Incidental Mutation 'IGL03108:Armh3'
ID 419087
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Armh3
Ensembl Gene ENSMUSG00000039901
Gene Name armadillo-like helical domain containing 3
Synonyms 9130011E15Rik
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # IGL03108
Quality Score
Status
Chromosome 19
Chromosomal Location 45805803-45986927 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 45808792 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 633 (T633I)
Ref Sequence ENSEMBL: ENSMUSP00000048454 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000026247] [ENSMUST00000045396] [ENSMUST00000079431] [ENSMUST00000161886] [ENSMUST00000162528] [ENSMUST00000162661]
AlphaFold Q6PD19
Predicted Effect probably benign
Transcript: ENSMUST00000026247
SMART Domains Protein: ENSMUSP00000026247
Gene: ENSMUSG00000025221

DomainStartEndE-ValueType
EFh 126 154 1e-1 SMART
EFh 162 190 1.88e-6 SMART
EFh 210 238 4.6e-1 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000045396
AA Change: T633I

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000048454
Gene: ENSMUSG00000039901
AA Change: T633I

DomainStartEndE-ValueType
low complexity region 155 167 N/A INTRINSIC
low complexity region 327 348 N/A INTRINSIC
DUF1741 435 671 5.65e-139 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000079431
SMART Domains Protein: ENSMUSP00000078400
Gene: ENSMUSG00000025221

DomainStartEndE-ValueType
EFh 126 154 1e-1 SMART
EFh 162 190 1.88e-6 SMART
EFh 210 238 4.6e-1 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000111906
Predicted Effect probably benign
Transcript: ENSMUST00000161886
SMART Domains Protein: ENSMUSP00000124482
Gene: ENSMUSG00000025221

DomainStartEndE-ValueType
EFh 94 122 1e-1 SMART
EFh 130 158 1.88e-6 SMART
EFh 178 206 4.6e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162528
SMART Domains Protein: ENSMUSP00000125142
Gene: ENSMUSG00000025221

DomainStartEndE-ValueType
low complexity region 64 75 N/A INTRINSIC
EFh 144 172 1e-1 SMART
EFh 180 208 1.88e-6 SMART
EFh 228 256 4.6e-1 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000162661
SMART Domains Protein: ENSMUSP00000124821
Gene: ENSMUSG00000025221

DomainStartEndE-ValueType
EFh 94 122 3.4e-4 SMART
EFh 142 170 1.63e-1 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 44 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 C A 13: 81,707,648 (GRCm39) V1253F probably damaging Het
Apbb2 A G 5: 66,557,574 (GRCm39) W296R probably damaging Het
Btbd3 T C 2: 138,126,043 (GRCm39) V409A possibly damaging Het
C130050O18Rik A T 5: 139,400,820 (GRCm39) D291V probably damaging Het
Catsper3 A G 13: 55,955,848 (GRCm39) N318D probably benign Het
Chd1 T A 17: 15,945,543 (GRCm39) D22E possibly damaging Het
Chrnb2 G A 3: 89,670,681 (GRCm39) probably benign Het
Col24a1 G A 3: 145,029,162 (GRCm39) G550D probably damaging Het
Cryl1 T C 14: 57,550,534 (GRCm39) D110G probably damaging Het
Deaf1 A G 7: 140,902,874 (GRCm39) I150T probably damaging Het
Eif3a A T 19: 60,770,747 (GRCm39) D33E possibly damaging Het
Fabp12 C A 3: 10,315,114 (GRCm39) G78C probably benign Het
Fat1 A G 8: 45,476,651 (GRCm39) D1899G probably damaging Het
Galnt13 G A 2: 54,744,660 (GRCm39) V120I probably benign Het
Ganab G A 19: 8,889,840 (GRCm39) A635T probably damaging Het
Gm17509 G A 13: 117,357,380 (GRCm39) probably benign Het
Gstm3 A T 3: 107,875,080 (GRCm39) probably null Het
Hfm1 T A 5: 107,043,800 (GRCm39) probably benign Het
Hoxd13 A C 2: 74,500,440 (GRCm39) D327A probably damaging Het
Ints4 G T 7: 97,140,137 (GRCm39) probably null Het
Kcna10 A T 3: 107,102,259 (GRCm39) T297S probably benign Het
Ldb2 G A 5: 44,699,057 (GRCm39) T127I probably damaging Het
Mapk7 T C 11: 61,382,498 (GRCm39) D68G probably damaging Het
Msh3 A T 13: 92,357,596 (GRCm39) probably benign Het
Muc6 A G 7: 141,217,402 (GRCm39) S2359P possibly damaging Het
Mup6 A T 4: 60,005,990 (GRCm39) I161F possibly damaging Het
Nup160 G A 2: 90,534,169 (GRCm39) V665I probably benign Het
Or13a22 A G 7: 140,073,034 (GRCm39) N161S possibly damaging Het
Or14a258 T C 7: 86,034,929 (GRCm39) Y313C possibly damaging Het
Or4e5 T A 14: 52,727,533 (GRCm39) D296V probably damaging Het
Otog G A 7: 45,900,762 (GRCm39) V352I probably damaging Het
Oxct1 T A 15: 4,064,764 (GRCm39) V34D probably benign Het
Pcdhb21 T A 18: 37,648,944 (GRCm39) probably null Het
Pcdhb8 T G 18: 37,490,299 (GRCm39) V659G probably damaging Het
Plxnb2 T C 15: 89,042,234 (GRCm39) N1590S probably benign Het
Rnf168 G T 16: 32,097,099 (GRCm39) R56L possibly damaging Het
Scn8a C T 15: 100,872,496 (GRCm39) P362S probably benign Het
Slc1a3 T A 15: 8,668,562 (GRCm39) I468F probably damaging Het
Slc39a14 G A 14: 70,556,368 (GRCm39) R3W probably damaging Het
Slc7a6 T A 8: 106,921,149 (GRCm39) N373K probably damaging Het
Snrnp200 T C 2: 127,080,087 (GRCm39) S1955P possibly damaging Het
Stat5a T A 11: 100,753,965 (GRCm39) Y98* probably null Het
Thsd7b G T 1: 130,138,013 (GRCm39) G1564C probably damaging Het
Zc3h13 T C 14: 75,569,206 (GRCm39) V1351A possibly damaging Het
Other mutations in Armh3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00392:Armh3 APN 19 45,928,927 (GRCm39) missense probably benign 0.19
IGL00788:Armh3 APN 19 45,920,789 (GRCm39) critical splice donor site probably null
IGL01356:Armh3 APN 19 45,954,742 (GRCm39) missense possibly damaging 0.94
IGL01477:Armh3 APN 19 45,967,043 (GRCm39) missense probably damaging 0.99
IGL01660:Armh3 APN 19 45,928,915 (GRCm39) missense probably damaging 1.00
IGL02193:Armh3 APN 19 45,961,323 (GRCm39) missense probably benign 0.02
IGL02863:Armh3 APN 19 45,946,850 (GRCm39) missense probably damaging 1.00
R0035:Armh3 UTSW 19 45,879,679 (GRCm39) missense probably damaging 1.00
R0791:Armh3 UTSW 19 45,922,307 (GRCm39) splice site probably null
R0792:Armh3 UTSW 19 45,922,307 (GRCm39) splice site probably null
R1487:Armh3 UTSW 19 45,928,882 (GRCm39) critical splice donor site probably null
R1843:Armh3 UTSW 19 45,963,691 (GRCm39) missense probably benign 0.17
R2061:Armh3 UTSW 19 45,967,106 (GRCm39) missense probably damaging 1.00
R2070:Armh3 UTSW 19 45,879,724 (GRCm39) missense probably damaging 1.00
R2072:Armh3 UTSW 19 45,953,820 (GRCm39) missense probably damaging 0.99
R2073:Armh3 UTSW 19 45,953,820 (GRCm39) missense probably damaging 0.99
R2074:Armh3 UTSW 19 45,953,820 (GRCm39) missense probably damaging 0.99
R2091:Armh3 UTSW 19 45,941,119 (GRCm39) missense probably damaging 1.00
R2263:Armh3 UTSW 19 45,920,788 (GRCm39) critical splice donor site probably null
R2863:Armh3 UTSW 19 45,874,396 (GRCm39) missense probably damaging 1.00
R3236:Armh3 UTSW 19 45,963,722 (GRCm39) splice site probably benign
R3796:Armh3 UTSW 19 45,910,049 (GRCm39) splice site probably benign
R4044:Armh3 UTSW 19 45,808,763 (GRCm39) missense probably damaging 1.00
R4716:Armh3 UTSW 19 45,948,781 (GRCm39) missense probably damaging 1.00
R4974:Armh3 UTSW 19 45,808,726 (GRCm39) missense probably damaging 1.00
R4983:Armh3 UTSW 19 45,939,146 (GRCm39) missense probably benign
R5063:Armh3 UTSW 19 45,874,394 (GRCm39) missense possibly damaging 0.95
R5313:Armh3 UTSW 19 45,807,414 (GRCm39) missense probably damaging 1.00
R5782:Armh3 UTSW 19 45,874,466 (GRCm39) missense probably benign 0.08
R5985:Armh3 UTSW 19 45,808,763 (GRCm39) missense probably damaging 1.00
R6220:Armh3 UTSW 19 45,834,554 (GRCm39) missense possibly damaging 0.79
R6379:Armh3 UTSW 19 45,910,136 (GRCm39) missense possibly damaging 0.46
R6674:Armh3 UTSW 19 45,963,437 (GRCm39) missense probably benign 0.06
R6842:Armh3 UTSW 19 45,807,416 (GRCm39) missense probably benign 0.05
R6890:Armh3 UTSW 19 45,948,796 (GRCm39) missense probably damaging 1.00
R7034:Armh3 UTSW 19 45,953,688 (GRCm39) missense probably damaging 0.98
R7036:Armh3 UTSW 19 45,953,688 (GRCm39) missense probably damaging 0.98
R7305:Armh3 UTSW 19 45,880,560 (GRCm39) missense probably benign 0.35
R7411:Armh3 UTSW 19 45,953,874 (GRCm39) missense probably benign 0.00
R7762:Armh3 UTSW 19 45,928,882 (GRCm39) critical splice donor site probably null
R8021:Armh3 UTSW 19 45,945,180 (GRCm39) critical splice acceptor site probably null
R8366:Armh3 UTSW 19 45,920,793 (GRCm39) missense probably damaging 1.00
R9336:Armh3 UTSW 19 45,945,120 (GRCm39) missense probably damaging 1.00
X0060:Armh3 UTSW 19 45,920,832 (GRCm39) missense possibly damaging 0.95
Z1088:Armh3 UTSW 19 45,807,344 (GRCm39) missense probably damaging 1.00
Posted On 2016-08-02