Incidental Mutation 'IGL03113:Zfp128'
| ID |
419291 |
| Institutional Source |
Australian Phenomics Network
(link to record)
|
| Gene Symbol |
Zfp128
|
| Ensembl Gene |
ENSMUSG00000060397 |
| Gene Name |
zinc finger protein 128 |
| Synonyms |
mZnf8, 9630016P15Rik |
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.100)
|
| Stock # |
IGL03113
|
| Quality Score |
|
|
Status
|
|
| Chromosome |
7 |
| Chromosomal Location |
12615105-12627349 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 12624314 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 227
(D227E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000115378
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000144578]
|
| AlphaFold |
Q8BGV5 |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000081891
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000144578
AA Change: D227E
PolyPhen 2
Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
|
| SMART Domains |
Protein: ENSMUSP00000115378
Gene: ENSMUSG00000060397
AA Change: D227E
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
25 |
85 |
2.51e-38 |
SMART |
|
ZnF_C2H2
|
254 |
276 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
282 |
304 |
5.21e-4 |
SMART |
|
ZnF_C2H2
|
310 |
332 |
4.17e-3 |
SMART |
|
ZnF_C2H2
|
338 |
360 |
3.89e-3 |
SMART |
|
ZnF_C2H2
|
366 |
388 |
1.47e-3 |
SMART |
|
ZnF_C2H2
|
394 |
416 |
8.47e-4 |
SMART |
|
ZnF_C2H2
|
464 |
486 |
3.39e-3 |
SMART |
|
| Coding Region Coverage |
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 41 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Apof |
G |
A |
10: 128,105,568 (GRCm39) |
V241M |
probably benign |
Het |
| Arhgef10 |
T |
A |
8: 15,004,505 (GRCm39) |
I91N |
probably damaging |
Het |
| Arhgef17 |
G |
A |
7: 100,578,938 (GRCm39) |
T670I |
probably benign |
Het |
| Barhl1 |
T |
C |
2: 28,805,468 (GRCm39) |
D75G |
probably benign |
Het |
| Capn13 |
T |
C |
17: 73,638,108 (GRCm39) |
T432A |
probably benign |
Het |
| Casd1 |
T |
A |
6: 4,640,951 (GRCm39) |
Y691N |
probably damaging |
Het |
| Ccdc175 |
C |
A |
12: 72,191,557 (GRCm39) |
V340L |
probably benign |
Het |
| Cdc5l |
A |
T |
17: 45,744,348 (GRCm39) |
M5K |
possibly damaging |
Het |
| Cgn |
A |
G |
3: 94,686,544 (GRCm39) |
F253L |
probably benign |
Het |
| Csmd1 |
T |
C |
8: 16,078,712 (GRCm39) |
K2003R |
probably benign |
Het |
| Disp2 |
T |
A |
2: 118,621,259 (GRCm39) |
|
probably null |
Het |
| Dnah7a |
T |
C |
1: 53,472,163 (GRCm39) |
N3535D |
possibly damaging |
Het |
| Exoc3 |
G |
A |
13: 74,341,232 (GRCm39) |
Q191* |
probably null |
Het |
| Fstl5 |
T |
A |
3: 76,337,099 (GRCm39) |
Y219* |
probably null |
Het |
| Gad2 |
T |
A |
2: 22,571,367 (GRCm39) |
L435Q |
probably benign |
Het |
| Gcnt3 |
A |
G |
9: 69,941,983 (GRCm39) |
V195A |
probably damaging |
Het |
| Haus6 |
G |
A |
4: 86,501,343 (GRCm39) |
Q843* |
probably null |
Het |
| Hivep2 |
T |
A |
10: 14,006,395 (GRCm39) |
F998I |
probably damaging |
Het |
| Hsf5 |
A |
T |
11: 87,548,190 (GRCm39) |
E624D |
probably benign |
Het |
| Klb |
A |
G |
5: 65,540,813 (GRCm39) |
N969D |
probably benign |
Het |
| Klhl6 |
T |
A |
16: 19,776,001 (GRCm39) |
S186C |
possibly damaging |
Het |
| Klk15 |
T |
C |
7: 43,587,805 (GRCm39) |
F78L |
probably benign |
Het |
| Ldlr |
A |
G |
9: 21,651,124 (GRCm39) |
E514G |
possibly damaging |
Het |
| Map9 |
T |
A |
3: 82,267,285 (GRCm39) |
|
probably benign |
Het |
| Miga2 |
A |
T |
2: 30,274,022 (GRCm39) |
I99F |
possibly damaging |
Het |
| Morc4 |
T |
C |
X: 138,758,605 (GRCm39) |
E189G |
probably benign |
Het |
| Nhlrc3 |
A |
T |
3: 53,365,984 (GRCm39) |
Y170N |
possibly damaging |
Het |
| Or3a1b |
G |
A |
11: 74,012,529 (GRCm39) |
R138Q |
probably benign |
Het |
| Or4c111 |
A |
G |
2: 88,844,379 (GRCm39) |
F10L |
probably damaging |
Het |
| Or51b6b |
A |
T |
7: 103,309,851 (GRCm39) |
V202D |
possibly damaging |
Het |
| Or52u1 |
A |
T |
7: 104,237,940 (GRCm39) |
R310W |
probably benign |
Het |
| Or5o1 |
T |
A |
X: 48,815,939 (GRCm39) |
N291Y |
probably damaging |
Het |
| Or5w15 |
T |
C |
2: 87,568,506 (GRCm39) |
Q54R |
probably benign |
Het |
| Or8g32 |
A |
C |
9: 39,305,981 (GRCm39) |
K295T |
probably damaging |
Het |
| Pkd1l1 |
G |
A |
11: 8,784,793 (GRCm39) |
T1997I |
probably benign |
Het |
| Poln |
A |
G |
5: 34,274,206 (GRCm39) |
S377P |
probably benign |
Het |
| Rab22a |
T |
A |
2: 173,503,265 (GRCm39) |
V26E |
probably damaging |
Het |
| Rhbdl3 |
T |
C |
11: 80,244,439 (GRCm39) |
V382A |
possibly damaging |
Het |
| Slitrk3 |
G |
T |
3: 72,957,723 (GRCm39) |
Q350K |
probably benign |
Het |
| Sult1d1 |
A |
T |
5: 87,707,738 (GRCm39) |
Y127* |
probably null |
Het |
| Vmn1r73 |
A |
T |
7: 11,490,527 (GRCm39) |
Y115F |
probably benign |
Het |
|
| Other mutations in Zfp128 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01140:Zfp128
|
APN |
7 |
12,624,949 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01293:Zfp128
|
APN |
7 |
12,625,351 (GRCm39) |
makesense |
probably null |
|
|
IGL02067:Zfp128
|
APN |
7 |
12,618,977 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL02146:Zfp128
|
APN |
7 |
12,623,959 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
IGL02654:Zfp128
|
APN |
7 |
12,618,606 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03066:Zfp128
|
APN |
7 |
12,624,044 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03076:Zfp128
|
APN |
7 |
12,618,636 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL03237:Zfp128
|
APN |
7 |
12,624,953 (GRCm39) |
missense |
probably benign |
0.28 |
|
prayer
|
UTSW |
7 |
12,624,563 (GRCm39) |
nonsense |
probably null |
|
|
R0783:Zfp128
|
UTSW |
7 |
12,624,199 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1686:Zfp128
|
UTSW |
7 |
12,624,563 (GRCm39) |
nonsense |
probably null |
|
|
R1806:Zfp128
|
UTSW |
7 |
12,624,949 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2021:Zfp128
|
UTSW |
7 |
12,623,956 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R3792:Zfp128
|
UTSW |
7 |
12,618,659 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4105:Zfp128
|
UTSW |
7 |
12,618,667 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4167:Zfp128
|
UTSW |
7 |
12,624,289 (GRCm39) |
missense |
probably benign |
0.28 |
|
R4168:Zfp128
|
UTSW |
7 |
12,624,289 (GRCm39) |
missense |
probably benign |
0.28 |
|
R5743:Zfp128
|
UTSW |
7 |
12,618,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6266:Zfp128
|
UTSW |
7 |
12,624,897 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6799:Zfp128
|
UTSW |
7 |
12,624,826 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7102:Zfp128
|
UTSW |
7 |
12,624,399 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7313:Zfp128
|
UTSW |
7 |
12,624,461 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7428:Zfp128
|
UTSW |
7 |
12,624,289 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7504:Zfp128
|
UTSW |
7 |
12,624,405 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7539:Zfp128
|
UTSW |
7 |
12,624,479 (GRCm39) |
nonsense |
probably null |
|
|
R7636:Zfp128
|
UTSW |
7 |
12,624,039 (GRCm39) |
missense |
probably benign |
|
|
R7755:Zfp128
|
UTSW |
7 |
12,624,240 (GRCm39) |
nonsense |
probably null |
|
|
R7820:Zfp128
|
UTSW |
7 |
12,624,949 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8269:Zfp128
|
UTSW |
7 |
12,624,663 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Zfp128
|
UTSW |
7 |
12,625,113 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R9361:Zfp128
|
UTSW |
7 |
12,624,364 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9381:Zfp128
|
UTSW |
7 |
12,624,897 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
| Posted On |
2016-08-02 |
Incidental Mutation