Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03115:Fmo9'

419366

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fmo9

Ensembl Gene

ENSMUSG00000026560

Gene Name

flavin containing monooxygenase 9

Synonyms

4831428F09Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

IGL03115

Quality Score

Status

Chromosome

Chromosomal Location

166489624-166509414 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to G at 166505220 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 7 (S7P)

Ref Sequence

ENSEMBL: ENSMUSP00000114750 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000027843] [ENSMUST00000148677]

AlphaFold

Q8C116

Predicted Effect

probably damaging
Transcript: ENSMUST00000027843
AA Change: S58P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000027843
Gene: ENSMUSG00000026560
AA Change: S58P

Domain	Start	End	E-Value	Type
Pfam:FMO-like	3	535	1.2e-252	PFAM
Pfam:Pyr_redox_2	4	262	2.9e-12	PFAM
Pfam:Pyr_redox_3	7	221	2.3e-14	PFAM
Pfam:NAD_binding_8	8	83	1.2e-6	PFAM
Pfam:K_oxygenase	77	334	8.9e-11	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000148677
AA Change: S7P

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000114750
Gene: ENSMUSG00000026560
AA Change: S7P

Domain	Start	End	E-Value	Type
Pfam:FMO-like	1	484	1.6e-222	PFAM
Pfam:Pyr_redox_3	3	170	1.2e-12	PFAM
Pfam:K_oxygenase	28	283	6.2e-11	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 51 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamdec1	T	A	14: 68,808,802 (GRCm39)	H302L	probably damaging	Het
Adamts12	T	A	15: 11,263,422 (GRCm39)	C595S	probably damaging	Het
Arid2	G	A	15: 96,268,154 (GRCm39)	V756I	probably damaging	Het
Asah1	A	T	8: 41,813,336 (GRCm39)	W26R	possibly damaging	Het
Brinp1	C	T	4: 68,822,973 (GRCm39)		probably null	Het
Cers2	A	G	3: 95,228,663 (GRCm39)	D162G	probably damaging	Het
Clasp1	G	T	1: 118,429,053 (GRCm39)	E106*	probably null	Het
Col12a1	T	C	9: 79,588,719 (GRCm39)	E1132G	probably damaging	Het
Dhdds	G	T	4: 133,710,182 (GRCm39)	H196N	probably benign	Het
Eps8	T	C	6: 137,504,379 (GRCm39)	D118G	probably damaging	Het
Gamt	A	G	10: 80,094,272 (GRCm39)	L197P	probably damaging	Het
Grb7	A	G	11: 98,341,945 (GRCm39)	I82V	probably damaging	Het
Hectd2	T	C	19: 36,577,121 (GRCm39)		probably null	Het
Ilk	T	C	7: 105,389,542 (GRCm39)	V83A	probably damaging	Het
Kif21a	T	A	15: 90,869,598 (GRCm39)	I418F	probably damaging	Het
Kndc1	A	G	7: 139,501,425 (GRCm39)	I905V	probably benign	Het
Lyl1	C	T	8: 85,429,300 (GRCm39)	P3L	possibly damaging	Het
Morc3	T	C	16: 93,667,971 (GRCm39)	I710T	probably damaging	Het
Nefm	T	C	14: 68,357,728 (GRCm39)		probably benign	Het
Or10d5	T	C	9: 39,862,040 (GRCm39)	E9G	probably damaging	Het
Or2f2	A	G	6: 42,767,599 (GRCm39)	T209A	probably benign	Het
Or8g23	C	A	9: 38,971,259 (GRCm39)	R234S	probably damaging	Het
Pard6g	T	G	18: 80,123,068 (GRCm39)	L34W	probably damaging	Het
Patj	C	T	4: 98,332,040 (GRCm39)	S562L	probably damaging	Het
Pcsk4	A	G	10: 80,164,883 (GRCm39)	I61T	probably damaging	Het
Pcsk7	T	A	9: 45,825,670 (GRCm39)	H300Q	probably damaging	Het
Pip5kl1	A	G	2: 32,470,033 (GRCm39)	D288G	probably damaging	Het
Plxnb2	T	A	15: 89,046,641 (GRCm39)		probably benign	Het
Poldip2	T	C	11: 78,411,970 (GRCm39)		probably benign	Het
Ralgapa2	T	C	2: 146,266,734 (GRCm39)	Y614C	probably damaging	Het
Rarres1	C	A	3: 67,403,145 (GRCm39)		probably null	Het
Samd3	C	T	10: 26,147,606 (GRCm39)	T427M	probably damaging	Het
Skap1	A	G	11: 96,593,446 (GRCm39)	I98V	probably benign	Het
Skint11	T	C	4: 114,101,820 (GRCm39)	S87P	probably damaging	Het
Slc22a22	T	G	15: 57,126,670 (GRCm39)	E133A	probably damaging	Het
Slc23a2	T	C	2: 131,933,185 (GRCm39)	Y91C	probably damaging	Het
Slc6a20b	T	A	9: 123,426,403 (GRCm39)	E494V	possibly damaging	Het
Slco1a4	A	T	6: 141,765,329 (GRCm39)	D304E	probably benign	Het
Slco1a4	A	C	6: 141,763,585 (GRCm39)	M377R	probably damaging	Het
Srpk2	T	C	5: 23,729,616 (GRCm39)		probably null	Het
Supt3	T	G	17: 45,352,114 (GRCm39)	C271W	probably damaging	Het
Taar7d	C	A	10: 23,903,539 (GRCm39)	F140L	probably benign	Het
Tmbim7	T	C	5: 3,729,158 (GRCm39)	*225Q	probably null	Het
Tpst1	T	C	5: 130,130,752 (GRCm39)	I74T	probably damaging	Het
Utp3	T	C	5: 88,703,179 (GRCm39)	V236A	possibly damaging	Het
Vmn2r55	A	T	7: 12,404,558 (GRCm39)	F282I	probably damaging	Het
Vwa5b1	A	T	4: 138,327,460 (GRCm39)	I372N	possibly damaging	Het
Wtip	C	T	7: 33,824,958 (GRCm39)	A209T	probably damaging	Het
Zbbx	T	C	3: 74,985,867 (GRCm39)	D395G	probably benign	Het
Zfp273	A	T	13: 67,973,769 (GRCm39)	H299L	probably damaging	Het
Zfp459	G	A	13: 67,556,796 (GRCm39)	R96*	probably null	Het

Other mutations in Fmo9

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00886:Fmo9	APN	1	166,507,714 (GRCm39)	splice site	probably null
IGL01796:Fmo9	APN	1	166,490,904 (GRCm39)	missense	probably benign	0.31
IGL03005:Fmo9	APN	1	166,502,088 (GRCm39)	missense	probably benign	0.02
IGL03163:Fmo9	APN	1	166,502,019 (GRCm39)	missense	possibly damaging	0.77
R0089:Fmo9	UTSW	1	166,494,878 (GRCm39)	missense	probably benign	0.05
R0570:Fmo9	UTSW	1	166,502,031 (GRCm39)	missense	probably null	0.00
R1520:Fmo9	UTSW	1	166,495,024 (GRCm39)	missense	probably benign	0.19
R1779:Fmo9	UTSW	1	166,490,868 (GRCm39)	missense	probably benign	0.18
R1783:Fmo9	UTSW	1	166,501,217 (GRCm39)	missense	probably benign	0.01
R2858:Fmo9	UTSW	1	166,501,236 (GRCm39)	missense	probably damaging	1.00
R2859:Fmo9	UTSW	1	166,501,236 (GRCm39)	missense	probably damaging	1.00
R3851:Fmo9	UTSW	1	166,490,936 (GRCm39)	missense	probably benign	0.00
R3924:Fmo9	UTSW	1	166,492,221 (GRCm39)	missense	probably benign	0.03
R4470:Fmo9	UTSW	1	166,507,799 (GRCm39)	missense	probably damaging	1.00
R4728:Fmo9	UTSW	1	166,490,880 (GRCm39)	missense	possibly damaging	0.82
R5538:Fmo9	UTSW	1	166,501,198 (GRCm39)	missense	probably benign	0.01
R5650:Fmo9	UTSW	1	166,491,015 (GRCm39)	missense	probably damaging	1.00
R5820:Fmo9	UTSW	1	166,492,170 (GRCm39)	missense	possibly damaging	0.67
R6163:Fmo9	UTSW	1	166,494,962 (GRCm39)	missense	probably benign
R6229:Fmo9	UTSW	1	166,505,126 (GRCm39)	missense	possibly damaging	0.64
R6243:Fmo9	UTSW	1	166,494,938 (GRCm39)	missense	probably benign	0.45
R6375:Fmo9	UTSW	1	166,492,164 (GRCm39)	critical splice donor site	probably null
R7144:Fmo9	UTSW	1	166,505,189 (GRCm39)	missense	probably benign	0.40
R7236:Fmo9	UTSW	1	166,504,140 (GRCm39)	missense	probably damaging	1.00
R7316:Fmo9	UTSW	1	166,491,215 (GRCm39)	missense	probably benign	0.21
R7341:Fmo9	UTSW	1	166,504,115 (GRCm39)	missense	probably damaging	1.00
R7382:Fmo9	UTSW	1	166,491,229 (GRCm39)	splice site	probably null
R7589:Fmo9	UTSW	1	166,501,997 (GRCm39)	missense	possibly damaging	0.61
R7679:Fmo9	UTSW	1	166,495,058 (GRCm39)	missense	probably benign	0.01
R8110:Fmo9	UTSW	1	166,491,095 (GRCm39)	missense	probably benign	0.03
R8500:Fmo9	UTSW	1	166,502,039 (GRCm39)	missense	probably damaging	1.00
R9098:Fmo9	UTSW	1	166,492,199 (GRCm39)	missense	possibly damaging	0.48
R9301:Fmo9	UTSW	1	166,494,794 (GRCm39)	missense	probably damaging	1.00
R9400:Fmo9	UTSW	1	166,505,243 (GRCm39)	missense	probably benign	0.09
R9401:Fmo9	UTSW	1	166,505,189 (GRCm39)	missense	probably damaging	0.99
Z1088:Fmo9	UTSW	1	166,501,114 (GRCm39)	critical splice donor site	probably null

Posted On

2016-08-02