Incidental Mutation 'R0480:Ttc3'
| ID |
41980 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc3
|
| Ensembl Gene |
ENSMUSG00000040785 |
| Gene Name |
tetratricopeptide repeat domain 3 |
| Synonyms |
D16Ium21e, TPRD, 2610202A04Rik, D16Ium21 |
| MMRRC Submission |
038680-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.597)
|
| Stock # |
R0480 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
16 |
| Chromosomal Location |
94171479-94270081 bp(+) (GRCm39) |
| Type of Mutation |
nonsense |
| DNA Base Change (assembly) |
T to A
at 94232863 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Leucine to Stop codon
at position 986
(L986*)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000156151
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000117648]
[ENSMUST00000122895]
[ENSMUST00000143145]
[ENSMUST00000147046]
[ENSMUST00000147352]
[ENSMUST00000155692]
[ENSMUST00000150346]
[ENSMUST00000151770]
[ENSMUST00000152117]
[ENSMUST00000232660]
[ENSMUST00000231569]
[ENSMUST00000153988]
[ENSMUST00000231850]
[ENSMUST00000232395]
[ENSMUST00000231915]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000101881
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000117648
AA Change: L986*
|
| SMART Domains |
Protein: ENSMUSP00000112801
Gene: ENSMUSG00000040785
AA Change: L986*
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
2e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
low complexity region
|
1170 |
1190 |
N/A |
INTRINSIC |
|
low complexity region
|
1248 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1278 |
1291 |
N/A |
INTRINSIC |
|
coiled coil region
|
1472 |
1570 |
N/A |
INTRINSIC |
|
low complexity region
|
1876 |
1887 |
N/A |
INTRINSIC |
|
RING
|
1931 |
1970 |
7e-9 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000122895
AA Change: L968*
|
| SMART Domains |
Protein: ENSMUSP00000123037
Gene: ENSMUSG00000040785
AA Change: L968*
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000141176
AA Change: L184*
|
| SMART Domains |
Protein: ENSMUSP00000114483
Gene: ENSMUSG00000040785
AA Change: L184*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
28 |
40 |
N/A |
INTRINSIC |
|
coiled coil region
|
72 |
103 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000143145
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000147046
|
| SMART Domains |
Protein: ENSMUSP00000119265
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
5.3e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
low complexity region
|
359 |
382 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000147352
AA Change: L968*
|
| SMART Domains |
Protein: ENSMUSP00000116097
Gene: ENSMUSG00000040785
AA Change: L968*
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
213 |
246 |
3.61e-2 |
SMART |
|
TPR
|
247 |
280 |
3.32e-1 |
SMART |
|
Blast:TPR
|
282 |
314 |
3e-12 |
BLAST |
|
low complexity region
|
426 |
441 |
N/A |
INTRINSIC |
|
TPR
|
558 |
591 |
2.55e-2 |
SMART |
|
low complexity region
|
702 |
714 |
N/A |
INTRINSIC |
|
coiled coil region
|
747 |
778 |
N/A |
INTRINSIC |
|
low complexity region
|
1000 |
1014 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000155692
AA Change: L1005*
|
| SMART Domains |
Protein: ENSMUSP00000122724
Gene: ENSMUSG00000040785
AA Change: L1005*
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
250 |
283 |
3.61e-2 |
SMART |
|
TPR
|
284 |
317 |
3.32e-1 |
SMART |
|
Blast:TPR
|
319 |
351 |
3e-12 |
BLAST |
|
low complexity region
|
463 |
478 |
N/A |
INTRINSIC |
|
TPR
|
595 |
628 |
2.55e-2 |
SMART |
|
low complexity region
|
739 |
751 |
N/A |
INTRINSIC |
|
coiled coil region
|
784 |
815 |
N/A |
INTRINSIC |
|
low complexity region
|
1037 |
1051 |
N/A |
INTRINSIC |
|
low complexity region
|
1055 |
1069 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000150346
AA Change: L585*
|
| SMART Domains |
Protein: ENSMUSP00000122726
Gene: ENSMUSG00000040785
AA Change: L585*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
Pfam:TPR_1
|
175 |
206 |
9.6e-6 |
PFAM |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000151770
AA Change: L986*
|
| SMART Domains |
Protein: ENSMUSP00000121349
Gene: ENSMUSG00000040785
AA Change: L986*
| Domain | Start | End | E-Value | Type |
|---|
|
TPR
|
231 |
264 |
3.61e-2 |
SMART |
|
TPR
|
265 |
298 |
3.32e-1 |
SMART |
|
Blast:TPR
|
300 |
332 |
3e-12 |
BLAST |
|
low complexity region
|
444 |
459 |
N/A |
INTRINSIC |
|
TPR
|
576 |
609 |
2.55e-2 |
SMART |
|
low complexity region
|
720 |
732 |
N/A |
INTRINSIC |
|
coiled coil region
|
765 |
796 |
N/A |
INTRINSIC |
|
low complexity region
|
1018 |
1032 |
N/A |
INTRINSIC |
|
low complexity region
|
1036 |
1050 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000152117
AA Change: L585*
|
| SMART Domains |
Protein: ENSMUSP00000116896
Gene: ENSMUSG00000040785
AA Change: L585*
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
43 |
58 |
N/A |
INTRINSIC |
|
SCOP:d1ihga1
|
69 |
201 |
6e-8 |
SMART |
|
Blast:TPR
|
175 |
208 |
1e-14 |
BLAST |
|
low complexity region
|
319 |
331 |
N/A |
INTRINSIC |
|
coiled coil region
|
364 |
395 |
N/A |
INTRINSIC |
|
low complexity region
|
617 |
631 |
N/A |
INTRINSIC |
|
low complexity region
|
635 |
649 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000232660
AA Change: L986*
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000231569
AA Change: L631*
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000153988
|
| SMART Domains |
Protein: ENSMUSP00000118763
Gene: ENSMUSG00000040785
| Domain | Start | End | E-Value | Type |
|---|
|
Blast:TPR
|
1 |
22 |
3e-6 |
BLAST |
|
low complexity region
|
134 |
149 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231850
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000232395
AA Change: L986*
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000231915
|
| Meta Mutation Damage Score |
0.9755 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.3%
- 20x: 92.6%
|
| Validation Efficiency |
99% (117/118) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 113 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2810021J22Rik |
C |
T |
11: 58,771,012 (GRCm39) |
L165F |
probably damaging |
Het |
| Adamts18 |
A |
G |
8: 114,465,450 (GRCm39) |
V714A |
possibly damaging |
Het |
| Adamtsl1 |
G |
T |
4: 86,171,055 (GRCm39) |
A518S |
probably benign |
Het |
| Adcy2 |
C |
T |
13: 68,880,231 (GRCm39) |
V363M |
probably damaging |
Het |
| Ago4 |
G |
T |
4: 126,419,870 (GRCm39) |
Q36K |
probably benign |
Het |
| Akr1a1 |
A |
G |
4: 116,497,044 (GRCm39) |
V172A |
possibly damaging |
Het |
| Alkbh2 |
T |
A |
5: 114,263,596 (GRCm39) |
N137I |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,715,756 (GRCm39) |
S470T |
probably damaging |
Het |
| Ankrd12 |
T |
C |
17: 66,356,823 (GRCm39) |
T65A |
possibly damaging |
Het |
| Aox1 |
A |
T |
1: 58,082,810 (GRCm39) |
|
probably benign |
Het |
| Arhgap11a |
A |
T |
2: 113,670,163 (GRCm39) |
I320N |
probably benign |
Het |
| Arhgap17 |
G |
A |
7: 122,893,867 (GRCm39) |
H518Y |
probably damaging |
Het |
| Ascc3 |
T |
C |
10: 50,611,348 (GRCm39) |
V1563A |
probably damaging |
Het |
| Atf2 |
G |
A |
2: 73,649,500 (GRCm39) |
|
probably benign |
Het |
| Bmpr2 |
C |
T |
1: 59,884,818 (GRCm39) |
T268I |
probably damaging |
Het |
| Bpifb9a |
A |
G |
2: 154,106,608 (GRCm39) |
I380V |
probably benign |
Het |
| C2cd2 |
G |
A |
16: 97,678,348 (GRCm39) |
T363I |
probably benign |
Het |
| Catsperg2 |
T |
G |
7: 29,420,723 (GRCm39) |
N190H |
probably damaging |
Het |
| Ccdc138 |
T |
C |
10: 58,397,789 (GRCm39) |
L543S |
probably damaging |
Het |
| Ccdc170 |
A |
T |
10: 4,468,939 (GRCm39) |
K162N |
probably benign |
Het |
| Cdca5 |
G |
T |
19: 6,140,328 (GRCm39) |
R163L |
probably damaging |
Het |
| Cdh24 |
A |
G |
14: 54,870,054 (GRCm39) |
F239S |
probably benign |
Het |
| Cdkl3 |
T |
C |
11: 51,895,882 (GRCm39) |
V43A |
probably damaging |
Het |
| Cep152 |
G |
T |
2: 125,423,639 (GRCm39) |
Q921K |
possibly damaging |
Het |
| Cftr |
G |
A |
6: 18,274,517 (GRCm39) |
|
probably benign |
Het |
| Chmp5 |
T |
C |
4: 40,948,690 (GRCm39) |
|
probably benign |
Het |
| Cit |
T |
A |
5: 116,071,452 (GRCm39) |
|
probably benign |
Het |
| Cngb3 |
T |
A |
4: 19,309,517 (GRCm39) |
|
probably benign |
Het |
| Cnr2 |
A |
G |
4: 135,644,912 (GRCm39) |
E330G |
probably benign |
Het |
| Cyp21a1 |
A |
T |
17: 35,020,800 (GRCm39) |
L473Q |
probably damaging |
Het |
| Dchs1 |
T |
C |
7: 105,420,696 (GRCm39) |
T575A |
probably benign |
Het |
| Dedd2 |
A |
G |
7: 24,903,050 (GRCm39) |
V303A |
probably damaging |
Het |
| Dmd |
G |
T |
X: 83,469,344 (GRCm39) |
A2370S |
probably benign |
Het |
| Dnah10 |
T |
A |
5: 124,885,915 (GRCm39) |
N3009K |
probably damaging |
Het |
| Dnajc13 |
G |
T |
9: 104,077,708 (GRCm39) |
N934K |
probably damaging |
Het |
| Dock1 |
C |
T |
7: 134,339,447 (GRCm39) |
L106F |
probably damaging |
Het |
| Fat3 |
A |
G |
9: 15,909,025 (GRCm39) |
Y2326H |
probably benign |
Het |
| Fhl5 |
A |
T |
4: 25,207,101 (GRCm39) |
C222* |
probably null |
Het |
| Gnmt |
T |
C |
17: 47,036,854 (GRCm39) |
T252A |
probably benign |
Het |
| Gpi-ps |
A |
G |
8: 5,689,888 (GRCm39) |
|
noncoding transcript |
Het |
| Gsta5 |
C |
T |
9: 78,210,099 (GRCm39) |
A135V |
probably benign |
Het |
| Gtf2f1 |
A |
G |
17: 57,311,307 (GRCm39) |
|
probably null |
Het |
| Gtf3a |
T |
C |
5: 146,890,039 (GRCm39) |
Y187H |
probably damaging |
Het |
| Hdac2 |
A |
G |
10: 36,850,788 (GRCm39) |
Y14C |
probably damaging |
Het |
| Hnrnph1 |
T |
G |
11: 50,276,589 (GRCm39) |
|
probably benign |
Het |
| Homer2 |
T |
C |
7: 81,268,351 (GRCm39) |
D92G |
possibly damaging |
Het |
| Hspg2 |
T |
C |
4: 137,277,335 (GRCm39) |
S2885P |
probably damaging |
Het |
| Insr |
A |
G |
8: 3,211,770 (GRCm39) |
S1084P |
probably damaging |
Het |
| Ints11 |
T |
A |
4: 155,972,081 (GRCm39) |
V362E |
probably damaging |
Het |
| Kank2 |
T |
C |
9: 21,691,195 (GRCm39) |
N513S |
probably damaging |
Het |
| Kl |
T |
G |
5: 150,876,753 (GRCm39) |
V191G |
probably damaging |
Het |
| Krt23 |
A |
G |
11: 99,377,524 (GRCm39) |
|
probably null |
Het |
| Lama3 |
A |
C |
18: 12,583,481 (GRCm39) |
T690P |
possibly damaging |
Het |
| Lamb1 |
G |
A |
12: 31,332,720 (GRCm39) |
A281T |
possibly damaging |
Het |
| Lck |
T |
C |
4: 129,449,433 (GRCm39) |
E299G |
probably damaging |
Het |
| Lonrf1 |
A |
G |
8: 36,689,864 (GRCm39) |
V703A |
probably damaging |
Het |
| Ly6f |
T |
C |
15: 75,143,526 (GRCm39) |
C78R |
probably damaging |
Het |
| Mapkap1 |
C |
T |
2: 34,423,793 (GRCm39) |
|
probably benign |
Het |
| Mast1 |
T |
A |
8: 85,639,718 (GRCm39) |
I1204F |
probably damaging |
Het |
| Mbd6 |
C |
T |
10: 127,121,742 (GRCm39) |
|
probably benign |
Het |
| Mef2c |
A |
T |
13: 83,741,020 (GRCm39) |
T60S |
probably damaging |
Het |
| Mgat4c |
C |
T |
10: 102,224,980 (GRCm39) |
T398I |
probably damaging |
Het |
| Mmp12 |
C |
A |
9: 7,350,016 (GRCm39) |
H102Q |
probably damaging |
Het |
| Mmp20 |
G |
A |
9: 7,645,374 (GRCm39) |
G308E |
probably damaging |
Het |
| Mms19 |
A |
T |
19: 41,943,285 (GRCm39) |
L395Q |
probably damaging |
Het |
| Mus81 |
A |
G |
19: 5,537,959 (GRCm39) |
|
probably benign |
Het |
| Mypn |
C |
T |
10: 63,028,982 (GRCm39) |
R27H |
probably benign |
Het |
| Nav3 |
T |
C |
10: 109,689,161 (GRCm39) |
E372G |
probably damaging |
Het |
| Ncoa1 |
T |
A |
12: 4,389,105 (GRCm39) |
I57F |
probably damaging |
Het |
| Ncstn |
T |
C |
1: 171,910,159 (GRCm39) |
|
probably benign |
Het |
| Nefm |
C |
T |
14: 68,361,608 (GRCm39) |
D219N |
probably damaging |
Het |
| Notch2 |
C |
T |
3: 98,053,853 (GRCm39) |
T2172I |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 59,024,772 (GRCm39) |
K423* |
probably null |
Het |
| Or51l14 |
A |
G |
7: 103,100,835 (GRCm39) |
N97S |
probably benign |
Het |
| Or5d37 |
A |
C |
2: 87,923,972 (GRCm39) |
S103A |
probably benign |
Het |
| Or5k1 |
T |
C |
16: 58,617,684 (GRCm39) |
N175S |
probably benign |
Het |
| Or9a2 |
A |
T |
6: 41,749,198 (GRCm39) |
C12S |
probably benign |
Het |
| Ostm1 |
T |
A |
10: 42,572,343 (GRCm39) |
M242K |
probably damaging |
Het |
| Oxnad1 |
T |
A |
14: 31,821,437 (GRCm39) |
I154N |
probably damaging |
Het |
| Pcdhb10 |
T |
A |
18: 37,546,152 (GRCm39) |
D409E |
probably damaging |
Het |
| Pdcd11 |
T |
C |
19: 47,113,476 (GRCm39) |
|
probably benign |
Het |
| Peak1 |
C |
A |
9: 56,165,916 (GRCm39) |
V671L |
probably benign |
Het |
| Pex1 |
G |
A |
5: 3,656,444 (GRCm39) |
|
probably null |
Het |
| Plk4 |
T |
A |
3: 40,760,075 (GRCm39) |
F324I |
probably benign |
Het |
| Poglut2 |
C |
T |
1: 44,149,917 (GRCm39) |
W424* |
probably null |
Het |
| Ppfibp1 |
C |
A |
6: 146,920,529 (GRCm39) |
|
probably null |
Het |
| Prcp |
T |
A |
7: 92,568,290 (GRCm39) |
W276R |
probably damaging |
Het |
| Prr14l |
T |
C |
5: 32,987,224 (GRCm39) |
E757G |
probably benign |
Het |
| Prss52 |
T |
A |
14: 64,351,093 (GRCm39) |
Y293N |
probably damaging |
Het |
| Prune2 |
A |
G |
19: 16,984,156 (GRCm39) |
|
probably benign |
Het |
| Ptprk |
G |
C |
10: 28,461,943 (GRCm39) |
A84P |
probably damaging |
Het |
| Ptprk |
C |
T |
10: 28,461,944 (GRCm39) |
A84V |
probably damaging |
Het |
| Rock1 |
A |
G |
18: 10,079,120 (GRCm39) |
L1116P |
possibly damaging |
Het |
| Sdha |
A |
T |
13: 74,475,452 (GRCm39) |
F526Y |
probably benign |
Het |
| Sema4b |
T |
C |
7: 79,869,954 (GRCm39) |
F414S |
probably damaging |
Het |
| Serpina12 |
T |
C |
12: 104,001,960 (GRCm39) |
D252G |
probably damaging |
Het |
| Siglecg |
C |
T |
7: 43,060,550 (GRCm39) |
A310V |
probably benign |
Het |
| Slc30a8 |
A |
G |
15: 52,188,966 (GRCm39) |
I194V |
probably benign |
Het |
| Spred3 |
A |
G |
7: 28,862,400 (GRCm39) |
S148P |
probably damaging |
Het |
| Taf9b |
A |
G |
X: 105,262,014 (GRCm39) |
S58P |
probably damaging |
Het |
| Tgm4 |
A |
T |
9: 122,891,484 (GRCm39) |
Y109F |
probably benign |
Het |
| Tmprss11c |
T |
G |
5: 86,385,468 (GRCm39) |
|
probably benign |
Het |
| Tmtc3 |
A |
T |
10: 100,307,266 (GRCm39) |
V246D |
probably damaging |
Het |
| Tnip1 |
C |
T |
11: 54,828,820 (GRCm39) |
G116R |
probably damaging |
Het |
| Tpr |
A |
G |
1: 150,303,992 (GRCm39) |
E1455G |
possibly damaging |
Het |
| Txndc15 |
A |
G |
13: 55,872,436 (GRCm39) |
I275V |
possibly damaging |
Het |
| Ugt2b1 |
T |
A |
5: 87,074,315 (GRCm39) |
I15L |
probably benign |
Het |
| Upf2 |
T |
C |
2: 5,962,445 (GRCm39) |
V49A |
possibly damaging |
Het |
| Vmn1r117 |
G |
A |
7: 20,617,371 (GRCm39) |
P226S |
probably benign |
Het |
| Vmn2r28 |
A |
T |
7: 5,493,456 (GRCm39) |
H163Q |
probably benign |
Het |
| Vstm2a |
T |
A |
11: 16,213,240 (GRCm39) |
S208R |
probably damaging |
Het |
| Zfp346 |
T |
A |
13: 55,260,910 (GRCm39) |
C79* |
probably null |
Het |
| Zfp628 |
A |
T |
7: 4,924,615 (GRCm39) |
T946S |
probably benign |
Het |
|
| Other mutations in Ttc3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00944:Ttc3
|
APN |
16 |
94,227,620 (GRCm39) |
splice site |
probably null |
|
|
IGL00979:Ttc3
|
APN |
16 |
94,257,577 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01520:Ttc3
|
APN |
16 |
94,191,066 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL01663:Ttc3
|
APN |
16 |
94,210,590 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01720:Ttc3
|
APN |
16 |
94,186,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01736:Ttc3
|
APN |
16 |
94,243,386 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02045:Ttc3
|
APN |
16 |
94,210,540 (GRCm39) |
splice site |
probably benign |
|
|
IGL02203:Ttc3
|
APN |
16 |
94,219,457 (GRCm39) |
splice site |
probably benign |
|
|
IGL02327:Ttc3
|
APN |
16 |
94,248,967 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02794:Ttc3
|
APN |
16 |
94,268,785 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02898:Ttc3
|
APN |
16 |
94,220,285 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4378001:Ttc3
|
UTSW |
16 |
94,211,765 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0064:Ttc3
|
UTSW |
16 |
94,223,106 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0098:Ttc3
|
UTSW |
16 |
94,191,124 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0112:Ttc3
|
UTSW |
16 |
94,186,181 (GRCm39) |
splice site |
probably benign |
|
|
R0135:Ttc3
|
UTSW |
16 |
94,263,127 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0513:Ttc3
|
UTSW |
16 |
94,227,071 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0532:Ttc3
|
UTSW |
16 |
94,188,189 (GRCm39) |
splice site |
probably benign |
|
|
R0607:Ttc3
|
UTSW |
16 |
94,257,644 (GRCm39) |
nonsense |
probably null |
|
|
R0742:Ttc3
|
UTSW |
16 |
94,260,739 (GRCm39) |
missense |
probably benign |
0.23 |
|
R0905:Ttc3
|
UTSW |
16 |
94,257,648 (GRCm39) |
nonsense |
probably null |
|
|
R1118:Ttc3
|
UTSW |
16 |
94,217,127 (GRCm39) |
splice site |
probably benign |
|
|
R1355:Ttc3
|
UTSW |
16 |
94,219,496 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1370:Ttc3
|
UTSW |
16 |
94,219,496 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1486:Ttc3
|
UTSW |
16 |
94,248,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1598:Ttc3
|
UTSW |
16 |
94,223,156 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1641:Ttc3
|
UTSW |
16 |
94,244,176 (GRCm39) |
missense |
probably benign |
0.19 |
|
R2092:Ttc3
|
UTSW |
16 |
94,243,691 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2232:Ttc3
|
UTSW |
16 |
94,260,831 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2339:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2342:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2842:Ttc3
|
UTSW |
16 |
94,232,857 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3117:Ttc3
|
UTSW |
16 |
94,243,422 (GRCm39) |
missense |
possibly damaging |
0.51 |
|
R4194:Ttc3
|
UTSW |
16 |
94,223,136 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4329:Ttc3
|
UTSW |
16 |
94,267,820 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4431:Ttc3
|
UTSW |
16 |
94,211,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4530:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4531:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4532:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4533:Ttc3
|
UTSW |
16 |
94,267,736 (GRCm39) |
intron |
probably benign |
|
|
R4588:Ttc3
|
UTSW |
16 |
94,243,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4625:Ttc3
|
UTSW |
16 |
94,189,131 (GRCm39) |
nonsense |
probably null |
|
|
R4676:Ttc3
|
UTSW |
16 |
94,243,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc3
|
UTSW |
16 |
94,240,100 (GRCm39) |
splice site |
probably null |
|
|
R4856:Ttc3
|
UTSW |
16 |
94,191,142 (GRCm39) |
missense |
probably benign |
0.32 |
|
R4867:Ttc3
|
UTSW |
16 |
94,255,374 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4885:Ttc3
|
UTSW |
16 |
94,220,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4885:Ttc3
|
UTSW |
16 |
94,227,690 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4899:Ttc3
|
UTSW |
16 |
94,230,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4997:Ttc3
|
UTSW |
16 |
94,253,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5023:Ttc3
|
UTSW |
16 |
94,230,218 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5105:Ttc3
|
UTSW |
16 |
94,267,793 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R5205:Ttc3
|
UTSW |
16 |
94,248,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R5287:Ttc3
|
UTSW |
16 |
94,260,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5338:Ttc3
|
UTSW |
16 |
94,184,900 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5347:Ttc3
|
UTSW |
16 |
94,230,479 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5403:Ttc3
|
UTSW |
16 |
94,260,703 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5460:Ttc3
|
UTSW |
16 |
94,258,241 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5739:Ttc3
|
UTSW |
16 |
94,240,183 (GRCm39) |
nonsense |
probably null |
|
|
R6242:Ttc3
|
UTSW |
16 |
94,243,554 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6253:Ttc3
|
UTSW |
16 |
94,258,272 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6455:Ttc3
|
UTSW |
16 |
94,219,482 (GRCm39) |
start codon destroyed |
probably null |
0.83 |
|
R6559:Ttc3
|
UTSW |
16 |
94,223,208 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6564:Ttc3
|
UTSW |
16 |
94,243,470 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6932:Ttc3
|
UTSW |
16 |
94,244,312 (GRCm39) |
missense |
probably benign |
|
|
R7331:Ttc3
|
UTSW |
16 |
94,195,218 (GRCm39) |
missense |
probably benign |
0.27 |
|
R7497:Ttc3
|
UTSW |
16 |
94,219,541 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7610:Ttc3
|
UTSW |
16 |
94,228,697 (GRCm39) |
missense |
probably benign |
0.11 |
|
R7738:Ttc3
|
UTSW |
16 |
94,188,241 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7970:Ttc3
|
UTSW |
16 |
94,258,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8052:Ttc3
|
UTSW |
16 |
94,268,848 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8087:Ttc3
|
UTSW |
16 |
94,243,812 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8309:Ttc3
|
UTSW |
16 |
94,267,838 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8320:Ttc3
|
UTSW |
16 |
94,219,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8322:Ttc3
|
UTSW |
16 |
94,255,351 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8518:Ttc3
|
UTSW |
16 |
94,258,238 (GRCm39) |
missense |
probably benign |
0.21 |
|
R8670:Ttc3
|
UTSW |
16 |
94,191,067 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8826:Ttc3
|
UTSW |
16 |
94,232,829 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R8868:Ttc3
|
UTSW |
16 |
94,252,002 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8873:Ttc3
|
UTSW |
16 |
94,243,842 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8940:Ttc3
|
UTSW |
16 |
94,230,358 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R8993:Ttc3
|
UTSW |
16 |
94,228,667 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R9068:Ttc3
|
UTSW |
16 |
94,204,219 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9119:Ttc3
|
UTSW |
16 |
94,192,950 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9124:Ttc3
|
UTSW |
16 |
94,236,389 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9129:Ttc3
|
UTSW |
16 |
94,185,208 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9189:Ttc3
|
UTSW |
16 |
94,268,831 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R9217:Ttc3
|
UTSW |
16 |
94,230,467 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R9490:Ttc3
|
UTSW |
16 |
94,245,360 (GRCm39) |
missense |
probably benign |
|
|
R9564:Ttc3
|
UTSW |
16 |
94,248,918 (GRCm39) |
missense |
probably benign |
0.07 |
|
R9631:Ttc3
|
UTSW |
16 |
94,171,581 (GRCm39) |
intron |
probably benign |
|
|
X0022:Ttc3
|
UTSW |
16 |
94,243,384 (GRCm39) |
missense |
probably benign |
0.00 |
|
Y5378:Ttc3
|
UTSW |
16 |
94,212,988 (GRCm39) |
splice site |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACTCGGTACGGAGCATCTCTCAAG -3'
(R):5'- AGCAGTTAGCACGGAAGAATCACAC -3'
Sequencing Primer
(F):5'- CAAGGAGCTTGATTTCCACG -3'
(R):5'- tccctcccctccccctc -3'
|
| Posted On |
2013-05-23 |
Incidental Mutation