Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL03347:Zfp953'

419518

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp953

Ensembl Gene

ENSMUSG00000098905

Gene Name

zinc finger protein 953

Synonyms

E130120F12Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.052) question?

Stock #

IGL03347

Quality Score

Status

Chromosome

Chromosomal Location

67487373-67508691 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 67491490 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamine to Leucine at position 154 (Q154L)

Ref Sequence

ENSEMBL: ENSMUSP00000076700 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000044819] [ENSMUST00000081582] [ENSMUST00000166080]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000044819

SMART Domains

Protein: ENSMUSP00000049225
Gene: ENSMUSG00000098781

Domain	Start	End	E-Value	Type
KRAB	5	65	1.15e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000081582
AA Change: Q154L

PolyPhen 2 Score 0.051 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000076700
Gene: ENSMUSG00000098905
AA Change: Q154L

Domain	Start	End	E-Value	Type
KRAB	5	65	1.15e-23	SMART
ZnF_C2H2	81	103	3.11e-2	SMART
ZnF_C2H2	109	131	8.94e-3	SMART
ZnF_C2H2	137	159	6.23e-2	SMART
ZnF_C2H2	165	187	3.63e-3	SMART
ZnF_C2H2	193	215	1.06e-4	SMART
ZnF_C2H2	221	243	7.05e-1	SMART
ZnF_C2H2	249	271	5.42e-2	SMART
ZnF_C2H2	277	299	6.88e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000166080

SMART Domains

Protein: ENSMUSP00000126669
Gene: ENSMUSG00000098692

Domain	Start	End	E-Value	Type
KRAB	2	62	3.07e-33	SMART

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000170543

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts8	T	A	9: 30,870,534 (GRCm39)	S670T	possibly damaging	Het
Adamts9	G	T	6: 92,864,413 (GRCm39)	Y185*	probably null	Het
Ahcyl	A	G	16: 45,974,852 (GRCm39)	V175A	probably benign	Het
Arid3a	T	A	10: 79,787,113 (GRCm39)	S512R	possibly damaging	Het
Atf6b	T	C	17: 34,872,214 (GRCm39)	V524A	probably damaging	Het
Camk2d	A	G	3: 126,590,550 (GRCm39)	T254A	probably damaging	Het
Camsap2	G	T	1: 136,208,724 (GRCm39)	Q923K	possibly damaging	Het
Car10	G	A	11: 92,991,122 (GRCm39)		probably benign	Het
Ccdc39	A	G	3: 33,891,992 (GRCm39)	L160P	probably damaging	Het
Cdh20	A	T	1: 110,065,973 (GRCm39)	D749V	possibly damaging	Het
Cox6a2	A	T	7: 127,804,900 (GRCm39)		probably benign	Het
Cpne1	A	T	2: 155,921,096 (GRCm39)	Y65N	probably damaging	Het
Dnm1	T	C	2: 32,243,199 (GRCm39)	D8G	probably benign	Het
Emsy	A	G	7: 98,259,892 (GRCm39)	S140P	probably damaging	Het
Fam13b	G	A	18: 34,595,104 (GRCm39)		probably benign	Het
Fbn2	T	C	18: 58,146,737 (GRCm39)	R2720G	probably damaging	Het
Fkbpl	A	G	17: 34,865,287 (GRCm39)		probably benign	Het
Gpr179	A	G	11: 97,242,664 (GRCm39)	L60P	probably damaging	Het
Iftap	A	G	2: 101,413,864 (GRCm39)		probably null	Het
Igsf10	A	T	3: 59,239,321 (GRCm39)	S287T	possibly damaging	Het
Kat2b	G	A	17: 53,931,379 (GRCm39)		probably null	Het
Kazald1	A	G	19: 45,066,855 (GRCm39)	D218G	possibly damaging	Het
Mbtd1	A	G	11: 93,814,005 (GRCm39)	E216G	probably benign	Het
Mtmr9	C	A	14: 63,781,016 (GRCm39)	V25L	probably benign	Het
Myo16	A	G	8: 10,426,120 (GRCm39)		probably null	Het
Nfkbil1	A	T	17: 35,439,559 (GRCm39)	V318E	probably damaging	Het
Or2ag15	A	T	7: 106,340,177 (GRCm39)		probably benign	Het
Or5g9	T	C	2: 85,552,151 (GRCm39)	V134A	probably benign	Het
Pidd1	A	G	7: 141,019,081 (GRCm39)	V800A	probably damaging	Het
Ptprs	G	A	17: 56,742,972 (GRCm39)	S390L	probably benign	Het
Ralgapb	G	A	2: 158,307,880 (GRCm39)	V729I	possibly damaging	Het
Sfrp5	T	A	19: 42,187,207 (GRCm39)	M288L	probably benign	Het
Slc26a1	C	A	5: 108,821,676 (GRCm39)	G71V	probably damaging	Het
Srcin1	A	T	11: 97,416,170 (GRCm39)	S1021T	probably damaging	Het
Supt6	A	T	11: 78,123,011 (GRCm39)	M124K	possibly damaging	Het
Thada	A	G	17: 84,705,633 (GRCm39)	F1157S	probably damaging	Het
Tmcc2	A	G	1: 132,285,390 (GRCm39)	S424P	probably damaging	Het
Trim37	G	A	11: 87,092,447 (GRCm39)	R752Q	possibly damaging	Het
Unc80	A	T	1: 66,734,625 (GRCm39)	Q238L	probably damaging	Het
Vmn2r23	C	A	6: 123,681,333 (GRCm39)	H80Q	probably benign	Het
Wnt9a	A	T	11: 59,221,740 (GRCm39)	T213S	probably damaging	Het

Other mutations in Zfp953

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03034:Zfp953	APN	13	67,491,526 (GRCm39)	missense	probably damaging	1.00
R0111:Zfp953	UTSW	13	67,491,139 (GRCm39)	missense	probably damaging	1.00
R1856:Zfp953	UTSW	13	67,493,422 (GRCm39)	missense	probably benign	0.02
R2518:Zfp953	UTSW	13	67,496,003 (GRCm39)	missense	probably damaging	0.99
R3925:Zfp953	UTSW	13	67,496,002 (GRCm39)	missense	probably damaging	0.99
R4777:Zfp953	UTSW	13	67,491,193 (GRCm39)	missense	probably benign	0.42
R5647:Zfp953	UTSW	13	67,491,536 (GRCm39)	missense	possibly damaging	0.90
R6232:Zfp953	UTSW	13	67,491,161 (GRCm39)	missense	possibly damaging	0.94
R6481:Zfp953	UTSW	13	67,496,001 (GRCm39)	nonsense	probably null
R7202:Zfp953	UTSW	13	67,491,706 (GRCm39)	missense	probably benign	0.02
R7543:Zfp953	UTSW	13	67,495,953 (GRCm39)	missense	probably damaging	1.00
R8155:Zfp953	UTSW	13	67,491,535 (GRCm39)	missense	probably damaging	0.99
R8516:Zfp953	UTSW	13	67,493,419 (GRCm39)	missense	possibly damaging	0.55
R9317:Zfp953	UTSW	13	67,491,457 (GRCm39)	missense	possibly damaging	0.79
R9765:Zfp953	UTSW	13	67,491,478 (GRCm39)	missense	possibly damaging	0.63
Z1177:Zfp953	UTSW	13	67,491,067 (GRCm39)	missense	probably damaging	1.00

Posted On

2016-08-02