Incidental Mutation 'IGL03114:Tmco3'
ID 419343
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Tmco3
Ensembl Gene ENSMUSG00000038497
Gene Name transmembrane and coiled-coil domains 3
Synonyms B230339H12Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL03114
Quality Score
Status
Chromosome 8
Chromosomal Location 13338190-13372924 bp(+) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) T to C at 13348205 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000040347 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000045229]
AlphaFold Q8BH01
Predicted Effect probably benign
Transcript: ENSMUST00000045229
SMART Domains Protein: ENSMUSP00000040347
Gene: ENSMUSG00000038497

DomainStartEndE-ValueType
signal peptide 1 23 N/A INTRINSIC
coiled coil region 124 204 N/A INTRINSIC
Pfam:Na_H_Exchanger 274 662 9.2e-74 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210063
Predicted Effect noncoding transcript
Transcript: ENSMUST00000210402
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211645
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aadacl2fm2 A T 3: 59,651,144 (GRCm39) I89F possibly damaging Het
Abca13 T A 11: 9,478,999 (GRCm39) H4282Q probably benign Het
Acta2 A G 19: 34,222,310 (GRCm39) probably null Het
Arl10 A G 13: 54,723,579 (GRCm39) probably benign Het
Avpr1a A G 10: 122,285,623 (GRCm39) Y305C probably damaging Het
Bmpr2 T A 1: 59,906,603 (GRCm39) N565K probably damaging Het
Boc A T 16: 44,307,115 (GRCm39) S1035R probably benign Het
Brd10 A T 19: 29,694,532 (GRCm39) S1654T probably benign Het
Ccdc7a T C 8: 129,753,170 (GRCm39) N187S possibly damaging Het
Cntn5 C T 9: 9,748,457 (GRCm39) E680K probably damaging Het
Copa T A 1: 171,946,835 (GRCm39) Y1014* probably null Het
Csmd3 A G 15: 47,683,847 (GRCm39) S1662P probably damaging Het
Cyp2e1 T C 7: 140,353,042 (GRCm39) F360L possibly damaging Het
Efnb3 A T 11: 69,447,628 (GRCm39) probably benign Het
Egf A T 3: 129,530,529 (GRCm39) L211Q probably damaging Het
Eno1 G A 4: 150,325,583 (GRCm39) R56H probably benign Het
Fyb2 A G 4: 104,852,975 (GRCm39) T552A probably damaging Het
Git2 G A 5: 114,871,918 (GRCm39) probably benign Het
Gtf2ird2 A G 5: 134,245,752 (GRCm39) probably null Het
Hyal4 A T 6: 24,755,964 (GRCm39) I61L probably benign Het
Kat14 T C 2: 144,217,885 (GRCm39) probably null Het
Kif13b T C 14: 65,025,897 (GRCm39) V1418A probably benign Het
Lcn12 T C 2: 25,383,274 (GRCm39) K35E probably benign Het
Lyrm7 G T 11: 54,741,198 (GRCm39) N45K possibly damaging Het
Mical2 G T 7: 111,996,764 (GRCm39) G559V probably damaging Het
Mtrr A T 13: 68,712,441 (GRCm39) C648* probably null Het
Muc5b C A 7: 141,412,556 (GRCm39) S1834* probably null Het
Mup16 G A 4: 61,436,250 (GRCm39) T101M probably benign Het
Myof A T 19: 37,892,309 (GRCm39) L1148Q probably damaging Het
Nags A T 11: 102,039,814 (GRCm39) I501F probably damaging Het
Nbeal1 A T 1: 60,317,886 (GRCm39) Y672F probably damaging Het
Ncapg2 A G 12: 116,415,993 (GRCm39) probably benign Het
Obscn A G 11: 58,891,365 (GRCm39) S7056P unknown Het
Or52s1 T C 7: 102,861,928 (GRCm39) I287T probably damaging Het
Pde2a C A 7: 101,157,890 (GRCm39) probably benign Het
Piezo2 T C 18: 63,163,343 (GRCm39) probably null Het
Pkhd1 C A 1: 20,268,395 (GRCm39) D3328Y probably damaging Het
Plxdc2 T C 2: 16,654,935 (GRCm39) V178A probably damaging Het
Prdx3 T C 19: 60,861,556 (GRCm39) probably benign Het
Prkce T A 17: 86,961,983 (GRCm39) D694E probably damaging Het
Prss1l T A 6: 41,374,012 (GRCm39) C205S probably damaging Het
Ptdss1 T A 13: 67,142,058 (GRCm39) Y405* probably null Het
Rad54l A T 4: 115,955,729 (GRCm39) W608R probably damaging Het
Rassf6 G T 5: 90,756,649 (GRCm39) probably benign Het
Sema5a A T 15: 32,673,573 (GRCm39) I804F probably damaging Het
Slc15a2 A T 16: 36,572,267 (GRCm39) I668N probably damaging Het
Thsd7b A G 1: 130,116,288 (GRCm39) E1347G probably benign Het
Ttn T C 2: 76,551,996 (GRCm39) M31214V probably null Het
Uck1 G A 2: 32,148,334 (GRCm39) R161C probably benign Het
Ugt2b5 T C 5: 87,276,209 (GRCm39) Y355C probably damaging Het
Usp48 C A 4: 137,383,436 (GRCm39) T1031K probably damaging Het
Vmn1r202 G A 13: 22,685,640 (GRCm39) T259I probably benign Het
Vmn1r202 T A 13: 22,685,500 (GRCm39) probably benign Het
Vmn2r90 T C 17: 17,953,771 (GRCm39) I645T probably damaging Het
Vps18 T C 2: 119,124,132 (GRCm39) V353A possibly damaging Het
Vwf C T 6: 125,576,326 (GRCm39) Q469* probably null Het
Other mutations in Tmco3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00824:Tmco3 APN 8 13,342,825 (GRCm39) missense probably damaging 1.00
IGL01139:Tmco3 APN 8 13,369,887 (GRCm39) missense possibly damaging 0.92
IGL02116:Tmco3 APN 8 13,342,706 (GRCm39) unclassified probably benign
Ganado UTSW 8 13,342,077 (GRCm39) splice site probably null
R0244:Tmco3 UTSW 8 13,342,037 (GRCm39) missense probably damaging 1.00
R0385:Tmco3 UTSW 8 13,346,027 (GRCm39) missense probably damaging 1.00
R0711:Tmco3 UTSW 8 13,342,039 (GRCm39) missense probably damaging 0.96
R1594:Tmco3 UTSW 8 13,342,052 (GRCm39) missense probably damaging 0.98
R1727:Tmco3 UTSW 8 13,368,866 (GRCm39) missense possibly damaging 0.52
R1752:Tmco3 UTSW 8 13,341,741 (GRCm39) missense probably benign
R2375:Tmco3 UTSW 8 13,342,059 (GRCm39) missense possibly damaging 0.72
R2850:Tmco3 UTSW 8 13,345,024 (GRCm39) missense probably benign 0.00
R3843:Tmco3 UTSW 8 13,346,114 (GRCm39) splice site probably benign
R4003:Tmco3 UTSW 8 13,341,959 (GRCm39) missense probably damaging 0.96
R4059:Tmco3 UTSW 8 13,370,848 (GRCm39) missense probably benign 0.27
R5071:Tmco3 UTSW 8 13,342,860 (GRCm39) nonsense probably null
R5072:Tmco3 UTSW 8 13,342,860 (GRCm39) nonsense probably null
R5456:Tmco3 UTSW 8 13,369,815 (GRCm39) missense probably damaging 0.96
R5556:Tmco3 UTSW 8 13,344,870 (GRCm39) missense probably damaging 0.99
R5826:Tmco3 UTSW 8 13,360,314 (GRCm39) missense probably damaging 0.99
R6200:Tmco3 UTSW 8 13,342,077 (GRCm39) splice site probably null
R6586:Tmco3 UTSW 8 13,370,894 (GRCm39) utr 3 prime probably benign
R6858:Tmco3 UTSW 8 13,363,924 (GRCm39) missense probably damaging 1.00
R6867:Tmco3 UTSW 8 13,363,927 (GRCm39) missense probably damaging 1.00
R6944:Tmco3 UTSW 8 13,353,729 (GRCm39) missense probably damaging 1.00
R7082:Tmco3 UTSW 8 13,370,847 (GRCm39) nonsense probably null
R7192:Tmco3 UTSW 8 13,369,605 (GRCm39) splice site probably null
R7283:Tmco3 UTSW 8 13,369,605 (GRCm39) splice site probably null
R7285:Tmco3 UTSW 8 13,369,605 (GRCm39) splice site probably null
R7287:Tmco3 UTSW 8 13,369,605 (GRCm39) splice site probably null
R7314:Tmco3 UTSW 8 13,369,605 (GRCm39) splice site probably null
R7442:Tmco3 UTSW 8 13,370,781 (GRCm39) missense probably damaging 1.00
R8084:Tmco3 UTSW 8 13,353,873 (GRCm39) missense probably damaging 0.96
R8708:Tmco3 UTSW 8 13,345,998 (GRCm39) missense probably benign
R8755:Tmco3 UTSW 8 13,341,782 (GRCm39) missense probably benign
R9156:Tmco3 UTSW 8 13,360,228 (GRCm39) missense possibly damaging 0.79
R9226:Tmco3 UTSW 8 13,360,143 (GRCm39) critical splice acceptor site probably null
Posted On 2016-08-02