Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03113:Hsf5'

419293

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Hsf5

Ensembl Gene

ENSMUSG00000070345

Gene Name

heat shock transcription factor family member 5

Synonyms

LOC327992

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.203) question?

Stock #

IGL03113

Quality Score

Status

Chromosome

Chromosomal Location

87507990-87550368 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 87548190 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Aspartic acid at position 624 (E624D)

Ref Sequence

ENSEMBL: ENSMUSP00000091488 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000093956]

AlphaFold

Q5ND04

Predicted Effect

probably benign
Transcript: ENSMUST00000093956
AA Change: E624D

PolyPhen 2 Score 0.033 (Sensitivity: 0.95; Specificity: 0.82)

SMART Domains

Protein: ENSMUSP00000091488
Gene: ENSMUSG00000070345
AA Change: E624D

Domain	Start	End	E-Value	Type
HSF	11	153	2.35e-9	SMART
Blast:HSF	163	423	1e-149	BLAST
low complexity region	442	457	N/A	INTRINSIC

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Apof	G	A	10: 128,105,568 (GRCm39)	V241M	probably benign	Het
Arhgef10	T	A	8: 15,004,505 (GRCm39)	I91N	probably damaging	Het
Arhgef17	G	A	7: 100,578,938 (GRCm39)	T670I	probably benign	Het
Barhl1	T	C	2: 28,805,468 (GRCm39)	D75G	probably benign	Het
Capn13	T	C	17: 73,638,108 (GRCm39)	T432A	probably benign	Het
Casd1	T	A	6: 4,640,951 (GRCm39)	Y691N	probably damaging	Het
Ccdc175	C	A	12: 72,191,557 (GRCm39)	V340L	probably benign	Het
Cdc5l	A	T	17: 45,744,348 (GRCm39)	M5K	possibly damaging	Het
Cgn	A	G	3: 94,686,544 (GRCm39)	F253L	probably benign	Het
Csmd1	T	C	8: 16,078,712 (GRCm39)	K2003R	probably benign	Het
Disp2	T	A	2: 118,621,259 (GRCm39)		probably null	Het
Dnah7a	T	C	1: 53,472,163 (GRCm39)	N3535D	possibly damaging	Het
Exoc3	G	A	13: 74,341,232 (GRCm39)	Q191*	probably null	Het
Fstl5	T	A	3: 76,337,099 (GRCm39)	Y219*	probably null	Het
Gad2	T	A	2: 22,571,367 (GRCm39)	L435Q	probably benign	Het
Gcnt3	A	G	9: 69,941,983 (GRCm39)	V195A	probably damaging	Het
Haus6	G	A	4: 86,501,343 (GRCm39)	Q843*	probably null	Het
Hivep2	T	A	10: 14,006,395 (GRCm39)	F998I	probably damaging	Het
Klb	A	G	5: 65,540,813 (GRCm39)	N969D	probably benign	Het
Klhl6	T	A	16: 19,776,001 (GRCm39)	S186C	possibly damaging	Het
Klk15	T	C	7: 43,587,805 (GRCm39)	F78L	probably benign	Het
Ldlr	A	G	9: 21,651,124 (GRCm39)	E514G	possibly damaging	Het
Map9	T	A	3: 82,267,285 (GRCm39)		probably benign	Het
Miga2	A	T	2: 30,274,022 (GRCm39)	I99F	possibly damaging	Het
Morc4	T	C	X: 138,758,605 (GRCm39)	E189G	probably benign	Het
Nhlrc3	A	T	3: 53,365,984 (GRCm39)	Y170N	possibly damaging	Het
Or3a1b	G	A	11: 74,012,529 (GRCm39)	R138Q	probably benign	Het
Or4c111	A	G	2: 88,844,379 (GRCm39)	F10L	probably damaging	Het
Or51b6b	A	T	7: 103,309,851 (GRCm39)	V202D	possibly damaging	Het
Or52u1	A	T	7: 104,237,940 (GRCm39)	R310W	probably benign	Het
Or5o1	T	A	X: 48,815,939 (GRCm39)	N291Y	probably damaging	Het
Or5w15	T	C	2: 87,568,506 (GRCm39)	Q54R	probably benign	Het
Or8g32	A	C	9: 39,305,981 (GRCm39)	K295T	probably damaging	Het
Pkd1l1	G	A	11: 8,784,793 (GRCm39)	T1997I	probably benign	Het
Poln	A	G	5: 34,274,206 (GRCm39)	S377P	probably benign	Het
Rab22a	T	A	2: 173,503,265 (GRCm39)	V26E	probably damaging	Het
Rhbdl3	T	C	11: 80,244,439 (GRCm39)	V382A	possibly damaging	Het
Slitrk3	G	T	3: 72,957,723 (GRCm39)	Q350K	probably benign	Het
Sult1d1	A	T	5: 87,707,738 (GRCm39)	Y127*	probably null	Het
Vmn1r73	A	T	7: 11,490,527 (GRCm39)	Y115F	probably benign	Het
Zfp128	T	A	7: 12,624,314 (GRCm39)	D227E	probably benign	Het

Other mutations in Hsf5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00514:Hsf5	APN	11	87,513,922 (GRCm39)	missense	probably damaging	0.99
IGL01726:Hsf5	APN	11	87,526,951 (GRCm39)	missense	probably benign	0.22
IGL02480:Hsf5	APN	11	87,522,483 (GRCm39)	missense	possibly damaging	0.67
IGL02572:Hsf5	APN	11	87,522,521 (GRCm39)	splice site	probably benign
R0015:Hsf5	UTSW	11	87,548,161 (GRCm39)	missense	probably benign
R0015:Hsf5	UTSW	11	87,548,161 (GRCm39)	missense	probably benign
R1381:Hsf5	UTSW	11	87,528,995 (GRCm39)	missense	probably benign
R1807:Hsf5	UTSW	11	87,548,168 (GRCm39)	missense	probably benign	0.04
R1838:Hsf5	UTSW	11	87,526,881 (GRCm39)	missense	probably benign	0.45
R2187:Hsf5	UTSW	11	87,529,010 (GRCm39)	missense	possibly damaging	0.51
R3930:Hsf5	UTSW	11	87,522,508 (GRCm39)	missense	probably damaging	1.00
R3931:Hsf5	UTSW	11	87,522,508 (GRCm39)	missense	probably damaging	1.00
R4420:Hsf5	UTSW	11	87,548,130 (GRCm39)	missense	probably benign	0.02
R4423:Hsf5	UTSW	11	87,522,460 (GRCm39)	missense	probably damaging	0.99
R4744:Hsf5	UTSW	11	87,513,617 (GRCm39)	missense	probably benign	0.02
R4795:Hsf5	UTSW	11	87,526,446 (GRCm39)	missense	probably benign	0.18
R5862:Hsf5	UTSW	11	87,513,817 (GRCm39)	missense	probably damaging	0.96
R6232:Hsf5	UTSW	11	87,508,120 (GRCm39)	missense	probably benign	0.05
R6234:Hsf5	UTSW	11	87,508,120 (GRCm39)	missense	probably benign	0.05
R6609:Hsf5	UTSW	11	87,526,779 (GRCm39)	missense	probably damaging	0.99
R7821:Hsf5	UTSW	11	87,528,954 (GRCm39)	missense	probably benign	0.04
R7989:Hsf5	UTSW	11	87,526,450 (GRCm39)	missense	probably benign	0.07
R9299:Hsf5	UTSW	11	87,526,770 (GRCm39)	missense	probably benign
R9419:Hsf5	UTSW	11	87,528,935 (GRCm39)	missense	probably benign	0.02
R9752:Hsf5	UTSW	11	87,513,709 (GRCm39)	missense	probably benign	0.22
Z1177:Hsf5	UTSW	11	87,528,959 (GRCm39)	nonsense	probably null

Posted On

2016-08-02