Incidental Mutation 'R0480:Dock1'
| ID |
41933 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dock1
|
| Ensembl Gene |
ENSMUSG00000058325 |
| Gene Name |
dedicator of cytokinesis 1 |
| Synonyms |
D630004B07Rik, 9130006G06Rik, b2b3190Clo, Dock180 |
| MMRRC Submission |
038680-MU
|
| Accession Numbers |
|
| Essential gene? |
Essential
(E-score: 1.000)
|
| Stock # |
R0480 (G1)
|
| Quality Score |
197 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
134272416-134775376 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to T
at 134339447 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Phenylalanine
at position 106
(L106F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000081531
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000084488]
[ENSMUST00000211593]
|
| AlphaFold |
Q8BUR4 |
| PDB Structure |
Solution structure of the SH3 domain of DOCK180 [SOLUTION NMR]
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000084488
AA Change: L106F
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000081531
Gene: ENSMUSG00000058325
AA Change: L106F
| Domain | Start | End | E-Value | Type |
|---|
|
SH3
|
12 |
69 |
7.57e-17 |
SMART |
|
Pfam:DOCK_N
|
72 |
416 |
1.7e-113 |
PFAM |
|
Pfam:DOCK-C2
|
421 |
618 |
1.2e-61 |
PFAM |
|
low complexity region
|
628 |
639 |
N/A |
INTRINSIC |
|
Pfam:DHR-2
|
1111 |
1610 |
3.3e-102 |
PFAM |
|
low complexity region
|
1639 |
1664 |
N/A |
INTRINSIC |
|
low complexity region
|
1683 |
1701 |
N/A |
INTRINSIC |
|
low complexity region
|
1756 |
1773 |
N/A |
INTRINSIC |
|
low complexity region
|
1823 |
1857 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210464
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000210617
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000211570
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000211593
AA Change: L106F
PolyPhen 2
Score 0.990 (Sensitivity: 0.72; Specificity: 0.97)
|
| Meta Mutation Damage Score |
0.2178 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.3%
- 20x: 92.6%
|
| Validation Efficiency |
99% (117/118) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
PHENOTYPE: Mice homozygous for a null allele exhibit postnatal lethality associated with abnormal muscle development and failure of lungs to inflate. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
C |
T |
11: 58,771,012 (GRCm39) |
L165F |
probably damaging |
Het |
| Adamts18 |
A |
G |
8: 114,465,450 (GRCm39) |
V714A |
possibly damaging |
Het |
| Adamtsl1 |
G |
T |
4: 86,171,055 (GRCm39) |
A518S |
probably benign |
Het |
| Adcy2 |
C |
T |
13: 68,880,231 (GRCm39) |
V363M |
probably damaging |
Het |
| Ago4 |
G |
T |
4: 126,419,870 (GRCm39) |
Q36K |
probably benign |
Het |
| Akr1a1 |
A |
G |
4: 116,497,044 (GRCm39) |
V172A |
possibly damaging |
Het |
| Alkbh2 |
T |
A |
5: 114,263,596 (GRCm39) |
N137I |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,715,756 (GRCm39) |
S470T |
probably damaging |
Het |
| Ankrd12 |
T |
C |
17: 66,356,823 (GRCm39) |
T65A |
possibly damaging |
Het |
| Aox1 |
A |
T |
1: 58,082,810 (GRCm39) |
|
probably benign |
Het |
| Arhgap11a |
A |
T |
2: 113,670,163 (GRCm39) |
I320N |
probably benign |
Het |
| Arhgap17 |
G |
A |
7: 122,893,867 (GRCm39) |
H518Y |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,611,348 (GRCm39) |
V1563A |
probably damaging |
Het |
| Atf2 |
G |
A |
2: 73,649,500 (GRCm39) |
|
probably benign |
Het |
| Bmpr2 |
C |
T |
1: 59,884,818 (GRCm39) |
T268I |
probably damaging |
Het |
| Bpifb9a |
A |
G |
2: 154,106,608 (GRCm39) |
I380V |
probably benign |
Het |
| C2cd2 |
G |
A |
16: 97,678,348 (GRCm39) |
T363I |
probably benign |
Het |
| Catsperg2 |
T |
G |
7: 29,420,723 (GRCm39) |
N190H |
probably damaging |
Het |
| Ccdc138 |
T |
C |
10: 58,397,789 (GRCm39) |
L543S |
probably damaging |
Het |
| Ccdc170 |
A |
T |
10: 4,468,939 (GRCm39) |
K162N |
probably benign |
Het |
| Cdca5 |
G |
T |
19: 6,140,328 (GRCm39) |
R163L |
probably damaging |
Het |
| Cdh24 |
A |
G |
14: 54,870,054 (GRCm39) |
F239S |
probably benign |
Het |
| Cdkl3 |
T |
C |
11: 51,895,882 (GRCm39) |
V43A |
probably damaging |
Het |
| Cep152 |
G |
T |
2: 125,423,639 (GRCm39) |
Q921K |
possibly damaging |
Het |
| Cftr |
G |
A |
6: 18,274,517 (GRCm39) |
|
probably benign |
Het |
| Chmp5 |
T |
C |
4: 40,948,690 (GRCm39) |
|
probably benign |
Het |
| Cit |
T |
A |
5: 116,071,452 (GRCm39) |
|
probably benign |
Het |
| Cngb3 |
T |
A |
4: 19,309,517 (GRCm39) |
|
probably benign |
Het |
| Cnr2 |
A |
G |
4: 135,644,912 (GRCm39) |
E330G |
probably benign |
Het |
| Cyp21a1 |
A |
T |
17: 35,020,800 (GRCm39) |
L473Q |
probably damaging |
Het |
| Dchs1 |
T |
C |
7: 105,420,696 (GRCm39) |
T575A |
probably benign |
Het |
| Dedd2 |
A |
G |
7: 24,903,050 (GRCm39) |
V303A |
probably damaging |
Het |
| Dmd |
G |
T |
X: 83,469,344 (GRCm39) |
A2370S |
probably benign |
Het |
| Dnah10 |
T |
A |
5: 124,885,915 (GRCm39) |
N3009K |
probably damaging |
Het |
| Dnajc13 |
G |
T |
9: 104,077,708 (GRCm39) |
N934K |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 15,909,025 (GRCm39) |
Y2326H |
probably benign |
Het |
| Fhl5 |
A |
T |
4: 25,207,101 (GRCm39) |
C222* |
probably null |
Het |
| Gnmt |
T |
C |
17: 47,036,854 (GRCm39) |
T252A |
probably benign |
Het |
| Gpi-ps |
A |
G |
8: 5,689,888 (GRCm39) |
|
noncoding transcript |
Het |
| Gsta5 |
C |
T |
9: 78,210,099 (GRCm39) |
A135V |
probably benign |
Het |
| Gtf2f1 |
A |
G |
17: 57,311,307 (GRCm39) |
|
probably null |
Het |
| Gtf3a |
T |
C |
5: 146,890,039 (GRCm39) |
Y187H |
probably damaging |
Het |
| Hdac2 |
A |
G |
10: 36,850,788 (GRCm39) |
Y14C |
probably damaging |
Het |
| Hnrnph1 |
T |
G |
11: 50,276,589 (GRCm39) |
|
probably benign |
Het |
| Homer2 |
T |
C |
7: 81,268,351 (GRCm39) |
D92G |
possibly damaging |
Het |
| Hspg2 |
T |
C |
4: 137,277,335 (GRCm39) |
S2885P |
probably damaging |
Het |
| Insr |
A |
G |
8: 3,211,770 (GRCm39) |
S1084P |
probably damaging |
Het |
| Ints11 |
T |
A |
4: 155,972,081 (GRCm39) |
V362E |
probably damaging |
Het |
| Kank2 |
T |
C |
9: 21,691,195 (GRCm39) |
N513S |
probably damaging |
Het |
| Kl |
T |
G |
5: 150,876,753 (GRCm39) |
V191G |
probably damaging |
Het |
| Krt23 |
A |
G |
11: 99,377,524 (GRCm39) |
|
probably null |
Het |
| Lama3 |
A |
C |
18: 12,583,481 (GRCm39) |
T690P |
possibly damaging |
Het |
| Lamb1 |
G |
A |
12: 31,332,720 (GRCm39) |
A281T |
possibly damaging |
Het |
| Lck |
T |
C |
4: 129,449,433 (GRCm39) |
E299G |
probably damaging |
Het |
| Lonrf1 |
A |
G |
8: 36,689,864 (GRCm39) |
V703A |
probably damaging |
Het |
| Ly6f |
T |
C |
15: 75,143,526 (GRCm39) |
C78R |
probably damaging |
Het |
| Mapkap1 |
C |
T |
2: 34,423,793 (GRCm39) |
|
probably benign |
Het |
| Mast1 |
T |
A |
8: 85,639,718 (GRCm39) |
I1204F |
probably damaging |
Het |
| Mbd6 |
C |
T |
10: 127,121,742 (GRCm39) |
|
probably benign |
Het |
| Mef2c |
A |
T |
13: 83,741,020 (GRCm39) |
T60S |
probably damaging |
Het |
| Mgat4c |
C |
T |
10: 102,224,980 (GRCm39) |
T398I |
probably damaging |
Het |
| Mmp12 |
C |
A |
9: 7,350,016 (GRCm39) |
H102Q |
probably damaging |
Het |
| Mmp20 |
G |
A |
9: 7,645,374 (GRCm39) |
G308E |
probably damaging |
Het |
| Mms19 |
A |
T |
19: 41,943,285 (GRCm39) |
L395Q |
probably damaging |
Het |
| Mus81 |
A |
G |
19: 5,537,959 (GRCm39) |
|
probably benign |
Het |
| Mypn |
C |
T |
10: 63,028,982 (GRCm39) |
R27H |
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,689,161 (GRCm39) |
E372G |
probably damaging |
Het |
| Ncoa1 |
T |
A |
12: 4,389,105 (GRCm39) |
I57F |
probably damaging |
Het |
| Ncstn |
T |
C |
1: 171,910,159 (GRCm39) |
|
probably benign |
Het |
| Nefm |
C |
T |
14: 68,361,608 (GRCm39) |
D219N |
probably damaging |
Het |
| Notch2 |
C |
T |
3: 98,053,853 (GRCm39) |
T2172I |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 59,024,772 (GRCm39) |
K423* |
probably null |
Het |
| Or51l14 |
A |
G |
7: 103,100,835 (GRCm39) |
N97S |
probably benign |
Het |
| Or5d37 |
A |
C |
2: 87,923,972 (GRCm39) |
S103A |
probably benign |
Het |
| Or5k1 |
T |
C |
16: 58,617,684 (GRCm39) |
N175S |
probably benign |
Het |
| Or9a2 |
A |
T |
6: 41,749,198 (GRCm39) |
C12S |
probably benign |
Het |
| Ostm1 |
T |
A |
10: 42,572,343 (GRCm39) |
M242K |
probably damaging |
Het |
| Oxnad1 |
T |
A |
14: 31,821,437 (GRCm39) |
I154N |
probably damaging |
Het |
| Pcdhb10 |
T |
A |
18: 37,546,152 (GRCm39) |
D409E |
probably damaging |
Het |
| Pdcd11 |
T |
C |
19: 47,113,476 (GRCm39) |
|
probably benign |
Het |
| Peak1 |
C |
A |
9: 56,165,916 (GRCm39) |
V671L |
probably benign |
Het |
| Pex1 |
G |
A |
5: 3,656,444 (GRCm39) |
|
probably null |
Het |
| Plk4 |
T |
A |
3: 40,760,075 (GRCm39) |
F324I |
probably benign |
Het |
| Poglut2 |
C |
T |
1: 44,149,917 (GRCm39) |
W424* |
probably null |
Het |
| Ppfibp1 |
C |
A |
6: 146,920,529 (GRCm39) |
|
probably null |
Het |
| Prcp |
T |
A |
7: 92,568,290 (GRCm39) |
W276R |
probably damaging |
Het |
| Prr14l |
T |
C |
5: 32,987,224 (GRCm39) |
E757G |
probably benign |
Het |
| Prss52 |
T |
A |
14: 64,351,093 (GRCm39) |
Y293N |
probably damaging |
Het |
| Prune2 |
A |
G |
19: 16,984,156 (GRCm39) |
|
probably benign |
Het |
| Ptprk |
G |
C |
10: 28,461,943 (GRCm39) |
A84P |
probably damaging |
Het |
| Ptprk |
C |
T |
10: 28,461,944 (GRCm39) |
A84V |
probably damaging |
Het |
| Rock1 |
A |
G |
18: 10,079,120 (GRCm39) |
L1116P |
possibly damaging |
Het |
| Sdha |
A |
T |
13: 74,475,452 (GRCm39) |
F526Y |
probably benign |
Het |
| Sema4b |
T |
C |
7: 79,869,954 (GRCm39) |
F414S |
probably damaging |
Het |
| Serpina12 |
T |
C |
12: 104,001,960 (GRCm39) |
D252G |
probably damaging |
Het |
| Siglecg |
C |
T |
7: 43,060,550 (GRCm39) |
A310V |
probably benign |
Het |
| Slc30a8 |
A |
G |
15: 52,188,966 (GRCm39) |
I194V |
probably benign |
Het |
| Spred3 |
A |
G |
7: 28,862,400 (GRCm39) |
S148P |
probably damaging |
Het |
| Taf9b |
A |
G |
X: 105,262,014 (GRCm39) |
S58P |
probably damaging |
Het |
| Tgm4 |
A |
T |
9: 122,891,484 (GRCm39) |
Y109F |
probably benign |
Het |
| Tmprss11c |
T |
G |
5: 86,385,468 (GRCm39) |
|
probably benign |
Het |
| Tmtc3 |
A |
T |
10: 100,307,266 (GRCm39) |
V246D |
probably damaging |
Het |
| Tnip1 |
C |
T |
11: 54,828,820 (GRCm39) |
G116R |
probably damaging |
Het |
| Tpr |
A |
G |
1: 150,303,992 (GRCm39) |
E1455G |
possibly damaging |
Het |
| Ttc3 |
T |
A |
16: 94,232,863 (GRCm39) |
L986* |
probably null |
Het |
| Txndc15 |
A |
G |
13: 55,872,436 (GRCm39) |
I275V |
possibly damaging |
Het |
| Ugt2b1 |
T |
A |
5: 87,074,315 (GRCm39) |
I15L |
probably benign |
Het |
| Upf2 |
T |
C |
2: 5,962,445 (GRCm39) |
V49A |
possibly damaging |
Het |
| Vmn1r117 |
G |
A |
7: 20,617,371 (GRCm39) |
P226S |
probably benign |
Het |
| Vmn2r28 |
A |
T |
7: 5,493,456 (GRCm39) |
H163Q |
probably benign |
Het |
| Vstm2a |
T |
A |
11: 16,213,240 (GRCm39) |
S208R |
probably damaging |
Het |
| Zfp346 |
T |
A |
13: 55,260,910 (GRCm39) |
C79* |
probably null |
Het |
| Zfp628 |
A |
T |
7: 4,924,615 (GRCm39) |
T946S |
probably benign |
Het |
|
| Other mutations in Dock1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00484:Dock1
|
APN |
7 |
134,748,260 (GRCm39) |
splice site |
probably benign |
|
|
IGL01319:Dock1
|
APN |
7 |
134,391,007 (GRCm39) |
missense |
probably benign |
|
|
IGL01390:Dock1
|
APN |
7 |
134,346,776 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01394:Dock1
|
APN |
7 |
134,367,945 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL01489:Dock1
|
APN |
7 |
134,601,050 (GRCm39) |
splice site |
probably benign |
|
|
IGL01505:Dock1
|
APN |
7 |
134,760,239 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
IGL01586:Dock1
|
APN |
7 |
134,355,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01637:Dock1
|
APN |
7 |
134,739,542 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
IGL01649:Dock1
|
APN |
7 |
134,379,139 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01652:Dock1
|
APN |
7 |
134,379,226 (GRCm39) |
splice site |
probably benign |
|
|
IGL01859:Dock1
|
APN |
7 |
134,678,890 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02068:Dock1
|
APN |
7 |
134,373,277 (GRCm39) |
missense |
probably benign |
0.26 |
|
IGL02168:Dock1
|
APN |
7 |
134,678,860 (GRCm39) |
splice site |
probably benign |
|
|
IGL02200:Dock1
|
APN |
7 |
134,346,000 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02244:Dock1
|
APN |
7 |
134,379,174 (GRCm39) |
nonsense |
probably null |
|
|
IGL02285:Dock1
|
APN |
7 |
134,683,649 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02319:Dock1
|
APN |
7 |
134,374,178 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02334:Dock1
|
APN |
7 |
134,747,294 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02338:Dock1
|
APN |
7 |
134,734,804 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02351:Dock1
|
APN |
7 |
134,710,548 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02358:Dock1
|
APN |
7 |
134,710,548 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
IGL02607:Dock1
|
APN |
7 |
134,453,242 (GRCm39) |
missense |
probably benign |
0.13 |
|
IGL02638:Dock1
|
APN |
7 |
134,748,209 (GRCm39) |
missense |
probably benign |
0.09 |
|
IGL02724:Dock1
|
APN |
7 |
134,765,082 (GRCm39) |
missense |
probably benign |
|
|
IGL02820:Dock1
|
APN |
7 |
134,768,944 (GRCm39) |
missense |
probably benign |
0.11 |
|
IGL02950:Dock1
|
APN |
7 |
134,331,753 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02993:Dock1
|
APN |
7 |
134,346,027 (GRCm39) |
missense |
probably benign |
|
|
IGL03000:Dock1
|
APN |
7 |
134,390,969 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL03092:Dock1
|
APN |
7 |
134,366,945 (GRCm39) |
splice site |
probably benign |
|
|
IGL03131:Dock1
|
APN |
7 |
134,475,912 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03136:Dock1
|
APN |
7 |
134,770,118 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03210:Dock1
|
APN |
7 |
134,358,668 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
IGL03220:Dock1
|
APN |
7 |
134,710,251 (GRCm39) |
critical splice donor site |
probably null |
|
|
P0028:Dock1
|
UTSW |
7 |
134,601,053 (GRCm39) |
splice site |
probably benign |
|
|
PIT4453001:Dock1
|
UTSW |
7 |
134,754,029 (GRCm39) |
missense |
probably benign |
|
|
R0003:Dock1
|
UTSW |
7 |
134,331,793 (GRCm39) |
splice site |
probably benign |
|
|
R0058:Dock1
|
UTSW |
7 |
134,710,490 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0058:Dock1
|
UTSW |
7 |
134,710,490 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R0062:Dock1
|
UTSW |
7 |
134,379,224 (GRCm39) |
splice site |
probably null |
|
|
R0062:Dock1
|
UTSW |
7 |
134,379,224 (GRCm39) |
splice site |
probably null |
|
|
R0179:Dock1
|
UTSW |
7 |
134,700,566 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0180:Dock1
|
UTSW |
7 |
134,700,566 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0347:Dock1
|
UTSW |
7 |
134,365,596 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0399:Dock1
|
UTSW |
7 |
134,765,171 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0457:Dock1
|
UTSW |
7 |
134,739,874 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R0521:Dock1
|
UTSW |
7 |
134,745,507 (GRCm39) |
missense |
probably benign |
0.21 |
|
R0792:Dock1
|
UTSW |
7 |
134,475,879 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1136:Dock1
|
UTSW |
7 |
134,449,902 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1224:Dock1
|
UTSW |
7 |
134,710,548 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R1267:Dock1
|
UTSW |
7 |
134,348,165 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1373:Dock1
|
UTSW |
7 |
134,768,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1401:Dock1
|
UTSW |
7 |
134,735,665 (GRCm39) |
nonsense |
probably null |
|
|
R1454:Dock1
|
UTSW |
7 |
134,453,338 (GRCm39) |
splice site |
probably benign |
|
|
R1465:Dock1
|
UTSW |
7 |
134,384,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1465:Dock1
|
UTSW |
7 |
134,384,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1523:Dock1
|
UTSW |
7 |
134,345,976 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1643:Dock1
|
UTSW |
7 |
134,700,508 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1659:Dock1
|
UTSW |
7 |
134,390,972 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1793:Dock1
|
UTSW |
7 |
134,700,456 (GRCm39) |
splice site |
probably null |
|
|
R1864:Dock1
|
UTSW |
7 |
134,748,236 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1911:Dock1
|
UTSW |
7 |
134,601,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2567:Dock1
|
UTSW |
7 |
134,747,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3816:Dock1
|
UTSW |
7 |
134,346,015 (GRCm39) |
nonsense |
probably null |
|
|
R3971:Dock1
|
UTSW |
7 |
134,348,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4063:Dock1
|
UTSW |
7 |
134,717,021 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4163:Dock1
|
UTSW |
7 |
134,346,051 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R4271:Dock1
|
UTSW |
7 |
134,335,783 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4684:Dock1
|
UTSW |
7 |
134,326,138 (GRCm39) |
nonsense |
probably null |
|
|
R4717:Dock1
|
UTSW |
7 |
134,449,899 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4725:Dock1
|
UTSW |
7 |
134,346,743 (GRCm39) |
nonsense |
probably null |
|
|
R4788:Dock1
|
UTSW |
7 |
134,747,213 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4869:Dock1
|
UTSW |
7 |
134,335,800 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4889:Dock1
|
UTSW |
7 |
134,346,705 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4953:Dock1
|
UTSW |
7 |
134,754,017 (GRCm39) |
missense |
probably benign |
0.34 |
|
R5031:Dock1
|
UTSW |
7 |
134,753,975 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5161:Dock1
|
UTSW |
7 |
134,335,791 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R5168:Dock1
|
UTSW |
7 |
134,720,637 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5212:Dock1
|
UTSW |
7 |
134,390,923 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R5648:Dock1
|
UTSW |
7 |
134,348,683 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5685:Dock1
|
UTSW |
7 |
134,374,091 (GRCm39) |
missense |
probably benign |
0.19 |
|
R5834:Dock1
|
UTSW |
7 |
134,365,662 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6181:Dock1
|
UTSW |
7 |
134,760,251 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6334:Dock1
|
UTSW |
7 |
134,453,305 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6406:Dock1
|
UTSW |
7 |
134,747,215 (GRCm39) |
missense |
probably benign |
0.26 |
|
R6425:Dock1
|
UTSW |
7 |
134,765,110 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R6489:Dock1
|
UTSW |
7 |
134,592,270 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6616:Dock1
|
UTSW |
7 |
134,710,221 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R6706:Dock1
|
UTSW |
7 |
134,735,615 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R6766:Dock1
|
UTSW |
7 |
134,358,522 (GRCm39) |
splice site |
probably null |
|
|
R6861:Dock1
|
UTSW |
7 |
134,373,207 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6985:Dock1
|
UTSW |
7 |
134,765,132 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R7259:Dock1
|
UTSW |
7 |
134,384,477 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7285:Dock1
|
UTSW |
7 |
134,346,737 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7471:Dock1
|
UTSW |
7 |
134,765,072 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7497:Dock1
|
UTSW |
7 |
134,367,003 (GRCm39) |
missense |
probably benign |
|
|
R7691:Dock1
|
UTSW |
7 |
134,739,886 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7732:Dock1
|
UTSW |
7 |
134,346,699 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7818:Dock1
|
UTSW |
7 |
134,365,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7918:Dock1
|
UTSW |
7 |
134,747,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7960:Dock1
|
UTSW |
7 |
134,678,917 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7961:Dock1
|
UTSW |
7 |
134,346,786 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R7985:Dock1
|
UTSW |
7 |
134,348,683 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8009:Dock1
|
UTSW |
7 |
134,346,786 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R8060:Dock1
|
UTSW |
7 |
134,592,358 (GRCm39) |
splice site |
probably benign |
|
|
R8060:Dock1
|
UTSW |
7 |
134,770,132 (GRCm39) |
missense |
probably benign |
|
|
R8061:Dock1
|
UTSW |
7 |
134,374,052 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8101:Dock1
|
UTSW |
7 |
134,601,017 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8405:Dock1
|
UTSW |
7 |
134,379,192 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8508:Dock1
|
UTSW |
7 |
134,384,138 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8803:Dock1
|
UTSW |
7 |
134,475,816 (GRCm39) |
missense |
probably benign |
0.28 |
|
R9007:Dock1
|
UTSW |
7 |
134,500,825 (GRCm39) |
intron |
probably benign |
|
|
R9026:Dock1
|
UTSW |
7 |
134,720,746 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9111:Dock1
|
UTSW |
7 |
134,601,017 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9359:Dock1
|
UTSW |
7 |
134,770,125 (GRCm39) |
missense |
probably benign |
|
|
R9398:Dock1
|
UTSW |
7 |
134,774,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9403:Dock1
|
UTSW |
7 |
134,770,125 (GRCm39) |
missense |
probably benign |
|
|
R9408:Dock1
|
UTSW |
7 |
134,717,065 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9476:Dock1
|
UTSW |
7 |
134,592,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9478:Dock1
|
UTSW |
7 |
134,367,962 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9510:Dock1
|
UTSW |
7 |
134,592,279 (GRCm39) |
missense |
probably benign |
0.10 |
|
R9544:Dock1
|
UTSW |
7 |
134,348,186 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R9605:Dock1
|
UTSW |
7 |
134,384,141 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R9657:Dock1
|
UTSW |
7 |
134,339,429 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R9767:Dock1
|
UTSW |
7 |
134,342,796 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
X0062:Dock1
|
UTSW |
7 |
134,710,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1088:Dock1
|
UTSW |
7 |
134,406,276 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1177:Dock1
|
UTSW |
7 |
134,384,129 (GRCm39) |
nonsense |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ATGGCTTCCAGGCAGGATAATGTG -3'
(R):5'- GCTCTGTCCTTCAGAAGCAAGACC -3'
Sequencing Primer
(F):5'- GCAGGATAATGTGTAGACATCTCC -3'
(R):5'- GCAAGACCCTGCTCAGAG -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation