTSW |
1 |
150,312,598 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6928:Tpr
|
UTSW |
1 |
150,284,536 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7011:Tpr
|
UTSW |
1 |
150,309,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7034:Tpr
|
UTSW |
1 |
150,299,358 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7036:Tpr
|
UTSW |
1 |
150,299,358 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7183:Tpr
|
UTSW |
1 |
150,282,302 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7221:Tpr
|
UTSW |
1 |
150,321,929 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7223:Tpr
|
UTSW |
1 |
150,315,007 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7294:Tpr
|
UTSW |
1 |
150,279,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Tpr
|
UTSW |
1 |
150,269,245 (GRCm39) |
missense |
unknown |
|
|
R7361:Tpr
|
UTSW |
1 |
150,323,372 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R7405:Tpr
|
UTSW |
1 |
150,317,878 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7637:Tpr
|
UTSW |
1 |
150,299,267 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7720:Tpr
|
UTSW |
1 |
150,305,283 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7721:Tpr
|
UTSW |
1 |
150,320,180 (GRCm39) |
missense |
probably benign |
|
|
R7751:Tpr
|
UTSW |
1 |
150,295,646 (GRCm39) |
missense |
probably benign |
0.17 |
|
R7804:Tpr
|
UTSW |
1 |
150,308,310 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7878:Tpr
|
UTSW |
1 |
150,299,411 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7973:Tpr
|
UTSW |
1 |
150,279,638 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8013:Tpr
|
UTSW |
1 |
150,274,359 (GRCm39) |
missense |
probably benign |
|
|
R8220:Tpr
|
UTSW |
1 |
150,308,164 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8274:Tpr
|
UTSW |
1 |
150,299,230 (GRCm39) |
splice site |
probably benign |
|
|
R8428:Tpr
|
UTSW |
1 |
150,290,564 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8482:Tpr
|
UTSW |
1 |
150,309,451 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8699:Tpr
|
UTSW |
1 |
150,293,772 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8859:Tpr
|
UTSW |
1 |
150,284,597 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9119:Tpr
|
UTSW |
1 |
150,279,753 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9326:Tpr
|
UTSW |
1 |
150,301,407 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9618:Tpr
|
UTSW |
1 |
150,321,979 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R9680:Tpr
|
UTSW |
1 |
150,314,887 (GRCm39) |
missense |
probably benign |
0.32 |
|
R9776:Tpr
|
UTSW |
1 |
150,324,939 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0021:Tpr
|
UTSW |
1 |
150,270,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Tpr
|
UTSW |
1 |
150,303,986 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TTCGTTCAAGTTCATTCACAGCTCTGA -3'
(R):5'- GGCTTTTACCTTCCTACAAAGCAGGAT -3'
Sequencing Primer
(F):5'- ACTTACTACTCTGTAGGCAAGAC -3'
(R):5'- TCACAGAGAACATATtgtcattcagc -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation