Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03104:Sirpd'

418892

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Sirpd

Ensembl Gene

ENSMUSG00000078783

Gene Name

signal regulatory protein delta

Synonyms

Gm9733

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.049) question?

Stock #

IGL03104

Quality Score

Status

Chromosome

Chromosomal Location

15361611-15397362 bp(-) (GRCm39)

Type of Mutation

utr 5 prime

DNA Base Change (assembly)

G to T at 15397283 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000103998 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000108361]

AlphaFold

Q1AN91

Predicted Effect

probably benign
Transcript: ENSMUST00000108361

SMART Domains

Protein: ENSMUSP00000103998
Gene: ENSMUSG00000078783

Domain	Start	End	E-Value	Type
low complexity region	9	26	N/A	INTRINSIC
IG	37	142	6.71e-5	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 49 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aox1	C	A	1: 58,321,918 (GRCm39)	T70K	probably benign	Het
Armt1	T	A	10: 4,389,615 (GRCm39)	Y91N	possibly damaging	Het
Atp1a2	A	G	1: 172,120,934 (GRCm39)	L46S	probably damaging	Het
Baz1a	A	G	12: 54,941,743 (GRCm39)	S1488P	probably damaging	Het
Coro7	T	A	16: 4,446,990 (GRCm39)	E793V	probably damaging	Het
Ctnnbl1	G	T	2: 157,732,885 (GRCm39)	R555L	probably damaging	Het
Dclk2	A	G	3: 86,743,666 (GRCm39)	C268R	probably damaging	Het
Dock7	A	T	4: 98,847,260 (GRCm39)	M1684K	possibly damaging	Het
Dock8	T	A	19: 25,178,384 (GRCm39)	C2092*	probably null	Het
Dtx1	T	A	5: 120,833,030 (GRCm39)	Q136L	possibly damaging	Het
Egln3	C	T	12: 54,249,981 (GRCm39)		probably benign	Het
Eml5	A	T	12: 98,827,504 (GRCm39)	Y575*	probably null	Het
Entpd5	A	T	12: 84,431,022 (GRCm39)	V310E	probably damaging	Het
Fkbp5	A	G	17: 28,634,946 (GRCm39)	F188L	probably damaging	Het
Frrs1	T	C	3: 116,675,431 (GRCm39)	S120P	probably benign	Het
Gadl1	T	C	9: 115,903,108 (GRCm39)	I479T	possibly damaging	Het
Gfra2	A	T	14: 71,205,725 (GRCm39)	M106L	probably benign	Het
Gm17455	T	A	10: 60,239,060 (GRCm39)	C108*	probably null	Het
Grhpr	A	G	4: 44,983,867 (GRCm39)		probably benign	Het
Hsp90ab1	G	A	17: 45,882,449 (GRCm39)	R82C	probably damaging	Het
Igsf10	T	C	3: 59,226,905 (GRCm39)	Y2256C	probably damaging	Het
Ivd	A	T	2: 118,703,384 (GRCm39)	I160F	probably benign	Het
Krtap5-5	A	G	7: 141,783,450 (GRCm39)	C67R	unknown	Het
Lhx4	A	T	1: 155,580,967 (GRCm39)	V186E	probably damaging	Het
Lrrk2	T	C	15: 91,631,958 (GRCm39)	I1294T	possibly damaging	Het
Map3k5	C	T	10: 20,007,801 (GRCm39)	S1202L	probably benign	Het
Mdfic	T	A	6: 15,770,319 (GRCm39)	N108K	probably damaging	Het
Mov10	G	A	3: 104,704,623 (GRCm39)	R763W	probably damaging	Het
Mto1	T	C	9: 78,356,802 (GRCm39)	S106P	probably damaging	Het
Naca	C	T	10: 127,876,233 (GRCm39)		probably benign	Het
Or10j27	A	G	1: 172,958,526 (GRCm39)	V86A	probably benign	Het
Or8s10	A	G	15: 98,336,127 (GRCm39)	Y259C	possibly damaging	Het
Pan2	T	C	10: 128,151,532 (GRCm39)		probably benign	Het
Pold1	T	C	7: 44,190,004 (GRCm39)	Y394C	probably damaging	Het
Sipa1l1	T	A	12: 82,388,904 (GRCm39)	S377T	probably benign	Het
Slc36a3	A	G	11: 55,015,946 (GRCm39)	S403P	probably damaging	Het
Slc4a4	A	G	5: 89,297,231 (GRCm39)	T480A	probably damaging	Het
Slu7	G	A	11: 43,332,883 (GRCm39)	V315I	probably benign	Het
St6galnac3	T	C	3: 152,911,115 (GRCm39)	E282G	probably damaging	Het
Tlr12	A	G	4: 128,509,685 (GRCm39)	V855A	probably benign	Het
Tut7	T	C	13: 59,962,717 (GRCm39)	D350G	probably benign	Het
Vmn1r53	T	A	6: 90,200,944 (GRCm39)	K127*	probably null	Het
Vmn1r72	T	G	7: 11,403,812 (GRCm39)	H212P	probably damaging	Het
Vmn2r86	T	A	10: 130,282,501 (GRCm39)	Q705L	probably damaging	Het
Vps33b	C	T	7: 79,925,831 (GRCm39)	R93C	probably damaging	Het
Wdr91	T	A	6: 34,882,491 (GRCm39)	E219D	probably benign	Het
Zan	G	A	5: 137,461,762 (GRCm39)	T1139I	unknown	Het
Zc3hav1	T	A	6: 38,317,278 (GRCm39)	K107N	probably damaging	Het
Zmym2	A	G	14: 57,187,784 (GRCm39)	E1150G	possibly damaging	Het

Other mutations in Sirpd

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00990:Sirpd	APN	3	15,397,205 (GRCm39)	splice site	probably null
R0239:Sirpd	UTSW	3	15,361,661 (GRCm39)	missense	probably damaging	1.00
R0239:Sirpd	UTSW	3	15,361,661 (GRCm39)	missense	probably damaging	1.00
R0771:Sirpd	UTSW	3	15,385,506 (GRCm39)	missense	probably benign	0.33
R1452:Sirpd	UTSW	3	15,397,212 (GRCm39)	missense	unknown
R1541:Sirpd	UTSW	3	15,385,744 (GRCm39)	missense	possibly damaging	0.59
R5124:Sirpd	UTSW	3	15,385,639 (GRCm39)	nonsense	probably null
R5328:Sirpd	UTSW	3	15,397,234 (GRCm39)	missense	unknown
R5991:Sirpd	UTSW	3	15,385,818 (GRCm39)	missense	probably benign	0.00
R6333:Sirpd	UTSW	3	15,385,671 (GRCm39)	missense	probably damaging	1.00
R6656:Sirpd	UTSW	3	15,385,558 (GRCm39)	missense	probably damaging	0.99
R7270:Sirpd	UTSW	3	15,385,704 (GRCm39)	missense	probably benign	0.18
R7615:Sirpd	UTSW	3	15,385,545 (GRCm39)	missense	probably damaging	1.00
R7799:Sirpd	UTSW	3	15,361,723 (GRCm39)	critical splice acceptor site	probably null
R8536:Sirpd	UTSW	3	15,361,614 (GRCm39)	makesense	probably null
R9777:Sirpd	UTSW	3	15,385,813 (GRCm39)	nonsense	probably null

Posted On

2016-08-02